LOCUS       NM_001002257            4879 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens lysocardiolipin acyltransferase 1 (LCLAT1), transcript
            variant 2, mRNA.
ACCESSION   NM_001002257
VERSION     NM_001002257.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4879)
  AUTHORS   Hao,Y., Fan,Y., Feng,J., Zhu,Z., Luo,Z., Hu,H., Li,W., Yang,H. and
            Ding,G.
  TITLE     ALCAT1-mediated abnormal cardiolipin remodelling promotes
            mitochondrial injury in podocytes in diabetic kidney disease
  JOURNAL   Cell Commun Signal 22 (1), 26 (2024)
   PUBMED   38200543
  REMARK    GeneRIF: ALCAT1-mediated abnormal cardiolipin remodelling promotes
            mitochondrial injury in podocytes in diabetic kidney disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4879)
  AUTHORS   Yin,X., Wang,S., Ge,R., Chen,J., Gao,Y., Xu,S. and Yang,T.
  TITLE     Long non-coding RNA DNMBP-AS1 promotes prostate cancer development
            by regulating LCLAT1
  JOURNAL   Syst Biol Reprod Med 69 (2), 142-152 (2023)
   PUBMED   36602957
  REMARK    GeneRIF: Long non-coding RNA DNMBP-AS1 promotes prostate cancer
            development by regulating LCLAT1.
REFERENCE   3  (bases 1 to 4879)
  AUTHORS   Huang,L.S., Kotha,S.R., Avasarala,S., VanScoyk,M., Winn,R.A.,
            Pennathur,A., Yashaswini,P.S., Bandela,M., Salgia,R., Tyurina,Y.Y.,
            Kagan,V.E., Zhu,X., Reddy,S.P., Sudhadevi,T., Punathil-Kannan,P.K.,
            Harijith,A., Ramchandran,R., Bikkavilli,R.K. and Natarajan,V.
  TITLE     Lysocardiolipin acyltransferase regulates NSCLC cell proliferation
            and migration by modulating mitochondrial dynamics
  JOURNAL   J Biol Chem 295 (38), 13393-13406 (2020)
   PUBMED   32732285
  REMARK    GeneRIF: Lysocardiolipin acyltransferase regulates NSCLC cell
            proliferation and migration by modulating mitochondrial dynamics.
REFERENCE   4  (bases 1 to 4879)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4879)
  AUTHORS   Huang,L.S., Jiang,P., Feghali-Bostwick,C., Reddy,S.P.,
            Garcia,J.G.N. and Natarajan,V.
  TITLE     Lysocardiolipin acyltransferase regulates TGF-beta mediated lung
            fibroblast differentiation
  JOURNAL   Free Radic Biol Med 112, 162-173 (2017)
   PUBMED   28751023
  REMARK    GeneRIF: LYCAT regulates TGF-beta mediated lung fibroblast
            differentiation in pulmonary fibrosis.
REFERENCE   6  (bases 1 to 4879)
  AUTHORS   Wang,C., Faloon,P.W., Tan,Z., Lv,Y., Zhang,P., Ge,Y., Deng,H. and
            Xiong,J.W.
  TITLE     Mouse lysocardiolipin acyltransferase controls the development of
            hematopoietic and endothelial lineages during in vitro embryonic
            stem-cell differentiation
  JOURNAL   Blood 110 (10), 3601-3609 (2007)
   PUBMED   17675553
REFERENCE   7  (bases 1 to 4879)
  AUTHORS   Tsuritani,K., Irie,T., Yamashita,R., Sakakibara,Y., Wakaguri,H.,
            Kanai,A., Mizushima-Sugano,J., Sugano,S., Nakai,K. and Suzuki,Y.
  TITLE     Distinct class of putative 'non-conserved' promoters in humans:
            comparative studies of alternative promoters of human and mouse
            genes
  JOURNAL   Genome Res 17 (7), 1005-1014 (2007)
   PUBMED   17567985
REFERENCE   8  (bases 1 to 4879)
  AUTHORS   Agarwal,A.K., Barnes,R.I. and Garg,A.
  TITLE     Functional characterization of human 1-acylglycerol-3-phosphate
            acyltransferase isoform 8: cloning, tissue distribution, gene
            structure, and enzymatic activity
  JOURNAL   Arch Biochem Biophys 449 (1-2), 64-76 (2006)
   PUBMED   16620771
REFERENCE   9  (bases 1 to 4879)
  AUTHORS   Cao,J., Liu,Y., Lockwood,J., Burn,P. and Shi,Y.
  TITLE     A novel cardiolipin-remodeling pathway revealed by a gene encoding
            an endoplasmic reticulum-associated acyl-CoA:lysocardiolipin
            acyltransferase (ALCAT1) in mouse
  JOURNAL   J Biol Chem 279 (30), 31727-31734 (2004)
   PUBMED   15152008
REFERENCE   10 (bases 1 to 4879)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC146817.1, AC132154.3 and BX537607.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001002257.2.
            
            Transcript Variant: This variant (2) differs in the 5' structure,
            and uses a downstream start codon, compared to variant 1. The
            encoded isoform (2) has a shorter N-terminus compared to isoform 1.
            Variants 2 and 4 encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX647953.1, SRR1803611.258104.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000379509.8/ ENSP00000368823.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1206              BC146817.1         11-1216
            1207-4780           AC132154.3         71447-75020
            4781-4879           BX537607.1         1412-1510
FEATURES             Location/Qualifiers
     source          1..4879
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.1"
     gene            1..4879
                     /gene="LCLAT1"
                     /gene_synonym="1AGPAT8; AGPAT8; ALCAT1; HSRG1849; LPLAT6;
                     LYCAT; UNQ1849"
                     /note="lysocardiolipin acyltransferase 1"
                     /db_xref="GeneID:253558"
                     /db_xref="HGNC:HGNC:26756"
                     /db_xref="MIM:614241"
     exon            1..138
                     /gene="LCLAT1"
                     /gene_synonym="1AGPAT8; AGPAT8; ALCAT1; HSRG1849; LPLAT6;
                     LYCAT; UNQ1849"
                     /inference="alignment:Splign:2.1.0"
     exon            139..307
                     /gene="LCLAT1"
                     /gene_synonym="1AGPAT8; AGPAT8; ALCAT1; HSRG1849; LPLAT6;
                     LYCAT; UNQ1849"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1273
                     /gene="LCLAT1"
                     /gene_synonym="1AGPAT8; AGPAT8; ALCAT1; HSRG1849; LPLAT6;
                     LYCAT; UNQ1849"
                     /EC_number="2.3.1.51"
                     /note="isoform 2 is encoded by transcript variant 2;
                     acyl-CoA:lysocardiolipin acyltransferase 1;
                     1-acylglycerol-3-phosphate O-acyltransferase 8; 1-AGP
                     acyltransferase 8; 1-AGPAT 8; 1ysophospholipid
                     acyltransferase 6"
                     /codon_start=1
                     /product="lysocardiolipin acyltransferase 1 isoform 2"
                     /protein_id="NP_001002257.1"
                     /db_xref="CCDS:CCDS42670.1"
                     /db_xref="GeneID:253558"
                     /db_xref="HGNC:HGNC:26756"
                     /db_xref="MIM:614241"
                     /translation="MVSWKGIYFILTLFWGSFFGSIFMLSPFLPLMFVNPSWYRWINN
                     RLVATWLTLPVALLETMFGVKVIITGDAFVPGERSVIIMNHRTRMDWMFLWNCLMRYS
                     YLRLEKICLKASLKGVPGFGWAMQAAAYIFIHRKWKDDKSHFEDMIDYFCDIHEPLQL
                     LIFPEGTDLTENSKSRSNAFAEKNGLQKYEYVLHPRTTGFTFVVDRLREGKNLDAVHD
                     ITVAYPHNIPQSEKHLLQGDFPREIHFHVHRYPIDTLPTSKEDLQLWCHKRWEEKEER
                     LRSFYQGEKNFYFTGQSVIPPCKSELRVLVVKLLSILYWTLFSPAMCLLIYLYSLVKW
                     YFIITIVIFVLQERIFGGLEIIELACYRLLHKQPHLNSKKNE"
     exon            308..506
                     /gene="LCLAT1"
                     /gene_synonym="1AGPAT8; AGPAT8; ALCAT1; HSRG1849; LPLAT6;
                     LYCAT; UNQ1849"
                     /inference="alignment:Splign:2.1.0"
     exon            507..653
                     /gene="LCLAT1"
                     /gene_synonym="1AGPAT8; AGPAT8; ALCAT1; HSRG1849; LPLAT6;
                     LYCAT; UNQ1849"
                     /inference="alignment:Splign:2.1.0"
     exon            654..770
                     /gene="LCLAT1"
                     /gene_synonym="1AGPAT8; AGPAT8; ALCAT1; HSRG1849; LPLAT6;
                     LYCAT; UNQ1849"
                     /inference="alignment:Splign:2.1.0"
     exon            771..4879
                     /gene="LCLAT1"
                     /gene_synonym="1AGPAT8; AGPAT8; ALCAT1; HSRG1849; LPLAT6;
                     LYCAT; UNQ1849"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4854..4859
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LCLAT1"
                     /gene_synonym="1AGPAT8; AGPAT8; ALCAT1; HSRG1849; LPLAT6;
                     LYCAT; UNQ1849"
                     /note="hexamer: AATAAA"
     polyA_site      4879
                     /gene="LCLAT1"
                     /gene_synonym="1AGPAT8; AGPAT8; ALCAT1; HSRG1849; LPLAT6;
                     LYCAT; UNQ1849"
                     /note="major polyA site"
ORIGIN      
        1 actagggcga cggccggacg cctccgcgtt acgggatgaa ttaacggcgg gttccgcacg
       61 gaggttgtga cccctacgga gccccagctt gcccacgcac cccactcggc gtcgcgcggc
      121 gtgccctgct tgtcacagaa tcatggtgtc atggaaaggg atttacttta tactgactct
      181 gttttgggga agcttttttg gaagcatttt catgctgagt ccctttttac ctttgatgtt
      241 tgtaaaccca tcttggtatc gctggatcaa caaccgcctt gtggcaacat ggctcaccct
      301 acctgtggca ttattggaga ccatgtttgg tgtaaaagtg attataactg gggatgcatt
      361 tgttcctgga gaaagaagtg tcattatcat gaaccatcgg acaagaatgg actggatgtt
      421 cctgtggaat tgcctgatgc gatatagcta cctcagattg gagaaaattt gcctcaaagc
      481 gagtctcaaa ggtgttcctg gatttggttg ggccatgcag gctgctgcct atatcttcat
      541 tcataggaaa tggaaggatg acaagagcca tttcgaagac atgattgatt acttttgtga
      601 tattcacgaa ccacttcaac tcctcatatt cccagaaggg actgatctca cagaaaacag
      661 caagtctcga agtaatgcat ttgctgaaaa aaatggactt cagaaatatg aatatgtttt
      721 acatccaaga actacaggct ttacttttgt ggtagaccgt ctaagagaag gtaagaacct
      781 tgatgctgtc catgatatca ctgtggcgta tcctcacaac attcctcaat cagagaagca
      841 cctcctccaa ggagactttc ccagggaaat ccactttcac gtccaccggt atccaataga
      901 caccctcccc acatccaagg aggaccttca actctggtgc cacaaacggt gggaagagaa
      961 agaagagagg ctgcgttcct tctatcaagg ggagaagaat ttttatttta ccggacagag
     1021 tgtcattcca ccttgcaagt ctgaactcag ggtccttgtg gtcaaattgc tctctatact
     1081 gtattggacc ctgttcagcc ctgcaatgtg cctactcata tatttgtaca gtcttgttaa
     1141 gtggtatttt ataatcacca ttgtaatctt tgtgctgcaa gagagaatat ttggtggact
     1201 ggagatcata gaacttgcat gttaccgact tttacacaaa cagccacatt taaattcaaa
     1261 gaaaaatgag taagattata aggtttgcca tgtgaaaacc tagagcatat tttggaaatg
     1321 ttctaaacct ttctaagctc agatgcattt ttgcatgact atgtcgaata tttcttactg
     1381 ccatcattat ttgttaaaga tattttgcac ttaattttgt gggaaaaata ttgctacaat
     1441 tttttttaat ctctgaatgt aatttcgata ctgtgtacat agcagggagt gatcggggtg
     1501 aaataacttg ggccagaata ttattaaaca atcatcaggc ttttagcgac aaggaacaca
     1561 cacatttttc ttaaaggccc aatcctaaca gactccccgt accagaggca gatctggaac
     1621 tcgtcaacaa cagcccggat cacatgctgt tactggactg cccaggtcac ctcattgagg
     1681 tgagcgctgt ccctccaggt actcaggcag gtggtgccca ggctccctcc cttggcgtcc
     1741 ttcttcctgc gccaaaccca tctcatcctt aagatcagaa aatggaaccc cctttgtcgt
     1801 gaaaccgatc aagcattttg acaggaagcc cttcattatt cataacattg tatgctgacc
     1861 aagacgtcag aagaccacct gtgccctttt ctctcgtgga agataaaacc tggactcagg
     1921 gagcaaccac aggctctcca ctttgaaact ttagtttgaa ttttaaaaga taggaagtaa
     1981 tacagtttaa gttcctttct cacactcagt attgcatgct tagtgctggt tttcttacaa
     2041 cattttggca ggtgtagctt tttctgttaa aaatggtata catgaagtca catacttttt
     2101 taaaggaaca ctcagaacat tctgtcattc cagtcagaaa ctgtcttttg aaatatttct
     2161 ttacaaccta ccaaaaaagg aaggttgttt tttctacatg tgcttgggta tctaacatct
     2221 accattaaaa caacaaatgg cttgcagaca gggcagtaat ggtttatcct aaattactca
     2281 accccttgta gccttgacaa attttacctt aaaaccaaaa tgaaacacaa aaattaatcc
     2341 ttaataatga tagcaagtga tctttctttt tagttttagc cttccttttt caatagtaat
     2401 atttaaaccc acttttgacc aattgtttgc ccaaatattc ttgtcatttg gagtcagtgg
     2461 aaaatccagc acaccaagca ccagtcttct tctgaggcaa aagaaaagtg ttgtcatttt
     2521 cactctgttg gagctgcaca cttttttttc tttttttttt tctttttttt tttgtcgtgt
     2581 aagaaggatg ctggtcagag ctgcagaaaa tatgaggcaa ttaaaagtct ttagctgtta
     2641 gcaaacctgt tagttttact tctgcattga accagcctca gaagctactt actgctttat
     2701 gtactctttg ggcattaatg ccttctctgt aattatatct cgtttttgct tgacagtgac
     2761 ctacccaata attgcatcgt gcattgccat gaaaggtaaa cacattgtga actgaactta
     2821 ccaagcagat tctgtgagaa agcactggtt gaggctgaac actgttgaca catcattttt
     2881 attggaagag tattaactgg tgcctcttct gaaacacacc aacccatatt cctctgctcc
     2941 cccaaagctg tttctgatcc tgctgggagc aactaactag ttattatgca catctgctcc
     3001 agacccagct ctttaacttc atggttttac agcttgtttt ttctttttct tttctttttt
     3061 tttttttttt tttaaaaaag cacctttttt tgttgtttcc ccttaataaa agaggtttct
     3121 aatttatgtt tctctaagat ttcctttggt tgtatttaga aacacaaata gttttataat
     3181 caggattgca tttgtgctgg gtaaaagagg agagctgtgc tttctacccc aaagttgttg
     3241 gtaatggagc cggtctgccc ttcctacaaa ctcaagaggc tcattgttca aggtgtaaca
     3301 acatttaatt gcatgtcctc taacgctttg aaacctttag agggaagatc ctcatttttt
     3361 acaattttgt tccttttcat catagaaaac atgtttaaga taaaatacaa actttaccta
     3421 ccccaaattc ataaagtaca tttagtgctg tatagcacta aaacttagag atacagacac
     3481 tgtacttact ttttaagaat tagagacagt aactccaaaa ataattgtcc ttttttcttt
     3541 ctttcttttt ttacaataag gctcttgaaa attgtcatta cttgtgtttt cctatacatt
     3601 catctgtgtg aaagcctttt tcttctttga tttaaaaaaa ttaactatac agttaatggt
     3661 ttagaactta gaactactta gaattaatgc taaagtgtca ggaagaaatt aatttagctt
     3721 caataattgt gactggcctc aggaattctc ccttccacac ctgcccacct cacctcactg
     3781 caccgcaccg caccagagcc agagcagctg cttgtctgca gcaggacaca gttcctacat
     3841 acgtttcagt tctttcatgg taagctcaat ggactttgaa ttgtttacag tgctgtatgt
     3901 ccaattgtta aatgtaccat tctgaacgat gttaaagcaa gtgtggttta tttatggcat
     3961 gaaccatgta acttgaaata tgaacttaca aggaggggca ctcattaggt aacaagttct
     4021 tacaccaaac ttccttgatg aaataagcca aaataatcct aaaattcatt agaagaactt
     4081 gataaaagac tcaaataaat gttagaaaga gcccgtaatt ttaggactcc tataaaattc
     4141 ttccttgttt gttaatgcta ttaaaactca gattcaaggg aaataccagc ttccacttga
     4201 gtcactttga aatagttaat tcaacagcac catgttagaa atatattggc agccaagact
     4261 ctgaactctg cagaaacatt tgtttcaccc agacttcaaa ctctagccct gactatgatg
     4321 cccctgtgtg catttacaat aaagactcca acggagggag cctgttggtg ttaaattgtt
     4381 tacatttctt tatacaaata atgtgctttc agtgccttag ttacagctcc ctttctgttt
     4441 cttgttccaa ggattctgta gtatgtagtg tgtttcttag gtaaagtctc tttttgctac
     4501 tgaaagggaa atggtctcta aacactggtc actgtagcag gtaaacacta ctctaacgtg
     4561 gagaaatgag cttcatgctg aggtagtggt tgccttagag ctgttattta tgctgtagaa
     4621 aacgaaaatg gttttgctac ctgataagct tcagattaga tatagcccta aagttatcct
     4681 gtacctgcat taaattttca ttttagaaga gaatcttggt tttggtaatt catttttttt
     4741 taagatcatt atgtgcaaaa caccaagttt taaaaataac tcacagaatg gccttagttt
     4801 tcaatgtctg atggtatatt tgtgagttgt gttatctgta atatacatcc cagaataaag
     4861 gagtgaatta aatagttta
//
