LOCUS       NM_001113407            3098 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens LIM domain binding 1 (LDB1), transcript variant 1,
            mRNA.
ACCESSION   NM_001113407
VERSION     NM_001113407.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3098)
  AUTHORS   Wang,C., Hu,M., Yu,K., Liu,W., Hu,A., Kuang,Y., Huang,L.,
            Gajendran,B., Zacksenhaus,E., Xiao,X. and Ben-David,Y.
  TITLE     An intricate regulatory circuit between FLI1 and
            GATA1/GATA2/LDB1/ERG dictates erythroid vs. megakaryocytic
            differentiation
  JOURNAL   Mol Med Rep 29 (6) (2024)
   PUBMED   38695236
  REMARK    GeneRIF: An intricate regulatory circuit between FLI1 and
            GATA1/GATA2/LDB1/ERG dictates erythroid vs. megakaryocytic
            differentiation.
REFERENCE   2  (bases 1 to 3098)
  AUTHORS   Lu,L., Wang,J., Fang,F., Guo,A., Jiang,S., Tao,Y., Zhang,Y., Li,Y.,
            Zhang,K., Zhang,Z., Zhuo,R., Chu,X., Li,X., Tian,Y., Ma,L.,
            Sang,X., Chen,Y., Yu,J., Yang,Y., Cao,H., Gao,J., Lu,J., Hu,S.,
            Pan,J. and He,H.
  TITLE     LMO2 promotes the development of AML through interaction with
            transcription co-regulator LDB1
  JOURNAL   Cell Death Dis 14 (8), 518 (2023)
   PUBMED   37573405
  REMARK    GeneRIF: LMO2 promotes the development of AML through interaction
            with transcription co-regulator LDB1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3098)
  AUTHORS   Hsu,Y.H., Pintacuda,G., Liu,R., Nacu,E., Kim,A., Tsafou,K.,
            Petrossian,N., Crotty,W., Suh,J.M., Riseman,J., Martin,J.M.,
            Biagini,J.C., Mena,D., Ching,J.K.T., Malolepsza,E., Li,T.,
            Singh,T., Ge,T., Egri,S.B., Tanenbaum,B., Stanclift,C.R.,
            Apffel,A.M., Carr,S.A., Schenone,M., Jaffe,J., Fornelos,N.,
            Huang,H., Eggan,K.C. and Lage,K.
  CONSRTM   Schizophrenia Working Group of the Psychiatric Genomics Consortium;
            Stanley Global Asia Initiatives
  TITLE     Using brain cell-type-specific protein interactomes to interpret
            neurodevelopmental genetic signals in schizophrenia
  JOURNAL   iScience 26 (5), 106701 (2023)
   PUBMED   37207277
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3098)
  AUTHORS   Pintacuda,G., Hsu,Y.H., Tsafou,K., Li,K.W., Martin,J.M.,
            Riseman,J., Biagini,J.C., Ching,J.K.T., Mena,D.,
            Gonzalez-Lozano,M.A., Egri,S.B., Jaffe,J., Smit,A.B., Fornelos,N.,
            Eggan,K.C. and Lage,K.
  TITLE     Protein interaction studies in human induced neurons indicate
            convergent biology underlying autism spectrum disorders
  JOURNAL   Cell Genom 3 (3), 100250 (2023)
   PUBMED   36950384
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3098)
  AUTHORS   Toren,E., Liu,Y., Bethea,M., Wade,A. and Hunter,C.S.
  TITLE     The Ldb1 transcriptional co-regulator is required for establishment
            and maintenance of the pancreatic endocrine lineage
  JOURNAL   FASEB J 36 (8), e22460 (2022)
   PUBMED   35881062
  REMARK    GeneRIF: The Ldb1 transcriptional co-regulator is required for
            establishment and maintenance of the pancreatic endocrine lineage.
REFERENCE   6  (bases 1 to 3098)
  AUTHORS   Jurata,L.W., Pfaff,S.L. and Gill,G.N.
  TITLE     The nuclear LIM domain interactor NLI mediates homo- and
            heterodimerization of LIM domain transcription factors
  JOURNAL   J Biol Chem 273 (6), 3152-3157 (1998)
   PUBMED   9452425
REFERENCE   7  (bases 1 to 3098)
  AUTHORS   Visvader,J.E., Mao,X., Fujiwara,Y., Hahm,K. and Orkin,S.H.
  TITLE     The LIM-domain binding protein Ldb1 and its partner LMO2 act as
            negative regulators of erythroid differentiation
  JOURNAL   Proc Natl Acad Sci U S A 94 (25), 13707-13712 (1997)
   PUBMED   9391090
REFERENCE   8  (bases 1 to 3098)
  AUTHORS   Jurata,L.W. and Gill,G.N.
  TITLE     Functional analysis of the nuclear LIM domain interactor NLI
  JOURNAL   Mol Cell Biol 17 (10), 5688-5698 (1997)
   PUBMED   9315627
REFERENCE   9  (bases 1 to 3098)
  AUTHORS   Wadman,I.A., Osada,H., Grutz,G.G., Agulnick,A.D., Westphal,H.,
            Forster,A. and Rabbitts,T.H.
  TITLE     The LIM-only protein Lmo2 is a bridging molecule assembling an
            erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1
            and Ldb1/NLI proteins
  JOURNAL   EMBO J 16 (11), 3145-3157 (1997)
   PUBMED   9214632
REFERENCE   10 (bases 1 to 3098)
  AUTHORS   Osada,H., Grutz,G.G., Axelson,H., Forster,A. and Rabbitts,T.H.
  TITLE     LIM-only protein Lmo2 forms a protein complex with erythroid
            transcription factor GATA-1
  JOURNAL   Leukemia 11 Suppl 3, 307-312 (1997)
   PUBMED   9209374
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL500527.19.
            
            On Aug 8, 2019 this sequence version replaced NM_001113407.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.176290.1,
                                           SRR12921934.1809785.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467148 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000673968.1/ ENSP00000501277.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-283               AL500527.19        61843-62125         c
            284-386             AL500527.19        53191-53293         c
            387-431             AL500527.19        53013-53057         c
            432-507             AL500527.19        52826-52901         c
            508-610             AL500527.19        52626-52728         c
            611-783             AL500527.19        52286-52458         c
            784-906             AL500527.19        51678-51800         c
            907-990             AL500527.19        51357-51440         c
            991-1114            AL500527.19        51141-51264         c
            1115-1263           AL500527.19        50786-50934         c
            1264-3098           AL500527.19        48246-50080         c
FEATURES             Location/Qualifiers
     source          1..3098
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.32"
     gene            1..3098
                     /gene="LDB1"
                     /gene_synonym="CLIM-2; CLIM2; LDB-1; NLI"
                     /note="LIM domain binding 1"
                     /db_xref="GeneID:8861"
                     /db_xref="HGNC:HGNC:6532"
                     /db_xref="MIM:603451"
     exon            1..283
                     /gene="LDB1"
                     /gene_synonym="CLIM-2; CLIM2; LDB-1; NLI"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..1494
                     /gene="LDB1"
                     /gene_synonym="CLIM-2; CLIM2; LDB-1; NLI"
                     /note="isoform 1 is encoded by transcript variant 1;
                     carboxy terminal LIM domain protein 2; LIM domain-binding
                     factor-1; LIM domain-binding protein 1; nuclear LIM
                     interactor; LIM domain-binding factor CLIM2;
                     carboxyl-terminal LIM domain-binding protein 2"
                     /codon_start=1
                     /product="LIM domain-binding protein 1 isoform 1"
                     /protein_id="NP_001106878.1"
                     /db_xref="CCDS:CCDS44472.1"
                     /db_xref="GeneID:8861"
                     /db_xref="HGNC:HGNC:6532"
                     /db_xref="MIM:603451"
                     /translation="MSVGCACPGCSSKSFKLYSPKEPPNGNAFPPFHPGTMLDRDVGP
                     TPMYPPTYLEPGIGRHTPYGNQTDYRIFELNKRLQNWTEECDNLWWDAFTTEFFEDDA
                     MLTITFCLEDGPKRYTIGRTLIPRYFRSIFEGGATELYYVLKHPKEAFHSNFVSLDCD
                     QGSMVTQHGKPMFTQVCVEGRLYLEFMFDDMMRIKTWHFSIRQHRELIPRSILAMHAQ
                     DPQMLDQLSKNITRCGLSNSTLNYLRLCVILEPMQELMSRHKTYSLSPRDCLKTCLFQ
                     KWQRMVAPPAEPTRQQPSKRRKRKMSGGSTMSSGGGNTNNSNSKKKSPASTFALSSQV
                     PDVMVVGEPTLMGGEFGDEDERLITRLENTQFDAANGIDDEDSFNNSPALGANSPWNS
                     KPPSSQESKSENPTSQASQ"
     exon            284..386
                     /gene="LDB1"
                     /gene_synonym="CLIM-2; CLIM2; LDB-1; NLI"
                     /inference="alignment:Splign:2.1.0"
     exon            387..431
                     /gene="LDB1"
                     /gene_synonym="CLIM-2; CLIM2; LDB-1; NLI"
                     /inference="alignment:Splign:2.1.0"
     exon            432..507
                     /gene="LDB1"
                     /gene_synonym="CLIM-2; CLIM2; LDB-1; NLI"
                     /inference="alignment:Splign:2.1.0"
     exon            508..610
                     /gene="LDB1"
                     /gene_synonym="CLIM-2; CLIM2; LDB-1; NLI"
                     /inference="alignment:Splign:2.1.0"
     exon            611..783
                     /gene="LDB1"
                     /gene_synonym="CLIM-2; CLIM2; LDB-1; NLI"
                     /inference="alignment:Splign:2.1.0"
     exon            784..906
                     /gene="LDB1"
                     /gene_synonym="CLIM-2; CLIM2; LDB-1; NLI"
                     /inference="alignment:Splign:2.1.0"
     exon            907..990
                     /gene="LDB1"
                     /gene_synonym="CLIM-2; CLIM2; LDB-1; NLI"
                     /inference="alignment:Splign:2.1.0"
     exon            991..1114
                     /gene="LDB1"
                     /gene_synonym="CLIM-2; CLIM2; LDB-1; NLI"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1263
                     /gene="LDB1"
                     /gene_synonym="CLIM-2; CLIM2; LDB-1; NLI"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..3098
                     /gene="LDB1"
                     /gene_synonym="CLIM-2; CLIM2; LDB-1; NLI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3076..3081
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LDB1"
                     /gene_synonym="CLIM-2; CLIM2; LDB-1; NLI"
                     /note="hexamer: AATAAA"
     polyA_site      3098
                     /gene="LDB1"
                     /gene_synonym="CLIM-2; CLIM2; LDB-1; NLI"
                     /note="major polyA site"
ORIGIN      
        1 acacactccg cggactcaca cccgcgcgca cacacgcaga ggccgctcgc cttcctgcct
       61 ggcttccttc ctgtctgctc cgcgcctgac aggcccctcg ccgcagccag gggccgcccg
      121 caccgggccg aggccgggcc gggccggcgg cgagcgcagc gggggccgcg ggcggcggcg
      181 gcggctcatg cccggcctgt ccccgcgagg ggcgggcacc gtgactcggc tgggccccca
      241 gaggcgggcg atgtgaagat gtcagtgggc tgtgcctgtc ctggttgttc ctcaaagtca
      301 ttcaagctgt actcgccgaa ggagcccccg aacggcaacg cctttccccc cttccatccc
      361 ggcaccatgc tggataggga tgtgggccca actcccatgt atccgcctac atacctggag
      421 ccagggattg ggaggcacac accatatggc aaccaaactg actacagaat atttgagctt
      481 aacaaacggc ttcagaactg gacagaggag tgtgacaatc tctggtggga tgcattcacg
      541 actgagttct ttgaggatga tgccatgttg accatcactt tctgcctgga ggatggacca
      601 aagagatata ccattggccg gaccctgatc ccacgctact tccgcagcat ctttgagggg
      661 ggtgctacgg agctgtacta tgttcttaag caccccaagg aggcattcca cagcaacttt
      721 gtgtccctcg actgtgacca gggcagcatg gtgacccagc atggcaagcc catgttcacc
      781 caggtgtgtg tggagggccg gttgtacctg gagttcatgt ttgacgacat gatgcggata
      841 aagacgtggc acttcagcat ccggcagcac cgagagctca tcccccgcag catccttgcc
      901 atgcatgccc aagaccccca gatgttggat cagctctcca aaaacatcac tcggtgtggg
      961 ctgtccaatt ccactctcaa ctacctccga ctctgtgtga tactcgagcc catgcaagag
     1021 ctcatgtcac gccacaagac ctacagcctc agcccccgcg actgcctcaa gacctgcctt
     1081 ttccagaagt ggcagcgcat ggtagcaccc cctgcggagc ccacacgtca gcagcccagc
     1141 aaacggcgga aacggaagat gtcagggggc agcaccatga gctctggtgg tggcaacacc
     1201 aacaacagca acagcaagaa gaagagccca gctagcacct tcgccctctc cagccaggta
     1261 cctgatgtga tggtggtggg ggagcccacc ctgatgggcg gggagttcgg ggacgaggac
     1321 gagaggctca tcacccggct ggagaacacc cagtttgacg cagccaacgg cattgacgac
     1381 gaggacagct ttaacaactc ccctgcactg ggcgccaaca gcccctggaa cagcaagcct
     1441 ccgtccagcc aagaaagcaa atcggagaac cccacgtcac aggcctccca gtaaaaggcc
     1501 ctgctgtggc cacccagtgc tctgcctacc tgccccaccc ctcacagccc cagggagcag
     1561 aagacagaat gaagagactg agcatctaaa atgggcagcc tccatccacc cgcttcaggg
     1621 aggaactgga ctctctgggg gcaggtgcca agatttgccc ccccagtggc cctgggctgg
     1681 gcctggcctc tacagagcct tttaggggga gggggtactc atgtggatgc ctacttggaa
     1741 cctgggcctc tgagacatgt cctgaccacc ccccagggca tttgcctcca tcttcacccc
     1801 agattgtggg tttcccatcc ccctgacttt acccctttca agcctggggt tgtctatacc
     1861 cacagccctt agggacttaa agttacgggg cttcgttgaa tgctccttcc cctaggcagc
     1921 tggtaataga ggggtaaagc tctgggcccc tcctccctgc tgccacttat cccagctcca
     1981 agttttttta aaaataatat tattaaaaat gtaagttaaa aaaaaaatca ctcatgtccc
     2041 cccctcttcc ccctattaaa agtccagcta cctccctact cttggcagat gggggcctag
     2101 ggcctaggtg ggggtgagag tgggggaggg aggtgtgcat accattttat atggtgtgag
     2161 agcttcagac caaggagaca tttcaccatc tctccccctt tcctctgggg tgactgcagt
     2221 tgaggaaagc atgccatggg gtagggggac attggtggcc acattttggt gacagacccc
     2281 tgctgttgtc tctgtgtccc cattctctgg actctggcct gccctcctag tgcttgtgac
     2341 tccctctctt ccagccccac ccccatggta tgtatattcc ttacaagtcc tccacaagag
     2401 cagctgtcta ggatgcgggg aggggaggct ccttccctta gggagcgtgg agagaaggga
     2461 gcagccttgt tgctgtattt ttggttttgt ttcagttggg caggcatggg atgggagagg
     2521 ggctcagcca ctttcctcca gaatcttccc tcagcccctc caactgcata tgtaatccta
     2581 ctctgtcctt catagagggg aaggagccac agatgacatc ccagttctaa gcccaccagg
     2641 gaggaacagg cctctgtccc cataggtgag gtagaggtag agggtcttca cctgccagta
     2701 tcccctgccg ctccttcctc acagaaggaa ggaggaggag gcagccggga tcctcggctc
     2761 tgccagggtg cagccaggag cagggtttca cgcagctggt ccagctctgt ggctttgctg
     2821 ccttttcctg tggccagtcc caggaagtgc taacaccacc tctctcccca ctcttccctc
     2881 tggattctgg ggtcccccac accgtatttc ctccactcca gctgccactt ttggaagggt
     2941 attgagtcag gagctgaggg aaggggtgag gaaggtggac atcccatccc aactgtaatg
     3001 cctttttttt tttttttttt tttttttttt tttttttttt tttttgggcc atttgagtca
     3061 tgtatggtac caatcaataa agagactttt cggtttga
//
