LOCUS       NM_178431                270 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens late cornified envelope 3A (LCE3A), mRNA.
ACCESSION   NM_178431
VERSION     NM_178431.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 270)
  AUTHORS   Niehues,H., Rikken,G., Kersten,F.F.J., Eeftens,J.M., van
            Vlijmen-Willems,I.M.J.J., Rodijk-Olthuis,D., Jansen,P.A.M.,
            Hendriks,W.J.A.J., Ederveen,T.H.A., Schalkwijk,J., van den
            Bogaard,E.H. and Zeeuwen,P.L.J.M.
  TITLE     CYSRT1: An Antimicrobial Epidermal Protein that Can Interact with
            Late Cornified Envelope Proteins
  JOURNAL   J Invest Dermatol 143 (8), 1498-1508 (2023)
   PUBMED   36804407
REFERENCE   2  (bases 1 to 270)
  AUTHORS   Chandra,A., Das,S., Mazumder,S., Senapati,S., Chatterjee,G. and
            Chatterjee,R.
  TITLE     Functional Mapping of Genetic Interactions between HLA-Cw6 and
            LCE3A in Psoriasis
  JOURNAL   J Invest Dermatol 141 (11), 2630-2638 (2021)
   PUBMED   34029573
  REMARK    GeneRIF: Functional Mapping of Genetic Interactions between HLA-Cw6
            and LCE3A in Psoriasis.
REFERENCE   3  (bases 1 to 270)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 270)
  AUTHORS   Sun,L., Cao,Y., He,N., Han,J., Hai,R., Arlud,S., He,B., Wu,W.,
            Li,L., Su,X., Cui,H., Zhao,W., Chao,B., Liu,D., Sun,Z. and Huang,Y.
  TITLE     Association between LCE gene polymorphisms and psoriasis vulgaris
            among Mongolians from Inner Mongolia
  JOURNAL   Arch Dermatol Res 310 (4), 321-327 (2018)
   PUBMED   29397434
  REMARK    GeneRIF: genetic polymorphism is associated with psoriasis vulgaris
            among Mongolians from Inner Mongolia
REFERENCE   5  (bases 1 to 270)
  AUTHORS   Niehues,H., Tsoi,L.C., van der Krieken,D.A., Jansen,P.A.M.,
            Oortveld,M.A.W., Rodijk-Olthuis,D., van Vlijmen,I.M.J.J.,
            Hendriks,W.J.A.J., Helder,R.W., Bouwstra,J.A., van den
            Bogaard,E.H., Stuart,P.E., Nair,R.P., Elder,J.T., Zeeuwen,P.L.J.M.
            and Schalkwijk,J.
  TITLE     Psoriasis-Associated Late Cornified Envelope (LCE) Proteins Have
            Antibacterial Activity
  JOURNAL   J Invest Dermatol 137 (11), 2380-2388 (2017)
   PUBMED   28634035
REFERENCE   6  (bases 1 to 270)
  AUTHORS   Stemmler,S., Nothnagel,M., Parwez,Q., Petrasch-Parwez,E.,
            Epplen,J.T. and Hoffjan,S.
  TITLE     Variation in genes of the epidermal differentiation complex in
            German atopic dermatitis patients
  JOURNAL   Int J Immunogenet 36 (4), 217-222 (2009)
   PUBMED   19601998
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 270)
  AUTHORS   Zhang,X.J., Huang,W., Yang,S., Sun,L.D., Zhang,F.Y., Zhu,Q.X.,
            Zhang,F.R., Zhang,C., Du,W.H., Pu,X.M., Li,H., Xiao,F.L.,
            Wang,Z.X., Cui,Y., Hao,F., Zheng,J., Yang,X.Q., Cheng,H., He,C.D.,
            Liu,X.M., Xu,L.M., Zheng,H.F., Zhang,S.M., Zhang,J.Z., Wang,H.Y.,
            Cheng,Y.L., Ji,B.H., Fang,Q.Y., Li,Y.Z., Zhou,F.S., Han,J.W.,
            Quan,C., Chen,B., Liu,J.L., Lin,D., Fan,L., Zhang,A.P., Liu,S.X.,
            Yang,C.J., Wang,P.G., Zhou,W.M., Lin,G.S., Wu,W.D., Fan,X., Gao,M.,
            Yang,B.Q., Lu,W.S., Zhang,Z., Zhu,K.J., Shen,S.K., Li,M.,
            Zhang,X.Y., Cao,T.T., Ren,W., Zhang,X., He,J., Tang,X.F., Lu,S.,
            Yang,J.Q., Zhang,L., Wang,D.N., Yuan,F., Yin,X.Y., Huang,H.J.,
            Wang,H.F., Lin,X.Y. and Liu,J.J.
  TITLE     Psoriasis genome-wide association study identifies susceptibility
            variants within LCE gene cluster at 1q21
  JOURNAL   Nat Genet 41 (2), 205-210 (2009)
   PUBMED   19169255
REFERENCE   8  (bases 1 to 270)
  AUTHORS   Nagase,T., Yamakawa,H., Tadokoro,S., Nakajima,D., Inoue,S.,
            Yamaguchi,K., Itokawa,Y., Kikuno,R.F., Koga,H. and Ohara,O.
  TITLE     Exploration of human ORFeome: high-throughput preparation of ORF
            clones and efficient characterization of their protein products
  JOURNAL   DNA Res 15 (3), 137-149 (2008)
   PUBMED   18316326
REFERENCE   9  (bases 1 to 270)
  AUTHORS   Jackson,B., Tilli,C.M., Hardman,M.J., Avilion,A.A., MacLeod,M.C.,
            Ashcroft,G.S. and Byrne,C.
  TITLE     Late cornified envelope family in differentiating
            epithelia--response to calcium and ultraviolet irradiation
  JOURNAL   J Invest Dermatol 124 (5), 1062-1070 (2005)
   PUBMED   15854049
  REMARK    GeneRIF: paper describing nomenclature changes and expression in
            range of tissues and in response to UV
REFERENCE   10 (bases 1 to 270)
  AUTHORS   Marshall,D., Hardman,M.J., Nield,K.M. and Byrne,C.
  TITLE     Differentially expressed late constituents of the epidermal
            cornified envelope
  JOURNAL   Proc Natl Acad Sci U S A 98 (23), 13031-13036 (2001)
   PUBMED   11698679
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139247.12.
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data to make the sequence consistent with the reference genome
            assembly. The genomic coordinates used for the transcript record
            were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC120933.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335674.1/ ENSP00000335006.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               AL139247.12        22321-22590         c
FEATURES             Location/Qualifiers
     source          1..270
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..270
                     /gene="LCE3A"
                     /gene_synonym="LEP13"
                     /note="late cornified envelope 3A"
                     /db_xref="GeneID:353142"
                     /db_xref="HGNC:HGNC:29461"
                     /db_xref="MIM:612613"
     CDS             1..270
                     /gene="LCE3A"
                     /gene_synonym="LEP13"
                     /note="late envelope protein 13"
                     /codon_start=1
                     /product="late cornified envelope protein 3A"
                     /protein_id="NP_848518.1"
                     /db_xref="CCDS:CCDS1017.1"
                     /db_xref="GeneID:353142"
                     /db_xref="HGNC:HGNC:29461"
                     /db_xref="MIM:612613"
                     /translation="MSCQQNQQQCQPPPKCPAKSPAQCLPPASSSCAPSSGGCGPSSE
                     RSCCLSHHRCRRSHRCRCQSSNSCDRGSGQQGGSSSCGHSSAGCC"
     exon            1..270
                     /gene="LCE3A"
                     /gene_synonym="LEP13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgtcctgcc agcagaacca gcagcagtgc cagcctccgc ccaagtgccc tgcaaagagc
       61 ccagcacagt gtctgcctcc agcttcctcc agctgtgccc caagctctgg gggctgtggg
      121 cccagctccg agcgcagctg ctgcctgagt caccacagat gccgcaggtc tcaccgttgc
      181 cgttgccaga gctccaactc ctgtgacagg ggaagtggtc agcaaggcgg gagctccagc
      241 tgtggccaca gttctgcggg ctgctgctga
//
