LOCUS       NM_178536                732 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens lipocalin 12 (LCN12), mRNA.
ACCESSION   NM_178536
VERSION     NM_178536.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 732)
  AUTHORS   Lu,Y., Vitart,V., Burdon,K.P., Khor,C.C., Bykhovskaya,Y.,
            Mirshahi,A., Hewitt,A.W., Koehn,D., Hysi,P.G., Ramdas,W.D.,
            Zeller,T., Vithana,E.N., Cornes,B.K., Tay,W.T., Tai,E.S.,
            Cheng,C.Y., Liu,J., Foo,J.N., Saw,S.M., Thorleifsson,G.,
            Stefansson,K., Dimasi,D.P., Mills,R.A., Mountain,J., Ang,W.,
            Hoehn,R., Verhoeven,V.J., Grus,F., Wolfs,R., Castagne,R.,
            Lackner,K.J., Springelkamp,H., Yang,J., Jonasson,F., Leung,D.Y.,
            Chen,L.J., Tham,C.C., Rudan,I., Vatavuk,Z., Hayward,C., Gibson,J.,
            Cree,A.J., MacLeod,A., Ennis,S., Polasek,O., Campbell,H.,
            Wilson,J.F., Viswanathan,A.C., Fleck,B., Li,X., Siscovick,D.,
            Taylor,K.D., Rotter,J.I., Yazar,S., Ulmer,M., Li,J., Yaspan,B.L.,
            Ozel,A.B., Richards,J.E., Moroi,S.E., Haines,J.L., Kang,J.H.,
            Pasquale,L.R., Allingham,R.R., Ashley-Koch,A., Mitchell,P.,
            Wang,J.J., Wright,A.F., Pennell,C., Spector,T.D., Young,T.L.,
            Klaver,C.C., Martin,N.G., Montgomery,G.W., Anderson,M.G., Aung,T.,
            Willoughby,C.E., Wiggs,J.L., Pang,C.P., Thorsteinsdottir,U.,
            Lotery,A.J., Hammond,C.J., van Duijn,C.M., Hauser,M.A.,
            Rabinowitz,Y.S., Pfeiffer,N., Mackey,D.A., Craig,J.E., Macgregor,S.
            and Wong,T.Y.
  CONSRTM   NEIGHBOR Consortium
  TITLE     Genome-wide association analyses identify multiple loci associated
            with central corneal thickness and keratoconus
  JOURNAL   Nat Genet 45 (2), 155-163 (2013)
   PUBMED   23291589
REFERENCE   2  (bases 1 to 732)
  AUTHORS   Suzuki,K., Lareyre,J.J., Sanchez,D., Gutierrez,G., Araki,Y.,
            Matusik,R.J. and Orgebin-Crist,M.C.
  TITLE     Molecular evolution of epididymal lipocalin genes localized on
            mouse chromosome 2
  JOURNAL   Gene 339, 49-59 (2004)
   PUBMED   15363845
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807752.10, BX281250.1, AY301272.1 and AI681012.1.
            
            On Nov 22, 2018 this sequence version replaced NM_178536.3.
            
            Summary: Members of the lipocalin family, such as LCN12, have a
            common structure consisting of an 8-stranded antiparallel
            beta-barrel that forms a cup-shaped ligand-binding pocket or calyx.
            Lipocalins generally bind small hydrophobic ligands and transport
            them to specific cells (Suzuki et al., 2004 [PubMed
            15363845]).[supplied by OMIM, Aug 2009].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY301272.1, GQ891520.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145240, SAMEA2162328
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371633.8/ ENSP00000360696.3
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AL807752.10        22235-22277
            44-55               BX281250.1         1-12
            56-634              AY301272.1         1-579
            635-732             AI681012.1         8-105               c
FEATURES             Location/Qualifiers
     source          1..732
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..732
                     /gene="LCN12"
                     /note="lipocalin 12"
                     /db_xref="GeneID:286256"
                     /db_xref="HGNC:HGNC:28733"
                     /db_xref="MIM:612905"
     exon            1..169
                     /gene="LCN12"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..634
                     /gene="LCN12"
                     /note="lipocalcin 12; epididymal-specific lipocalin-12;
                     epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="epididymal-specific lipocalin-12 precursor"
                     /protein_id="NP_848631.2"
                     /db_xref="CCDS:CCDS7018.2"
                     /db_xref="GeneID:286256"
                     /db_xref="HGNC:HGNC:28733"
                     /db_xref="MIM:612905"
                     /translation="MRLLCGLWLWLSLLKVLQAQTPTPLPLPPPMQSFQGNQFQGEWF
                     VLGLAGNSFRPEHRALLNAFTATFELSDDGRFEVWNAMTRGQHCDTWSYVLIPAAQPG
                     QFTVDHGVEPGADREETRVVDSDYTQFALMLSRRHTSRLAVLRISLLGRSWLLPPGTL
                     DQFICLGRAQGLSDDNIVFPDVTGWSPQASVC"
     exon            170..306
                     /gene="LCN12"
                     /inference="alignment:Splign:2.1.0"
     exon            307..386
                     /gene="LCN12"
                     /inference="alignment:Splign:2.1.0"
     exon            387..503
                     /gene="LCN12"
                     /inference="alignment:Splign:2.1.0"
     exon            504..605
                     /gene="LCN12"
                     /inference="alignment:Splign:2.1.0"
     exon            606..732
                     /gene="LCN12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      712..717
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LCN12"
                     /note="hexamer: AATAAA"
     polyA_site      732
                     /gene="LCN12"
                     /note="major polyA site"
ORIGIN      
        1 acctgcccat ggccacttcc ttctctctgt ccctgtgggc ccagcagctg ccaggatgag
       61 gctgctgtgt ggcctgtggc tgtggctctc cttgctgaaa gtcctgcagg cccagacccc
      121 aacccccctg ccactcccgc ccccgatgca gagcttccaa ggaaaccagt tccaggggga
      181 atggttcgtc ctgggcctgg cgggcaacag cttcaggccg gagcacaggg cgctgctgaa
      241 cgctttcacc gcaacttttg agctaagtga tgatggccgc tttgaggtgt ggaatgcgat
      301 gactcgaggc cagcactgtg acacatggtc ttatgtgctg ataccggcag cccagcctgg
      361 gcagttcact gtggaccacg gtgtggagcc cggggcggac agagaggaga cccgggtggt
      421 ggacagcgac tacacccagt tcgccctgat gctgtcccgc agacacacga gcaggctggc
      481 cgtcctcagg atcagcctgc tgggcaggag ctggttgctg cctcccggga cgctggacca
      541 gttcatctgc ctgggcagag ctcagggcct ctcggatgac aacatcgtct tcccagatgt
      601 gactggctgg tcaccccagg ccagcgtctg ttgaaggatg aagcagctcc tgtccggccc
      661 agccctgcct cacagctgtg cgagctctgc cctcctcagc tctcaaacct gaataaatgc
      721 accaagccca ga
//
