LOCUS       NM_001387222             615 bp    mRNA    linear   PRI 10-JUN-2024
DEFINITION  Homo sapiens late cornified envelope 4A (LCE4A), transcript variant
            1, mRNA.
ACCESSION   NM_001387222
VERSION     NM_001387222.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 615)
  AUTHORS   Niehues,H., Rikken,G., Kersten,F.F.J., Eeftens,J.M., van
            Vlijmen-Willems,I.M.J.J., Rodijk-Olthuis,D., Jansen,P.A.M.,
            Hendriks,W.J.A.J., Ederveen,T.H.A., Schalkwijk,J., van den
            Bogaard,E.H. and Zeeuwen,P.L.J.M.
  TITLE     CYSRT1: An Antimicrobial Epidermal Protein that Can Interact with
            Late Cornified Envelope Proteins
  JOURNAL   J Invest Dermatol 143 (8), 1498-1508 (2023)
   PUBMED   36804407
REFERENCE   2  (bases 1 to 615)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 615)
  AUTHORS   Kumar,V., Cheng,S.C., Johnson,M.D., Smeekens,S.P., Wojtowicz,A.,
            Giamarellos-Bourboulis,E., Karjalainen,J., Franke,L., Withoff,S.,
            Plantinga,T.S., van de Veerdonk,F.L., van der Meer,J.W.M.,
            Joosten,L.A.B., Bochud,P.Y., Marchetti,O., Perfect,J.R., Xavier,R.,
            Kullberg,B.J., Wijmenga,C. and Netea,M.G.
  TITLE     Immunochip SNP array identifies novel genetic variants conferring
            susceptibility to candidaemia
  JOURNAL   Nat Commun 5, 4675 (2014)
   PUBMED   25197941
  REMARK    GeneRIF: SNPs in LCE4A are associated with increased risk of
            candidemia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 615)
  AUTHORS   Jackson,B., Tilli,C.M., Hardman,M.J., Avilion,A.A., MacLeod,M.C.,
            Ashcroft,G.S. and Byrne,C.
  TITLE     Late cornified envelope family in differentiating
            epithelia--response to calcium and ultraviolet irradiation
  JOURNAL   J Invest Dermatol 124 (5), 1062-1070 (2005)
   PUBMED   15854049
  REMARK    GeneRIF: paper describing nomenclature changes and expression in
            range of tissues and in response to UV
REFERENCE   5  (bases 1 to 615)
  AUTHORS   Marshall,D., Hardman,M.J., Nield,K.M. and Byrne,C.
  TITLE     Differentially expressed late constituents of the epidermal
            cornified envelope
  JOURNAL   Proc Natl Acad Sci U S A 98 (23), 13031-13036 (2001)
   PUBMED   11698679
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139247.12 and KF455034.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG187025.1, BG185981.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: lack of evidence for use of
                                                upstream AUG
            MANE Ensembl match               :: ENST00000368777.2/
                                                ENSP00000357766.1
            RefSeq Select criteria           :: based on expression, longest
                                                protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-235               AL139247.12        107647-107881
            236-382             KF455034.1         135-281
            383-615             AL139247.12        108689-108921
FEATURES             Location/Qualifiers
     source          1..615
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..615
                     /gene="LCE4A"
                     /gene_synonym="LEP8; SPRL4A"
                     /note="late cornified envelope 4A"
                     /db_xref="GeneID:199834"
                     /db_xref="HGNC:HGNC:16613"
                     /db_xref="MIM:612618"
     exon            1..235
                     /gene="LCE4A"
                     /gene_synonym="LEP8; SPRL4A"
                     /inference="alignment:Splign:2.1.0"
     exon            236..615
                     /gene="LCE4A"
                     /gene_synonym="LEP8; SPRL4A"
                     /inference="alignment:Splign:2.1.0"
     CDS             257..556
                     /gene="LCE4A"
                     /gene_synonym="LEP8; SPRL4A"
                     /note="small proline rich-like (epidermal differentiation
                     complex) 4A; late envelope protein 8; small
                     proline-rich-like epidermal differentiation complex
                     protein 4A"
                     /codon_start=1
                     /product="late cornified envelope protein 4A"
                     /protein_id="NP_001374151.1"
                     /db_xref="CCDS:CCDS1022.1"
                     /db_xref="GeneID:199834"
                     /db_xref="HGNC:HGNC:16613"
                     /db_xref="MIM:612618"
                     /translation="MSCQQNQQQCQPPPKCPIPKYPPKCPSKCASSCPPPISSCCGSS
                     SGGCGCCSSEGGGCCLSHHRHHRSHCHRPKSSNCYGSGSGQQSGGSGCCSGGGCC"
ORIGIN      
        1 tgccgaagag gctatctggg aagctcatca tccagctcag gaagagatga aaccaggagg
       61 caggagaatg tcaggcatga ccccacactt gtgcaacagc cacgtcctgc tcctgccatt
      121 agcatggctc atccgaggcc cagccccagg atccatacaa agtgtgttcc tgctgctggc
      181 ttctcatctg ctctgcttcc taagggacgt atctgttgct gcgtctgaac ccacggttta
      241 tcgaaatccc accaagatgt cctgccagca gaaccaacag cagtgccagc cccctcccaa
      301 gtgtcctatc cccaagtatc ccccaaaatg tccctcaaag tgtgcatcct catgcccacc
      361 tccaatctct tcctgctgtg gctccagctc tgggggctgt ggttgctgca gctctgaggg
      421 aggtggctgc tgcctgagcc accacagaca ccataggtcc cactgccaca gacccaagag
      481 ctccaattgc tatggcagtg gcagtggcca gcagtctggg ggttctggct gctgctctgg
      541 agggggctgt tgctgacctg gaccaggagc agcaccaaag gaattagtgg gcgaaggacc
      601 cattgcagcc tggtg
//
