LOCUS       NM_014357                608 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens late cornified envelope 2B (LCE2B), mRNA.
ACCESSION   NM_014357
VERSION     NM_014357.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 608)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 608)
  AUTHORS   Jackson,B., Tilli,C.M., Hardman,M.J., Avilion,A.A., MacLeod,M.C.,
            Ashcroft,G.S. and Byrne,C.
  TITLE     Late cornified envelope family in differentiating
            epithelia--response to calcium and ultraviolet irradiation
  JOURNAL   J Invest Dermatol 124 (5), 1062-1070 (2005)
   PUBMED   15854049
  REMARK    GeneRIF: paper describing nomenclature changes and expression in
            range of tissues and in response to UV
REFERENCE   3  (bases 1 to 608)
  AUTHORS   Marshall,D., Hardman,M.J., Nield,K.M. and Byrne,C.
  TITLE     Differentially expressed late constituents of the epidermal
            cornified envelope
  JOURNAL   Proc Natl Acad Sci U S A 98 (23), 13031-13036 (2001)
   PUBMED   11698679
  REMARK    GeneRIF: XP5 is part of a cluster of genes (LEP genes) whose
            proteins incorporate into keratinocyte cornified envelopes. Strong
            skin expression confirmed.
REFERENCE   4  (bases 1 to 608)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
REFERENCE   5  (bases 1 to 608)
  AUTHORS   Zhao,X.P. and Elder,J.T.
  TITLE     Positional cloning of novel skin-specific genes from the human
            epidermal differentiation complex
  JOURNAL   Genomics 45 (2), 250-258 (1997)
   PUBMED   9344646
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF086289.1 and BG211939.1.
            
            On May 17, 2019 this sequence version replaced NM_014357.4.
            
            Summary: This gene is one of the at least 20 genes expressed during
            epidermal differentiation and located on chromosomal band 1q21.
            This gene is involved in epidermal differentiation, and it is
            expressed at high levels in normal and psoriatic skin, but not in
            cultured keratinocytes or in any other tested cell types or
            tissues. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX117218.1, AF086289.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368780.4/ ENSP00000357769.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-539               AF086289.1         1-539
            540-594             BG211939.1         10-64               c
            595-608             AF086289.1         595-608
FEATURES             Location/Qualifiers
     source          1..608
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..608
                     /gene="LCE2B"
                     /gene_synonym="LEP10; SPRL1B; XP5"
                     /note="late cornified envelope 2B"
                     /db_xref="GeneID:26239"
                     /db_xref="HGNC:HGNC:16610"
                     /db_xref="MIM:612610"
     exon            1..34
                     /gene="LCE2B"
                     /gene_synonym="LEP10; SPRL1B; XP5"
                     /inference="alignment:Splign:2.1.0"
     exon            35..608
                     /gene="LCE2B"
                     /gene_synonym="LEP10; SPRL1B; XP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..387
                     /gene="LCE2B"
                     /gene_synonym="LEP10; SPRL1B; XP5"
                     /note="small proline rich-like (epidermal differentiation
                     complex) 1B; late envelope protein 10; skin-specific
                     protein Xp5; small proline-rich-like epidermal
                     differentiation complex protein 1B"
                     /codon_start=1
                     /product="late cornified envelope protein 2B"
                     /protein_id="NP_055172.1"
                     /db_xref="CCDS:CCDS1020.1"
                     /db_xref="GeneID:26239"
                     /db_xref="HGNC:HGNC:16610"
                     /db_xref="MIM:612610"
                     /translation="MSCQQNQQQCQPPPKCPPKCTPKCPPKCPPKCLPQCPAPCSPAV
                     SSCCGPISGGCCGPSSGGCCNSGAGGCCLSHHRPRLFHRRRHQSPDCCESEPSGGSGC
                     CHSSGGCC"
     regulatory      585..590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LCE2B"
                     /gene_synonym="LEP10; SPRL1B; XP5"
                     /note="hexamer: AATAAA"
     polyA_site      608
                     /gene="LCE2B"
                     /gene_synonym="LEP10; SPRL1B; XP5"
                     /note="major polyA site"
ORIGIN      
        1 cagggacgtg tctgtgctcc tgcgtgtgac cagggttgac taaactctgc caggatgtct
       61 tgccagcaaa accagcagca gtgccagccc cctcccaagt gtcctcccaa gtgtacccca
      121 aaatgtccac ctaagtgtcc ccctaaatgc ctgccccagt gcccagctcc atgttcccct
      181 gcagtctctt cttgctgtgg tcccatctct gggggctgct gtggtcccag ctctgggggc
      241 tgctgcaact ctggggctgg tggctgctgc ctgagccacc acaggccccg tctcttccac
      301 cggcgccggc accagagccc cgactgctgt gagagtgaac cttctggggg ctctggctgc
      361 tgccacagct ctgggggctg ctgctgacct gggctaagaa gaactctttg gacagaatgt
      421 ttaagaacct cctacagcct gatgcttaac cctttccatt tcctctcatt ccattcatgg
      481 gtggacagcg accacaaaga ctcatggggc ttccctggga gaactttgca cttgatggag
      541 cacctcaatt gcaggttttg ttttcctcct ttacctcatg ttataataaa gctctgattt
      601 ctgactca
//
