LOCUS       NM_005565               4232 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens lymphocyte cytosolic protein 2 (LCP2), mRNA.
ACCESSION   NM_005565
VERSION     NM_005565.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4232)
  AUTHORS   Ruiz-Martin,V., Marcos,T., de Pereda,J.M., Sanchez-Crespo,M., de la
            Fuente,M.A., Bayon,Y. and Alonso,A.
  TITLE     LYP regulates SLP76 and other adaptor proteins in T cells
  JOURNAL   Biol Res 57 (1), 69 (2024)
   PUBMED   39342392
  REMARK    GeneRIF: LYP regulates SLP76 and other adaptor proteins in T cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4232)
  AUTHORS   Tan,M., He,Y., Yi,J., Chen,J., Guo,Q., Liao,N. and Peng,L.
  TITLE     WTAP Mediates NUPR1 Regulation of LCN2 Through m6A Modification to
            Influence Ferroptosis, Thereby Promoting Breast Cancer
            Proliferation, Migration and Invasion
  JOURNAL   Biochem Genet 62 (2), 876-891 (2024)
   PUBMED   37477758
  REMARK    GeneRIF: WTAP Mediates NUPR1 Regulation of LCN2 Through m[6]A
            Modification to Influence Ferroptosis, Thereby Promoting Breast
            Cancer Proliferation, Migration and Invasion.
REFERENCE   3  (bases 1 to 4232)
  AUTHORS   Trepte,P., Secker,C., Kostova,S., Maseko,S.B., Choi,S.G.,
            Blavier,J., Minia,I., Ramos,E.S., Cassonnet,P., Golusik,S.,
            Zenkner,M., Beetz,S., Liebich,M.J., Scharek,N., Schutz,A.,
            Sperling,M., Lisurek,M., Wang,Y., Spirohn,K., Hao,T.,
            Calderwood,M.A., Hill,D.E., Landthaler,M., Olivet,J., Twizere,J.C.,
            Vidal,M. and Wanker,E.E.
  TITLE     AI-guided pipeline for protein-protein interaction drug discovery
            identifies a SARS-CoV-2 inhibitor
  JOURNAL   bioRxiv (2023)
   PUBMED   37398436
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4232)
  AUTHORS   Lev,A., Asleh,M., Levy,S., Lee,Y.N., Simon,A.J., Stepensky,P.,
            Nalbandyan,K., Nahum,A., Ben-Harosh,M., Yablonski,D., Broides,A.
            and Somech,R.
  TITLE     SLP76 Mutation Associated with Combined Immunodeficiency and
            EBV-Related Lymphoma
  JOURNAL   J Clin Immunol 43 (3), 625-635 (2023)
   PUBMED   36474126
  REMARK    GeneRIF: SLP76 Mutation Associated with Combined Immunodeficiency
            and EBV-Related Lymphoma.
REFERENCE   5  (bases 1 to 4232)
  AUTHORS   Bubeck Wardenburg,J., Fu,C., Jackman,J.K., Flotow,H.,
            Wilkinson,S.E., Williams,D.H., Johnson,R., Kong,G., Chan,A.C. and
            Findell,P.R.
  TITLE     Phosphorylation of SLP-76 by the ZAP-70 protein-tyrosine kinase is
            required for T-cell receptor function
  JOURNAL   J Biol Chem 271 (33), 19641-19644 (1996)
   PUBMED   8702662
REFERENCE   6  (bases 1 to 4232)
  AUTHORS   Sunden,S.L., Carr,L.L., Clements,J.L., Motto,D.G. and Koretzky,G.A.
  TITLE     Polymorphism in and localization of the gene LCP2 (SLP-76) to
            chromosome 5q33.1-qter
  JOURNAL   Genomics 35 (1), 269-270 (1996)
   PUBMED   8661136
REFERENCE   7  (bases 1 to 4232)
  AUTHORS   Wu,J., Motto,D.G., Koretzky,G.A. and Weiss,A.
  TITLE     Vav and SLP-76 interact and functionally cooperate in IL-2 gene
            activation
  JOURNAL   Immunity 4 (6), 593-602 (1996)
   PUBMED   8673706
REFERENCE   8  (bases 1 to 4232)
  AUTHORS   Motto,D.G., Ross,S.E., Wu,J., Hendricks-Taylor,L.R. and
            Koretzky,G.A.
  TITLE     Implication of the GRB2-associated phosphoprotein SLP-76 in T cell
            receptor-mediated interleukin 2 production
  JOURNAL   J Exp Med 183 (4), 1937-1943 (1996)
   PUBMED   8666952
REFERENCE   9  (bases 1 to 4232)
  AUTHORS   Rivero-Lezcano,O.M., Marcilla,A., Sameshima,J.H. and Robbins,K.C.
  TITLE     Wiskott-Aldrich syndrome protein physically associates with Nck
            through Src homology 3 domains
  JOURNAL   Mol Cell Biol 15 (10), 5725-5731 (1995)
   PUBMED   7565724
REFERENCE   10 (bases 1 to 4232)
  AUTHORS   Jackman,J.K., Motto,D.G., Sun,Q., Tanemoto,M., Turck,C.W.,
            Peltz,G.A., Koretzky,G.A. and Findell,P.R.
  TITLE     Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein
            associated with Grb2 in T cells
  JOURNAL   J Biol Chem 270 (13), 7029-7032 (1995)
   PUBMED   7706237
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB116470.1, U20158.2,
            AC034199.6, BC016618.1, BY995095.1 and AW291566.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005565.4.
            
            Summary: This gene encodes an adapter protein that acts as a
            substrate of the T cell antigen receptor (TCR)-activated protein
            tyrosine kinase pathway. The encoded protein associates with growth
            factor receptor bound protein 2, and is thought to play a role
            TCR-mediated intracellular signal transduction. A similar protein
            in mouse plays a role in normal T-cell development and activation.
            Mice lacking this gene show subcutaneous and intraperitoneal fetal
            hemorrhaging, dysfunctional platelets and impaired viability.
            [provided by RefSeq, Nov 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016618.1, AK292890.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000046794.10/ ENSP00000046794.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                DB116470.1         66-80
            16-477              U20158.2           57-518
            478-478             AC034199.6         43287-43287         c
            479-1942            U20158.2           520-1983
            1943-2381           BC016618.1         1921-2359
            2382-3309           AC034199.6         16130-17057         c
            3310-3788           BY995095.1         10-488
            3789-4232           AW291566.1         16-459              c
FEATURES             Location/Qualifiers
     source          1..4232
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.1"
     gene            1..4232
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
                     /note="lymphocyte cytosolic protein 2"
                     /db_xref="GeneID:3937"
                     /db_xref="HGNC:HGNC:6529"
                     /db_xref="MIM:601603"
     exon            1..244
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1768
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
                     /note="76 kDa tyrosine phosphoprotein; SLP-76 tyrosine
                     phosphoprotein; SH2 domain-containing leukocyte protein of
                     76 kDa"
                     /codon_start=1
                     /product="lymphocyte cytosolic protein 2"
                     /protein_id="NP_005556.1"
                     /db_xref="CCDS:CCDS47339.1"
                     /db_xref="GeneID:3937"
                     /db_xref="HGNC:HGNC:6529"
                     /db_xref="MIM:601603"
                     /translation="MALRNVPFRSEVLGWDPDSLADYFKKLNYKDCEKAVKKYHIDGA
                     RFLNLTENDIQKFPKLRVPILSKLSQEINKNEERRSIFTRKPQVPRFPEETESHEEDN
                     GGWSSFEEDDYESPNDDQDGEDDGDYESPNEEEEAPVEDDADYEPPPSNDEEALQNSI
                     LPAKPFPNSNSMYIDRPPSGKTPQQPPVPPQRPMAALPPPPAGRNHSPLPPPQTNHEE
                     PSRSRNHKTAKLPAPSIDRSTKPPLDRSLAPFDREPFTLGKKPPFSDKPSIPAGRSLG
                     EHLPKIQKPPLPPTTERHERSSPLPGKKPPVPKHGWGPDRRENDEDDVHQRPLPQPAL
                     LPMSSNTFPSRSTKPSPMNPLPSSHMPGAFSESNSSFPQSASLPPYFSQGPSNRPPIR
                     AEGRNFPLPLPNKPRPPSPAEEENSLNEEWYVSYITRPEAEAALRKINQDGTFLVRDS
                     SKKTTTNPYVLMVLYKDKVYNIQIRYQKESQVYLLGTGLRGKEDFLSVSDIIDYFRKM
                     PLLLIDGKNRGSRYQCTLTHAAGYP"
     exon            245..307
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
                     /inference="alignment:Splign:2.1.0"
     exon            308..354
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
                     /inference="alignment:Splign:2.1.0"
     exon            355..420
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
                     /inference="alignment:Splign:2.1.0"
     exon            421..452
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
                     /inference="alignment:Splign:2.1.0"
     exon            453..490
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
                     /inference="alignment:Splign:2.1.0"
     exon            491..689
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
                     /inference="alignment:Splign:2.1.0"
     exon            690..787
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
                     /inference="alignment:Splign:2.1.0"
     exon            788..854
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
                     /inference="alignment:Splign:2.1.0"
     exon            855..938
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
                     /inference="alignment:Splign:2.1.0"
     exon            939..964
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
                     /inference="alignment:Splign:2.1.0"
     exon            965..984
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1092
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1123
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1136
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1266
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1316
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1411
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1489
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1645
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
                     /inference="alignment:Splign:2.1.0"
     exon            1646..4232
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1921..1926
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
                     /note="hexamer: AATGAA"
     polyA_site      1943
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
                     /note="major polyA site"
     regulatory      2360..2365
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
                     /note="hexamer: ATTAAA"
     polyA_site      2382
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
                     /note="major polyA site"
     regulatory      2872..2877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
                     /note="hexamer: ATTAAA"
     polyA_site      2905
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
     regulatory      3047..3052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
                     /note="hexamer: AATAAA"
     polyA_site      3069
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
     regulatory      4208..4213
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
                     /note="hexamer: ATTAAA"
     polyA_site      4232
                     /gene="LCP2"
                     /gene_synonym="IMD81; SLP-76; SLP76"
ORIGIN      
        1 gggatctggc tacgccagaa aagacatcgg ctccaacagg ggtgttccac agggtagctg
       61 ggagttggaa gagccaagaa cgcctccgag ctctggattt gagcttctct gcccatgggt
      121 gaagcgccca tgctcagctt gtgagcttct tcccgggaga gcagccatgg cactgaggaa
      181 tgtgcccttt cgctcagagg tcctgggctg ggaccccgac agccttgctg actatttcaa
      241 gaagctcaac tataaggact gtgagaaggc agtgaagaag taccacatcg atggggctcg
      301 cttcttgaac ctgacagaaa atgacatcca gaagttcccc aagctccggg tgccgattct
      361 cagtaagtta agtcaggaaa tcaacaagaa cgaagagagg aggagcatct tcacacgcaa
      421 accccaagtc ccgcggtttc ctgaagagac agaaagccac gaagaggaca atgggggctg
      481 gtcgtccttt gaagaagacg attatgaaag tcccaatgat gaccaggatg gggaggatga
      541 tggagactat gagtccccca atgaggagga agaggcaccc gtggaagatg acgcggatta
      601 tgagccgcca ccctccaatg acgaggaagc tctgcagaac tccatcctgc ctgccaagcc
      661 tttccccaac tccaactcca tgtacatcga ccggcccccc tctgggaaaa ccccccagca
      721 gcctcctgtg cccccccaga gaccgatggc cgccctcccg cccccaccag ccggccggaa
      781 tcactcgcca ctgcccccac cccagaccaa ccacgaagaa cccagcagaa gcagaaacca
      841 caaaacggca aagctccctg ctccttcaat agacagaagc acgaaacctc ccctagatcg
      901 ttcattagct ccgtttgata gagaaccctt cacactagga aagaaaccac cattttctga
      961 caagccctcg attccagcgg gaaggtcact cggggagcat ttacccaaga ttcaaaagcc
     1021 tcctttacca ccgaccacgg aaagacatga aaggagcagc cccctgccag ggaagaagcc
     1081 acctgtgcca aagcatggat ggggaccaga cagaagagag aatgatgaag atgatgtgca
     1141 tcagagacct ttgccccagc cagcactact tcctatgagc tccaacactt tcccttcaag
     1201 atctactaag ccaagtccca tgaaccctct cccatcctct cacatgcctg gagcattctc
     1261 agaaagtaac agcagttttc cacagagtgc ctccctgcca ccatacttct ctcaaggccc
     1321 tagcaacaga ccacctatca gagccgaagg cagaaacttc cccttgccac ttccaaacaa
     1381 acctcggccc ccatcccccg cggaggaaga gaattcatta aatgaagagt ggtacgtttc
     1441 ttatattacc cgaccagagg cagaagctgc tcttagaaag ataaaccagg atggcacatt
     1501 tctggtcaga gacagctcta aaaaaacaac aaccaatcca tatgtcctca tggtgttgta
     1561 caaagataaa gtttacaaca tccagatccg ttatcagaag gaaagtcaag tttacttgtt
     1621 gggaactgga ctccgaggga aagaggactt tctgtctgtg tcagatatta ttgactactt
     1681 caggaaaatg ccacttctgc tcattgatgg gaaaaaccga ggttccagat accagtgcac
     1741 attaacgcat gctgcagggt acccatagca agttatagcc gagcaaatga accgtcctcc
     1801 tgcctctgtt gccaacacga gatcaatcag ccttggtcaa tggacaaaca cttaggactg
     1861 aactgaaccc ctccccatga acacaagggt tttatccttt cctttaaaaa cagtgtttga
     1921 aatgaagact gtcaactatc ccataattta tttattcttc ttcaatgttt gtaaagtgca
     1981 tgagtcatgt tcacacttga agtctagtag tgcactgtaa taattcattt tttaaaagat
     2041 tatttaatgc ccatttcaaa atacagtagt ttacacagct acagaaacaa tttggggcaa
     2101 gttttaaaac actgaaacag taatagttat tggtgtcaca taaaactgat ttgtttttta
     2161 cagccaaacc tctgtcagtc agaggcattc attagtttta tacatgtaat ttgaaaatca
     2221 ctaaacctcg ttttctcagc agcaataatt taagaggctt caaaaatata atttcactct
     2281 tatttagtat tttttcctgg gggcattttt acgtaatttt tttatgaaaa gacaaatgca
     2341 tgttgagata acttctggga ttaaaatagt cttttgcttt acttttttgg tttcctaaaa
     2401 caactttatt gacttttagt ccatactgtt atatttttgt cttaaagaaa atttaaacta
     2461 caaataccaa aagaaaacat tttaaattta gggatgagac tttggtgtat cgtgggtcta
     2521 ggtttaatga acacatctgg ggttaagttg gcatttcttc acatctccac acccacacca
     2581 accatcacag ccccccacca accttctccc aaccccaaaa gcattgtcca gggatataga
     2641 ttttaccaaa ggcttcctgg gaagacgagg gagcaacact ttagattaaa tgtgatcaga
     2701 ctttcctatt agatatggct cttctgtctc ttgttatccc cctgacagct ctgccataaa
     2761 gtcccttctc ctcatccttc ccaaacaggc tgtataagtg ctttgaggta attaaactct
     2821 ttcctccagt ttacaaatat cacttaacaa aaaatatagg cattcagcca gattaaaaaa
     2881 ctggtattca gccaaatagt gacaatcagt tgttcttcaa gtttttccct ttgggacctt
     2941 ggttgttatt gcacaacttt tattagcaac aatttttggc gtctctgctt aatctacaag
     3001 ttttcgaaat ggaaaagagt atcttgcagc ttcattttca tgagctaata aaaggggtat
     3061 tggaaggaat ctaagaagtc accattttaa aactgatgat atgttaaaat aaggagtatg
     3121 cagaaggtag agacttttaa ctgatgataa aaatggtgtt tcacaaaatc tcatccttaa
     3181 caaccagaag ttctcagttt agggtccaaa acttgggagt ttaaggctga aaaccctgca
     3241 ttcatttaca cgtctacaca acgggctatt cagcaagtat ttacttagtg gctcttctgt
     3301 gttaaacaag tgagctaggt acaaggtagt aaggatagca tacaccatag gttctagtat
     3361 cgagtaagct ccacttgtct tgctttgccg tattctatct ttacaattca aaaatatcta
     3421 aaatgaagga cctgatagat ttcaaagcaa ctatttggta gcgaatcatg tttataaaac
     3481 aaaccaaagc tcattttaag tctattagtg gaaagtgcca tcaggattaa gatgttctgt
     3541 tccatggcta tgactgaaat caatgttggg aagctaatgt tttcatgact agcattctct
     3601 ctctgttcaa gcaccgacaa ctccttttgg ctgggccttg cctcttttgg ccacagacct
     3661 tctatatgac cccaggtgca tcagtcacag ttgctcagaa ccctgctcag tgataaacat
     3721 cttactaaag ctgggtcaat cagggtcact ctctggaatg ttaaacatga agcctgagac
     3781 aagatctctc ttttatctgg ggtccccaaa ggcaatgctg tacacttgga gctgcctgct
     3841 gccctgcaac tactcccatt taccaattat ctggaagaac cagtctacaa tagaagacaa
     3901 cgaggccaac acacaaaaac acagtaaaag tatggacaaa ttagtgggat ccctgaaatc
     3961 tattccaact atgtgcttcc aagtcacatg actcaataaa tgcttcagct ggttgagttg
     4021 tgcttggcgt tcactaccag gagagttctg attaataaaa actcattcca tcaattaata
     4081 atttagtagc tctctttcaa cctgagccaa attcaagcat aagctaaagg ataagcagtg
     4141 acccatggcc aatttcctat gtcatacact tgccattagt gacgtaagtt aagccattct
     4201 tcaaaacatt aaacagcctt caagaacatg aa
//
