LOCUS       NM_178354                726 bp    mRNA    linear   PRI 16-AUG-2024
DEFINITION  Homo sapiens late cornified envelope 1F (LCE1F), mRNA.
ACCESSION   NM_178354
VERSION     NM_178354.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 726)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 726)
  AUTHORS   Nagase,T., Yamakawa,H., Tadokoro,S., Nakajima,D., Inoue,S.,
            Yamaguchi,K., Itokawa,Y., Kikuno,R.F., Koga,H. and Ohara,O.
  TITLE     Exploration of human ORFeome: high-throughput preparation of ORF
            clones and efficient characterization of their protein products
  JOURNAL   DNA Res 15 (3), 137-149 (2008)
   PUBMED   18316326
REFERENCE   3  (bases 1 to 726)
  AUTHORS   Jackson,B., Tilli,C.M., Hardman,M.J., Avilion,A.A., MacLeod,M.C.,
            Ashcroft,G.S. and Byrne,C.
  TITLE     Late cornified envelope family in differentiating
            epithelia--response to calcium and ultraviolet irradiation
  JOURNAL   J Invest Dermatol 124 (5), 1062-1070 (2005)
   PUBMED   15854049
  REMARK    GeneRIF: paper describing nomenclature changes and expression in
            range of tissues and in response to UV
REFERENCE   4  (bases 1 to 726)
  AUTHORS   Marshall,D., Hardman,M.J., Nield,K.M. and Byrne,C.
  TITLE     Differentially expressed late constituents of the epidermal
            cornified envelope
  JOURNAL   Proc Natl Acad Sci U S A 98 (23), 13031-13036 (2001)
   PUBMED   11698679
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL353779.11.
            
            On Jul 29, 2020 this sequence version replaced NM_178354.2.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334371.4/ ENSP00000334187.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AL353779.11        59543-59593
            52-726              AL353779.11        60753-61427
FEATURES             Location/Qualifiers
     source          1..726
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..726
                     /gene="LCE1F"
                     /gene_synonym="LEP6"
                     /note="late cornified envelope 1F"
                     /db_xref="GeneID:353137"
                     /db_xref="HGNC:HGNC:29467"
                     /db_xref="MIM:612608"
     exon            1..51
                     /gene="LCE1F"
                     /gene_synonym="LEP6"
                     /inference="alignment:Splign:2.1.0"
     exon            52..726
                     /gene="LCE1F"
                     /gene_synonym="LEP6"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..430
                     /gene="LCE1F"
                     /gene_synonym="LEP6"
                     /note="late envelope protein 6"
                     /codon_start=1
                     /product="late cornified envelope protein 1F"
                     /protein_id="NP_848131.1"
                     /db_xref="CCDS:CCDS1023.1"
                     /db_xref="GeneID:353137"
                     /db_xref="HGNC:HGNC:29467"
                     /db_xref="MIM:612608"
                     /translation="MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPPVSSCC
                     SVSSGGCCGSSSGGCCSSGGGGCCSSGGGGCCLSHHRRRRSHRHRPQSSDCCSQPSAG
                     SSCCGGGSGQHSGGCC"
     regulatory      702..707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LCE1F"
                     /gene_synonym="LEP6"
                     /note="hexamer: AATAAA"
     polyA_site      726
                     /gene="LCE1F"
                     /gene_synonym="LEP6"
                     /note="major polyA site"
ORIGIN      
        1 atccactcac ctcctgcggt gctgaagaac cctgtgctgc ctgtgatcct gctcctgaac
       61 acccgccacc gagatgtctt gccagcagag ccagcagcag tgccagcccc ctcccaagtg
      121 cactcccaag tgccctccca agtgccccac accgaagtgc cccccaaagt gtccccctaa
      181 gtgccctcct gtctcttcct gctgcagcgt cagctccgga ggctgctgtg gctccagctc
      241 tgggggctgc tgcagctctg ggggtggtgg ctgctgcagc tctgggggag gcggctgttg
      301 cctgagccac cacagacggc gtaggtccca ccgccacaga ccccagagct ctgactgctg
      361 cagccagccc tcagcgggct ccagctgctg cggagggggc agtggccagc actctggagg
      421 ctgctgctga agtggaccct gtgcctaaaa gagcagattt agaggcatga aaggggcaac
      481 ttcatcttcc ttgggactga ctgtgttgct gggacatttt agtaaagatt tcaaactctg
      541 tcctggaaga ttcctccgac ctagaatcca gaaatctgcc ctctcacaag aattcctctt
      601 ctgacctctg attccatctg tgcgcctggc ctgggaatac caaatagaag tccttgcctc
      661 attcccctga tttccttggc aatctccatt gtgcatgaaa caataaaaca aataatctgc
      721 tcatca
//
