LOCUS       NM_001001712            1995 bp    mRNA    linear   PRI 27-JUL-2024
DEFINITION  Homo sapiens lipocalin 10 (LCN10), transcript variant 1, mRNA.
ACCESSION   NM_001001712 XM_497083
VERSION     NM_001001712.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1995)
  AUTHORS   Zhao,H., Wang,P., Wang,X., Du,W., Yang,H.H., Liu,Y., Cui,S.N.,
            Huang,W., Peng,T., Chen,J., Gao,C., Wang,Y., Sadayappan,S., Ma,C.,
            Fan,Y., Wang,C. and Fan,G.C.
  TITLE     Lipocalin 10 is essential for protection against
            inflammation-triggered vascular leakage by activating LDL
            receptor-related protein 2-slingshot homologue 1 signalling pathway
  JOURNAL   Cardiovasc Res 119 (10), 1981-1996 (2023)
   PUBMED   37392461
  REMARK    GeneRIF: Lipocalin 10 is essential for protection against
            inflammation-triggered vascular leakage by activating LDL
            receptor-related protein 2-slingshot homologue 1 signalling
            pathway.
REFERENCE   2  (bases 1 to 1995)
  AUTHORS   Li,Q., Li,Y., Huang,W., Wang,X., Liu,Z., Chen,J., Fan,Y., Peng,T.,
            Sadayappan,S., Wang,Y. and Fan,G.C.
  TITLE     Loss of Lipocalin 10 Exacerbates Diabetes-Induced Cardiomyopathy
            via Disruption of Nr4a1-Mediated Anti-Inflammatory Response in
            Macrophages
  JOURNAL   Front Immunol 13, 930397 (2022)
   PUBMED   35757735
  REMARK    GeneRIF: Loss of Lipocalin 10 Exacerbates Diabetes-Induced
            Cardiomyopathy via Disruption of Nr4a1-Mediated Anti-Inflammatory
            Response in Macrophages.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1995)
  AUTHORS   Wang,L., Xie,W., Li,G., Hu,B., Wu,W., Zhan,L. and Zou,H.
  TITLE     Lipocalin 10 as a New Prognostic Biomarker in Sepsis-Induced
            Myocardial Dysfunction and Mortality: A Pilot Study
  JOURNAL   Mediators Inflamm 2021, 6616270 (2021)
   PUBMED   34121925
  REMARK    GeneRIF: Lipocalin 10 as a New Prognostic Biomarker in
            Sepsis-Induced Myocardial Dysfunction and Mortality: A Pilot Study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1995)
  AUTHORS   Suzuki,K., Lareyre,J.J., Sanchez,D., Gutierrez,G., Araki,Y.,
            Matusik,R.J. and Orgebin-Crist,M.C.
  TITLE     Molecular evolution of epididymal lipocalin genes localized on
            mouse chromosome 2
  JOURNAL   Gene 339, 49-59 (2004)
   PUBMED   15363845
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL355987.31.
            
            On Jan 11, 2019 this sequence version replaced NM_001001712.2.
            
            Summary: Members of the lipocalin family, such as LCN10, have a
            common structure consisting of an 8-stranded antiparallel
            beta-barrel that forms a cup-shaped ligand-binding pocket or calyx.
            Lipocalins generally bind small hydrophobic ligands and transport
            them to specific cells (Suzuki et al., 2004 [PubMed
            15363845]).[supplied by OMIM, Aug 2009].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC133045.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158188 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000497771.6/ ENSP00000418491.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               AL355987.31        21272-21425         c
            155-294             AL355987.31        20366-20505         c
            295-404             AL355987.31        19737-19846         c
            405-512             AL355987.31        19321-19428         c
            513-611             AL355987.31        18435-18533         c
            612-1995            AL355987.31        16655-18038         c
FEATURES             Location/Qualifiers
     source          1..1995
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..1995
                     /gene="LCN10"
                     /note="lipocalin 10"
                     /db_xref="GeneID:414332"
                     /db_xref="HGNC:HGNC:20892"
                     /db_xref="MIM:612904"
     exon            1..154
                     /gene="LCN10"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..640
                     /gene="LCN10"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; epididymal-specific lipocalin-10"
                     /codon_start=1
                     /product="epididymal-specific lipocalin-10 isoform 1
                     precursor"
                     /protein_id="NP_001001712.2"
                     /db_xref="CCDS:CCDS35182.2"
                     /db_xref="GeneID:414332"
                     /db_xref="HGNC:HGNC:20892"
                     /db_xref="MIM:612904"
                     /translation="MRQGLLVLALVLVLVLVLAAGSQVQEWYPRESHALNWNKFSGFW
                     YILATATDAQGFLPARDKRKLGASVVKVNKVGQLRVLLAFRRLKGCQSQEVILRKDGK
                     KPVFGNACAYAAGPREGQEGVKGVKAFHVLSTDYSYGLVYLRLGRATQNYKNLLLFHR
                     QNVSSFQSLKEFMDACDILGLSKAAVILPKDASRTHTILP"
     exon            155..294
                     /gene="LCN10"
                     /inference="alignment:Splign:2.1.0"
     exon            295..404
                     /gene="LCN10"
                     /inference="alignment:Splign:2.1.0"
     exon            405..512
                     /gene="LCN10"
                     /inference="alignment:Splign:2.1.0"
     exon            513..611
                     /gene="LCN10"
                     /inference="alignment:Splign:2.1.0"
     exon            612..1995
                     /gene="LCN10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1970..1975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LCN10"
                     /note="hexamer: AATAAA"
     polyA_site      1995
                     /gene="LCN10"
                     /note="major polyA site"
ORIGIN      
        1 aaacactggc cttggcggct gagggaggag ggtgaagatg aggcaggggc tgctggtgct
       61 ggcgctggtg ctggtgctgg tgctagtgct ggctgcaggg tcccaggtgc aggagtggta
      121 ccccagggag tcccacgccc tcaactggaa caagttttca gggttctggt acattctggc
      181 cactgccact gatgcccagg gattcttgcc ggccagggac aagaggaagc tgggggcgtc
      241 cgtggtaaag gtgaacaaag tgggccagct ccgcgtgctc ctcgccttca gacggttgaa
      301 ggggtgccag tcccaggagg tgatcctgag gaaagacggg aagaagccgg tgtttgggaa
      361 cgcctgtgca tacgcggcgg gcccgaggga aggacaggag ggagtgaaag gggtgaaggc
      421 cttccacgtg ctgtccactg actacagcta cggcttggtc tacctccgcc tggggcgtgc
      481 aacccaaaac tacaagaacc tgctgctctt ccataggcag aatgtttcga gcttccagag
      541 tctgaaggaa ttcatggacg cttgtgacat tctggggctc tccaaggccg ccgtcatcct
      601 cccgaaagac gcgtcccgta cacacaccat cctgccatga gagccagcgt cctctgctct
      661 tccctttcga cgcgtggtcc tcccagaccc gaggagcgtt gttccagatg tcaagtggag
      721 accacggctt gttgagaggt gtttggtgac tctaggtcat tgacagtgtg aaaatcaagt
      781 ggctcaaggg atcctttatg atcacagaaa gatgggggaa ggaggataca ggctgaccgg
      841 gtggcgagat gtcagccagg ccccttcccc actgtcttct ggagcacact gcaggctgct
      901 gctattccct gtctgctgtg aaacagacca caggccggcc caacgcagtc ctcgccgtgt
      961 gccttgcctc tgccctccac gccgccgcca ccctccgcgt tcctttacat cctgcacttt
     1021 ctcaggaagc cgttcgcata tccacccaac atggaggagc ccccatgacg tgccaggcag
     1081 cgtgctggcc cctgcggctg cgttagggaa cagaatcggc aaacgcagtc ccagagttga
     1141 tgcctgatca ggagaagcca acttcagcag tgtggtcacc tggatactcg agtatagacc
     1201 ctagatcacc tggatactcg agtatagacc ctagaagtgt atctaggcgc ggccagggcc
     1261 ccacaacagc aggtctgact cattccatcc agggcagcat cagggagagc ttcctggggg
     1321 aagtggcatt tgggctgacc tgggaagggt ggtgggtgtt aagtcagttt gggtggggct
     1381 ggaggagcag gggtgcatcc ccagaacagg atgtgacttc tgaaaagaca tcagagtaga
     1441 gaaaatggtt tctcaaggag attggggacg ccagtatcag aatggcggcg gggagagcca
     1501 cagaggagca ggagggggcc caccagacca cggcacctcg aaggctgcgg tgaaggctta
     1561 ggtctcactc aaggggtgat gacgggaggt tgtctgagat gaacccccca actgaatgaa
     1621 tggaccttct tctggccaag gggatcccaa agaaaccctg aacccgagtc ctcagccatg
     1681 acggggtaag gggtcagccc ctccttctgg cccgagaaga gatcagagat tggttctggg
     1741 cagtccatgg agaatttgct cagctggacc agtacacgct tctcctttca tgaatattca
     1801 tgactcctcc tgaagcttat tgaacatctc tatttggcca tctccttcag cgtaaattcc
     1861 tgtcccctct gtccctcccc tccaagtgtc tgttccaggc ttctggcctg aggctacgct
     1921 tcctagcctg tcagaagggc tgccctgctg gctgcaatct cttatgagaa ataaagctct
     1981 cctgtgtgca aaaaa
//
