LOCUS       NM_005564                820 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens lipocalin 2 (LCN2), mRNA.
ACCESSION   NM_005564
VERSION     NM_005564.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 820)
  AUTHORS   Huang,Z., Li,Y., Qian,Y., Zhai,E., Zhao,Z., Zhang,T., Liu,Y.,
            Ye,L., Wei,R., Zhao,R., Li,Z., Liang,Z., Cai,S. and Chen,J.
  TITLE     Tumor-secreted LCN2 impairs gastric cancer progression via
            autocrine inhibition of the 24p3R/JNK/c-Jun/SPARC axis
  JOURNAL   Cell Death Dis 15 (10), 756 (2024)
   PUBMED   39424639
  REMARK    GeneRIF: Tumor-secreted LCN2 impairs gastric cancer progression via
            autocrine inhibition of the 24p3R/JNK/c-Jun/SPARC axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 820)
  AUTHORS   Yang,Y., Li,S., Liu,K., Zhang,Y., Zhu,F., Ben,T., Chen,Z. and
            Zhi,F.
  TITLE     Lipocalin-2-mediated intestinal epithelial cells pyroptosis via
            NF-kappaB/NLRP3/GSDMD signaling axis adversely affects inflammation
            in colitis
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (7), 167279 (2024)
   PUBMED   38844113
  REMARK    GeneRIF: Lipocalin-2-mediated intestinal epithelial cells
            pyroptosis via NF-kappaB/NLRP3/GSDMD signaling axis adversely
            affects inflammation in colitis.
REFERENCE   3  (bases 1 to 820)
  AUTHORS   Qiu,R., Cai,Y., Su,Y., Fan,K., Sun,Z. and Zhang,Y.
  TITLE     Emerging insights into Lipocalin-2: Unraveling its role in
            Parkinson's Disease
  JOURNAL   Biomed Pharmacother 177, 116947 (2024)
   PUBMED   38901198
  REMARK    GeneRIF: Emerging insights into Lipocalin-2: Unraveling its role in
            Parkinson's Disease.
            Review article
REFERENCE   4  (bases 1 to 820)
  AUTHORS   Olar,M.P., Iacobescu,M., Bolboaca,S.D., Pojoga,C., Mosteanu,O.,
            Seicean,R., Rusu,I., Banc,O., Iuga,C.A. and Seicean,A.
  TITLE     Neutrophil Gelatinase-Associated Lipocalin for the Differentiation
            of Mucinous Pancreatic Cystic Lesions
  JOURNAL   Int J Mol Sci 25 (6), 3224 (2024)
   PUBMED   38542201
  REMARK    GeneRIF: Neutrophil Gelatinase-Associated Lipocalin for the
            Differentiation of Mucinous Pancreatic Cystic Lesions.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 820)
  AUTHORS   Paparella,R., Ferraguti,G., Fiore,M., Menghi,M., Micangeli,G.,
            Tarani,F., Ligotino,A., Messina,M.P., Ceccanti,M., Minni,A.,
            Barbato,C., Lucarelli,M., Tarani,L. and Petrella,C.
  TITLE     Serum Lipocalin-2 Levels as a Biomarker in Pre- and Post-Pubertal
            Klinefelter Syndrome Patients: A Pilot Study
  JOURNAL   Int J Mol Sci 25 (4), 2214 (2024)
   PUBMED   38396890
  REMARK    GeneRIF: Serum Lipocalin-2 Levels as a Biomarker in Pre- and
            Post-Pubertal Klinefelter Syndrome Patients: A Pilot Study.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 820)
  AUTHORS   Cowland,J.B. and Borregaard,N.
  TITLE     Molecular characterization and pattern of tissue expression of the
            gene for neutrophil gelatinase-associated lipocalin from humans
  JOURNAL   Genomics 45 (1), 17-23 (1997)
   PUBMED   9339356
REFERENCE   7  (bases 1 to 820)
  AUTHORS   Blaser,J., Triebel,S. and Tschesche,H.
  TITLE     A sandwich enzyme immunoassay for the determination of neutrophil
            lipocalin in body fluids
  JOURNAL   Clin Chim Acta 235 (2), 137-145 (1995)
   PUBMED   7554268
REFERENCE   8  (bases 1 to 820)
  AUTHORS   Chan,P., Simon-Chazottes,D., Mattei,M.G., Guenet,J.L. and
            Salier,J.P.
  TITLE     Comparative mapping of lipocalin genes in human and mouse: the four
            genes for complement C8 gamma chain, prostaglandin-D-synthase,
            oncogene-24p3, and progestagen-associated endometrial protein map
            to HSA9 and MMU2
  JOURNAL   Genomics 23 (1), 145-150 (1994)
   PUBMED   7829063
REFERENCE   9  (bases 1 to 820)
  AUTHORS   Kjeldsen,L., Johnsen,A.H., Sengelov,H. and Borregaard,N.
  TITLE     Isolation and primary structure of NGAL, a novel protein associated
            with human neutrophil gelatinase
  JOURNAL   J Biol Chem 268 (14), 10425-10432 (1993)
   PUBMED   7683678
REFERENCE   10 (bases 1 to 820)
  AUTHORS   Triebel,S., Blaser,J., Reinke,H. and Tschesche,H.
  TITLE     A 25 kDa alpha 2-microglobulin-related protein is a component of
            the 125 kDa form of human gelatinase
  JOURNAL   FEBS Lett 314 (3), 386-388 (1992)
   PUBMED   1281792
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX644845.1, BC033089.1 and
            BM977724.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005564.4.
            
            Summary: This gene encodes a protein that belongs to the lipocalin
            family. Members of this family transport small hydrophobic
            molecules such as lipids, steroid hormones and retinoids. The
            protein encoded by this gene is a neutrophil gelatinase-associated
            lipocalin and plays a role in innate immunity by limiting bacterial
            growth as a result of sequestering iron-containing siderophores.
            The presence of this protein in blood and urine is an early
            biomarker of acute kidney injury. This protein is thought to be be
            involved in multiple cellular processes, including maintenance of
            skin homeostasis, and suppression of invasiveness and metastasis.
            Mice lacking this gene are more susceptible to bacterial infection
            than wild type mice. [provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ686961.1, BU196396.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000277480.7/ ENSP00000277480.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BX644845.1         37-49
            14-818              BC033089.1         1-805
            819-820             BM977724.1         21-22               c
FEATURES             Location/Qualifiers
     source          1..820
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..820
                     /gene="LCN2"
                     /gene_synonym="24p3; MSFI; NGAL; p25"
                     /note="lipocalin 2"
                     /db_xref="GeneID:3934"
                     /db_xref="HGNC:HGNC:6526"
                     /db_xref="MIM:600181"
     exon            1..211
                     /gene="LCN2"
                     /gene_synonym="24p3; MSFI; NGAL; p25"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..670
                     /gene="LCN2"
                     /gene_synonym="24p3; MSFI; NGAL; p25"
                     /note="oncogene 24p3; neutrophil gelatinase-associated
                     lipocalin; migration-stimulating factor inhibitor; 25 kDa
                     alpha-2-microglobulin-related subunit of MMP-9;
                     siderocalin LCN2"
                     /codon_start=1
                     /product="neutrophil gelatinase-associated lipocalin
                     precursor"
                     /protein_id="NP_005555.2"
                     /db_xref="CCDS:CCDS6892.1"
                     /db_xref="GeneID:3934"
                     /db_xref="HGNC:HGNC:6526"
                     /db_xref="MIM:600181"
                     /translation="MPLGLLWLGLALLGALHAQAQDSTSDLIPAPPLSKVPLQQNFQD
                     NQFQGKWYVVGLAGNAILREDKDPQKMYATIYELKEDKSYNVTSVLFRKKKCDYWIRT
                     FVPGCQPGEFTLGNIKSYPGLTSYLVRVVSTNYNQHAMVFFKKVSQNREYFKITLYGR
                     TKELTSELKENFIRFSKSLGLPENHIVFPVPIDQCIDG"
     exon            212..348
                     /gene="LCN2"
                     /gene_synonym="24p3; MSFI; NGAL; p25"
                     /inference="alignment:Splign:2.1.0"
     exon            349..428
                     /gene="LCN2"
                     /gene_synonym="24p3; MSFI; NGAL; p25"
                     /inference="alignment:Splign:2.1.0"
     exon            429..548
                     /gene="LCN2"
                     /gene_synonym="24p3; MSFI; NGAL; p25"
                     /inference="alignment:Splign:2.1.0"
     exon            549..650
                     /gene="LCN2"
                     /gene_synonym="24p3; MSFI; NGAL; p25"
                     /inference="alignment:Splign:2.1.0"
     exon            651..677
                     /gene="LCN2"
                     /gene_synonym="24p3; MSFI; NGAL; p25"
                     /inference="alignment:Splign:2.1.0"
     exon            678..820
                     /gene="LCN2"
                     /gene_synonym="24p3; MSFI; NGAL; p25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      801..806
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LCN2"
                     /gene_synonym="24p3; MSFI; NGAL; p25"
                     /note="hexamer: AATAAA"
     polyA_site      820
                     /gene="LCN2"
                     /gene_synonym="24p3; MSFI; NGAL; p25"
                     /note="major polyA site"
ORIGIN      
        1 actcgccacc tcctcttcca cccctgccag gcccagcagc caccacagcg cctgcttcct
       61 cggccctgaa atcatgcccc taggtctcct gtggctgggc ctagccctgt tgggggctct
      121 gcatgcccag gcccaggact ccacctcaga cctgatccca gccccacctc tgagcaaggt
      181 ccctctgcag cagaacttcc aggacaacca attccagggg aagtggtatg tggtaggcct
      241 ggcagggaat gcaattctca gagaagacaa agacccgcaa aagatgtatg ccaccatcta
      301 tgagctgaaa gaagacaaga gctacaatgt cacctccgtc ctgtttagga aaaagaagtg
      361 tgactactgg atcaggactt ttgttccagg ttgccagccc ggcgagttca cgctgggcaa
      421 cattaagagt taccctggat taacgagtta cctcgtccga gtggtgagca ccaactacaa
      481 ccagcatgct atggtgttct tcaagaaagt ttctcaaaac agggagtact tcaagatcac
      541 cctctacggg agaaccaagg agctgacttc ggaactaaag gagaacttca tccgcttctc
      601 caaatctctg ggcctccctg aaaaccacat cgtcttccct gtcccaatcg accagtgtat
      661 cgacggctga gtgcacaggt gccgccagct gccgcaccag cccgaacacc attgagggag
      721 ctgggagacc ctccccacag tgccacccat gcagctgctc cccaggccac cccgctgatg
      781 gagccccacc ttgtctgcta aataaacatg tgccctcagg
//
