LOCUS       NM_178469                884 bp    mRNA    linear   PRI 15-FEB-2024
DEFINITION  Homo sapiens lipocalin 8 (LCN8), transcript variant 2, mRNA.
ACCESSION   NM_178469 XM_059963
VERSION     NM_178469.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 884)
  AUTHORS   Suzuki,K., Lareyre,J.J., Sanchez,D., Gutierrez,G., Araki,Y.,
            Matusik,R.J. and Orgebin-Crist,M.C.
  TITLE     Molecular evolution of epididymal lipocalin genes localized on
            mouse chromosome 2
  JOURNAL   Gene 339, 49-59 (2004)
   PUBMED   15363845
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC042109.1, AK126902.1 and AL355987.31.
            
            On Aug 11, 2020 this sequence version replaced NM_178469.3.
            
            Summary: Members of the lipocalin family, such as LCN8, have a
            common structure consisting of an 8-stranded antiparallel
            beta-barrel that forms a cup-shaped ligand-binding pocket or calyx.
            Lipocalins generally bind small hydrophobic ligands and transport
            them to specific cells (Suzuki et al., 2004 [PubMed
            15363845]).[supplied by OMIM, Aug 2009].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (2)
            has a shorter and distinct N-terminus compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC132714.1, GQ891310.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968189,
                                           SAMEA2144335 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371688.8/ ENSP00000360753.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-539               BC042109.1         46-584
            540-882             AK126902.1         2129-2471
            883-884             AL355987.31        32871-32872         c
FEATURES             Location/Qualifiers
     source          1..884
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..884
                     /gene="LCN8"
                     /gene_synonym="EP17; LCN5"
                     /note="lipocalin 8"
                     /db_xref="GeneID:138307"
                     /db_xref="HGNC:HGNC:27038"
                     /db_xref="MIM:612902"
     exon            1..337
                     /gene="LCN8"
                     /gene_synonym="EP17; LCN5"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..772
                     /gene="LCN8"
                     /gene_synonym="EP17; LCN5"
                     /note="isoform 2 is encoded by transcript variant 2;
                     lipocalin 5; epididymal-specific lipocalin-8; epididymis
                     secretory sperm binding protein"
                     /codon_start=1
                     /product="epididymal-specific lipocalin-8 isoform 2"
                     /protein_id="NP_848564.2"
                     /db_xref="CCDS:CCDS35183.1"
                     /db_xref="GeneID:138307"
                     /db_xref="HGNC:HGNC:27038"
                     /db_xref="MIM:612902"
                     /translation="MEELDRQKIGGFWREVGVASDQSLVLTAPKRVEGLFLTLSGSNL
                     TVKVAYNSSGSCEIEKIVGSEIDSTGKFAFPGHREIHVLDTDYEGYAILRVSLMWRGR
                     NFRVLKYFTRSLEDKDRLGFWKFRELTADTGLYLAARPGRCAELLKEELI"
     exon            338..468
                     /gene="LCN8"
                     /gene_synonym="EP17; LCN5"
                     /inference="alignment:Splign:2.1.0"
     exon            469..539
                     /gene="LCN8"
                     /gene_synonym="EP17; LCN5"
                     /inference="alignment:Splign:2.1.0"
     exon            540..644
                     /gene="LCN8"
                     /gene_synonym="EP17; LCN5"
                     /inference="alignment:Splign:2.1.0"
     exon            645..734
                     /gene="LCN8"
                     /gene_synonym="EP17; LCN5"
                     /inference="alignment:Splign:2.1.0"
     exon            735..760
                     /gene="LCN8"
                     /gene_synonym="EP17; LCN5"
                     /inference="alignment:Splign:2.1.0"
     exon            761..884
                     /gene="LCN8"
                     /gene_synonym="EP17; LCN5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      867..872
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LCN8"
                     /gene_synonym="EP17; LCN5"
                     /note="hexamer: AATAAA"
     polyA_site      884
                     /gene="LCN8"
                     /gene_synonym="EP17; LCN5"
                     /note="major polyA site"
ORIGIN      
        1 agcgtccacc gctgtccata tgccaggagg gtggctgggc aggctgctgt ctaggccagg
       61 ctaacccctg cggtgggcgt gggtgtcacc agggccgatg gcgcttgtgc agaaacccac
      121 gtctctgagc tgccagcagc caagctgtcc tgatgacatt cccgggtggg cgcacaagcc
      181 tgcactgtcc gtatagaatc ggcccaggct gtgcagcagg ggaacccgga gcccggaccc
      241 cgccacggag gccaggctgc cgtgcaccat cctgggtgtc ctcgtggtgc tccgggcgca
      301 ggtggcagca gccatggagg agctggaccg gcagaagatt ggaggattct ggagggaagt
      361 cggtgtggcc tccgatcaaa gcctggtgct gacggccccg aagcgggtgg agggcttgtt
      421 cctcaccttg agcgggagta acctgaccgt gaaggttgca tataacagct caggaagctg
      481 tgagatagag aagatcgtgg gctcagaaat agacagtacg ggaaaattcg cttttcctgg
      541 ccacagagag atccacgtgc tggacaccga ctacgagggc tacgccatcc tgcgggtgtc
      601 cctgatgtgg cggggcagga actttcgcgt cctcaagtac tttactcgga gccttgagga
      661 caaggaccgg ctggggttct ggaagtttcg ggagctgaca gcagacactg gtctctacct
      721 ggcggcccgg cctgggcggt gtgccgagct cctgaaggag gagctgattt aatggagttc
      781 ctgcctcaga ccacaaggtt cggagcgccc gcccacccct gcccctcctg ggcaccctgc
      841 ccaccaggtc acctgcacct gctctgaata aactgtgaag tcaa
//
