LOCUS       NP_001333445            1557 aa            linear   PRI 29-APR-2025
DEFINITION  ligand-dependent corepressor isoform 3 [Homo sapiens].
ACCESSION   NP_001333445
VERSION     NP_001333445.1
DBSOURCE    REFSEQ: accession NM_001346516.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 1557)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (residues 1 to 1557)
  AUTHORS   Alerasool,N., Leng,H., Lin,Z.Y., Gingras,A.C. and Taipale,M.
  TITLE     Identification and functional characterization of transcriptional
            activators in human cells
  JOURNAL   Mol Cell 82 (3), 677-695 (2022)
   PUBMED   35016035
REFERENCE   3  (residues 1 to 1557)
  AUTHORS   Flindris,S., Katsoulas,N., Goussia,A., Lazaris,A.C.,
            Navrozoglou,I., Paschopoulos,M. and Thymara,I.
  TITLE     The Expression of NRIP1 and LCOR in Endometrioid Endometrial Cancer
  JOURNAL   In Vivo 35 (5), 2631-2640 (2021)
   PUBMED   34410950
  REMARK    GeneRIF: The Expression of NRIP1 and LCOR in Endometrioid
            Endometrial Cancer.
REFERENCE   4  (residues 1 to 1557)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (residues 1 to 1557)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (residues 1 to 1557)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   7  (residues 1 to 1557)
  AUTHORS   White,J.H., Fernandes,I., Mader,S. and Yang,X.J.
  TITLE     Corepressor recruitment by agonist-bound nuclear receptors
  JOURNAL   Vitam Horm 68, 123-143 (2004)
   PUBMED   15193453
  REMARK    Review article
REFERENCE   8  (residues 1 to 1557)
  AUTHORS   Shi,Y., Sawada,J., Sui,G., Affar el,B., Whetstine,J.R., Lan,F.,
            Ogawa,H., Luke,M.P., Nakatani,Y. and Shi,Y.
  TITLE     Coordinated histone modifications mediated by a CtBP co-repressor
            complex
  JOURNAL   Nature 422 (6933), 735-738 (2003)
   PUBMED   12700765
REFERENCE   9  (residues 1 to 1557)
  AUTHORS   Kunieda,T., Park,J.M., Takeuchi,H. and Kubo,T.
  TITLE     Identification and characterization of Mlr1,2: two mouse homologues
            of Mblk-1, a transcription factor from the honeybee brain(1)
  JOURNAL   FEBS Lett 535 (1-3), 61-65 (2003)
   PUBMED   12560079
REFERENCE   10 (residues 1 to 1557)
  AUTHORS   Fernandes,I., Bastien,Y., Wai,T., Nygard,K., Lin,R., Cormier,O.,
            Lee,H.S., Eng,F., Bertos,N.R., Pelletier,N., Mader,S., Han,V.K.,
            Yang,X.J. and White,J.H.
  TITLE     Ligand-dependent nuclear receptor corepressor LCoR functions by
            histone deacetylase-dependent and -independent mechanisms
  JOURNAL   Mol Cell 11 (1), 139-150 (2003)
   PUBMED   12535528
  REMARK    GeneRIF: Data show that LCoR (ligand-dependent nuclear receptor
            corepressor) represents a class of corepressor that attenuates
            agonist-activated nuclear receptor signaling by multiple mechanisms
            [Ligand-dependent nuclear receptor corepressor].
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL162502.17, AL442123.12 and AI571097.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: LCOR is a transcriptional corepressor widely expressed in
            fetal and adult tissues that is recruited to agonist-bound nuclear
            receptors through a single LxxLL motif, also referred to as a
            nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed
            12535528]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (4) contains an alternate 3'
            terminal exon, compared to variant 1. It encodes isoform 3, which
            is larger than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK308356.1, SRR18074967.658212.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000421806.4/ ENSP00000490116.2
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1557
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.1"
     Protein         1..1557
                     /product="ligand-dependent corepressor isoform 3"
                     /note="mblk1-related protein 2"
                     /calculated_mol_wt=170348
     Region          1..51
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96JN0.2)"
     Site            42
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q96JN0.2)"
     Region          53..57
                     /region_name="Interaction with nuclear receptors"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96JN0.2)"
     Site            63
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:20068231; propagated from
                     UniProtKB/Swiss-Prot (Q96JN0.2)"
     Region          579..>723
                     /region_name="PHA03307"
                     /note="transcriptional regulator ICP4; Provisional"
                     /db_xref="CDD:223039"
     Region          1095..1556
                     /region_name="DUF4553"
                     /note="Domain of unknown function (DUF4553); pfam15090"
                     /db_xref="CDD:464496"
     CDS             1..1557
                     /gene="LCOR"
                     /gene_synonym="C10orf12; MLR2"
                     /coded_by="NM_001346516.2:506..5179"
                     /note="isoform 3 is encoded by transcript variant 4"
                     /db_xref="CCDS:CCDS86132.1"
                     /db_xref="GeneID:84458"
                     /db_xref="HGNC:HGNC:29503"
                     /db_xref="MIM:607698"
ORIGIN      
        1 mqrmiqqfaa eytsknsstq dpsqpnstkn qslpkaspvt tsptaattqn pvlskllmad
       61 qdspldltvr ksqsepseqd gvldlstkks pcagstslsh spgcsstqgn gensteakav
      121 dsnnqskspl ekfmvklcth hqkqfirvln dlytesqpgt edlqpsdsga mdvstcnagc
      181 aqlstkhkek dalcldmkss asvdlfvdss dshsplhlte qtpkkpppei npvdgrenal
      241 tvvqkdssel pttksnsins ssvdsftpgy ltasncssvn fhhipkileg qttgqeqdtn
      301 vnicedgkdh mqssalvesl itvkmaaens eegntciipq rnlfkalsee awnsgfmgns
      361 srtadkentl qcpktplrqd leaneqdarp kqenhlhslg rnkvgyhlhp sdkgqfdhsk
      421 dgwlgpgpmp avhkaanghs rtkmistsik tarkskrasg lrindydnqc dvvyisqpit
      481 echfenqksi lssrktarks trgyffngdc celptvrtla rnlhsqekas csalaseavf
      541 tpkqtltipa prhtvdvqlp rednpeepsk eitsheeggg dvsprkepqe pevcptkikp
      601 nlsssprsee ttasslvwpl pahlpeedlp eggstvsapt asgmsspehn qppvalldte
      661 emsvpqdchl lpstesfsgg vsedvisrph sppeivsree spqcsenqss pmgleppmsl
      721 gkaednqsis aevesgdtqe lnvdpllkes stftdenpse teeseaaggi gklegedgdv
      781 kclsekdtyd tsidsleenl dkkkkgkkfp easdrclrsq lsdsssadrc lrnqssdsss
      841 acleikvpkn psakrskkeg hpggttpkgl lpdsfhtetl edtekpsvne rpsekdaeqe
      901 gegggiitrq tlknmldkev kelrgeifps rdpittagqp lpgerleiyv qskmdeknah
      961 ipsesiackr dpeqakeepg hiptqhveea vnevdnentq qkddesdapc sslglsssgs
     1021 gdaarapksv prpkrltsst ynlrhahslg sldaskvtse keaaqvnpim pkengasesg
     1081 dpldeddvdt vvdeqpkfme wcaeeenqel ianfnaqymk vqkgwiqlek egqptprarn
     1141 ksdklkeiwk skkrsrkcrs slesqkcspv qmlfmtnfkl snvckwflet tetrslvivk
     1201 klntrlpgdv ppvkhplqky apsslypssl qaerlkkhlk kfpgatpakn nwkmqklwak
     1261 frenpdqvep edgsdvspgp nsedsieevk edrnshppan lptpastril rkysnirgkl
     1321 raqqrlikne kmecpdalav eskpsrksvc inplmspkla lqvdadgfpv kpkstegmkg
     1381 rkgkqvseil pkaevqskrk rtegssppds knkgptvkas kekhadgatk tpaakrpaar
     1441 drssqppkkt slkenkvkip kksagkscpp srkekentnk rpsqsiaset ltkpakqkga
     1501 gesssrpqka tnrkqssgkt rarpstktpe ssaaqrkrkl kakldcshsk rrrldak
//
