LOCUS       NM_203347                767 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens lipocalin 15 (LCN15), mRNA.
ACCESSION   NM_203347 XM_372158
VERSION     NM_203347.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 767)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   2  (bases 1 to 767)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 767)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL355987.31 and AY358618.1.
            
            On Nov 23, 2018 this sequence version replaced NM_203347.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358618.1, BC093893.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267769 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316144.6/ ENSP00000313833.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AL355987.31        42999-43003         c
            6-767               AY358618.1         1-762
FEATURES             Location/Qualifiers
     source          1..767
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..767
                     /gene="LCN15"
                     /gene_synonym="PRO6093; UNQ2541"
                     /note="lipocalin 15"
                     /db_xref="GeneID:389812"
                     /db_xref="HGNC:HGNC:33777"
     exon            1..126
                     /gene="LCN15"
                     /gene_synonym="PRO6093; UNQ2541"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..585
                     /gene="LCN15"
                     /gene_synonym="PRO6093; UNQ2541"
                     /EC_number="5.3.99.2"
                     /note="MSFL2541"
                     /codon_start=1
                     /product="lipocalin-15 precursor"
                     /protein_id="NP_976222.1"
                     /db_xref="CCDS:CCDS7006.1"
                     /db_xref="GeneID:389812"
                     /db_xref="HGNC:HGNC:33777"
                     /translation="MMSFLLGAILTLLWAPTAQAEVLLQPDFNAEKFSGLWYVVSMAS
                     DCRVFLGKKDHLSMSTRAIRPTEEGGLHVHMEFPGADGCNQVDAEYLKVGSEGHFRVP
                     ALGYLDVRIVDTDYSSFAVLYIYKELEGALSTMVQLYSRTQDVSPQALKSFQDFYPTL
                     GLPKDMMVMLPQSDACNPESKEAP"
     exon            127..266
                     /gene="LCN15"
                     /gene_synonym="PRO6093; UNQ2541"
                     /inference="alignment:Splign:2.1.0"
     exon            267..337
                     /gene="LCN15"
                     /gene_synonym="PRO6093; UNQ2541"
                     /inference="alignment:Splign:2.1.0"
     exon            338..448
                     /gene="LCN15"
                     /gene_synonym="PRO6093; UNQ2541"
                     /inference="alignment:Splign:2.1.0"
     exon            449..550
                     /gene="LCN15"
                     /gene_synonym="PRO6093; UNQ2541"
                     /inference="alignment:Splign:2.1.0"
     exon            551..617
                     /gene="LCN15"
                     /gene_synonym="PRO6093; UNQ2541"
                     /inference="alignment:Splign:2.1.0"
     exon            618..767
                     /gene="LCN15"
                     /gene_synonym="PRO6093; UNQ2541"
                     /inference="alignment:Splign:2.1.0"
     regulatory      745..750
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LCN15"
                     /gene_synonym="PRO6093; UNQ2541"
                     /note="hexamer: AATAAA"
     polyA_site      767
                     /gene="LCN15"
                     /gene_synonym="PRO6093; UNQ2541"
                     /note="major polyA site"
ORIGIN      
        1 agcaccaggg gctggagggc aggggagggg atgatgtcat tcctgctcgg cgcaatcctg
       61 accctgctct gggcgcccac ggctcaggct gaggttctgc tgcagcctga cttcaatgct
      121 gaaaagttct caggcctctg gtacgtggtc tccatggcat ctgactgcag ggtcttcctg
      181 ggcaagaagg accacctgtc catgtccacc agggccatca ggcccacaga ggagggcggc
      241 ctccacgtcc acatggagtt cccgggggcg gacggctgta accaggtgga tgccgagtac
      301 ctgaaggtgg gctccgaggg acacttcaga gtcccggcct tgggctacct ggacgtgcgc
      361 atcgtggaca cagactacag ctccttcgcc gtcctttaca tctacaagga gctggagggg
      421 gccctcagca ccatggtgca gctctacagc cggacccagg atgtgagtcc ccaggctctg
      481 aagtccttcc aggacttcta cccgaccctg gggctcccca aggacatgat ggtcatgctg
      541 ccccagtcag atgcatgcaa ccctgagagc aaggaggcgc cctgacacct ccggagcccc
      601 acccccgccc ttcccaggtg gagccaaagc agcaggcgcc tttgcccctg gagtcaagac
      661 ccacagccct cggggaccac ctggagtctc tccatcctcc accccccgcc tgtgggatgc
      721 cttgtgggac gtctctttct attcaataaa cagatgctgc agcctca
//
