LOCUS       NM_007078               5363 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens LIM domain binding 3 (LDB3), transcript variant 1,
            mRNA.
ACCESSION   NM_007078 XM_005269464 XM_084376
VERSION     NM_007078.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5363)
  AUTHORS   Piga,D., Zanotti,S., Ripolone,M., Napoli,L., Ciscato,P.,
            Gibertini,S., Maggi,L., Fortunato,F., Rigamonti,A., Ronchi,D.,
            Comi,G.P., Corti,S. and Sciacco,M.
  TITLE     Association between ZASP/LDB3 Pro26Ser and Inclusion Body Myopathy
  JOURNAL   Int J Mol Sci 25 (12), 6547 (2024)
   PUBMED   38928252
  REMARK    GeneRIF: Association between ZASP/LDB3 Pro26Ser and Inclusion Body
            Myopathy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5363)
  AUTHORS   Koopmann,T.T., Jamshidi,Y., Naghibi-Sistani,M., van der Klift,H.M.,
            Birjandi,H., Al-Hassnan,Z., Alwadai,A., Zifarelli,G.,
            Karimiani,E.G., Sedighzadeh,S., Bahreini,A., Nouri,N., Peter,M.,
            Watanabe,K., van Duyvenvoorde,H.A., Ruivenkamp,C.A.L.,
            Teunissen,A.K.K., Ten Harkel,A.D.J., van Duinen,S.G., Haak,M.C.,
            Prada,C.E., Santen,G.W.E. and Maroofian,R.
  TITLE     Biallelic loss of LDB3 leads to a lethal pediatric dilated
            cardiomyopathy
  JOURNAL   Eur J Hum Genet 31 (1), 97-104 (2023)
   PUBMED   36253531
  REMARK    GeneRIF: Biallelic loss of LDB3 leads to a lethal pediatric dilated
            cardiomyopathy.
REFERENCE   3  (bases 1 to 5363)
  AUTHORS   Cassandrini,D., Merlini,L., Pilla,F., Cenni,V., Santi,S.,
            Faldini,C., Santorelli,F.M. and Sabatelli,P.
  TITLE     Protein aggregates and autophagy involvement in a family with a
            mutation in Z-band alternatively spliced PDZ-motif protein
  JOURNAL   Neuromuscul Disord 31 (1), 44-51 (2021)
   PUBMED   33308939
  REMARK    GeneRIF: Protein aggregates and autophagy involvement in a family
            with a mutation in Z-band alternatively spliced PDZ-motif protein.
REFERENCE   4  (bases 1 to 5363)
  AUTHORS   Wang,D.F., Lyu,J.L., Fang,J., Chen,J., Chen,W.W., Huang,J.Q.,
            Xia,S.D., Jin,J.M., Dong,F.H., Cheng,H.Q., Xu,Y.K. and Guo,X.G.
  TITLE     Impact of LDB3 gene polymorphisms on clinical presentation and
            implantable cardioverter defibrillator (ICD) implantation in
            Chinese patients with idiopathic dilated cardiomyopathy
  JOURNAL   J Zhejiang Univ Sci B 20 (9), 766-775 (2019)
   PUBMED   31379146
  REMARK    GeneRIF: The rs4468255 of LIM domain binding 3 (LDB3) is
            significantly correlated with idiopathic dilated cardiomyopathy of
            Chinese Han population
REFERENCE   5  (bases 1 to 5363)
  AUTHORS   Passier,R., Richardson,J.A. and Olson,E.N.
  TITLE     Oracle, a novel PDZ-LIM domain protein expressed in heart and
            skeletal muscle
  JOURNAL   Mech Dev 92 (2), 277-284 (2000)
   PUBMED   10727866
REFERENCE   6  (bases 1 to 5363)
  AUTHORS   Faulkner,G., Pallavicini,A., Formentin,E., Comelli,A.,
            Ievolella,C., Trevisan,S., Bortoletto,G., Scannapieco,P.,
            Salamon,M., Mouly,V., Valle,G. and Lanfranchi,G.
  TITLE     ZASP: a new Z-band alternatively spliced PDZ-motif protein
  JOURNAL   J Cell Biol 146 (2), 465-475 (1999)
   PUBMED   10427098
REFERENCE   7  (bases 1 to 5363)
  AUTHORS   Zhou,Q., Ruiz-Lozano,P., Martone,M.E. and Chen,J.
  TITLE     Cypher, a striated muscle-restricted PDZ and LIM domain-containing
            protein, binds to alpha-actinin-2 and protein kinase C
  JOURNAL   J Biol Chem 274 (28), 19807-19813 (1999)
   PUBMED   10391924
REFERENCE   8  (bases 1 to 5363)
  AUTHORS   Bowles,K.R., Gajarski,R., Porter,P., Goytia,V., Bachinski,L.,
            Roberts,R., Pignatelli,R. and Towbin,J.A.
  TITLE     Gene mapping of familial autosomal dominant dilated cardiomyopathy
            to chromosome 10q21-23
  JOURNAL   J Clin Invest 98 (6), 1355-1360 (1996)
   PUBMED   8823300
REFERENCE   9  (bases 1 to 5363)
  AUTHORS   Selcen,D. and Engel,A.G.
  TITLE     Myofibrillar Myopathy - RETIRED CHAPTER, FOR HISTORICAL REFERENCE
            ONLY
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301672
REFERENCE   10 (bases 1 to 5363)
  AUTHORS   Hershberger,R.E. and Jordan,E.
  TITLE     Dilated Cardiomyopathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301486
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC067750.5, BC010929.2 and
            AB014513.1.
            
            On or before Jan 10, 2019 this sequence version replaced
            XM_005269464.4, NM_007078.2.
            
            Summary: This gene encodes a PDZ domain-containing protein. PDZ
            motifs are modular protein-protein interaction domains consisting
            of 80-120 amino acid residues. PDZ domain-containing proteins
            interact with each other in cytoskeletal assembly or with other
            proteins involved in targeting and clustering of membrane proteins.
            The protein encoded by this gene interacts with alpha-actinin-2
            through its N-terminal PDZ domain and with protein kinase C via its
            C-terminal LIM domains. The LIM domain is a cysteine-rich motif
            defined by 50-60 amino acids containing two zinc-binding modules.
            This protein also interacts with all three members of the myozenin
            family. Mutations in this gene have been associated with
            myofibrillar myopathy and dilated cardiomyopathy. Alternatively
            spliced transcript variants encoding different isoforms have been
            identified; all isoforms have N-terminal PDZ domains while only
            longer isoforms (1, 2 and 5) have C-terminal LIM domains. [provided
            by RefSeq, Jan 2010].
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AB014513.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA1968540, SAMEA2145245 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361373.9/ ENSP00000355296.3
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AC067750.5         142703-142762       c
            61-71               BC010929.2         3-13
            72-4007             AB014513.1         10-3945
            4008-5363           AC067750.5         75201-76556         c
FEATURES             Location/Qualifiers
     source          1..5363
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q23.2"
     gene            1..5363
                     /gene="LDB3"
                     /gene_synonym="CMD1C; CMH24; CMPD3; CYPHER; LDB3Z1;
                     LDB3Z4; LVNC3; MFM4; ORACLE; PDLIM6; ZASP"
                     /note="LIM domain binding 3"
                     /db_xref="GeneID:11155"
                     /db_xref="HGNC:HGNC:15710"
                     /db_xref="MIM:605906"
     exon            1..60
                     /gene="LDB3"
                     /gene_synonym="CMD1C; CMH24; CMPD3; CYPHER; LDB3Z1;
                     LDB3Z4; LVNC3; MFM4; ORACLE; PDLIM6; ZASP"
                     /inference="alignment:Splign:2.1.0"
     exon            61..176
                     /gene="LDB3"
                     /gene_synonym="CMD1C; CMH24; CMPD3; CYPHER; LDB3Z1;
                     LDB3Z4; LVNC3; MFM4; ORACLE; PDLIM6; ZASP"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..2267
                     /gene="LDB3"
                     /gene_synonym="CMD1C; CMH24; CMPD3; CYPHER; LDB3Z1;
                     LDB3Z4; LVNC3; MFM4; ORACLE; PDLIM6; ZASP"
                     /note="isoform 1 is encoded by transcript variant 1; PDZ
                     and LIM domain 6; Z-band alternatively spliced PDZ-motif
                     protein; LIM domain-binding protein 3; protein cypher;
                     cardiomyopathy, dilated 1C (autosomal dominant)"
                     /codon_start=1
                     /product="LIM domain-binding protein 3 isoform 1"
                     /protein_id="NP_009009.1"
                     /db_xref="CCDS:CCDS7377.1"
                     /db_xref="GeneID:11155"
                     /db_xref="HGNC:HGNC:15710"
                     /db_xref="MIM:605906"
                     /translation="MSYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLS
                     QGDLVVAIDGVNTDTMTHLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTPLPV
                     IPHQKDPALDTNGSLVAPSPSPEARASPGTPGTPELRPTFSPAFSRPSAFSSLAEASD
                     PGPPRASLRAKTSPEGARDLLGPKALPGSSQPRQYNNPIGLYSAETLREMAQMYQMSL
                     RGKASGVGLPGGSLPIKDLAVDSASPVYQAVIKSQNKPEDEADEWARRSSNLQSRSFR
                     ILAQMTGTEFMQDPDEEALRRSSTPIEHAPVCTSQATTPLLPASAQPPAAASPSAASP
                     PLATAAAHTAIASASTTAPASSPADSPRPQASSYSPAVAASSAPATHTSYSEGPAAPA
                     PKPRVVTTASIRPSVYQPVPASTYSPSPGANYSPTPYTPSPAPAYTPSPAPAYTPSPV
                     PTYTPSPAPAYTPSPAPNYNPAPSVAYSGGPAEPASRPPWVTDDSFSQKFAPGKSTTS
                     ISKQTLPRGGPAYTPAGPQVPPLARGTVQRAERFPASSRTPLCGHCNNVIRGPFLVAM
                     GRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHA
                     LRQTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKF
                     IEALGHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHAHTINL"
     exon            177..328
                     /gene="LDB3"
                     /gene_synonym="CMD1C; CMH24; CMPD3; CYPHER; LDB3Z1;
                     LDB3Z4; LVNC3; MFM4; ORACLE; PDLIM6; ZASP"
                     /inference="alignment:Splign:2.1.0"
     exon            329..404
                     /gene="LDB3"
                     /gene_synonym="CMD1C; CMH24; CMPD3; CYPHER; LDB3Z1;
                     LDB3Z4; LVNC3; MFM4; ORACLE; PDLIM6; ZASP"
                     /inference="alignment:Splign:2.1.0"
     exon            405..772
                     /gene="LDB3"
                     /gene_synonym="CMD1C; CMH24; CMPD3; CYPHER; LDB3Z1;
                     LDB3Z4; LVNC3; MFM4; ORACLE; PDLIM6; ZASP"
                     /inference="alignment:Splign:2.1.0"
     exon            773..942
                     /gene="LDB3"
                     /gene_synonym="CMD1C; CMH24; CMPD3; CYPHER; LDB3Z1;
                     LDB3Z4; LVNC3; MFM4; ORACLE; PDLIM6; ZASP"
                     /inference="alignment:Splign:2.1.0"
     exon            943..979
                     /gene="LDB3"
                     /gene_synonym="CMD1C; CMH24; CMPD3; CYPHER; LDB3Z1;
                     LDB3Z4; LVNC3; MFM4; ORACLE; PDLIM6; ZASP"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1168
                     /gene="LDB3"
                     /gene_synonym="CMD1C; CMH24; CMPD3; CYPHER; LDB3Z1;
                     LDB3Z4; LVNC3; MFM4; ORACLE; PDLIM6; ZASP"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1314
                     /gene="LDB3"
                     /gene_synonym="CMD1C; CMH24; CMPD3; CYPHER; LDB3Z1;
                     LDB3Z4; LVNC3; MFM4; ORACLE; PDLIM6; ZASP"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1759
                     /gene="LDB3"
                     /gene_synonym="CMD1C; CMH24; CMPD3; CYPHER; LDB3Z1;
                     LDB3Z4; LVNC3; MFM4; ORACLE; PDLIM6; ZASP"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1940
                     /gene="LDB3"
                     /gene_synonym="CMD1C; CMH24; CMPD3; CYPHER; LDB3Z1;
                     LDB3Z4; LVNC3; MFM4; ORACLE; PDLIM6; ZASP"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2061
                     /gene="LDB3"
                     /gene_synonym="CMD1C; CMH24; CMPD3; CYPHER; LDB3Z1;
                     LDB3Z4; LVNC3; MFM4; ORACLE; PDLIM6; ZASP"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2177
                     /gene="LDB3"
                     /gene_synonym="CMD1C; CMH24; CMPD3; CYPHER; LDB3Z1;
                     LDB3Z4; LVNC3; MFM4; ORACLE; PDLIM6; ZASP"
                     /inference="alignment:Splign:2.1.0"
     exon            2178..5363
                     /gene="LDB3"
                     /gene_synonym="CMD1C; CMH24; CMPD3; CYPHER; LDB3Z1;
                     LDB3Z4; LVNC3; MFM4; ORACLE; PDLIM6; ZASP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5333..5338
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LDB3"
                     /gene_synonym="CMD1C; CMH24; CMPD3; CYPHER; LDB3Z1;
                     LDB3Z4; LVNC3; MFM4; ORACLE; PDLIM6; ZASP"
                     /note="hexamer: AATAAA"
     polyA_site      5363
                     /gene="LDB3"
                     /gene_synonym="CMD1C; CMH24; CMPD3; CYPHER; LDB3Z1;
                     LDB3Z4; LVNC3; MFM4; ORACLE; PDLIM6; ZASP"
                     /note="major polyA site"
ORIGIN      
        1 attcttagga gcctctcaag agctccacgc agcccggctg ggcagcaagg gacagaacag
       61 aggcggccgc tgacagcacc agcatgtctt acagtgtgac cctgactggg cccgggccct
      121 ggggcttccg tctgcagggg ggcaaggact tcaacatgcc cctcactatc tcccggatca
      181 caccaggcag caaggcagcc cagtcccagc tcagccaggg tgacctcgtg gtggccattg
      241 acggcgtcaa cacagacacc atgacccacc tggaagccca gaacaagatc aagtctgcca
      301 gctacaactt gagcctcacc ctgcagaaat caaagcgtcc cattcccatc tccacgacag
      361 cacctccagt ccagacccct ctgccggtga tccctcacca gaaggacccc gctctggaca
      421 cgaacggcag cctggtggca cccagcccca gccctgaggc gagggccagc ccaggcaccc
      481 caggcacccc ggagctcagg cccaccttta gccctgcctt ctcccggccc tccgccttct
      541 cctcactcgc cgaggcctct gaccctggcc ctccgcgggc cagcctgagg gccaagacca
      601 gcccagaggg ggcccgggac ctactcggcc caaaagccct gccgggctcg agccagccga
      661 ggcaatataa caaccccatt ggcctgtact cggcagagac cctgagggag atggctcaga
      721 tgtaccagat gagcctccga gggaaggcct cgggtgtcgg actcccagga gggagcctcc
      781 ctattaagga ccttgccgta gacagcgcct ctcccgtcta ccaggctgtg attaagagcc
      841 agaacaagcc agaagatgag gctgacgagt gggcacgccg ttcctccaac ctgcagtctc
      901 gctccttccg catcctggcc cagatgacgg ggacagaatt catgcaagac cctgatgaag
      961 aagctctgcg aaggtcaagc acccctattg agcatgcgcc ggtgtgcacc agccaggcca
     1021 ccaccccgct gctgcccgct tctgcccagc cacctgctgc tgcctctccc agtgcggctt
     1081 cgccacccct ggccacagct gctgcccaca ctgccatcgc ctccgcctcc accacagccc
     1141 ctgcttcaag tcctgccgac agcccaaggc cccaggcctc ttcctacagc cccgcagtgg
     1201 ccgcctcttc agcacctgcc acccacacca gctacagtga gggccccgcc gcccctgcac
     1261 ccaagccccg ggttgtcacc actgccagca tccggccttc tgtctaccag ccagtgcctg
     1321 catctaccta cagcccgtcc ccaggggcca attacagtcc cactccctac accccctccc
     1381 ctgcccctgc ctacaccccc tcccctgccc ctgcctacac cccctcacct gtccccacct
     1441 acactccatc cccagcacca gcctataccc cctcacctgc ccccaactat aaccctgcac
     1501 cctcggtggc ctacagcggg ggccctgcgg agcctgccag ccgtccaccc tgggtgacag
     1561 atgatagctt ctcccagaag tttgccccgg gcaagagcac cacctccatc agcaagcaga
     1621 ccctgccccg gggaggccca gcctacaccc cagcgggtcc tcaggtgcca ccacttgcca
     1681 gggggaccgt ccagagggct gagcgattcc cagccagcag ccggactcca ctctgcggtc
     1741 actgcaacaa tgtcatccgg ggcccatttc tggtagccat gggccgttct tggcaccctg
     1801 aagagttcac ctgtgcctac tgcaagactt ccctggcaga tgtgtgcttt gtggaagagc
     1861 agaacaacgt ttactgtgag cgatgttatg agcaattctt tgccccgctg tgtgccaagt
     1921 gcaacaccaa aattatgggg gaagtaatgc atgccttgag acagacatgg cacaccacct
     1981 gcttcgtctg tgcggcctgc aagaagcctt ttgggaacag cctcttccac atggaagacg
     2041 gggagcccta ctgcgagaaa gactacatca atctgttcag caccaagtgc catggctgcg
     2101 atttccccgt ggaggctggc gacaagttta tcgaagccct gggccacact tggcacgaca
     2161 cctgcttcat ttgcgcagtc tgccatgtga atctggaggg gcagccgttc tactccaaga
     2221 aggacagacc cctgtgcaag aagcacgcac acaccatcaa cttgtaggcg gccaaggccg
     2281 cctgtgctga cgaggcccgg agctgctcct gctgctggca acaaaggatt cgggaggctg
     2341 atgtttcttc tgaggggaat ggggagagag aggaagcgac tgagcccttt ggaagtataa
     2401 ttttaggttt tttcttctgt acacagatcg tgcatttgca tagttcagac taggagccaa
     2461 atgaagactc aaaaccaagc tagttattaa tccaagactg gaattgtact tcagacattt
     2521 agagcagaat tccaagaact caaaagtgaa aagcaacaag cagctttccc aaagcgatac
     2581 acttgctttg gtcaccagag gaggacagag cttagagcag ctgtggagaa tctgaagcat
     2641 tctgcggagt tcttaagcgc tcccctggca aacaaattga agtgccaaac agcactcgct
     2701 gcagggtatt tttagagtca tagctgagag cttgttagct aagacccatt gggctttcct
     2761 caccaaaaaa ggaagtgtta ttccattact agcgtcatgg agctacctct gcgcatcaga
     2821 cttcagacct tgaacaaact taaaaccttc ttgggagccc ggacgtccaa agagatgtct
     2881 tctgggagcc actgggcaat tgccagggct ccaggaaggg ctctggctca ggttgcagac
     2941 agctgagaaa agatggccct gtcagccacc ctctctcagt ctgaaacatc caacatcccc
     3001 agaaggctta gctccttttt gaattgtgat gggaaagtag agttgggttt ttccagtttt
     3061 gctctgtggt gtgtgagaga tttttttaaa ggctttgggt tgtctttggc ctttgtttag
     3121 ctttaagggt tcgttagcat gagtgtccag tcgtgtgcat gaatttcacc ccaacttgtg
     3181 actgctcact tatgacgtct cccccagtac cctccatctc aaataggctt ggtggcctgt
     3241 ggaaaagaag agagacagag agacagtgtc tgaaacagga tggcagaata ggctcacatg
     3301 cccaaactct gggtggggaa gaggaaactt actttctgcc accctcagta agaacacacg
     3361 aggaggcagg acctcccacc ttcaggtctg catcatcctt ttcaaatgtt cctttaaatg
     3421 cagcacactg agtttgtaca attgtgttaa ctgctggaag ggacagatgc actgatatat
     3481 atgcatttgc tgttttggcc aatattttga aaatgtatga gctgagttga tctagctatt
     3541 atttaagtat ttattgaagt agaggggcct tcaaactact ttatactagt gatagtttga
     3601 gttaggtaag catcttaaag ctgtttggtg ataaagaagg cagcttagat tctgtggttg
     3661 gaaacagtgt agtcgcttcc ctttttagga agccctgtta atatgctcat tgaaaacatg
     3721 gcattgaagc aggcacttgc gtggatgttt ctcacttgag cacgatattt aggctctctt
     3781 ccaactcact ctattctgtc ctcactcctg ttttggattt ttctctttgc atgtttgaaa
     3841 tgttttatgg gaatgtatta gaactctttt cttctaagga ctgagacttc caggggattg
     3901 ccatcttacc tgtctcttct ccatgaggga gaaggaagca gctagctatg tccctagctg
     3961 caggaagccc ctattttttc caagcacgaa gccaccagtc tcccccaggg agcatcagga
     4021 agggacatgg atgtgctcct gccacagggc ccttcctacc tttggatctg tgagaaggtg
     4081 aatacaaagc agcaggcaga gtaaaatctg ctgggactgc ctggagattt gtcaggagct
     4141 gcagacaagt accttggagc attctgttat ttttggaaag ttcaaatatg cagggacaag
     4201 gaggttgctg actgtactga caggctctaa gtcattttct ccaaaaacta tctattcaat
     4261 tatcaggggc tggtcttgag gaaggaaaaa aaaaaaaaaa cgttcccaga attcagtttc
     4321 caaaatctct ttttaaaggg tttacacaca cacacacaca cacacacaca cacacacaca
     4381 cacacacaca cgatcattaa aaagtgtatg ctctttaaga agaaaagtaa aatatctcaa
     4441 aggacggttt caccaccgtc ctttattgaa tcaatttttc tacatttcag agcaagtgta
     4501 gattctgagg gactcctatt tgccaaaaag acaaaactag caaaaaaaaa acaaaaaaac
     4561 aaaaaaaaaa ccacttaaaa ggtagcagga aaagaaggta gttttgagtg tggttcactc
     4621 agtgtctgtg agtctggtgt agtgtcagga gtaaggccgt gtctagctca agtttacatt
     4681 tggatgtcct acaacactaa acaaaatttt tcataatcca tggtggggag cacactttgg
     4741 agctacattt cttgtctcct cattgttgac attaattaaa catttatagg ccaggcacag
     4801 tggctcacgc ctgttatccc agcactttgg gaggccgagg caggtgaatc acctgaggtc
     4861 aggagtttga aaccagcctg gccaatatgg tgaaacccca tctctactaa aaatacacaa
     4921 aattagccag gtgtggtggc aggcgcctgt agttccagct acttgggagg ctgaggcagg
     4981 aatctcctga atcctggagg cggaggttgc agtgagccga gattatgcca ttgcactcca
     5041 gcctgggcaa caggagcgaa actccgttgc aaaaaaaaaa aaaaaaaaaa aattataatc
     5101 acaacttttt gcaatggagt gacttatatc tgcagcttat atctgcagtg tttgtgttag
     5161 gaacctagct tttataatgt gttaactttt taactcagta ttctggcttt gggatttttt
     5221 gttttgtttt tggaaacatt tcagaagtgg aatgtagcct gttaaaggtg tgcacaaaaa
     5281 tattttgcat gtgttttttt ttttgcctgt gtgaattcta ctttttagca aaaataaagc
     5341 cccccaaagg atgtgcaaat aca
//
