LOCUS       NM_001393661            1597 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens lipocalin 9 (LCN9), transcript variant 1, mRNA.
ACCESSION   NM_001393661
VERSION     NM_001393661.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1597)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1597)
  AUTHORS   Suzuki,K., Lareyre,J.J., Sanchez,D., Gutierrez,G., Araki,Y.,
            Matusik,R.J. and Orgebin-Crist,M.C.
  TITLE     Molecular evolution of epididymal lipocalin genes localized on
            mouse chromosome 2
  JOURNAL   Gene 339, 49-59 (2004)
   PUBMED   15363845
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL158822.19.
            
            Summary: Members of the lipocalin family, such as LCN9, have a
            common structure consisting of an 8-stranded antiparallel
            beta-barrel that forms a cup-shaped ligand-binding pocket or calyx.
            Lipocalins generally bind small hydrophobic ligands and transport
            them to specific cells (Suzuki et al., 2004 [PubMed
            15363845]).[supplied by OMIM, Aug 2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA2157437 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000619315.2/ ENSP00000482296.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-109               AL158822.19        172222-172330       c
            110-246             AL158822.19        171341-171477       c
            247-320             AL158822.19        170844-170917       c
            321-431             AL158822.19        170284-170394       c
            432-496             AL158822.19        169887-169951       c
            497-1597            AL158822.19        168678-169778       c
FEATURES             Location/Qualifiers
     source          1..1597
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..1597
                     /gene="LCN9"
                     /gene_synonym="HEL129"
                     /note="lipocalin 9"
                     /db_xref="GeneID:392399"
                     /db_xref="HGNC:HGNC:17442"
                     /db_xref="MIM:612903"
     exon            1..109
                     /gene="LCN9"
                     /gene_synonym="HEL129"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..487
                     /gene="LCN9"
                     /gene_synonym="HEL129"
                     /note="epididymal-specific lipocalin-9; MUP-like
                     lipocalin; epididymis luminal protein 129"
                     /codon_start=1
                     /product="epididymal-specific lipocalin-9 precursor"
                     /protein_id="NP_001380590.1"
                     /db_xref="CCDS:CCDS94528.1"
                     /db_xref="GeneID:392399"
                     /db_xref="HGNC:HGNC:17442"
                     /db_xref="MIM:612903"
                     /translation="MALLLLSLGLSLIAAQEFDPHTVMQRNYNVARVSGVWYSIFMAS
                     DDLNRIKENGDLRVFVRNIEHLKNGSLIFDFEYMVQGECVAVVVVCEKTEKNGEYSIN
                     YEGQNTVAVSETDYRLFITFHLQNFRNGTETHTLALYDLKKPAKSTDLAHKISST"
     exon            110..246
                     /gene="LCN9"
                     /gene_synonym="HEL129"
                     /inference="alignment:Splign:2.1.0"
     exon            247..320
                     /gene="LCN9"
                     /gene_synonym="HEL129"
                     /inference="alignment:Splign:2.1.0"
     exon            321..431
                     /gene="LCN9"
                     /gene_synonym="HEL129"
                     /inference="alignment:Splign:2.1.0"
     exon            432..496
                     /gene="LCN9"
                     /gene_synonym="HEL129"
                     /inference="alignment:Splign:2.1.0"
     exon            497..1597
                     /gene="LCN9"
                     /gene_synonym="HEL129"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1575..1580
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LCN9"
                     /gene_synonym="HEL129"
                     /note="hexamer: AATAAA"
     polyA_site      1597
                     /gene="LCN9"
                     /gene_synonym="HEL129"
                     /note="major polyA site"
ORIGIN      
        1 gtccacggca aagatggctc tgcttctgct gagcctgggg ctgagcctca tcgcagccca
       61 ggagttcgat ccccacaccg ttatgcagag gaactacaac gtggccaggg tttcaggggt
      121 ctggtattct attttcatgg cctcagatga cctgaatcgg attaaagaaa atggagacct
      181 gagggtcttc gtccggaata ttgaacactt gaagaacggc agcctaatat ttgatttcga
      241 atacatggtg cagggggagt gtgtggctgt ggtcgtggtc tgcgagaaga cagagaagaa
      301 tggggaatac tccatcaact atgagggcca gaacacagtg gccgtctcgg agactgacta
      361 caggctgttc atcaccttcc acctccagaa cttcaggaac gggaccgaga cccacacgct
      421 ggcgctctat gatttgaaga aacctgcgaa aagtacggac ttggctcaca aaatatcatc
      481 gacttgacca acaaagatcc ctgctactcc aagcattaca ggagcccgcc caggcctccc
      541 atgcgtgagc tgcgactcgg gacgggcagg gggctggatg gggagagctt ggggccaacg
      601 tcagaggctg cggggtccca ccccaggagg tgcccatccc tccccctggt ctgggaaccg
      661 aacacaaggt gctttggtga aagatgctgt gaaaagcatc ctggagtcgg ggcagtgatg
      721 gggccttcca gggtggtaag gtctgagcag gaagtgagat ggggccctgt gtgagtctcc
      781 aggggctgat gtcaccatat gcgggtgact aggacaacca ggatttactt tctcacagcc
      841 tggagcccga ggtctgaaac ccgaggtccg cagggctgtg ctccctccac cagctcccgg
      901 gaagggtcct tcctgcctct tccggctgct gggggctcca ggcatccctg gcttgtggct
      961 gtcactccag cctctgcctc tgtctgtgtc tcctcttctg tctcttctaa ggacacttgt
     1021 cattggattt cgggcccatc ttcatgcaga atgatctccc gtcaagacct caacttcaca
     1081 cctgcaaaga ccctttccca tcagatgccc ttcacaggct ccaggcacta ggaaaggagc
     1141 atgtcctttg agggacacca ctcaggtcac cacaggctcc ttctccgagc tgcccctccc
     1201 ttctcagaca tggtcccagc ccagtaaaaa cccccagggc ccccttccct tcccagagcc
     1261 tgagcctccc agagatacgc ctctgaaggc acctctgcat ttctgcacga gggttcctga
     1321 gggtaaagga gtggatgtac ctgtggtgcg tggtggcccc aagatgcggg tgagatgaga
     1381 tggcaaccgg caaccaaggc cctacccctc ccctctccgc ccctcccctc gctgaccttc
     1441 ccctccctgt ccctcccctc tctgcccctc ccctcctgtc ccctccctgg gctcagccac
     1501 tgcctttggg ggaagatgat caacaatgtc acagctgagg caggtgcctg cgcccccgcc
     1561 tccatgtttt ggtgaataaa agggaggtac cagccaa
//
