LOCUS       NM_178428                611 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens late cornified envelope 2A (LCE2A), mRNA.
ACCESSION   NM_178428
VERSION     NM_178428.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 611)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 611)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 611)
  AUTHORS   Jackson,B., Tilli,C.M., Hardman,M.J., Avilion,A.A., MacLeod,M.C.,
            Ashcroft,G.S. and Byrne,C.
  TITLE     Late cornified envelope family in differentiating
            epithelia--response to calcium and ultraviolet irradiation
  JOURNAL   J Invest Dermatol 124 (5), 1062-1070 (2005)
   PUBMED   15854049
  REMARK    GeneRIF: paper describing nomenclature changes and expression in
            range of tissues and in response to UV
REFERENCE   4  (bases 1 to 611)
  AUTHORS   Marshall,D., Hardman,M.J., Nield,K.M. and Byrne,C.
  TITLE     Differentially expressed late constituents of the epidermal
            cornified envelope
  JOURNAL   Proc Natl Acad Sci U S A 98 (23), 13031-13036 (2001)
   PUBMED   11698679
REFERENCE   5  (bases 1 to 611)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139247.12, BC119707.2 and BG217525.1.
            
            On Nov 23, 2018 this sequence version replaced NM_178428.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC119707.2 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368779.2/ ENSP00000357768.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AL139247.12        97832-97850
            20-505              BC119707.2         1-486
            506-611             BG217525.1         461-566
FEATURES             Location/Qualifiers
     source          1..611
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..611
                     /gene="LCE2A"
                     /gene_synonym="LEP9"
                     /note="late cornified envelope 2A"
                     /db_xref="GeneID:353139"
                     /db_xref="HGNC:HGNC:29469"
                     /db_xref="MIM:612609"
     exon            1..50
                     /gene="LCE2A"
                     /gene_synonym="LEP9"
                     /inference="alignment:Splign:2.1.0"
     exon            51..611
                     /gene="LCE2A"
                     /gene_synonym="LEP9"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..391
                     /gene="LCE2A"
                     /gene_synonym="LEP9"
                     /note="late envelope protein 9"
                     /codon_start=1
                     /product="late cornified envelope protein 2A"
                     /protein_id="NP_848515.1"
                     /db_xref="CCDS:CCDS1021.1"
                     /db_xref="GeneID:353139"
                     /db_xref="HGNC:HGNC:29469"
                     /db_xref="MIM:612609"
                     /translation="MSCQQNQQQCQPPPKCPPKCPPKCPPKCRPQCPAPCPPPVSSCC
                     GPSSGGCCGSSSGGCCSSGGGGCCLSHHRPRLFHRHRHQSPDCCECEPSGGSGCCHSS
                     GDCC"
     regulatory      585..590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LCE2A"
                     /gene_synonym="LEP9"
                     /note="hexamer: AATAAA"
     polyA_site      611
                     /gene="LCE2A"
                     /gene_synonym="LEP9"
                     /note="major polyA site"
ORIGIN      
        1 atctgctctg acttccccag gacgtgtctg tgctcctgtg tgtgaccagg gttgaaaaag
       61 tcgcactgag atgtcctgcc agcaaaacca gcagcagtgc cagccccctc ccaagtgccc
      121 cccaaaatgc ccacccaagt gtcctccaaa gtgccgacct cagtgcccag ccccatgccc
      181 acctccagtc tcttcctgct gtggtcccag ctctgggggc tgctgcggct ccagctctgg
      241 gggctgctgc agctctgggg gtggcggctg ctgcctgagc caccacaggc cccgtctctt
      301 ccaccggcac cggcaccaga gccccgattg ttgtgagtgt gaaccttctg ggggctctgg
      361 ctgctgccac agctctgggg actgctgctg accagacctc gaacatcaca gagcaaccct
      421 tatggagaaa cttgcaacca ggacctgtcc cagagtgatg cttctcctgc ccctttttct
      481 cctttccttg ggctgacaca ccttgtgagg tgttttgtct gttgtcatgg cccaagagcc
      541 catcctggat cctgatctta ccttcccact ttacctcata caacaataaa gctcttttgc
      601 ctcttcgtga a
//
