LOCUS       NM_178353               1200 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens late cornified envelope 1E (LCE1E), mRNA.
ACCESSION   NM_178353 XM_944296 XM_944301
VERSION     NM_178353.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1200)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1200)
  AUTHORS   Jackson,B., Tilli,C.M., Hardman,M.J., Avilion,A.A., MacLeod,M.C.,
            Ashcroft,G.S. and Byrne,C.
  TITLE     Late cornified envelope family in differentiating
            epithelia--response to calcium and ultraviolet irradiation
  JOURNAL   J Invest Dermatol 124 (5), 1062-1070 (2005)
   PUBMED   15854049
  REMARK    GeneRIF: paper describing nomenclature changes and expression in
            range of tissues and in response to UV
REFERENCE   3  (bases 1 to 1200)
  AUTHORS   Marshall,D., Hardman,M.J., Nield,K.M. and Byrne,C.
  TITLE     Differentially expressed late constituents of the epidermal
            cornified envelope
  JOURNAL   Proc Natl Acad Sci U S A 98 (23), 13031-13036 (2001)
   PUBMED   11698679
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL353779.11 and BC038391.1.
            
            On Nov 22, 2018 this sequence version replaced NM_178353.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038391.1, BG681090.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368770.4/ ENSP00000357759.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AL353779.11        70660-70679
            21-1200             BC038391.1         1-1180
FEATURES             Location/Qualifiers
     source          1..1200
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..1200
                     /gene="LCE1E"
                     /gene_synonym="LEP5"
                     /note="late cornified envelope 1E"
                     /db_xref="GeneID:353135"
                     /db_xref="HGNC:HGNC:29466"
                     /db_xref="MIM:612607"
     exon            1..51
                     /gene="LCE1E"
                     /gene_synonym="LEP5"
                     /inference="alignment:Splign:2.1.0"
     exon            52..1200
                     /gene="LCE1E"
                     /gene_synonym="LEP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..430
                     /gene="LCE1E"
                     /gene_synonym="LEP5"
                     /note="late envelope protein 5"
                     /codon_start=1
                     /product="late cornified envelope protein 1E"
                     /protein_id="NP_848130.1"
                     /db_xref="CCDS:CCDS1024.1"
                     /db_xref="GeneID:353135"
                     /db_xref="HGNC:HGNC:29466"
                     /db_xref="MIM:612607"
                     /translation="MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPPVSSCC
                     SVSSGGCCGSSSGGSCGSSSGGCCSSGGGGCCLSHHRHHRSHRHRPQSSDCCSQPSGG
                     SSCCGGGSGQHSGGCC"
     regulatory      672..677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LCE1E"
                     /gene_synonym="LEP5"
                     /note="hexamer: AATAAA"
     polyA_site      697
                     /gene="LCE1E"
                     /gene_synonym="LEP5"
                     /note="major polyA site"
     regulatory      1177..1182
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LCE1E"
                     /gene_synonym="LEP5"
                     /note="hexamer: AATAAA"
     regulatory      1183..1188
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LCE1E"
                     /gene_synonym="LEP5"
                     /note="hexamer: ATTAAA"
     polyA_site      1195
                     /gene="LCE1E"
                     /gene_synonym="LEP5"
     polyA_site      1200
                     /gene="LCE1E"
                     /gene_synonym="LEP5"
ORIGIN      
        1 attcactcac ttcctgaggt gccgaaggac cctgtgctgc ctgtgacttt gctcctaagt
       61 acctactgcc gagatgtcct gccagcagag ccagcagcag tgccagcccc ctcccaagtg
      121 cactcccaag tgccctccca agtgtcccac ccccaaatgc cctccaaagt gtccccctaa
      181 gtgccctcca gtctcttcct gctgcagtgt cagctccgga ggctgctgtg gctccagctc
      241 tgggggcagc tgtggctcca gctctggggg ctgctgcagc tctgggggag gtggctgctg
      301 cctgagccac cacaggcacc acaggtccca ccgtcacaga ccccagagct ctgactgctg
      361 cagccagccc tcagggggct ccagctgctg tggagggggc agcggccagc actctggagg
      421 ctgctgctga agtggacctt gacttcctct tccttctgat tctgcctgaa tagctgagag
      481 gttccagcaa aagcttgaag tcttgcctgg agaatccctc tgctctggtg tcaggaaacc
      541 caaaatcttt ctccttaatg gcatttagag actttcttct gcagatccat ggctgccctg
      601 ggaactccaa agcacacacc tacttcctcc ccagctcacg ctgctgtatt ctgtgctgcc
      661 tgaactgaag aaataaaatc cagaatctgc cccccaactt gctaccagcc tgcttgattt
      721 tcctgtttgt gtcatccttg ttctgctccc ctgtgtctgc tggtggctgc tgaggccttg
      781 gtggacagag gatggggaaa ggggtcagga ggaaaaagct tgcatttctg tgtgttttgt
      841 gttttttctt ctttcggtgt tttcctttta aaccaaggga ctgaaatagc attgagaaat
      901 atttttcttt caaattctgg ttcctttcac ctatgtaacc gcatccctca ggcatggcca
      961 ggaggccgac ttcatcctcc ttcccactat cacctcttca ttcttgtgtt cctcgttccc
     1021 cactccttcc actaacaatc tccctggact cctcctccat actgtatgtg catgcattca
     1081 cacacacata tgtacatgca catagatgag atgaatctgc attgtaaaaa aattaaatca
     1141 catttagtgc tgtataattt gcatgcaata aaattcaata aaattaaatg taaaattaaa
//
