LOCUS       NM_001394446           10321 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens ligand dependent nuclear receptor corepressor like
            (LCORL), transcript variant 17, mRNA.
ACCESSION   NM_001394446 XM_011513822
VERSION     NM_001394446.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10321)
  AUTHORS   Alerasool,N., Leng,H., Lin,Z.Y., Gingras,A.C. and Taipale,M.
  TITLE     Identification and functional characterization of transcriptional
            activators in human cells
  JOURNAL   Mol Cell 82 (3), 677-695 (2022)
   PUBMED   35016035
REFERENCE   2  (bases 1 to 10321)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 10321)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 10321)
  AUTHORS   Beck,D.B., Subramanian,T., Vijayalingam,S., Ezekiel,U.R.,
            Donkervoort,S., Yang,M.L., Dubbs,H.A., Ortiz-Gonzalez,X.R.,
            Lakhani,S., Segal,D., Au,M., Graham,J.M. Jr., Verma,S.,
            Waggoner,D., Shinawi,M., Bonnemann,C.G., Chung,W.K. and
            Chinnadurai,G.
  TITLE     A pathogenic CtBP1 missense mutation causes altered cofactor
            binding and transcriptional activity
  JOURNAL   Neurogenetics 20 (3), 129-143 (2019)
   PUBMED   31041561
REFERENCE   5  (bases 1 to 10321)
  AUTHORS   Conway,E., Jerman,E., Healy,E., Ito,S., Holoch,D., Oliviero,G.,
            Deevy,O., Glancy,E., Fitzpatrick,D.J., Mucha,M., Watson,A.,
            Rice,A.M., Chammas,P., Huang,C., Pratt-Kelly,I., Koseki,Y.,
            Nakayama,M., Ishikura,T., Streubel,G., Wynne,K., Hokamp,K.,
            McLysaght,A., Ciferri,C., Di Croce,L., Cagney,G., Margueron,R.,
            Koseki,H. and Bracken,A.P.
  TITLE     A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL
            Genes Balance PRC2 Subtype Activities
  JOURNAL   Mol Cell 70 (3), 408-421 (2018)
   PUBMED   29628311
REFERENCE   6  (bases 1 to 10321)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 10321)
  AUTHORS   Sovio,U., Bennett,A.J., Millwood,I.Y., Molitor,J., O'Reilly,P.F.,
            Timpson,N.J., Kaakinen,M., Laitinen,J., Haukka,J., Pillas,D.,
            Tzoulaki,I., Molitor,J., Hoggart,C., Coin,L.J., Whittaker,J.,
            Pouta,A., Hartikainen,A.L., Freimer,N.B., Widen,E., Peltonen,L.,
            Elliott,P., McCarthy,M.I. and Jarvelin,M.R.
  TITLE     Genetic determinants of height growth assessed longitudinally from
            infancy to adulthood in the northern Finland birth cohort 1966
  JOURNAL   PLoS Genet 5 (3), e1000409 (2009)
   PUBMED   19266077
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 10321)
  AUTHORS   Weedon,M.N., Lango,H., Lindgren,C.M., Wallace,C., Evans,D.M.,
            Mangino,M., Freathy,R.M., Perry,J.R., Stevens,S., Hall,A.S.,
            Samani,N.J., Shields,B., Prokopenko,I., Farrall,M., Dominiczak,A.,
            Johnson,T., Bergmann,S., Beckmann,J.S., Vollenweider,P.,
            Waterworth,D.M., Mooser,V., Palmer,C.N., Morris,A.D.,
            Ouwehand,W.H., Zhao,J.H., Li,S., Loos,R.J., Barroso,I.,
            Deloukas,P., Sandhu,M.S., Wheeler,E., Soranzo,N., Inouye,M.,
            Wareham,N.J., Caulfield,M., Munroe,P.B., Hattersley,A.T.,
            McCarthy,M.I. and Frayling,T.M.
  CONSRTM   Diabetes Genetics Initiative; Wellcome Trust Case Control
            Consortium; Cambridge GEM Consortium
  TITLE     Genome-wide association analysis identifies 20 loci that influence
            adult height
  JOURNAL   Nat Genet 40 (5), 575-583 (2008)
   PUBMED   18391952
REFERENCE   9  (bases 1 to 10321)
  AUTHORS   Gudbjartsson,D.F., Walters,G.B., Thorleifsson,G., Stefansson,H.,
            Halldorsson,B.V., Zusmanovich,P., Sulem,P., Thorlacius,S.,
            Gylfason,A., Steinberg,S., Helgadottir,A., Ingason,A.,
            Steinthorsdottir,V., Olafsdottir,E.J., Olafsdottir,G.H.,
            Jonsson,T., Borch-Johnsen,K., Hansen,T., Andersen,G., Jorgensen,T.,
            Pedersen,O., Aben,K.K., Witjes,J.A., Swinkels,D.W., den Heijer,M.,
            Franke,B., Verbeek,A.L., Becker,D.M., Yanek,L.R., Becker,L.C.,
            Tryggvadottir,L., Rafnar,T., Gulcher,J., Kiemeney,L.A., Kong,A.,
            Thorsteinsdottir,U. and Stefansson,K.
  TITLE     Many sequence variants affecting diversity of adult human height
  JOURNAL   Nat Genet 40 (5), 609-615 (2008)
   PUBMED   18391951
REFERENCE   10 (bases 1 to 10321)
  AUTHORS   Kunieda,T., Park,J.M., Takeuchi,H. and Kubo,T.
  TITLE     Identification and characterization of Mlr1,2: two mouse homologues
            of Mblk-1, a transcription factor from the honeybee brain(1)
  JOURNAL   FEBS Lett 535 (1-3), 61-65 (2003)
   PUBMED   12560079
  REMARK    GeneRIF: Identification and characterization of an homologous gene
            in mouse.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC079399.5 and AC005768.17.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Apr 20, 2021 this sequence version replaced XM_011513822.3.
            
            Summary: This gene encodes a transcription factor that appears to
            function in spermatogenesis. Polymorphisms in this gene are
            associated with measures of skeletal frame size and adult height.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Oct 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074968.116730.1,
                                           SRR14038194.2747102.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000635767.2/ ENSP00000490600.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               AC079399.5         135884-136041       c
            159-224             AC079399.5         87106-87171         c
            225-304             AC079399.5         77256-77335         c
            305-434             AC079399.5         76189-76318         c
            435-686             AC079399.5         23380-23631         c
            687-780             AC079399.5         354-447             c
            781-5606            AC005768.17        9502-14327
            5607-10321          AC005768.17        41814-46528
FEATURES             Location/Qualifiers
     source          1..10321
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p15.31"
     gene            1..10321
                     /gene="LCORL"
                     /gene_synonym="MLR1"
                     /note="ligand dependent nuclear receptor corepressor like"
                     /db_xref="GeneID:254251"
                     /db_xref="HGNC:HGNC:30776"
                     /db_xref="MIM:611799"
     exon            1..158
                     /gene="LCORL"
                     /gene_synonym="MLR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..5620
                     /gene="LCORL"
                     /gene_synonym="MLR1"
                     /note="isoform 9 is encoded by transcript variant 17;
                     transcription factor MLR1; LCOR-like protein;
                     MBLK1-related protein"
                     /codon_start=1
                     /product="ligand-dependent nuclear receptor
                     corepressor-like protein isoform 9"
                     /protein_id="NP_001381375.1"
                     /db_xref="CCDS:CCDS93485.1"
                     /db_xref="GeneID:254251"
                     /db_xref="HGNC:HGNC:30776"
                     /db_xref="MIM:611799"
                     /translation="MDKGRERMAAAAAAAAAAAAAAQCRSPRCAAERRGFRRELDSWR
                     HRLMHCVGFESILEGLYGPRLRRDLSLFEDCEPEELTDWSMDEKCSFCNLQREAVSDC
                     IPSLDSSQSTPTEELSSQGQSNTDKIECQAENYLNALFRKKDLPQNCDPNIPLVAQEL
                     MKKMIRQFAIEYISKSGKTQENRNGSIGPSIVCKSIQMNQAENSLQEEQEGPLDLTVN
                     RMQEQNTQQGDGVLDLSTKKTSIKSEESSICDPSSENSVAGSTVDAKSEEATKMEKRK
                     SALNKVLESLCIHHQQQVLAMLKFLVQEQNAASLCCCNTSCVVSSESQKPLIEDDLCG
                     LFCSCEYRLAERGCLQNEKQSPGLEPLPVCIKDLHCLSCQTVTVEHVKPVVNRGIADS
                     YNSHRCCSGLLPNIHSTKSAFRSPLLSKEVCDLSVTLKDACRSRSPSPPPLSPIETEG
                     FEKLKDVISEISALENNKLEANINQPPSLTPAEISSNKSDHQDKILKTKKSSNSYSLL
                     SNDSNNSTTNHEKGETAVIFQDLMDRINEKLKSIETTDMTSLVKLSSSDYNTYNDLKL
                     GDFITSLLHNAKASDYSFMELLSQHDKKVENKIIQTRFRKRQETLFAMRNSSDSPMFR
                     RQSLQIKRELASLDENFTRKKYTEKSSRKLTQNNEISSSDKGEFYHDQGPSLQNSKRL
                     QGKNHAETSFSPNYALQSLQLPLHSSETNLSFNEFSESFKTTSPEKMSIRKPQEKSAD
                     GKQFLQNDRKNPKLGNTQTLLRNDVSGLLSRTKRNIVPPGWYSVYVTNNYVFKKSPKA
                     KKVSESTTKNDPVKNIHIESSHNIDLNKIAMNSNLQVVVKRLEDTISIAKKSWNNQPL
                     SEGYKASKKLIEIDGKDQHADRNMTLTLNRMTCKEQSLSKSVVASGNIINSHCMPTVD
                     LNNKRLENLKKSSILDMGRLISSVENVPAKYEGTESSSVSNYSSPIKLMFLSEVKSSE
                     GVKYTLTSVGTSHSNVVLPSEKPTTHHVTEEKTETNEDISNANSENYHSSHYDTDTFQ
                     RELNKFSHAKETAGSSTMFIGDINSDKPQEEPKDNSSSATDPSFKRKPGRPKKIGPQV
                     VKQIKRPIGRPPKPKIDQTNITVCQNEPFSAGRKSPECLISEVKEGIYKKSITVTVIY
                     GRSRRTKRHVSEGRVNISNLMSLNNNAGDFPTEYNSPRNISEDKIDLGERISAVASLT
                     TESEILGSGFEYVRPIKNKSVIPQPSKNIIRPNQKPLAISRKPGRPAKVKISGISVTI
                     NRTSPQEREVSISSCLPPLEQDNTSGKNLPEEKYDQQCTQMDKIRHTEADIFKNGSKR
                     MIATVPLRHSIRDRKPSLHFLHSLASSSSLIYRNALLHKSYKLHLQKNKSQKEKHRHS
                     KMKIAYKDTPRNRLSRNAKKCLEDNKLVPISEVSLDPIISSNPLLRWWATSASNDSLL
                     EELNNRFEQITNAWVQVSGDEAENCIHKKREHIENDHFKVASPLETCLLELEVSPVKM
                     LFQKKYDLNELCTWFMQTTETQSLSLVRKANARNPLEVINTRGIKLGTKYSDFNASPF
                     RKHFKKFALSSPSKSAEKLHILHKVANSPLLNVKSNLAIARLKRTEFKRLHHERWKRE
                     GKLHNHGTVDWNSKRRNLRFFCQNQFLNKTEGETNADIPLQGKSIVDNQCVLPPEIRG
                     DLQQRVVMPDFKIHASFENKFKSEAKENGTNCSQKDFQKGPRLENVCPNSWRSKTLKD
                     CRIFLRKLNCLEHRNTFKLNTIIYSPESTDSGNTHQTHMEESKRFTLRSHSARQNSFK
                     KQSKEIENANTNNPSADEFADHLGNSKLSKCVNFDKNPDSFEVLSNLNKRKRPPWKIT
                     EMSTKRHKRQSCNSGQMANYFSKSLACYK"
     exon            159..224
                     /gene="LCORL"
                     /gene_synonym="MLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            225..304
                     /gene="LCORL"
                     /gene_synonym="MLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            305..434
                     /gene="LCORL"
                     /gene_synonym="MLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            435..686
                     /gene="LCORL"
                     /gene_synonym="MLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            687..780
                     /gene="LCORL"
                     /gene_synonym="MLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..5606
                     /gene="LCORL"
                     /gene_synonym="MLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            5607..10321
                     /gene="LCORL"
                     /gene_synonym="MLR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5898..5903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LCORL"
                     /gene_synonym="MLR1"
                     /note="hexamer: ATTAAA"
     polyA_site      5916
                     /gene="LCORL"
                     /gene_synonym="MLR1"
                     /note="major polyA site"
     regulatory      8267..8272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LCORL"
                     /gene_synonym="MLR1"
                     /note="hexamer: AATAAA"
     polyA_site      8288
                     /gene="LCORL"
                     /gene_synonym="MLR1"
                     /note="major polyA site"
     regulatory      9830..9835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LCORL"
                     /gene_synonym="MLR1"
                     /note="hexamer: AATAAA"
     polyA_site      9853
                     /gene="LCORL"
                     /gene_synonym="MLR1"
     regulatory      10292..10297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LCORL"
                     /gene_synonym="MLR1"
                     /note="hexamer: AATAAA"
     regulatory      10300..10305
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LCORL"
                     /gene_synonym="MLR1"
                     /note="hexamer: AATAAA"
     polyA_site      10310
                     /gene="LCORL"
                     /gene_synonym="MLR1"
     polyA_site      10321
                     /gene="LCORL"
                     /gene_synonym="MLR1"
ORIGIN      
        1 gcagatggac aagggaagag agagaatggc cgctgccgcc gccgctgctg ccgccgccgc
       61 cgccgccgct cagtgccgga gccctcggtg cgcggcggag agaagaggat tccggcggga
      121 actcgactct tggcgccacc gcctcatgca ctgtgtaggt tttgagagta ttttagaagg
      181 gctttatgga ccacggctac gaagagacct cagtttattt gaagactgtg aaccagaaga
      241 gctgactgac tggtctatgg atgaaaaatg ttcattttgt aacctacaga gagaagcagt
      301 cagtgattgt ataccatctc ttgattcttc acagtcaaca ccaacagagg agctatcatc
      361 tcagggccag tccaacactg ataagattga atgccaagca gaaaattacc taaatgcact
      421 ctttcgaaag aaagatcttc ctcagaactg tgatcctaac attcccctag ttgctcagga
      481 attaatgaaa aagatgatac gtcaatttgc gattgagtac atttcaaaaa gtggtaaaac
      541 tcaagagaat agaaatggtt caattggacc aagtatagta tgtaaaagta tccaaatgaa
      601 tcaagcagaa aactcccttc aggaagagca ggaaggcccc ttagacctca ctgtgaatcg
      661 aatgcaagaa caaaatactc agcaagggga tggagtgtta gatctctcta caaagaaaac
      721 cagcataaaa tctgaagagt catccatatg tgatccttct tctgaaaatt cagtggctgg
      781 ttcaactgtt gatgcaaaat cagaggaagc tactaaaatg gaaaaaagaa aatcagcatt
      841 aaacaaagtt ttggaatctt tgtgcataca tcaccagcaa caagttttgg ctatgttgaa
      901 atttctagtc caagagcaga atgctgcttc tctttgctgt tgtaatacat catgtgttgt
      961 gtcttcagaa tctcaaaagc ccttaatcga agatgattta tgtggtctgt tctgtagttg
     1021 tgaatatagg ctggcagaaa gaggttgttt acaaaacgaa aaacaaagcc ctggtttaga
     1081 acctctgcca gtctgtatta aagatttaca ttgtttatct tgccaaactg taactgttga
     1141 acacgttaag ccagtagtga atagaggaat tgcagacagt tataattctc acaggtgctg
     1201 ttctggactg ttaccaaaca ttcactctac aaaatcagcc tttcgtagtc ctcttttgtc
     1261 aaaggaagta tgtgatcttt cagtcactct taaagatgcc tgtagatctc gaagtccctc
     1321 acccccacca ttatcaccta tagaaactga aggatttgaa aaattgaaag acgtcatctc
     1381 agagatttca gccttagaaa ataacaaact tgaagcaaac attaaccagc ctccatctct
     1441 cacaccagca gaaatcagca gcaataagag tgatcatcaa gataaaatac ttaaaactaa
     1501 aaaatccagt aactcttatt ctttactctc aaatgacagc aataattcta ctacaaatca
     1561 tgaaaaaggt gaaactgctg taatttttca agatttaatg gatcgcatta atgaaaaact
     1621 aaaatcaata gaaaccacgg atatgacaag ccttgtaaaa ttatctagca gtgattataa
     1681 tacatataat gatttaaaat tgggagattt cataacatct ctcttgcata atgcaaaagc
     1741 cagtgattat agttttatgg aattattgag tcaacatgat aaaaaggtag aaaataaaat
     1801 tattcagaca agatttcgaa agcgtcaaga aactttattt gcaatgcgca actcctctga
     1861 ttcacccatg tttagaaggc agtctttaca gataaaaaga gaacttgcta gtcttgatga
     1921 aaattttaca agaaaaaaat acaccgaaaa aagttcaagg aaattgacac aaaacaatga
     1981 gatatcttca tcagacaaag gagaattcta tcatgaccaa gggccttctt tacaaaattc
     2041 taaaagactt caaggtaaaa atcatgctga aacatcattt tcaccaaatt atgcattaca
     2101 gtcactgcaa ctacctcttc atagttcaga aactaacttg tcttttaatg aattttcaga
     2161 aagctttaaa acaacttccc ctgagaaaat gagcataaga aagccacagg agaaatctgc
     2221 agatggaaaa caatttttgc aaaatgatag gaaaaatcca aagttaggta atactcaaac
     2281 tcttttgaga aatgatgttt ctggactttt gagcagaact aaacgaaata ttgtgcctcc
     2341 agggtggtat tctgtatatg taacaaataa ttatgttttt aaaaaatccc ctaaagccaa
     2401 aaaagtatcc gaatccacaa caaaaaacga tccagtgaaa aatattcaca ttgaaagctc
     2461 acacaatata gacctaaaca aaattgcaat gaattctaat ttacaagtgg ttgtgaagcg
     2521 tttggaagat acaataagta tagccaaaaa atcctggaat aatcagccat tatcagaagg
     2581 atataaagca tccaagaaat tgatagaaat tgatggtaaa gaccaacatg ctgacagaaa
     2641 tatgactctt actctaaata gaatgacatg caaagaacag agcttatcaa aatctgtggt
     2701 agcatccggc aatattatca atagtcactg catgcctaca gtggatttga ataacaaaag
     2761 acttgaaaat ctgaaaaagt catctatttt agatatgggt cgcttgattt ccagtgttga
     2821 aaatgtacca gcaaaatatg aaggtactga aagttcatct gtttccaact attctagtcc
     2881 tatcaaactc atgtttttat ctgaggttaa aagtagtgaa ggggtcaaat atactttaac
     2941 ttcagttggc acttcccatt caaatgttgt tctcccttct gaaaaaccta caacccatca
     3001 cgtaactgaa gaaaaaacag aaacaaatga ggatatctca aatgcgaact ctgaaaatta
     3061 tcactccagt cattatgata ctgatacttt tcaaagagaa ctaaacaaat tcagtcatgc
     3121 aaaagaaact gcaggatcct ctacaatgtt tataggtgat ataaatagtg ataagccaca
     3181 agaagaacct aaggacaatt caagcagtgc tactgatcca tcttttaaaa gaaaaccagg
     3241 tagaccaaaa aaaataggtc cccaagttgt gaaacagatt aagcgaccaa ttggaagacc
     3301 accaaagcct aaaattgatc aaacaaacat cactgtttgc cagaatgagc cctttagtgc
     3361 tggaaggaaa agcccagaat gtctcatatc agaagtaaaa gaaggtattt ataaaaagag
     3421 tattacagta actgttattt acggaaggtc aagaagaact aaaaggcatg tttctgaagg
     3481 aagggtaaac ataagcaacc ttatgtcttt aaacaataat gctggtgatt ttccaactga
     3541 atataatagt cccagaaata ttagtgaaga caaaattgac ttgggtgaaa gaataagtgc
     3601 tgtagcaagc ttgactactg aaagtgagat cttggggtct ggctttgaat atgtgagacc
     3661 catcaagaac aaatctgtga tacctcagcc ttccaagaac attattcgac caaatcagaa
     3721 gcctttggca ataagtagga agcctggtag accggcaaaa gtgaaaatct ctggcatatc
     3781 tgtgactatt aatagaactt cacctcagga aagagaagta agtattagca gctgcttgcc
     3841 tcctttagaa caggataata cgtcaggaaa aaatctgcct gaagaaaagt atgaccaaca
     3901 gtgcactcaa atggataaaa taaggcacac tgaagctgat atatttaaaa atggatcaaa
     3961 acgtatgatt gctactgtac ctttgagaca ttctattagg gatagaaaac catctctgca
     4021 tttcttacat tcattagcat cttctagctc acttatttat agaaacgctc tgctccataa
     4081 atcatataaa ctgcatttgc agaaaaataa aagtcagaag gaaaaacata ggcactcaaa
     4141 gatgaaaata gcttacaaag ataccccaag aaacagactt tcgcggaatg caaaaaagtg
     4201 tttggaagat aataaattag tacctatttc tgaagtatcc ttggatccta taatttcatc
     4261 aaaccctttg ctcaggtggt gggctacttc tgcttcaaat gattccttat tagaggaatt
     4321 aaacaataga tttgagcaaa taacaaatgc ttgggtgcaa gtaagtggag atgaagctga
     4381 aaattgtatt cataaaaaaa gagaacacat tgaaaatgat catttcaaag tagcaagccc
     4441 tttggaaact tgtcttttag aacttgaagt ttcacctgta aaaatgcttt ttcagaaaaa
     4501 gtatgatttg aatgaactct gtacttggtt tatgcaaaca acagaaacac agtctctttc
     4561 actagttaga aaagcaaatg cccgaaaccc tttggaagta ataaatacca ggggaatcaa
     4621 attagggacc aaatattctg actttaatgc cagccccttc agaaagcact ttaaaaaatt
     4681 tgcactctct tctccttcaa aatcagcaga gaaattgcat atactgcata aagtggctaa
     4741 ctctccactc ttaaatgtga aaagtaattt agcaatagct agattaaaaa ggactgagtt
     4801 taagaggttg catcatgaaa ggtggaaaag agagggaaag ctgcacaacc atggaacagt
     4861 tgactggaac tctaaaagga gaaacttaag atttttctgc cagaaccaat ttttaaataa
     4921 gactgaggga gaaacaaatg ctgacatccc actccaagga aaaagcatag tagataatca
     4981 gtgtgttttg ccacctgaga tcaggggtga cttgcagcag agggtagtaa tgcctgactt
     5041 caaaatacat gctagttttg agaataaatt taagtcagaa gcaaaagaga atggaacaaa
     5101 ttgcagccaa aaagactttc aaaagggacc aagactagaa aatgtatgtc ctaatagttg
     5161 gaggtcaaaa accttaaaag actgtagaat atttttgagg aagctcaact gtcttgaaca
     5221 cagaaatact tttaagctaa atacaatcat ttactctcct gaatctactg acagtggaaa
     5281 tactcatcag actcatatgg aagaatcaaa gcgctttact ttaagatctc attctgctag
     5341 gcaaaattct tttaaaaagc aatctaaaga aatagaaaat gctaacacaa ataatccttc
     5401 agctgatgaa tttgctgacc atcttggcaa tagtaaatta agcaaatgtg ttaactttga
     5461 caagaatcct gatagttttg aagttcttag caatttgaac aaaagaaaaa gaccaccatg
     5521 gaagatcaca gaaatgtcaa caaaaagaca taaacgacag tcttgcaaca gtggacaaat
     5581 ggcaaactat ttttccaaat ccctagcatg ctacaagtga aaactgatga gaaactgaat
     5641 gtgtctgatg agaatacagc aagttgccct ttgagcccca ttaagatgtg ccttaatcgt
     5701 cccattgaat ggaatctgaa tttgacaaca gcatctctaa cgagctgtac agttcataac
     5761 caaaatctca aaagcgaaga gaaatagatt gcagttcttc ttgcactatc tttattttgt
     5821 atgtcagtat tccttctgaa caataagcat ttatcaattg atcttgaagt atttctagtc
     5881 ctgtgatttg tctttatatt aaatcattag cattaatcat tttgattata ttctttatat
     5941 gtttttttta catgttttac atcagatcat tgtggaattt tgtaaacgga ttttgatgtt
     6001 tctcttttag tggtattatg tgaatttttt atgccctaag tttaaatacg taattgtccc
     6061 tagttttatt tctgtgcaca aagttttaat atataacaca ttgtgattta taaagctagt
     6121 attgtaaaga tttgtgatga taacctgacc catgagcagt tgtaaaacag gtggatacca
     6181 actacctcga agcaaattgg tgaaagaaaa ggcaaaggta tctcttagaa gtaaatctcc
     6241 ttcaacgtta tatatgtaca gaagaaaaaa agttgatcat agctttttgt caagtagcat
     6301 gtttcccatt cacaggaaaa tgtgagctta tcagttcttt ctctgtattt taaatctaag
     6361 tctgtgggct ttaagagcaa tggcacaatt gcatgtttac tgttcagcaa atctgtgcct
     6421 cttgatagag aaaaatacta tgtggtttct gtaagttacc agttttgaat gaaaaatggt
     6481 aaatggattt acatctgttt tattgtacct tagcctttta ttttaaagtt aaagggatga
     6541 cttttaaaag caggacattc cctaccttta atagtgcaaa gcacagtttc agcaatggct
     6601 acatgactat gtctaaaaac tgaatactca gaatactaaa ggtttggtgc ttaaatttat
     6661 ttttcccatg ccagagaaag caagctttgg tatggtaaac cacatgagaa catggctcct
     6721 ttctttttgg atagcctggc catgtgtgaa tgggatttta gcttattatg tttctaagac
     6781 ttttccttac agcacactta atgtaccttt tcagtccttc tcccaacccc ctgcaaattg
     6841 tctttaaaac aacaacacat aaggaatctg aagcacagga gaacacagag ccaacaaaca
     6901 gaatgaagaa caatcatcta tttttaactg actttctatc attaccattt ttccttttgc
     6961 ttaataacta tcttgctttg aaactttgac tccttttata agttctatga ggcacatatg
     7021 tatagcaatt tggttctaaa aaccagtgat cttactttag ctccatctta aaatttcacc
     7081 ttaagtaaat ggcctctagt agatgataag cctaaaaaaa gcacaattat taaaacaaac
     7141 agatccatgt taggacattt ctgaataata aagagaaaag gtgtttcgtt gggtattgca
     7201 gaaaagagga ccaatttcat atagtacaag tttcgtaagt caggccaagt gtcaatttca
     7261 aaagacaaga aatgaaattg acagtgaata gtgctcataa attggtagcg tatataaaga
     7321 gaagttcctg tcacattata ttcccactag aattattatc cacagtaaat aaatattatt
     7381 ttgttatgcc aaaaatatag cgagcagctt catggttaat aatacattta tgttgacacc
     7441 tccctaatcc aggaaacatt cacaaacaag gactcccata tacaaatact ttaggaagag
     7501 agatttccca ggcagatatc accaaaaatg ttttcactgt aggaatcaca aaataagttt
     7561 ttgtcaaaat aactgttgtt gaacgttata ctggtcttcc tcactggtga ttgataagct
     7621 cctttctagc cagtttgtgg tacttccttc attttcccta gaaatgttac ttgttaaatg
     7681 tgtcctcagg cggtttcatc tttgttgatt ctgcccatct aagtcataag cttctcaaat
     7741 gcaagctact agctagttac acttgtaagt tttccataat gacatgattt taaacataaa
     7801 gagttcataa gaatcacttg gagagactat ttaaaaatga gattcctagg cccacctcag
     7861 attgtgataa atctgtgtga ctgactgatg cacacttttt ctggactata ataactgatg
     7921 ctgctctact gctttaatac aggccaaagt aacgtggaag cgcacagcag aaaatcttca
     7981 gaaagacatc aggtttgttc tgattttgac aagggtaact tcttctttat taaagcaaat
     8041 aactggacat aatcttaaag gattccacct ccatcgtctt tcctaactta gatcttcatt
     8101 gagaaattgg gcaaggttaa gtttactttt ttctagtgct gcggttttgg ctcgtcttgg
     8161 tagtctcatc ttcatttctg attctggttc tggaacttca tgatcactaa atagatgttg
     8221 aaaatacacg aatttagata caagctttaa aaccagttta tttataaata aaactttttt
     8281 gtttctgact cacattctat cagtgtttaa ttgatagcct gattccattg acttagctta
     8341 aaactaaaat ctcaatgtca aaaaaacact gacttggcta tctagcaaag tgaatcaggg
     8401 aaaatctagc taatgatttt atatactata acagaacctg gtgttataca ggaaaaaaag
     8461 ccacaaactt gtaatgaagc ttgtaattaa acgaggacca taactgtcca aaagagattt
     8521 ctttgaaact caagaagtga caaaaaaatt aagttctctc tcttgattta agcaataaat
     8581 tccaaaaaca tagtaaaaaa caagtttccc cccaaaaaag acaaatttaa tcaacagtgt
     8641 aaaactatgt actgaaaata cacacaatac aattttgcaa atgaatacaa gacagctacc
     8701 aactttcagc tctaacagtg gcttgactga cagaagccaa aaataaaaca ctctaccaca
     8761 caatataccc aaattataga cagaattatt ctatcagtat gtaagtgtag agaacccaaa
     8821 tattatcaaa atcaagagtt tgctaactga agatcaaaga ggagtcacat catgtaatta
     8881 aaaattgaaa caacatatta aagatagtac taaagaccat gccagctaat aggcaaaagc
     8941 aaacacgccg taagaagtca aatgctcttg atgatggaat tttagactat atacctaaga
     9001 cagctattta tagttttcac tatcttgtta tatattctct ctcattcgca agaaaattag
     9061 tttttttcta cttgtagaaa taaaaagtga agataggcct ccatatattc tagacatgca
     9121 tgacatacct ttcagagtcg gcttcagcag tctgacacct cctgttcgtc ctagctgaaa
     9181 ctgtcacttt tctctgtcct tgaagatagt ataattcatt atcaggattt attatcagtt
     9241 gctttttgtt tttaatctag tttctaggct aactaaatcc tttgtcttca acacaacaat
     9301 cctttcaaca catgtatctc ctacttgttc tagccatctt ggtaccagtt atcactgcca
     9361 cagaaaaagg aacccaagca agattaaaac ttaatttatt ttgtaagcac taataatgag
     9421 taagggaaaa taaggaaatt tcaagcaagt taaaagaagg caaattttag ttcaatgtat
     9481 ttgaggacag tatatgaaaa atgtgttata atgaagtacc tctattattg ctatagcaca
     9541 aagtctgtgg agactcatga aaattaaggg ttagaaaggt aggttaggtg cataaacagg
     9601 tgctaaagaa acaacttttt tttttcttgg aaggtgataa aacatagtaa ggtaataatg
     9661 gcttcttgta aaataacata catgaccaat tcaaatgtgt tctaaaatat atttcaatgt
     9721 aaaaactaga acctttatat actggggatt ataagattct acttactaga aatttacaag
     9781 gttaaggagt aagacaaagt ttggcttgtg atgtttctca tttataagga ataaaacaat
     9841 atgaatatat gaagtttggt ctattaaaaa ggatggtgtt ctcatggtgt gatataccac
     9901 aaaaaaaatc tgatcaaaac caaactgttc aatgtgacag tctgaaaatt atatactcta
     9961 cttcattcat gttacacttt tttctactcc ttacctgctt ttactaatgc atttatcccc
    10021 aagaaaacat ccaacaatat gggactaatt tggaacaata tccagcaatt ggtatttaaa
    10081 taatttactg gttacaaaac aatattatga ccagactcca ttttagaaaa aattaaatct
    10141 gcatcgaaaa gggccttaaa aaatagattt ctaaaatcaa aatcatggtt ggctcatggg
    10201 tgggattatt agtgttcctt atagtagttt gtctggatgt actttctgat tcttctgtaa
    10261 taagcatgca ttgcttttgt aatgaggaaa taataaaaca ataaaaagat cttgaatttc
    10321 a
//
