LOCUS       NM_001346516           16001 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens ligand dependent nuclear receptor corepressor (LCOR),
            transcript variant 4, mRNA.
ACCESSION   NM_001346516
VERSION     NM_001346516.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 16001)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 16001)
  AUTHORS   Alerasool,N., Leng,H., Lin,Z.Y., Gingras,A.C. and Taipale,M.
  TITLE     Identification and functional characterization of transcriptional
            activators in human cells
  JOURNAL   Mol Cell 82 (3), 677-695 (2022)
   PUBMED   35016035
REFERENCE   3  (bases 1 to 16001)
  AUTHORS   Flindris,S., Katsoulas,N., Goussia,A., Lazaris,A.C.,
            Navrozoglou,I., Paschopoulos,M. and Thymara,I.
  TITLE     The Expression of NRIP1 and LCOR in Endometrioid Endometrial Cancer
  JOURNAL   In Vivo 35 (5), 2631-2640 (2021)
   PUBMED   34410950
  REMARK    GeneRIF: The Expression of NRIP1 and LCOR in Endometrioid
            Endometrial Cancer.
REFERENCE   4  (bases 1 to 16001)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 16001)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 16001)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   7  (bases 1 to 16001)
  AUTHORS   White,J.H., Fernandes,I., Mader,S. and Yang,X.J.
  TITLE     Corepressor recruitment by agonist-bound nuclear receptors
  JOURNAL   Vitam Horm 68, 123-143 (2004)
   PUBMED   15193453
  REMARK    Review article
REFERENCE   8  (bases 1 to 16001)
  AUTHORS   Shi,Y., Sawada,J., Sui,G., Affar el,B., Whetstine,J.R., Lan,F.,
            Ogawa,H., Luke,M.P., Nakatani,Y. and Shi,Y.
  TITLE     Coordinated histone modifications mediated by a CtBP co-repressor
            complex
  JOURNAL   Nature 422 (6933), 735-738 (2003)
   PUBMED   12700765
REFERENCE   9  (bases 1 to 16001)
  AUTHORS   Kunieda,T., Park,J.M., Takeuchi,H. and Kubo,T.
  TITLE     Identification and characterization of Mlr1,2: two mouse homologues
            of Mblk-1, a transcription factor from the honeybee brain(1)
  JOURNAL   FEBS Lett 535 (1-3), 61-65 (2003)
   PUBMED   12560079
REFERENCE   10 (bases 1 to 16001)
  AUTHORS   Fernandes,I., Bastien,Y., Wai,T., Nygard,K., Lin,R., Cormier,O.,
            Lee,H.S., Eng,F., Bertos,N.R., Pelletier,N., Mader,S., Han,V.K.,
            Yang,X.J. and White,J.H.
  TITLE     Ligand-dependent nuclear receptor corepressor LCoR functions by
            histone deacetylase-dependent and -independent mechanisms
  JOURNAL   Mol Cell 11 (1), 139-150 (2003)
   PUBMED   12535528
  REMARK    GeneRIF: Data show that LCoR (ligand-dependent nuclear receptor
            corepressor) represents a class of corepressor that attenuates
            agonist-activated nuclear receptor signaling by multiple mechanisms
            [Ligand-dependent nuclear receptor corepressor].
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL162502.17, AL442123.12 and AI571097.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001346516.1.
            
            Summary: LCOR is a transcriptional corepressor widely expressed in
            fetal and adult tissues that is recruited to agonist-bound nuclear
            receptors through a single LxxLL motif, also referred to as a
            nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed
            12535528]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (4) contains an alternate 3'
            terminal exon, compared to variant 1. It encodes isoform 3, which
            is larger than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK308356.1, SRR18074967.658212.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000421806.4/ ENSP00000490116.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               AL162502.17        58372-58473
            103-176             AL162502.17        59480-59553
            177-242             AL162502.17        133339-133404
            243-322             AL162502.17        133742-133821
            323-455             AL442123.12        8568-8700
            456-743             AL442123.12        13463-13750
            744-837             AL442123.12        16558-16651
            838-5880            AL442123.12        45248-50290
            5881-6257           AI571097.1         18-394              c
            6258-16001          AL442123.12        50668-60411
FEATURES             Location/Qualifiers
     source          1..16001
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.1"
     gene            1..16001
                     /gene="LCOR"
                     /gene_synonym="C10orf12; MLR2"
                     /note="ligand dependent nuclear receptor corepressor"
                     /db_xref="GeneID:84458"
                     /db_xref="HGNC:HGNC:29503"
                     /db_xref="MIM:607698"
     exon            1..102
                     /gene="LCOR"
                     /gene_synonym="C10orf12; MLR2"
                     /inference="alignment:Splign:2.1.0"
     exon            103..176
                     /gene="LCOR"
                     /gene_synonym="C10orf12; MLR2"
                     /inference="alignment:Splign:2.1.0"
     exon            177..242
                     /gene="LCOR"
                     /gene_synonym="C10orf12; MLR2"
                     /inference="alignment:Splign:2.1.0"
     exon            243..322
                     /gene="LCOR"
                     /gene_synonym="C10orf12; MLR2"
                     /inference="alignment:Splign:2.1.0"
     exon            323..455
                     /gene="LCOR"
                     /gene_synonym="C10orf12; MLR2"
                     /inference="alignment:Splign:2.1.0"
     exon            456..743
                     /gene="LCOR"
                     /gene_synonym="C10orf12; MLR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             506..5179
                     /gene="LCOR"
                     /gene_synonym="C10orf12; MLR2"
                     /note="isoform 3 is encoded by transcript variant 4;
                     mblk1-related protein 2"
                     /codon_start=1
                     /product="ligand-dependent corepressor isoform 3"
                     /protein_id="NP_001333445.1"
                     /db_xref="CCDS:CCDS86132.1"
                     /db_xref="GeneID:84458"
                     /db_xref="HGNC:HGNC:29503"
                     /db_xref="MIM:607698"
                     /translation="MQRMIQQFAAEYTSKNSSTQDPSQPNSTKNQSLPKASPVTTSPT
                     AATTQNPVLSKLLMADQDSPLDLTVRKSQSEPSEQDGVLDLSTKKSPCAGSTSLSHSP
                     GCSSTQGNGENSTEAKAVDSNNQSKSPLEKFMVKLCTHHQKQFIRVLNDLYTESQPGT
                     EDLQPSDSGAMDVSTCNAGCAQLSTKHKEKDALCLDMKSSASVDLFVDSSDSHSPLHL
                     TEQTPKKPPPEINPVDGRENALTVVQKDSSELPTTKSNSINSSSVDSFTPGYLTASNC
                     SSVNFHHIPKILEGQTTGQEQDTNVNICEDGKDHMQSSALVESLITVKMAAENSEEGN
                     TCIIPQRNLFKALSEEAWNSGFMGNSSRTADKENTLQCPKTPLRQDLEANEQDARPKQ
                     ENHLHSLGRNKVGYHLHPSDKGQFDHSKDGWLGPGPMPAVHKAANGHSRTKMISTSIK
                     TARKSKRASGLRINDYDNQCDVVYISQPITECHFENQKSILSSRKTARKSTRGYFFNG
                     DCCELPTVRTLARNLHSQEKASCSALASEAVFTPKQTLTIPAPRHTVDVQLPREDNPE
                     EPSKEITSHEEGGGDVSPRKEPQEPEVCPTKIKPNLSSSPRSEETTASSLVWPLPAHL
                     PEEDLPEGGSTVSAPTASGMSSPEHNQPPVALLDTEEMSVPQDCHLLPSTESFSGGVS
                     EDVISRPHSPPEIVSREESPQCSENQSSPMGLEPPMSLGKAEDNQSISAEVESGDTQE
                     LNVDPLLKESSTFTDENPSETEESEAAGGIGKLEGEDGDVKCLSEKDTYDTSIDSLEE
                     NLDKKKKGKKFPEASDRCLRSQLSDSSSADRCLRNQSSDSSSACLEIKVPKNPSAKRS
                     KKEGHPGGTTPKGLLPDSFHTETLEDTEKPSVNERPSEKDAEQEGEGGGIITRQTLKN
                     MLDKEVKELRGEIFPSRDPITTAGQPLPGERLEIYVQSKMDEKNAHIPSESIACKRDP
                     EQAKEEPGHIPTQHVEEAVNEVDNENTQQKDDESDAPCSSLGLSSSGSGDAARAPKSV
                     PRPKRLTSSTYNLRHAHSLGSLDASKVTSEKEAAQVNPIMPKENGASESGDPLDEDDV
                     DTVVDEQPKFMEWCAEEENQELIANFNAQYMKVQKGWIQLEKEGQPTPRARNKSDKLK
                     EIWKSKKRSRKCRSSLESQKCSPVQMLFMTNFKLSNVCKWFLETTETRSLVIVKKLNT
                     RLPGDVPPVKHPLQKYAPSSLYPSSLQAERLKKHLKKFPGATPAKNNWKMQKLWAKFR
                     ENPDQVEPEDGSDVSPGPNSEDSIEEVKEDRNSHPPANLPTPASTRILRKYSNIRGKL
                     RAQQRLIKNEKMECPDALAVESKPSRKSVCINPLMSPKLALQVDADGFPVKPKSTEGM
                     KGRKGKQVSEILPKAEVQSKRKRTEGSSPPDSKNKGPTVKASKEKHADGATKTPAAKR
                     PAARDRSSQPPKKTSLKENKVKIPKKSAGKSCPPSRKEKENTNKRPSQSIASETLTKP
                     AKQKGAGESSSRPQKATNRKQSSGKTRARPSTKTPESSAAQRKRKLKAKLDCSHSKRR
                     RLDAK"
     exon            744..837
                     /gene="LCOR"
                     /gene_synonym="C10orf12; MLR2"
                     /inference="alignment:Splign:2.1.0"
     exon            838..16001
                     /gene="LCOR"
                     /gene_synonym="C10orf12; MLR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      15980..15985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LCOR"
                     /gene_synonym="C10orf12; MLR2"
                     /note="hexamer: ATTAAA"
     polyA_site      16001
                     /gene="LCOR"
                     /gene_synonym="C10orf12; MLR2"
                     /note="major polyA site"
ORIGIN      
        1 agaagatggc gagggtgtgt aggcggcagc aatgctccgt tgagagacgc ggctttcggc
       61 aagaactgga ttcgtggcgc cacaagctca ttcactgtgt aggtcccgtt tccctctgtg
      121 cggcggccgg cgggaccata agggcttaac tcatatattt aacccccctc caaaaaggtt
      181 tgaaagtatt cttgaagggc tgtttggacc tgcattatta aaagatctca gtttatttaa
      241 agactgtgaa cctgaaagca tttctgattg gacttttgat gaaaactgtt tattctgttg
      301 cttgagaaga gataaagtaa agggacactt agtcggtctg gatgaaccag cttcgggagc
      361 tgggcaagaa gctctgctta aacaagagca agcaaaaatc attcgattcg agagacaagc
      421 agaagaattc ctcaatgcag tcttttatag aaaagacagt ccctgggtct ccgaccccaa
      481 tattccccta gtggcccgtg agatcatgca gcgaatgatc caacaatttg ctgctgaata
      541 tacctcaaaa aatagctcta ctcaggaccc cagccagccc aatagcacaa agaaccaaag
      601 cctgccgaaa gcatctccag tcaccacctc tcccacggct gcaactactc agaaccctgt
      661 gctcagcaaa cttctcatgg ctgaccaaga ctcacctctg gaccttactg tcagaaagtc
      721 tcagtcagaa cctagcgaac aagacggtgt acttgatctg tccactaaga aaagtccatg
      781 tgctggcagc acttccctga gccactctcc aggctgctcc agtactcaag ggaacggtga
      841 gaactcaaca gaggcaaaag cagtagattc taacaatcag tcgaagtccc cactggagaa
      901 atttatggtc aaactgtgta ctcatcatca aaagcaattc attcgtgttc tgaacgacct
      961 gtacactgaa tctcaaccag gcactgagga cctgcagcct tctgattcgg gagcaatgga
     1021 tgtatccact tgcaatgctg gctgtgccca gctcagcacc aaacataagg aaaaagatgc
     1081 tctgtgtctc gatatgaagt cttctgcttc tgtagatttg ttcgtagact cgtcagactc
     1141 tcacagccct ctacacttga cggaacagac cccgaagaag cctcctcctg agataaaccc
     1201 tgtagatgga agagagaatg ccttgactgt tgtccagaaa gattcctctg aacttccaac
     1261 cactaaatcg aattctatta atagcagttc agtggatagt ttcactccgg gatacctcac
     1321 tgcatctaat tgttcctcag tgaacttcca ccacatccct aaaatcttgg aggggcagac
     1381 cactggacaa gagcaagaca caaatgtgaa catatgtgag gatggtaaag accatatgca
     1441 gagttcagct ttagtagaaa gtctaattac agtaaaaatg gcagctgaga atagtgagga
     1501 aggcaatacc tgtattattc ctcaaagaaa tttgttcaaa gctttatcag aagaggcttg
     1561 gaactcaggg tttatgggga actcatctag aactgctgac aaagagaata ctttacagtg
     1621 tccaaaaaca cctttgcgcc aggatttaga ggcaaatgaa caagatgcaa ggccaaagca
     1681 agagaaccat cttcactctc tgggaagaaa taaggtgggt taccatttac atcccagtga
     1741 taagggccag tttgatcatt ccaaagatgg ttggttaggc cccggcccta tgccagctgt
     1801 acacaaagcg gcaaatggac actcaagaac caagatgata tcaacctcca tcaagacagc
     1861 tcggaaaagt aaaagggcat cagggctgag gataaatgat tatgataacc agtgtgatgt
     1921 tgtttatatc agtcaaccaa taacagaatg ccactttgag aatcaaaaat caatattatc
     1981 ttctcggaaa acagccagaa agagtactcg aggatacttt ttcaatggtg actgttgtga
     2041 gctgccaact gttcgtacac tggccagaaa tttacactcc caggaaaaag caagctgctc
     2101 agcattggca tcagaggcag ttttcactcc taagcagacc cttacaattc cagcccctag
     2161 acatacagta gatgtgcagc ttcccagaga agacaaccct gaagaaccta gcaaggaaat
     2221 cacctctcac gaggaaggag gtggagacgt ttcacctcga aaagaacctc aagagcctga
     2281 ggtttgcccc acaaagatta agccgaacct gagcagctcc cctaggtcag aggaaacgac
     2341 agcctccagc ctggtgtggc ctctccctgc tcaccttcct gaagaggacc tgccagaagg
     2401 tggctccaca gtctcagctc ccacagcaag tgggatgtct tctcctgaac acaaccaacc
     2461 accagttgca ctgttggata cggaggagat gagtgtaccc caggactgtc acctccttcc
     2521 ctccactgaa agcttttccg ggggagtcag tgaagatgtc atttctaggc ctcattctcc
     2581 tcctgaaata gtcagtagag aagaaagtcc tcagtgctca gaaaatcaga gttccccaat
     2641 gggcttggag ccccccatga gtctgggaaa ggctgaggac aaccaaagca tcagtgctga
     2701 ggttgagtct ggagacaccc aggagctaaa tgtcgaccca ctcttgaagg aaagcagcac
     2761 ttttactgat gaaaacccca gtgaaactga ggaaagtgag gcagcaggtg gtataggaaa
     2821 attagaggga gaggacggtg atgtaaaatg cctgtcagaa aaagacacgt atgatacaag
     2881 cattgactca ctcgaagaga atttggacaa gaagaaaaaa ggtaaaaaat tccctgaggc
     2941 ctctgatagg tgcctaagaa gtcaactttc ggattcttcc tctgctgaca gatgcctaag
     3001 aaatcagagt tcagattctt cctcagcttg tcttgaaatc aaagttccta aaaatcctag
     3061 tgcaaaacgt tcaaaaaaag aagggcaccc tggtgggaca acacctaagg gccttctacc
     3121 tgacagtttc cacacggaaa ctctggagga cacagaaaag ccaagtgtca atgaacgccc
     3181 ctctgagaaa gatgctgagc aggagggcga aggcgggggg atcatcacca ggcagacttt
     3241 gaaaaacatg ctggacaaag aagtcaagga gttacgagga gagattttcc ccagcaggga
     3301 ccccataacc acagctggac agccactgcc tggagagaga ttggaaatct atgttcagtc
     3361 taaaatggat gagaagaatg ctcatatccc ctcagaaagt attgcttgta agagggaccc
     3421 agaacaggca aaagaagagc cagggcatat tcccacacag catgtggagg aggctgtgaa
     3481 tgaggtagac aacgaaaaca cccagcagaa agatgatgag agtgatgccc catgcagctc
     3541 tcttgggttg tcgagtagtg gaagtggtga tgctgctagg gcaccaaaat cggtgccaag
     3601 gcctaaaaga ttgacctctt caacctacaa cctaagacac gctcattctc tgggctcctt
     3661 ggatgcttca aaagtgactt cagaaaagga agctgcacaa gtaaacccca taatgccaaa
     3721 ggaaaatgga gcttcagaga gtggagaccc cctagatgag gacgatgttg acaccgtggt
     3781 agatgaacag ccaaagttta tggaatggtg tgctgaggag gagaaccaag agctcatcgc
     3841 caacttcaat gcccagtaca tgaaagttca gaagggctgg atccagttgg agaaagaagg
     3901 acagccaaca ccaagagcaa ggaacaaatc agataaactg aaagagattt ggaaaagcaa
     3961 gaaaaggtca cggaaatgta ggagttcatt ggagagtcag aagtgttctc ctgttcagat
     4021 gctctttatg acaaacttta aattatctaa tgtttgtaaa tggttcttag agacaactga
     4081 aacccggtct ctagtcattg tgaagaagct caatactcgc cttccaggag acgttccccc
     4141 tgtcaagcat cctcttcaga aatacgctcc ttccagccta tatcccagtt cactacaggc
     4201 tgagcgcttg aaaaagcact tgaagaaatt tcctggagct acccctgcta agaataattg
     4261 gaaaatgcag aagctctggg ccaaatttcg agagaatcct gatcaagtgg agccagaaga
     4321 tggcagtgat gtcagccccg gccctaattc tgaagacagc atagaggaag tcaaggaaga
     4381 tagaaacagt catcctccag caaacctgcc cactccagcc agtacccgga ttcttagaaa
     4441 atattccaat attcgaggaa agctcagagc ccagcaacgt ttaatcaaga atgagaaaat
     4501 ggaatgccca gatgctctgg ctgtggaaag taagccaagt cgtaagagcg tatgcatcaa
     4561 ccctctgatg tcccccaagc ttgccctgca agtggatgca gatgggtttc ctgttaagcc
     4621 caagagtact gaaggaatga agggaaggaa ggggaagcag gtgtctgaaa tcttgcctaa
     4681 agcagaagtt cagagtaaac gcaagagaac agaaggcagc agccctccag atagtaagaa
     4741 caaggggcct acggtgaaag ccagcaaaga aaagcatgct gatggagcca ccaaaacccc
     4801 tgctgccaag aggccagctg caagggacag aagcagccaa ccccccaaaa agacgtcttt
     4861 gaaagagaat aaagtgaaga tccctaaaaa gtccgctggg aagagctgcc ctccctccag
     4921 gaaagaaaaa gagaatacaa acaaaaggcc ttcccagtct attgcctcgg aaacactgac
     4981 gaaacctgca aaacagaagg gggccggtga atcctcttca aggcctcaga aagccacgaa
     5041 taggaagcag agtagtggaa agactcgggc cagaccctca acgaaaaccc cagagagcag
     5101 tgcagctcag agaaagcgaa agctgaaggc aaagctggac tgttcgcaca gcaaacggag
     5161 gcggctggat gcaaagtgat tggaaagatg gtagccaaga gtaaaactgt tctatagaag
     5221 taacctttta ttttgcatta actaaatctg cttttataag cttatcaagc ctttcaaatt
     5281 tacagttaat ggagaacacc gtaatttgag atgtcagaaa atgcatctca gatggagaag
     5341 ggaacttgca gagtccttct ctgaggctaa gggaagttat atattatatt ctggttgttc
     5401 cttgggtttt aaacttggaa ccaagcagtt ttcgttttta aaagtacagt gccttattta
     5461 tcctttttgt ttttaaattt acaaaagcta aaaagctgat ctatgtgatt aaaggcttgt
     5521 attttatact tgatgcacaa gcacttgtac tgtagccgag aagaccacca tcatgcacat
     5581 aaaaggagct tttcagcagc caccctgcag catctgccca cgaacagatg cccttctttg
     5641 caaaccccag cagtgaactt ccctctctgt cttgtttgtt tgtttagatg atgtttgaaa
     5701 gctaaaccaa atcattttat ggtatgcaga ggatttataa ttataaaaga ttactatttc
     5761 tgttaccccc ttttaaaaaa gatcatgttc attgttggtc cctcctctca cctttgatgt
     5821 tttgtcattt gagagcatgt attctaaatt atgtgcccat gggacaagag atatgtcaca
     5881 agtgttaatt tttgtttaca aactctaaaa aatcatttgc atccccaaac tgtattacta
     5941 attctcacca tcttcttcat ttctggtctt gctagcactc ctgcaaggct tccatcctac
     6001 ttcgggagga aaaagcctag gatttttttt ttccatcttg tagctgtaat ttgatgatta
     6061 ggatgaaaat gactcttatt ttctttctta cccagagtac ttccatattc aaagaaagcc
     6121 gaactattat ttccagtaat agaaaggttt aagaatatgt atgtccatgt gtgtttgggt
     6181 gcatttgcat gtggttatca gccacaaatg tctcccaatc ccaattttac agtaaaattt
     6241 tttccctatg cagtgtgctt gggtgtccct gagttgagta attagcaaag gacagatggt
     6301 ttaaaagtag cccagtgtct ctgtgagcat ccccaatacc actttggtac cagactcaga
     6361 aagatctaaa acagcatgga gttatgtaaa ggttagagca gccttgcagt tggaggaagc
     6421 agctccagca tctgtgaaga gcccacacac cccctacacc cagagctgat gttcagctgt
     6481 atgctccaat gtgaatgtac ttgttggagt agacgttcat tctgattgat taacaccatc
     6541 ctagtagtta aatgcttgta gtatcactcc tgccatgtca tgtcaggctc tattccgtgt
     6601 ctcagaagtg agagccacaa tgttttaatg actttgtttg cctttcccag gtgaagcctg
     6661 agacaggcgc attggcttca acctagtgcc tgtgaccttg ctccattatt atagtgcagc
     6721 gtgtacttga cttttccatt gggccgctct acaaaaaaag gcttggttgt tgaagcctca
     6781 gtcagcttcc ttaaccggtt ctgtcaccaa aatcagcttg tatggacagc tgctgccctg
     6841 tcctttttat ttgaaaattt tccatttagg ttgtttcaga tctctttaga taagcccaga
     6901 tggacttttt tcatgcaaat catgataata caggccttct acccattctg ttaaaggttt
     6961 gctgtatatc atgggaactt ctgatgattg gataagactg gagaaaagta tttgatttgt
     7021 gagaaattta gaattgtgtt gaatttcata gctagagaag cttgctgtct tatgaagccc
     7081 tgattttttt tcatgtcttc tctatctgat gagtcttttt ctttttagta tctttgactt
     7141 tggccattca agagctacct acattaataa aactgctgag tgtgtatgtt ggcaaccctt
     7201 tctcagcatt aagttgcaca gaggcattaa tgtgttttga ataggttcat ttaatcttaa
     7261 aaaatggttt taaggtttta aaaatgtctt ttcatatagt tgtcactgga tattgtgttt
     7321 gtggtgactt aaacagctga tgtttgccaa tgtcaggcat gctgattcct gtacagaaga
     7381 ggtgccccgt tggctgcata ccgactacct tgtaaggtgc ttggattagg ttagggagag
     7441 gtgtaaggta gtaagtgggt ggaacttttc cagttccaag tttgtaattc attccattcc
     7501 ttttctaagt tctttttcat ttttaaaagc tcagttaaag ataatagcct tctttcccat
     7561 tctaggctgt gtgtgagaaa aggtgttaat gtgtatgtat gtattttata tacctaacaa
     7621 tgcaatggat catctttaaa atcaacttat actttataat aaggacattt aaatagacca
     7681 agagtctaca taattatgac acttaaaagt ttagaatttt ttatatttgt tgaatctcat
     7741 ttttgctgat tcagttaatt ttgttaatag aagaaagaaa acagcaaaac ttgagggcta
     7801 atcctgcaag gccctttgat acctacagca ggtactggca aagcagtttc ccagatacct
     7861 ccaagctcag gtgtggtatt gactcaagtc tgctattgtt ttccctacct tgcaaaaacc
     7921 ttcttcccag agccatcttc aagaatggct taccacacca gatgcaaaag cagtccatcc
     7981 cacattccga tccaaatcag aaaggaattc tcctgggtgt acactcagtg aaatgactgt
     8041 tccagtcttg gggctgaagt tgatgaccaa aggacactgg tattctctga gtttctggag
     8101 aagctggaag atgcctggga agcaatcact gaagctctgc catagctccc gtagaggagg
     8161 gccctcttca ggacacccat cttctatcct acgagactcc ctgctataga tggacatgca
     8221 ggagaccact ccctcacttg gggtcctgag cctcacccct agcacttcct cagacaggta
     8281 acaatcttgc agcacagcag gaaggttgtg aacctttatt ctgctcctga ggcttccttc
     8341 ataggaatgc tgtcagtttc tgtaagtcac cagtcactag ccccttggat tccttgttaa
     8401 agacttctgt gcagccttat ctaaaatgat aatcttaggc tgtgagtctc ctgctgtatt
     8461 gttcctaaaa tcgtatggat agaagaggtg cccttagtca tccctttaca tatgtggtgc
     8521 tttctaatgg gatctctatg catcacatac tatgcaggtg aatttctcac tgttcagata
     8581 ggtcatcagt aaaaggcatc acttcaagat aattactttg aattgaggtt tggcctcttt
     8641 tcctgctttg taatgggttc ggtcatgagg gtgggagctg tcattcacat ttatgggcag
     8701 cattcctgtt gattagtgga cctaagagcc aagtaggaaa atatagcatg ctatgtgata
     8761 caagctggag atgctgtagt gttactatca gcaagttctg tgcagactgc ctttcggatt
     8821 ccagatgatc tgtcaagggt ctgccaactg tgggctggtc gcttgtttgt gtaaataaaa
     8881 tgtgtttgga atatagccac acccattttc ttaagttctg tctgcggctg ctttcgcact
     8941 gcaagagcag agttgagtag ctgcggcaga gacccgtgtg gcccttacag cctaagatac
     9001 tatctggacc ttcagaaaac atctgctgat ccctgcttga gaaagtcatc cttttcagga
     9061 acaaatattc ttgattttcc ttctctcttc tgcccttttc tctctgttct tctttacttc
     9121 tcattttcct tgtctccatt ttttcttttc aaaggagaca tgttatatcg atatgcacta
     9181 ctatcccctt aaacttgagc aaccttagca ttccatcttc ttaaaaaaaa ccatcacagt
     9241 agccaaaatg aggccacctt accgtatcga gccggaaccc atgagcaaat agggattcag
     9301 agttctaaaa ttatgtggcc tgggcctctc atttcactca cacagaactg actctggctt
     9361 tatttcttgt ttattaaagt aagccaagat tttgtttctg gtaaaattag ttgagactac
     9421 tttagttgga cttttagtcc tctgaatgtc acatttagat atggaaaatg ttttttcaca
     9481 gagtagaaac aaagtctgat cacaatccca aagctttgtt tattcttata taatattttg
     9541 gtactgatac cttttcagcc acatactttc aaaataattt tattaaaggt aagccaacaa
     9601 ataaaacata gaggcttttg aagtgcttta atattgattt aaaaaattgg agttataacc
     9661 agagtatgac tgaaaagcta ttatagtctt cctccttttc caaaaactca aggataagga
     9721 tatatatata tatatatata tttttttttt tttttttttt ttttaataga gacgaggtta
     9781 cgctatgttg ccgaggctga tctgaaactc ctggcctcaa gcagtgctcc cacctcagcc
     9841 tcccaaagtg ctgggattac aagtgagcca ccgcaccaac ccaagtatga gtttctatgc
     9901 tggttttttt ttaatgtgat tcaatgtcct gtcagtgaaa aatttttgtc agtggcccca
     9961 aatcactgat cgttttagtt gttttgaaac aattatcatt ttgaattctt agtattactt
    10021 tgatgtctta ttgtgacttg atatccactg aaatactgga atttttttta agtataaaat
    10081 tgatctgtgt aaggcggtct tcatatccta gcagtaagtg ctattcccca tgcttgctct
    10141 caaatccttt tcaggggaaa aataaaaaga ttattgtatt taaaacgagc agaattgtgg
    10201 gagggccttc ccctccccct gcccagcccc cagacagggt ctcactctgt cgccccaggc
    10261 tggagtgcaa tgggcatatg gtcttatcta ttagggtatg tagtttaaaa gtacagtttt
    10321 ttgaaagtat agtcatcttc atttttatga cgcccactgc aggctcaaag agattttcac
    10381 acctcagcct cctgagtagc tgggactaca ggtgcatgcc accacaccca gttaattttt
    10441 tttttttttc cagttttagc agaaatgagg tctcactgtg ttgcccagac tgggaagtct
    10501 tttgaggcag ccttcaatat aattcatcct ttgaaacatc agaacagagt cctgtattct
    10561 acaatggatg gattggaaga cttgaggatc cagtctcttt cctttataga taattagact
    10621 caggcagaaa ctcagagctc tcagggcttt gctgtgctgt gctgtgtcat gccgtcctgg
    10681 ggcccgggga accaccctga gcactttgtg gagtgtgtcc ttgctcaggc ttttgccttg
    10741 ggattgaacc gaagctgctc agttccttcc acttacctcc tctctgtctg atcttccttt
    10801 tcccagagcc tcagtgcttg atgctcagtg ctcaggagat gtcctttgct ccatccttca
    10861 gaggggcagt tgtgtagtta tgctgccggg tgagcacaga cacacatact ttctccccta
    10921 gctgggacca tcccacacgg ggtgctcaat atgcatgcct catgaaagca tagactgtcc
    10981 atttaaaaaa aaatcaggta ctcatggtat tacaatatgc caggggttgg acaaatggat
    11041 tttttaccct tttttaaagg gttatgtaaa aaaaaaaaaa aaaaaaaaaa gcaactatat
    11101 gtggcccgca tagcctgaaa tatttacttc ctgacccttt tgtggaaaag ctctactgat
    11161 ccttatagta gtcattaaag atcaaattgt gtagacaggc acaacttttt tttttcatat
    11221 gctccaacat ttttttcata cagtccagca attcttttag attttagagt gtcttgcctg
    11281 ttcatctcag tacacagctg ctgttacaga ttattcctga ataatgcttt tgcgttaaga
    11341 aaaattatcc ccctttgcca gttgtctact tgttaataag ttgtgggcca tgtgatcata
    11401 tctattaggg tatgtagtga aaactaaaag tgcagtcttt aaaagtacag tcttcatttt
    11461 tatgaatcag agtgaacttg actgtggtag acattccatt aacagcagtt cagcacaaac
    11521 aaattactca tgaacttaaa gccaagaata gtgcctctcc ctgaaagtat gcgatgtgtt
    11581 ggttttaccc ctagaaccct tcatttctct tttgtatcat atacttgaag gtttctcact
    11641 cttcaagctc tggtcgtgat atgagaacat agatgcctgg tgtttgcctg tttgactttc
    11701 gagtgcagac cacacattct cttaaaaata ccagcatgtc tgtggcatct tgtcaggaca
    11761 ccggcagctt tagacagaac aagttcaggg ctctccagcc cagcccgagt cactgctcgt
    11821 tctgaggagc catccttggc accttgccct ccctcctcct gcctctgctt atgccgccag
    11881 cccccttcca ggaggcatat tctctgggac agtcccccac ttccccagtg tggccctgaa
    11941 cacaaatttg tcacattgga agcatttttc tctcaaaact cttttcctct agtatttagt
    12001 tgttgggttt aaatgctatt caatttatcc actttttttt aaaccccagt tttctgtgat
    12061 ctgcacctca tagttgtctt gtagctaaag ctgaggtatt tgggagctaa tttttgggaa
    12121 agagactata ccaacaagat ttgcataatt ttttatattt ataccacagg tagggattat
    12181 ttttagagtc actatagctt aaggttattg atttcactag tgtggtttct gcattctaaa
    12241 tagttctcgg agactgtgtt agtaactggt ttcaaataca tatatataat atttatacac
    12301 accactgtgg aatttatttc actgtgtaaa tagtgatatt ttcctgttca gatacttcta
    12361 tagaaagtat ttattttaac aagaaaatta actgtcaaaa gggctttcca aaaagtgttc
    12421 tttctagcca cccatcctcc ccagctacca tgctcaacca ttgagccccc aaacaacagt
    12481 gaaagcagaa aggtgtggcc ttgaaacctt cactgtattt ggacagatgc aacagaagca
    12541 cgtctccccc actgtcaccc catcccacaa caaagtggga atcccatcat gggtatggct
    12601 gtgccaggca tggcatcggg tgtgccccat gcagcctact tcttgcatgc acagttggta
    12661 catttagctg tatggcatcg ggtgtgcccc acgcagccta cttcttgcat gcacagttgg
    12721 tacattcagc tgtacactta acagcctgta caggaaaatg agccttagtt gtagccccaa
    12781 ggaaatccaa acccatgctt gtgagatatg gagaaaccac tggttgccta gagaaagcat
    12841 taaggtgtat ttccagttcc cctttcatgt tggtgaaaga cacctattca cactctaatt
    12901 aatcatggga gataagcatg ttaccttctg caccttgact ttgctcgtga gcacctggct
    12961 ttcctcttcc tccttctccc ctctctccct gtctcagtgt gcatctgtgc agatgtgggc
    13021 cagtccccct gtaaccagtg gttacagaat gataccatct gttctaagat gtggtcagct
    13081 ttacttctca ggagtcctgt cctacaattc agagcacccc tagatgggat ggaaccagtg
    13141 ctttatgatc atgttcctct tctctgtgcc ctgtccttcg gcacccccat gttagtcatg
    13201 atcctcattg tgcagggctg gctggactga gaattgcaac tccaggacag cagggagctt
    13261 tgggactagg cacgcagggg ttttgtcatc catttgaacc ataatttgca tattttctta
    13321 cggcctccct ttgtcttttc taaacaaatg aggcagacac ttgaacagta atgctggaga
    13381 atgttttttc taggagactt tgtaagcaaa tctgatttta agatgaaatg tgaatgagaa
    13441 actaggtgcc agggaattta gcactgaact agacagtcaa aactttttta actttgcagg
    13501 aagaaataaa ttttgctctc gtctaaatgt tcacaagaag taatgttgta aatagttttc
    13561 taaaaatatt tattacttgt gctgtataca aattcatgtt ctgagtgatg ttggtttgca
    13621 ttgtagtatt atagaatata ttttgagcag tggacttcct ttcataacac agttcacaca
    13681 tggagaaaga acaaaaacca gcaggttgag agctgtttgg ggcctttgat ctgtaatgtt
    13741 acatcaaatc tgagctttaa ctgccccctc ttctcatctg gttatgttat attatatata
    13801 tatattatat atatatatat acaggtgtat gataaactgg tcagtggtca gtactcagat
    13861 ctgcagagca gatttccaga tgttctttct gatgtgttgc ccataagcaa taagatccta
    13921 ggtaataaca tttattccag ggcccacatt ggcccttgtc tcagaggata gggtgggggt
    13981 agaacagctc ttgctaagac ctcttgcctt tgctggagag gttgctgtac ttgaattttt
    14041 gcttctgttt gtctgcacgc tccttcatgt catagaactc tagcaatgga tgagaaatct
    14101 gccagcacca gacacatcaa aattgggcac atagatggaa aattttgcaa tttttcatga
    14161 atttataggg tttccagaat ctagttgagg caaagctcat ttggctatag agtaaatgta
    14221 agacttgtta caacagaaat ttaagtggcc agttcaatgt cctttggcta tatttgacct
    14281 acctttaaaa cctagcccat ttcatatcag cctcttctgt gcctgggctt gaaatgtcta
    14341 aagctgcctt cgtgtctggg attacaccat gtaggtcagt ataaagaggg cagtcactcc
    14401 tccatttctc ccagcgtgtc cagttcagca gatttctaaa gctgttaagc agcctctctt
    14461 tttgaccgtc ctaaactttg tgaaaataaa taccccacac ccagataacc attaatagaa
    14521 gtaatgtagt tttttaggct tttggaatat gtcttctctt ttgtatttat gatggtgttt
    14581 ggaatttttc actagtgtat ttttagactg aagtgggtgc attaggataa aactttccct
    14641 tgctgagcct gaaggcaagc aagagggaag aaattgacct gtattgtatc attggggagg
    14701 cgactacttc ttgtggtggt agggggtggg gggaatgggg cattgtagat tatgtggggg
    14761 tacaatagaa ttctggcctg aggctcccca agtcttatta ccttgtatga aaaatcccca
    14821 tattagcctc acttaatctc aatagaagcc tgctgtttac cctcagggaa caagtagttt
    14881 tcaaaattga gctcctccaa ggtcattggc caatgctgtg tgcaggcatt ggtcatcttt
    14941 gtaaactcat ggcattattt cctcatatgc attatgatac taagaaattc aaccccaacc
    15001 tgtatgaaaa gcacagccca gggccctaat tgaggctagc atgaatgcct ttgaggggcc
    15061 agggggccat aggaggccca tgcaatttaa ctgaagctca ggtgccacgt tggattttta
    15121 ttcttattag gccgcaacct ttctgaatga gtttagggca ggggctgctg atccggctgt
    15181 ggattcaggg agctctaaaa tgaatctcta ccgttccttt aaaggtcttt ctggttcctc
    15241 ccagtgttgt cattgctgag gtcgatctcg tagttgttca gttgtgctct ttttgctgtc
    15301 ttgtgagtct tagccagtga tccagctgcc caaggacagg gcctccagag ggcctagcgc
    15361 cctcctggta ccaagcgtgt gctcctggcc tgtgtgacag tgtctttccc gaagcagtga
    15421 aatgagaaat tctgcaagtg gccacccgga agatcagtct gtagctcttg ggcctggatt
    15481 tctactatgt tagtgagtgt aggaatatac tgtgtcttta atggatgaaa attcaatgta
    15541 tgctgtgaat ttgttggttt gaaacattga aatttttcat tagacaatgt ttacatacct
    15601 cacctgaaga acctttgaga gtgtatatat aaaattttaa aatatattaa gttgctttaa
    15661 aacaatatgt atagctataa aagttggagt tattttaact ttgaatatgt accaagtctc
    15721 ttaaatattg aaatcttgta gacttcttgt gcttctgtgt tttgctttcc tatcaggcca
    15781 tgtaggaaac tgtgttcttg ttattggtag aggggccctc actgaaatcc aagcttggaa
    15841 ggatgtcctg tgttgtttca gattctcttg tttggttttg aaggatgcgg tgtggagcca
    15901 gaggatgtgt gggaggggtt tctctaacac tgacttctat tccatgagct ttttcaaggc
    15961 gcttatttta tggcagcgta ttaaacttct ttgatattca a
//
