LOCUS       NM_178348                625 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens late cornified envelope 1A (LCE1A), mRNA.
ACCESSION   NM_178348
VERSION     NM_178348.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 625)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 625)
  AUTHORS   Jackson,B., Tilli,C.M., Hardman,M.J., Avilion,A.A., MacLeod,M.C.,
            Ashcroft,G.S. and Byrne,C.
  TITLE     Late cornified envelope family in differentiating
            epithelia--response to calcium and ultraviolet irradiation
  JOURNAL   J Invest Dermatol 124 (5), 1062-1070 (2005)
   PUBMED   15854049
  REMARK    GeneRIF: a paper relating nomenclature changes and expression in
            range of tissues and in response to UV
REFERENCE   3  (bases 1 to 625)
  AUTHORS   Marshall,D., Hardman,M.J., Nield,K.M. and Byrne,C.
  TITLE     Differentially expressed late constituents of the epidermal
            cornified envelope
  JOURNAL   Proc Natl Acad Sci U S A 98 (23), 13031-13036 (2001)
   PUBMED   11698679
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL162596.30.
            
            On Aug 25, 2010 this sequence version replaced NM_178348.1.
            
            Summary: LCE1A belongs to the late cornified envelope (LCE) gene
            cluster within the epidermal differentiation complex (EDC) on
            chromosome 1. The LCE cluster contains multiple conserved genes
            that encode stratum corneum proteins, and these genes are expressed
            relatively late during fetal assembly of the skin cornified
            envelope (Jackson et al., 2005 [PubMed 15854049]). For further
            information on the LCE gene cluster, see GENE FAMILY
            below.[supplied by OMIM, Feb 2009].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335123.4/ ENSP00000334869.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-625               AL162596.30        17863-18487
FEATURES             Location/Qualifiers
     source          1..625
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..625
                     /gene="LCE1A"
                     /gene_synonym="LEP1"
                     /note="late cornified envelope 1A"
                     /db_xref="GeneID:353131"
                     /db_xref="HGNC:HGNC:29459"
                     /db_xref="MIM:612603"
     exon            1..625
                     /gene="LCE1A"
                     /gene_synonym="LEP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1..333
                     /gene="LCE1A"
                     /gene_synonym="LEP1"
                     /note="late envelope protein 1"
                     /codon_start=1
                     /product="late cornified envelope protein 1A"
                     /protein_id="NP_848125.1"
                     /db_xref="CCDS:CCDS1028.1"
                     /db_xref="GeneID:353131"
                     /db_xref="HGNC:HGNC:29459"
                     /db_xref="MIM:612603"
                     /translation="MSCQQSQQQCQPPPKCTPKCPPKCPTPKCPPKCPPKCPPVSSCC
                     SVSSGGCCGSSSGGGCSSGGGGCCLSHHRRHRSHRHRLQSSGCCSQPSGGSSCCGGDS
                     GQHSGGCC"
ORIGIN      
        1 atgtcctgcc agcagagcca gcagcagtgc cagccccctc ccaagtgcac ccccaagtgc
       61 cctcccaagt gccccactcc taagtgcccc ccaaagtgtc cccctaagtg ccctccagtc
      121 tcttcctgct gcagtgtcag ctccggaggc tgctgtggct ccagctctgg gggcggctgc
      181 agctctgggg gaggtggctg ctgcctgagc caccacaggc gccacaggtc ccaccgtcac
      241 agactccaga gctctggctg ctgcagccag ccctcgggag gctccagctg ctgtggaggg
      301 gacagcggcc agcactctgg aggctgctgc tgaagcggac tctgcaccta gaagagcaga
      361 ctcgggtgaa atgagtgatc aaacatttcc tcctcacctg tctcctcctg ggcctgcaag
      421 agtggctgag atgcccgcgt gaaggctctg agctctggcc tagaggatcc ctctgccctg
      481 ggatccagaa acttgattct tctcccacaa acctatctgc tgcccctgac accaactgtg
      541 ttgtctactc tgggatccca agccacaaac tcactctcca gctcatttcc tgcagcctca
      601 agtgaaacaa taaagcaaaa gatct
//
