LOCUS       NM_144972               2555 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens lactate dehydrogenase A like 6A (LDHAL6A), transcript
            variant 1, mRNA.
ACCESSION   NM_144972
VERSION     NM_144972.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2555)
  AUTHORS   Chen,X., Gu,X., Shan,Y., Tang,W., Yuan,J., Zhong,Z., Wang,Y.,
            Huang,W., Wan,B. and Yu,L.
  TITLE     Identification of a novel human lactate dehydrogenase gene LDHAL6A,
            which activates transcriptional activities of AP1(PMA)
  JOURNAL   Mol Biol Rep 36 (4), 669-676 (2009)
   PUBMED   18351441
  REMARK    GeneRIF: expression of LDHAL6A was able to activate transcriptional
            activities of AP1(PMA)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC027544.11 and AY581313.1.
            
            On May 17, 2019 this sequence version replaced NM_144972.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The extent of this RefSeq is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131523.1, SRR1803614.178101.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145240
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000280706.3/ ENSP00000280706.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-816               AC027544.11        159216-160031       c
            817-2277            AY581313.1         253-1713
            2278-2555           AC027544.11        136286-136563       c
FEATURES             Location/Qualifiers
     source          1..2555
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..2555
                     /gene="LDHAL6A"
                     /gene_synonym="LDH6A"
                     /note="lactate dehydrogenase A like 6A"
                     /db_xref="GeneID:160287"
                     /db_xref="HGNC:HGNC:28335"
                     /db_xref="MIM:618928"
     exon            1..951
                     /gene="LDHAL6A"
                     /gene_synonym="LDH6A"
                     /inference="alignment:Splign:2.1.0"
     CDS             826..1824
                     /gene="LDHAL6A"
                     /gene_synonym="LDH6A"
                     /EC_number="1.1.1.27"
                     /note="LDHA-like protein 6A"
                     /codon_start=1
                     /product="L-lactate dehydrogenase A-like 6A"
                     /protein_id="NP_659409.2"
                     /db_xref="CCDS:CCDS7841.1"
                     /db_xref="GeneID:160287"
                     /db_xref="HGNC:HGNC:28335"
                     /db_xref="MIM:618928"
                     /translation="MATIKSELIKNFAEEEAIHHNKISIVGTGSVGVACAISILLKGL
                     SDELVLVDVDEGKLKGETMDLQHGSPFMKMPNIVSSKDYLVTANSNLVIITAGARQKK
                     GETRLDLVQRNVSIFKLMIPNITQYSPHCKLLIVTNPVDILTYVAWKLSGFPKNRVIG
                     SGCNLDSARFRYFIGQRLGIHSESCHGLILGEHGDSSVPVWSGVNIAGVPLKDLNPDI
                     GTDKDPEQWENVHKKVISSGYEMVKMKGYTSWGISLSVADLTESILKNLRRVHPVSTL
                     SKGLYGINEDIFLSVPCILGENGITDLIKVKLTLEEEACLQKSAETLWEIQKELKL"
     exon            952..1069
                     /gene="LDHAL6A"
                     /gene_synonym="LDH6A"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1243
                     /gene="LDHAL6A"
                     /gene_synonym="LDH6A"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1417
                     /gene="LDHAL6A"
                     /gene_synonym="LDH6A"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1535
                     /gene="LDHAL6A"
                     /gene_synonym="LDH6A"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1659
                     /gene="LDHAL6A"
                     /gene_synonym="LDH6A"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..2555
                     /gene="LDHAL6A"
                     /gene_synonym="LDH6A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1896..1901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LDHAL6A"
                     /gene_synonym="LDH6A"
                     /note="hexamer: AATAAA"
     polyA_site      1926
                     /gene="LDHAL6A"
                     /gene_synonym="LDH6A"
                     /note="major polyA site"
     regulatory      2478..2483
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LDHAL6A"
                     /gene_synonym="LDH6A"
                     /note="hexamer: AATAAA"
     polyA_site      2503
                     /gene="LDHAL6A"
                     /gene_synonym="LDH6A"
ORIGIN      
        1 gcttccggcc tcacacctgc caagcatcac acctgccaag catcacacct gccaagcatc
       61 acacctgcca agcatcacac ctgcgatgcc tgcacgagct gggtgcggtc cgcgcagctg
      121 cagtaagggg gcgacccggc gtctgttagt cggcggttca tctccttcgt gcctcgatga
      181 gctttaacgc cattttcctc cattctcttt cttcacctct tgagtgagtg gccatgagct
      241 gggctgcaag agtcctgggg agcagccaga gagcgggcgc cgcgggagcg aattgttttt
      301 gcccaaggat ggttctgtgt ctccgccagg cggcatgtga cctgctcggg cgcgggtggc
      361 ccttcacccc tgtgagtgtg gccagaagta cctctcacct ggacctgcgg accccgggcg
      421 cagtcctgga gctgagaact ggaggttggg ggaacagcag ggtaaagggg agagaaaagg
      481 gggtcagctg cgggacggag tgccgtccca gctgtagttt catgtttggt ggagcaaccc
      541 ctgttccttt cctctctctc tctcttaatt cctcttaact gtactcacgc ttccttctcc
      601 ttcccctggt ccgcttcatg gatgctgagc tgcctggcca gaacctaccc agcttctttg
      661 ctggtcagat ttgtcggtct tttgtgtgtc tgcagcacct ccttccacac gggcccagga
      721 gttctctata cgcgctctca ccgcaggtct tggaattcca agccatttcc aattccaggt
      781 cttggaaatg gctgtgcaat ttgtcttcac tgttaggttt ccaagatggc aactatcaag
      841 agtgaactta ttaagaattt cgcggaagag gaggccattc atcacaataa gatctccatt
      901 gtaggaactg gatcggttgg tgtggcttgt gctatcagca tcttattaaa aggtttgagt
      961 gatgaacttg tccttgtgga tgttgatgaa ggcaaactga agggtgagac aatggatctt
     1021 caacatggca gcccttttat gaaaatgcca aatattgtct ccagcaaaga ttacctggtc
     1081 actgcaaact ccaatctagt gattatcaca gcaggtgcac gccagaaaaa aggagaaaca
     1141 cgccttgatt tagtccagcg aaatgtatcc atctttaaat taatgattcc caatattacc
     1201 cagtacagtc ctcactgcaa actgcttatt gttactaatc cagtggatat cttaacttat
     1261 gtagcctgga agttgagtgg atttcccaaa aaccgtgtta ttggaagtgg ttgtaatctg
     1321 gactctgctc gttttcgtta ctttattggg caaaggcttg gcatccactc tgaaagctgt
     1381 catgggctga tccttggaga gcatggcgac tcaagtgttc ctgtgtggag tggtgtgaac
     1441 attgctggcg tccctctgaa ggatctgaac ccagatatag gaactgataa agatcctgag
     1501 cagtgggaaa atgtccacaa aaaagtgatt tccagtggct atgagatggt caaaatgaaa
     1561 ggttatactt cttggggcat tagcctatct gtagctgatt taacagaaag tattttgaag
     1621 aatcttagga gagtgcatcc agtttctacc ctaagtaagg gcctctatgg aataaatgaa
     1681 gacatattcc ttagtgtccc atgtatcctg ggagagaatg gtatcacaga cctcataaaa
     1741 gtaaaactga ctcttgaaga ggaggcctgc ttgcaaaaga gtgcagaaac actttgggaa
     1801 attcagaagg agctcaagct ttaaagttgc ttaaagctaa ttctgtagat tgaagatgaa
     1861 atagtagtta tggaattgta tatgtcaaac ttttgaataa atttgaattt ctaaaagttg
     1921 gaaaaataga ggaaagagtg acctatttag tatagccttc cagctttttt ttttttcttt
     1981 tttgggaggg tctcattctg tcacccaggc tggagtgcag tggcacaatc atggctcact
     2041 gcaaccttga cctcccgagc tcaggtgagc ctcccacttc agcctccaga gtaggtggga
     2101 ccacatgcgt gtgcctccat gcctgcctaa tttttgtatc tttttgtaga gatggggttt
     2161 tgccatgtca tccaagctgg ttttgaactc ccaaagtgct gagattacag gggtgagcca
     2221 ctgtgcctgg ccttagcttt gatttagtat ccagatgata gatgacactt tttttttttt
     2281 ttttttaaag tgacggcatc aaagatgttt ttggtacttc tcagtacttg ccttgtatgt
     2341 atacgtaatt gccatctggt ccacaagaat gtgtttactg tgttacacaa atcctgattc
     2401 ttttcatcag gtgcatagta attcttctct atggcttaat acctatgttc atttacatgc
     2461 tatctctaca atgtaaaaat aaaagtgtat atatatacac acacacacag agagtaatct
     2521 aaatgttcct aacactagat aaaacattga tttga
//
