LOCUS       NM_198946                708 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens lipocalin 6 (LCN6), mRNA.
ACCESSION   NM_198946 XM_353492
VERSION     NM_198946.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 708)
  AUTHORS   .
  TITLE     Anti-hLCN6 Monoclonal Antibody
  JOURNAL   Monoclon Antib Immunodiagn Immunother 36 (5), 242 (2017)
   PUBMED   29053426
  REMARK    GeneRIF: Anti-hLCN6 Monoclonal Antibody.
REFERENCE   2  (bases 1 to 708)
  AUTHORS   Suzuki,K., Lareyre,J.J., Sanchez,D., Gutierrez,G., Araki,Y.,
            Matusik,R.J. and Orgebin-Crist,M.C.
  TITLE     Molecular evolution of epididymal lipocalin genes localized on
            mouse chromosome 2
  JOURNAL   Gene 339, 49-59 (2004)
   PUBMED   15363845
REFERENCE   3  (bases 1 to 708)
  AUTHORS   Hamil,K.G., Liu,Q., Sivashanmugam,P., Anbalagan,M., Yenugu,S.,
            Soundararajan,R., Grossman,G., Rao,A.J., Birse,C.E., Ruben,S.M.,
            Richardson,R.T., Zhang,Y.L., O'Rand,M.G., Petrusz,P., French,F.S.
            and Hall,S.H.
  TITLE     LCN6, a novel human epididymal lipocalin
  JOURNAL   Reprod Biol Endocrinol 1, 112 (2003)
   PUBMED   14617364
  REMARK    GeneRIF: Predominant expression in the epididymis and location on
            sperm surface are consistent with a role for LCN6 in male fertility
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 708)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC062746.1 and AF303084.1.
            
            On Nov 23, 2018 this sequence version replaced NM_198946.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF303084.1, BC062746.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341206.9/ ENSP00000339621.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BC062746.1         5-20
            17-706              AF303084.1         17-706
            707-708             BC062746.1         711-712
FEATURES             Location/Qualifiers
     source          1..708
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..708
                     /gene="LCN6"
                     /gene_synonym="hLcn5; LCN5; UNQ643"
                     /note="lipocalin 6"
                     /db_xref="GeneID:158062"
                     /db_xref="HGNC:HGNC:17337"
                     /db_xref="MIM:609379"
     exon            1..132
                     /gene="LCN6"
                     /gene_synonym="hLcn5; LCN5; UNQ643"
                     /inference="alignment:Splign:2.1.0"
     CDS             43..534
                     /gene="LCN6"
                     /gene_synonym="hLcn5; LCN5; UNQ643"
                     /note="epididymal-specific lipocalin-6;
                     epididymal-specific lipocalin LCN6; lipocalin 5;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="epididymal-specific lipocalin-6 precursor"
                     /protein_id="NP_945184.1"
                     /db_xref="CCDS:CCDS7005.1"
                     /db_xref="GeneID:158062"
                     /db_xref="HGNC:HGNC:17337"
                     /db_xref="MIM:609379"
                     /translation="MGGLLLAAFLALVSVPRAQAVWLGRLDPEQLLGPWYVLAVASRE
                     KGFAMEKDMKNVVGVVVTLTPENNLRTLSSQHGLGGCDQSVMDLIKRNSGWVFENPSI
                     GVLELWVLATNFRDYAIIFTQLEFGDEPFNTVELYSLTETASQEAMGLFTKWSRSLGF
                     LSQ"
     exon            133..272
                     /gene="LCN6"
                     /gene_synonym="hLcn5; LCN5; UNQ643"
                     /inference="alignment:Splign:2.1.0"
     exon            273..343
                     /gene="LCN6"
                     /gene_synonym="hLcn5; LCN5; UNQ643"
                     /inference="alignment:Splign:2.1.0"
     exon            344..454
                     /gene="LCN6"
                     /gene_synonym="hLcn5; LCN5; UNQ643"
                     /inference="alignment:Splign:2.1.0"
     exon            455..556
                     /gene="LCN6"
                     /gene_synonym="hLcn5; LCN5; UNQ643"
                     /inference="alignment:Splign:2.1.0"
     exon            557..582
                     /gene="LCN6"
                     /gene_synonym="hLcn5; LCN5; UNQ643"
                     /inference="alignment:Splign:2.1.0"
     exon            583..708
                     /gene="LCN6"
                     /gene_synonym="hLcn5; LCN5; UNQ643"
                     /inference="alignment:Splign:2.1.0"
     regulatory      687..692
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LCN6"
                     /gene_synonym="hLcn5; LCN5; UNQ643"
                     /note="hexamer: AATAAA"
     polyA_site      708
                     /gene="LCN6"
                     /gene_synonym="hLcn5; LCN5; UNQ643"
                     /note="major polyA site"
ORIGIN      
        1 actgcacatc ctgggcctgc ggcgcagtgt agacctggga ggatgggcgg cctgctgctg
       61 gctgcttttc tggctttggt ctcggtgccc agggcccagg ccgtgtggtt gggaagactg
      121 gaccctgagc agcttcttgg gccctggtac gtgcttgcgg tggcctcccg ggaaaagggc
      181 tttgccatgg agaaggacat gaagaacgtc gtgggggtgg tggtgaccct cactccagaa
      241 aacaacctgc ggacgctgtc ctctcagcac gggctgggag ggtgtgacca gagtgtcatg
      301 gacctgataa agcgaaactc cggatgggtg tttgagaatc cctcaatagg cgtgctggag
      361 ctctgggtgc tggccaccaa cttcagagac tatgccatca tcttcactca gctggagttc
      421 ggggacgagc ccttcaacac cgtggagctg tacagtctga cggagacagc cagccaggag
      481 gccatggggc tcttcaccaa gtggagcagg agcctgggct tcctgtcaca gtagcaggcc
      541 cagctgcaga aggacctcac ctgtgctcac aagatccttc tgtgagtgct gcgtccccag
      601 tagggatggc gcccacaggg tcctgtgacc tcggccagtg tccacccacc tcgctcagcg
      661 gctcccgggg cccagcacca gctcagaata aagcgattcc acagcaaa
//
