LOCUS       NM_178433                288 bp    mRNA    linear   PRI 27-JUL-2024
DEFINITION  Homo sapiens late cornified envelope 3B (LCE3B), mRNA.
ACCESSION   NM_178433
VERSION     NM_178433.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 288)
  AUTHORS   Niehues,H., van der Krieken,D.A., Ederveen,T.H.A., Jansen,P.A.M.,
            van Niftrik,L., Mesman,R., Netea,M.G., Smits,J.P.H., Schalkwijk,J.,
            van den Bogaard,E.H. and Zeeuwen,P.L.J.M.
  TITLE     Antimicrobial Late Cornified Envelope Proteins: The Psoriasis Risk
            Factor Deletion of LCE3B/C Genes Affects Microbiota Composition
  JOURNAL   J Invest Dermatol 142 (7), 1947-1955 (2022)
   PUBMED   34942199
  REMARK    GeneRIF: Antimicrobial Late Cornified Envelope Proteins: The
            Psoriasis Risk Factor Deletion of LCE3B/C Genes Affects Microbiota
            Composition.
REFERENCE   2  (bases 1 to 288)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 288)
  AUTHORS   Niehues,H., Tsoi,L.C., van der Krieken,D.A., Jansen,P.A.M.,
            Oortveld,M.A.W., Rodijk-Olthuis,D., van Vlijmen,I.M.J.J.,
            Hendriks,W.J.A.J., Helder,R.W., Bouwstra,J.A., van den
            Bogaard,E.H., Stuart,P.E., Nair,R.P., Elder,J.T., Zeeuwen,P.L.J.M.
            and Schalkwijk,J.
  TITLE     Psoriasis-Associated Late Cornified Envelope (LCE) Proteins Have
            Antibacterial Activity
  JOURNAL   J Invest Dermatol 137 (11), 2380-2388 (2017)
   PUBMED   28634035
REFERENCE   4  (bases 1 to 288)
  AUTHORS   Chandra,A., Lahiri,A., Senapati,S., Basu,B., Ghosh,S.,
            Mukhopadhyay,I., Behra,A., Sarkar,S., Chatterjee,G. and
            Chatterjee,R.
  TITLE     Increased Risk of Psoriasis due to combined effect of HLA-Cw6 and
            LCE3 risk alleles in Indian population
  JOURNAL   Sci Rep 6, 24059 (2016)
   PUBMED   27048876
  REMARK    GeneRIF: analysis of disease variants at the LCE3 cluster among the
            psoriasis patients in India
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 288)
  AUTHORS   Chiraz,B.S., Myriam,A., Ines,Z., Catherine,J., Fatma,B., Ilhem,C.,
            Raoudha,T., Hela,Z., Hela,F., Elyes,B., Nejib,D., Cindy,H., Amel,E.
            and Slaheddine,S.
  TITLE     Deletion of late cornified envelope genes, LCE3C_LCE3B-del, is not
            associated with psoriatic arthritis in Tunisian patients
  JOURNAL   Mol Biol Rep 41 (6), 4141-4146 (2014)
   PUBMED   24566688
  REMARK    GeneRIF: Our data suggest that The LCE deletion, previously
            identified in patients with psoriasis, is not of a major importance
            in the development of PsA in Tunisian patients
REFERENCE   6  (bases 1 to 288)
  AUTHORS   Docampo,E., Rabionet,R., Riveira-Munoz,E., Escaramis,G., Julia,A.,
            Marsal,S., Martin,J.E., Gonzalez-Gay,M.A., Balsa,A., Raya,E.,
            Martin,J. and Estivill,X.
  TITLE     Deletion of the late cornified envelope genes, LCE3C and LCE3B, is
            associated with rheumatoid arthritis
  JOURNAL   Arthritis Rheum 62 (5), 1246-1251 (2010)
   PUBMED   20213803
  REMARK    GeneRIF: we have verified a pleiotropic effect of a common genetic
            risk factor (LCE3C_LCE3B-del) for autoimmune diseases that is
            involved in both psoriasis and rheumatoid arthritis
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 288)
  AUTHORS   Huffmeier,U., Bergboer,J.G., Becker,T., Armour,J.A., Traupe,H.,
            Estivill,X., Riveira-Munoz,E., Mossner,R., Reich,K., Kurrat,W.,
            Wienker,T.F., Schalkwijk,J., Zeeuwen,P.L. and Reis,A.
  TITLE     Replication of LCE3C-LCE3B CNV as a risk factor for psoriasis and
            analysis of interaction with other genetic risk factors
  JOURNAL   J Invest Dermatol 130 (4), 979-984 (2010)
   PUBMED   20016497
  REMARK    GeneRIF: study confirms the recently published finding that the
            deletion of the two LCE genes is a susceptibility factor for
            psoriasis vulgaris with dosage effect
            GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   8  (bases 1 to 288)
  AUTHORS   de Cid,R., Riveira-Munoz,E., Zeeuwen,P.L., Robarge,J., Liao,W.,
            Dannhauser,E.N., Giardina,E., Stuart,P.E., Nair,R., Helms,C.,
            Escaramis,G., Ballana,E., Martin-Ezquerra,G., den Heijer,M.,
            Kamsteeg,M., Joosten,I., Eichler,E.E., Lazaro,C., Pujol,R.M.,
            Armengol,L., Abecasis,G., Elder,J.T., Novelli,G., Armour,J.A.,
            Kwok,P.Y., Bowcock,A., Schalkwijk,J. and Estivill,X.
  TITLE     Deletion of the late cornified envelope LCE3B and LCE3C genes as a
            susceptibility factor for psoriasis
  JOURNAL   Nat Genet 41 (2), 211-215 (2009)
   PUBMED   19169253
  REMARK    GeneRIF: LCE3C_LCE3B-del shows epistatic effects with the HLA-Cw6
            allele on the development of psoriasis.
            GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   9  (bases 1 to 288)
  AUTHORS   Jackson,B., Tilli,C.M., Hardman,M.J., Avilion,A.A., MacLeod,M.C.,
            Ashcroft,G.S. and Byrne,C.
  TITLE     Late cornified envelope family in differentiating
            epithelia--response to calcium and ultraviolet irradiation
  JOURNAL   J Invest Dermatol 124 (5), 1062-1070 (2005)
   PUBMED   15854049
  REMARK    GeneRIF: paper describing nomenclature changes and expression in
            range of tissues and in response to UV
REFERENCE   10 (bases 1 to 288)
  AUTHORS   Marshall,D., Hardman,M.J., Nield,K.M. and Byrne,C.
  TITLE     Differentially expressed late constituents of the epidermal
            cornified envelope
  JOURNAL   Proc Natl Acad Sci U S A 98 (23), 13031-13036 (2001)
   PUBMED   11698679
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139247.12.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data because no transcript data was available for this gene. The
            extent of this transcript is supported by published experimental
            data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335633.1/ ENSP00000335358.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-288               AL139247.12        13298-13585
FEATURES             Location/Qualifiers
     source          1..288
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..288
                     /gene="LCE3B"
                     /gene_synonym="LEP14"
                     /note="late cornified envelope 3B"
                     /db_xref="GeneID:353143"
                     /db_xref="HGNC:HGNC:29462"
                     /db_xref="MIM:612614"
     CDS             1..288
                     /gene="LCE3B"
                     /gene_synonym="LEP14"
                     /note="late envelope protein 14"
                     /codon_start=1
                     /product="late cornified envelope protein 3B"
                     /protein_id="NP_848520.1"
                     /db_xref="CCDS:CCDS1016.1"
                     /db_xref="GeneID:353143"
                     /db_xref="HGNC:HGNC:29462"
                     /db_xref="MIM:612614"
                     /translation="MSCQQNQQQCQPLPKCPSPKCPPKSSAQCLPPASSCCAPRPGCC
                     GGPSSEGGCCLSHHRCCRSHRCRRQSSNSCDRGSGQQDGASDCGYGSGGCC"
     exon            1..288
                     /gene="LCE3B"
                     /gene_synonym="LEP14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtcctgcc agcagaacca gcagcagtgc cagcctctgc ccaagtgccc ctcacccaag
       61 tgccccccaa agagctcagc acagtgtctg cctccagcct cctcctgctg tgctccaaga
      121 cctgggtgct gtggtggccc cagctctgag ggcggctgct gcctgagcca ccacaggtgc
      181 tgcaggtccc accgatgccg gcgccagagc tccaactcct gtgacagagg cagtggtcag
      241 caagatggtg cctccgactg tggctatggc tctggaggct gctgctga
//
