LOCUS       NM_002297                787 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens lipocalin 1 (LCN1), transcript variant 1, mRNA.
ACCESSION   NM_002297
VERSION     NM_002297.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 787)
  AUTHORS   Giri,K., Maity,S. and Ambatipudi,K.
  TITLE     Targeted proteomics using parallel reaction monitoring confirms
            salivary proteins indicative of metastatic triple-negative breast
            cancer
  JOURNAL   J Proteomics 267, 104701 (2022)
   PUBMED   35995384
  REMARK    GeneRIF: Targeted proteomics using parallel reaction monitoring
            confirms salivary proteins indicative of metastatic triple-negative
            breast cancer.
REFERENCE   2  (bases 1 to 787)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 787)
  AUTHORS   Glasgow,B.J. and Abduragimov,A.R.
  TITLE     Lipocalin-1 is the acceptor protein for phospholipid transfer
            protein in tears
  JOURNAL   Biochem Biophys Res Commun 548, 35-38 (2021)
   PUBMED   33631671
  REMARK    GeneRIF: Lipocalin-1 is the acceptor protein for phospholipid
            transfer protein in tears.
REFERENCE   4  (bases 1 to 787)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 787)
  AUTHORS   McReynolds,S., Vanderlinden,L., Stevens,J., Hansen,K.,
            Schoolcraft,W.B. and Katz-Jaffe,M.G.
  TITLE     Lipocalin-1: a potential marker for noninvasive aneuploidy
            screening
  JOURNAL   Fertil Steril 95 (8), 2631-2633 (2011)
   PUBMED   21324447
  REMARK    GeneRIF: Study has identified the first protein, lipocalin-1, in
            the secretome of human blastocysts that is associated with
            chromosome aneuploidy.
REFERENCE   6  (bases 1 to 787)
  AUTHORS   Breustedt,D.A., Chatwell,L. and Skerra,A.
  TITLE     A new crystal form of human tear lipocalin reveals high flexibility
            in the loop region and induced fit in the ligand cavity
  JOURNAL   Acta Crystallogr D Biol Crystallogr 65 (Pt 10), 1118-1125 (2009)
   PUBMED   19770509
  REMARK    GeneRIF: Tear lipocalin with the bound artificial ligand
            1,4-butanediol has been crystallized in space group P2(1) with four
            protein molecules in the asymmetric unit and its X-ray structure
            has been solved at 2.6 A resolution.
REFERENCE   7  (bases 1 to 787)
  AUTHORS   Navone,R., Lunardi,C., Gerli,R., Tinazzi,E., Peterlana,D.,
            Bason,C., Corrocher,R. and Puccetti,A.
  TITLE     Identification of tear lipocalin as a novel autoantigen target in
            Sjogren's syndrome
  JOURNAL   J Autoimmun 25 (3), 229-234 (2005)
   PUBMED   16249071
  REMARK    GeneRIF: Lipocalin is a novel autoantigen target in Sjogren's
            syndrome.
REFERENCE   8  (bases 1 to 787)
  AUTHORS   Lassagne,H., Nguyen,V.C., Mattei,M.G. and Gachon,A.M.
  TITLE     Assignment of LCN1 to human chromosome 9 is confirmed
  JOURNAL   Cytogenet Cell Genet 71 (1), 104 (1995)
   PUBMED   7606920
REFERENCE   9  (bases 1 to 787)
  AUTHORS   Blaker,M., Kock,K., Ahlers,C., Buck,F. and Schmale,H.
  TITLE     Molecular cloning of human von Ebner's gland protein, a member of
            the lipocalin superfamily highly expressed in lingual salivary
            glands
  JOURNAL   Biochim Biophys Acta 1172 (1-2), 131-137 (1993)
   PUBMED   7679926
REFERENCE   10 (bases 1 to 787)
  AUTHORS   Redl,B., Holzfeind,P. and Lottspeich,F.
  TITLE     cDNA cloning and sequencing reveals human tear prealbumin to be a
            member of the lipophilic-ligand carrier protein superfamily
  JOURNAL   J Biol Chem 267 (28), 20282-20287 (1992)
   PUBMED   1400345
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M90424.1, X62418.1 and
            CK431106.1.
            
            On Jun 2, 2019 this sequence version replaced NM_002297.3.
            
            Summary: This gene encodes a member of the lipocalin family of
            small secretory proteins. Lipocalins are extracellular transport
            proteins that bind to a variety of hydrophobic ligands. The encoded
            protein is the primary lipid binding protein in tears and is
            overproduced in response to multiple stimuli including infection
            and stress. The encoded protein may be a marker for chromosome
            aneuploidy as well as an autoantigen in Sjogren's syndrome.
            Alternatively spliced transcript variants encoding multiple
            isoforms have been observed for this gene, and two pseudogenes of
            this gene are also located on the long arm of chromosome 9.
            [provided by RefSeq, Nov 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the shortest isoform (1). Variants 1 and 2
            encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065721.1, CB985755.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03465420 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371781.4/ ENSP00000360846.3
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                M90424.1           3-46
            45-779              X62418.1           9-743
            780-787             CK431106.1         503-510
FEATURES             Location/Qualifiers
     source          1..787
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.3"
     gene            1..787
                     /gene="LCN1"
                     /gene_synonym="PMFA; TLC; TP; VEGP"
                     /note="lipocalin 1"
                     /db_xref="GeneID:3933"
                     /db_xref="HGNC:HGNC:6525"
                     /db_xref="MIM:151675"
     exon            1..148
                     /gene="LCN1"
                     /gene_synonym="PMFA; TLC; TP; VEGP"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..589
                     /gene="LCN1"
                     /gene_synonym="PMFA; TLC; TP; VEGP"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; Von Ebner gland protein; protein migrating
                     faster than albumin; VEG protein; tear prealbumin"
                     /codon_start=1
                     /product="lipocalin-1 isoform 1 precursor"
                     /protein_id="NP_002288.1"
                     /db_xref="CCDS:CCDS6991.1"
                     /db_xref="GeneID:3933"
                     /db_xref="HGNC:HGNC:6525"
                     /db_xref="MIM:151675"
                     /translation="MKPLLLAVSLGLIAALQAHHLLASDEEIQDVSGTWYLKAMTVDR
                     EFPEMNLESVTPMTLTTLEGGNLEAKVTMLISGRCQEVKAVLEKTDEPGKYTADGGKH
                     VAYIIRSHVKDHYIFYCEGELHGKPVRGVKLVGRDPKNNLEALEDFEKAAGARGLSTE
                     SILIPRQSETCSPGSD"
     exon            149..279
                     /gene="LCN1"
                     /gene_synonym="PMFA; TLC; TP; VEGP"
                     /inference="alignment:Splign:2.1.0"
     exon            280..350
                     /gene="LCN1"
                     /gene_synonym="PMFA; TLC; TP; VEGP"
                     /inference="alignment:Splign:2.1.0"
     exon            351..461
                     /gene="LCN1"
                     /gene_synonym="PMFA; TLC; TP; VEGP"
                     /inference="alignment:Splign:2.1.0"
     exon            462..563
                     /gene="LCN1"
                     /gene_synonym="PMFA; TLC; TP; VEGP"
                     /inference="alignment:Splign:2.1.0"
     exon            564..590
                     /gene="LCN1"
                     /gene_synonym="PMFA; TLC; TP; VEGP"
                     /inference="alignment:Splign:2.1.0"
     exon            591..787
                     /gene="LCN1"
                     /gene_synonym="PMFA; TLC; TP; VEGP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcctctccc agccccagca agcgacctgt caggcggccg tggactcaga ctccggagat
       61 gaagcccctg ctcctggccg tcagccttgg cctcattgct gccctgcagg cccaccacct
      121 cctggcctca gacgaggaga ttcaggatgt gtcagggacg tggtatctga aggccatgac
      181 ggtggacagg gagttccctg agatgaatct ggaatcggtg acacccatga ccctcacgac
      241 cctggaaggg ggcaacctgg aagccaaggt caccatgctg ataagtggcc ggtgccagga
      301 ggtgaaggcc gtcctggaga aaactgacga gccgggaaaa tacacggccg acgggggcaa
      361 gcacgtggca tacatcatca ggtcgcacgt gaaggaccac tacatctttt actgtgaggg
      421 cgagctgcac gggaagccgg tccgaggggt gaagctcgtg ggcagagacc ccaagaacaa
      481 cctggaagcc ttggaggact ttgagaaagc cgcaggagcc cgcggactca gcacggagag
      541 catcctcatc cccaggcaga gcgaaacctg ctctccaggg agcgattagg ggcaggggac
      601 accttggctc ctcagcagcc caaggacggc accatccagc acctccgtca ttcacaggga
      661 catggaaaaa gctccccacc cctgcagaac gcggctggct gcaccccttc ctaccacccc
      721 ccgccttccc cctgccctgc gccccctctc ctggttctcc ataaagagct tcagcagttc
      781 ccagtga
//
