LOCUS       NM_178435                619 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens late cornified envelope 3E (LCE3E), mRNA.
ACCESSION   NM_178435
VERSION     NM_178435.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 619)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 619)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 619)
  AUTHORS   McClay,J.L., Adkins,D.E., Aberg,K., Stroup,S., Perkins,D.O.,
            Vladimirov,V.I., Lieberman,J.A., Sullivan,P.F. and van den
            Oord,E.J.
  TITLE     Genome-wide pharmacogenomic analysis of response to treatment with
            antipsychotics
  JOURNAL   Mol Psychiatry 16 (1), 76-85 (2011)
   PUBMED   19721433
REFERENCE   4  (bases 1 to 619)
  AUTHORS   Eriksson,N., Macpherson,J.M., Tung,J.Y., Hon,L.S., Naughton,B.,
            Saxonov,S., Avey,L., Wojcicki,A., Pe'er,I. and Mountain,J.
  TITLE     Web-based, participant-driven studies yield novel genetic
            associations for common traits
  JOURNAL   PLoS Genet 6 (6), e1000993 (2010)
   PUBMED   20585627
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 619)
  AUTHORS   Jackson,B., Tilli,C.M., Hardman,M.J., Avilion,A.A., MacLeod,M.C.,
            Ashcroft,G.S. and Byrne,C.
  TITLE     Late cornified envelope family in differentiating
            epithelia--response to calcium and ultraviolet irradiation
  JOURNAL   J Invest Dermatol 124 (5), 1062-1070 (2005)
   PUBMED   15854049
  REMARK    GeneRIF: paper describing nomenclature changes and expression in
            range of tissues and in response to UV
REFERENCE   6  (bases 1 to 619)
  AUTHORS   Marshall,D., Hardman,M.J., Nield,K.M. and Byrne,C.
  TITLE     Differentially expressed late constituents of the epidermal
            cornified envelope
  JOURNAL   Proc Natl Acad Sci U S A 98 (23), 13031-13036 (2001)
   PUBMED   11698679
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL356426.11 and BC131716.1.
            
            On May 17, 2019 this sequence version replaced NM_178435.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC131716.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368789.2/ ENSP00000357778.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AL356426.11        16596-16622         c
            28-412              BC131716.1         1-385
            413-619             AL356426.11        15496-15702         c
FEATURES             Location/Qualifiers
     source          1..619
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..619
                     /gene="LCE3E"
                     /gene_synonym="LEP17"
                     /note="late cornified envelope 3E"
                     /db_xref="GeneID:353145"
                     /db_xref="HGNC:HGNC:29463"
                     /db_xref="MIM:612617"
     exon            1..43
                     /gene="LCE3E"
                     /gene_synonym="LEP17"
                     /inference="alignment:Splign:2.1.0"
     exon            44..619
                     /gene="LCE3E"
                     /gene_synonym="LEP17"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..343
                     /gene="LCE3E"
                     /gene_synonym="LEP17"
                     /note="late envelope protein 17"
                     /codon_start=1
                     /product="late cornified envelope protein 3E"
                     /protein_id="NP_848522.1"
                     /db_xref="CCDS:CCDS1013.1"
                     /db_xref="GeneID:353145"
                     /db_xref="HGNC:HGNC:29463"
                     /db_xref="MIM:612617"
                     /translation="MSCQQNQKQCQPPPKCPSPKCPPKNPVQCLPPASSGCAPSSGGC
                     GPSSEGGCFLNHHRRHHRCRRQRSNSCDRGSGQQGGGSGCCHGSGGCC"
ORIGIN      
        1 acagtctcct caggaacagc cttctcctgc ctctctgcac ctggacatct caactcctgc
       61 caagatgtcc tgccagcaga accagaagca gtgccaaccc ccacccaagt gcccctcacc
      121 caagtgtccc ccaaagaacc cagtacagtg tctgcctcca gcttcctctg gctgtgcccc
      181 aagctctggg ggctgtggcc ctagctccga gggcggctgc ttcctgaacc accacaggcg
      241 ccaccaccga tgccggcgcc agaggtccaa ctcctgtgac aggggcagtg gtcagcaagg
      301 cgggggctct ggctgctgcc acggttctgg gggctgctgc tgatccagat cctgatgctg
      361 agacaagcga tctttggagg aaacaagaat cccaagaggc caagaacagc cccatctgac
      421 gcatgccttc ccatataccc tcttctgact ttcacaggct gagctggagg ttttcctgtg
      481 ggggatctga gctctcccca gaaggcactt cttgttttat gtacaggatg tcatatgtcc
      541 ccctacccct gtacctgcca aggattggca gtgcttgtgc ccaacctcgt aaaaaagata
      601 aagttccttg tcctcatta
//
