LOCUS       XM_011541453            2112 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens LCK proto-oncogene, Src family tyrosine
            kinase (LCK), transcript variant X4, mRNA.
ACCESSION   XM_011541453
VERSION     XM_011541453.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000001.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Mar 26, 2018 this sequence version replaced XM_011541453.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..2112
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
     gene            1..2112
                     /gene="LCK"
                     /gene_synonym="IMD22; LSK; p56lck; pp58lck; YT16"
                     /note="LCK proto-oncogene, Src family tyrosine kinase;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 3 mRNAs, 11 ESTs, 110 long SRA reads, 5
                     Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 42 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:3932"
                     /db_xref="HGNC:HGNC:6524"
                     /db_xref="MIM:153390"
     CDS             113..1663
                     /gene="LCK"
                     /gene_synonym="IMD22; LSK; p56lck; pp58lck; YT16"
                     /codon_start=1
                     /product="tyrosine-protein kinase Lck isoform X3"
                     /protein_id="XP_011539755.1"
                     /db_xref="GeneID:3932"
                     /db_xref="HGNC:HGNC:6524"
                     /db_xref="MIM:153390"
                     /translation="MGCGCSSHPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEV
                     RDPLVTYEGSNPPASPLQGDPRQQGLKDKACGSLAVGFHLSPTYFLPGLAFLVPHPVT
                     PGFLPIPARFSLMPLVFTDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQS
                     LTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTA
                     GSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTRYYNGHTK
                     VAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDF
                     LKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGL
                     ARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPG
                     MTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFFTAT
                     EGQYQPQP"
ORIGIN      
        1 gagacaggtg gtggctacga cggcgaaggg agctgagact gtccaggcag ccaggttagg
       61 ccaggaggac catgtgaatg gggccagagg gctcccgggc tgggcaggga ccatgggctg
      121 tggctgcagc tcacacccgg aagatgactg gatggaaaac atcgatgtgt gtgagaactg
      181 ccattatccc atagtcccac tggatggcaa gggcacgctg ctcatccgaa atggctctga
      241 ggtgcgggac ccactggtta cctacgaagg ctccaatccg ccggcttccc cactgcaagg
      301 tgaccccagg cagcagggcc tgaaagacaa ggcctgcgga tccctggctg ttggcttcca
      361 cctctccccc acctactttc tccccggtct tgccttcctt gtcccccacc ctgtaactcc
      421 aggcttcctg ccgatcccag ctcggttctc cctgatgccc cttgtcttta cagacaacct
      481 ggttatcgct ctgcacagct atgagccctc tcacgacgga gatctgggct ttgagaaggg
      541 ggaacagctc cgcatcctgg agcagagcgg cgagtggtgg aaggcgcagt ccctgaccac
      601 gggccaggaa ggcttcatcc ccttcaattt tgtggccaaa gcgaacagcc tggagcccga
      661 accctggttc ttcaagaacc tgagccgcaa ggacgcggag cggcagctcc tggcgcccgg
      721 gaacactcac ggctccttcc tcatccggga gagcgagagc accgcgggat cgttttcact
      781 gtcggtccgg gacttcgacc agaaccaggg agaggtggtg aaacattaca agatccgtaa
      841 tctggacaac ggtggcttct acatctcccc tcgaatcact tttcccggcc tgcatgaact
      901 ggtccgccat tacaccaggt actacaacgg gcacacgaag gtggcggtga agagcctgaa
      961 gcagggcagc atgtccccgg acgccttcct ggccgaggcc aacctcatga agcagctgca
     1021 acaccagcgg ctggttcggc tctacgctgt ggtcacccag gagcccatct acatcatcac
     1081 tgaatacatg gagaatggga gtctagtgga ttttctcaag accccttcag gcatcaagtt
     1141 gaccatcaac aaactcctgg acatggcagc ccaaattgca gaaggcatgg cattcattga
     1201 agagcggaat tatattcatc gtgaccttcg ggctgccaac attctggtgt ctgacaccct
     1261 gagctgcaag attgcagact ttggcctagc acgcctcatt gaggacaacg agtacacagc
     1321 cagggagggg gccaagtttc ccattaagtg gacagcgcca gaagccatta actacgggac
     1381 attcaccatc aagtcagatg tgtggtcttt tgggatcctg ctgacggaaa ttgtcaccca
     1441 cggccgcatc ccttacccag ggatgaccaa cccggaggtg attcagaacc tggagcgagg
     1501 ctaccgcatg gtgcgccctg acaactgtcc agaggagctg taccaactca tgaggctgtg
     1561 ctggaaggag cgcccagagg accggcccac ctttgactac ctgcgcagtg tgctggagga
     1621 cttcttcacg gccacagagg gccagtacca gcctcagcct tgagaggcct tgagaggccc
     1681 tggggttctc cccctttctc tccagcctga cttggggaga tggagttctt gtgccatagt
     1741 cacatggcct atgcacatat ggactctgca catgaatccc acccacatgt gacacatatg
     1801 caccttgtgt ctgtacacgt gtcctgtagt tgcgtggact ctgcacatgt cttgtacatg
     1861 tgtagcctgt gcatgtatgt cttggacact gtacaaggta cccctttctg gctctcccat
     1921 ttcctgagac cacagagaga ggggagaagc ctgggattga cagaagcttc tgcccaccta
     1981 cttttctttc ctcagatcat ccagaagttc ctcaagggcc aggactttat ctaatacctc
     2041 tgtgtgctcc tccttggtgc ctggcctggc acacatcagg agttcaataa atgtctgttg
     2101 atgactgttg ta
//
