LOCUS       NM_001282430            1073 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ladybird homeobox 2 (LBX2), transcript variant 1,
            mRNA.
ACCESSION   NM_001282430 XM_005264624
VERSION     NM_001282430.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1073)
  AUTHORS   Xiong,J., Liang,H., Sun,X. and Gao,K.
  TITLE     Histone modification-linked prognostic model for ovarian cancer
            reveals LBX2 as a novel growth promoter
  JOURNAL   J Cell Mol Med 28 (8), e18260 (2024)
   PUBMED   38520216
  REMARK    GeneRIF: Histone modification-linked prognostic model for ovarian
            cancer reveals LBX2 as a novel growth promoter.
REFERENCE   2  (bases 1 to 1073)
  AUTHORS   Li,H., Zhang,H., Wang,G., Chen,Z. and Pan,Y.
  TITLE     LncRNA LBX2-AS1 facilitates abdominal aortic aneurysm through
            miR-4685-5p/LBX2 feedback loop
  JOURNAL   Biomed Pharmacother 129, 109904 (2020)
   PUBMED   32559617
  REMARK    GeneRIF: LncRNA LBX2-AS1 facilitates abdominal aortic aneurysm
            through miR-4685-5p/LBX2 feedback loop.
REFERENCE   3  (bases 1 to 1073)
  AUTHORS   Hu,J., Bai,Y., Zhang,Q., Li,M., Yin,R. and Xu,L.
  TITLE     Identification of LBX2 as a novel causal gene of lung
            adenocarcinoma
  JOURNAL   Thorac Cancer 11 (8), 2137-2145 (2020)
   PUBMED   32567804
  REMARK    GeneRIF: Identification of LBX2 as a novel causal gene of lung
            adenocarcinoma.
REFERENCE   4  (bases 1 to 1073)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1073)
  AUTHORS   Wang,J., Luo,J., Chen,Q., Wang,X., He,J., Zhang,W., Yin,Z.,
            Zheng,F., Pan,H., Li,T., Lou,Q. and Wang,B.
  TITLE     Identification of LBX2 as a novel causal gene of atrial septal
            defect
  JOURNAL   Int J Cardiol 265, 188-194 (2018)
   PUBMED   29669692
  REMARK    GeneRIF: LBX2 was identified as a pathogenic gene in Chinese
            patients with atrial septal defect.
REFERENCE   6  (bases 1 to 1073)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   7  (bases 1 to 1073)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   8  (bases 1 to 1073)
  AUTHORS   Chen,F., Collin,G.B., Liu,K.C., Beier,D.R., Eccles,M.,
            Nishina,P.M., Moshang,T. and Epstein,J.A.
  TITLE     Characterization of the murine Lbx2 promoter, identification of the
            human homologue, and evaluation as a candidate for Alstrom syndrome
  JOURNAL   Genomics 74 (2), 219-227 (2001)
   PUBMED   11386758
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC005041.2, AY203953.1, BC150517.1 and AY305861.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001282430.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY203953.1, BC150517.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377566.9/ ENSP00000366789.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                AC005041.2         35696-35740
            46-61               AY203953.1         160-175
            62-572              BC150517.1         1-511
            573-1073            AY305861.1         952-1452
FEATURES             Location/Qualifiers
     source          1..1073
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p13.1"
     gene            1..1073
                     /gene="LBX2"
                     /gene_synonym="LP3727"
                     /note="ladybird homeobox 2"
                     /db_xref="GeneID:85474"
                     /db_xref="HGNC:HGNC:15525"
                     /db_xref="MIM:607164"
     exon            1..271
                     /gene="LBX2"
                     /gene_synonym="LP3727"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..663
                     /gene="LBX2"
                     /gene_synonym="LP3727"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transcription factor LBX2; ladybird-like homeobox 2;
                     ladybird-like homeodomain protein 2; ladybird homeobox
                     protein homolog 2"
                     /codon_start=1
                     /product="transcription factor LBX2 isoform 1"
                     /protein_id="NP_001269359.1"
                     /db_xref="CCDS:CCDS62938.1"
                     /db_xref="GeneID:85474"
                     /db_xref="HGNC:HGNC:15525"
                     /db_xref="MIM:607164"
                     /translation="MNSGREPRTPRTLLSIADILAPRMVPRAPSAPQLPESGPGPTSP
                     LCALEELTSKTFRGLDARALQPSEGRAGPDALGPGPFGRKRRKSRTAFTAQQVLELER
                     RFVFQKYLAPSERDGLATRLGLANAQVVTWFQNRRAKLKRDVEEMRADVASLRALSPE
                     VLCSLALPEGAPDPGLCLGPAGPDSRPHLSDEEIQVDD"
     exon            272..1073
                     /gene="LBX2"
                     /gene_synonym="LP3727"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1051..1056
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LBX2"
                     /gene_synonym="LP3727"
                     /note="hexamer: AATAAA"
     polyA_site      1073
                     /gene="LBX2"
                     /gene_synonym="LP3727"
                     /note="major polyA site"
ORIGIN      
        1 actggggccc aggcgtttgc ggagcctagc gcaacggaca gccggaccgc cccagcccgg
       61 ccgaccatga actcgggacg cgagccccga acaccccgga cactcttaag catcgcagac
      121 atcctagccc cgcgcatggt cccccgagca ccctctgcgc cgcagcttcc agagtcgggt
      181 ccgggtccaa cgtcgccgct gtgcgcgctg gaggagctga ctagtaaaac tttccgcgga
      241 cttgacgcgc gcgctctgca gccctctgaa gggcgggcag gtccggacgc gctgggccct
      301 ggtcccttcg gccgcaaacg gcgcaagtca cgcactgcgt tcaccgcgca acaggtgctg
      361 gagctggagc ggcgcttcgt cttccagaag tacctggcgc cgtccgagcg agacgggcta
      421 gctacgcgac tcggcctggc caacgcgcag gtggtcactt ggttccagaa ccggcgagcc
      481 aagctcaagc gcgatgtgga ggagatgcgc gccgacgtcg cctcgctacg cgcgttgtcc
      541 ccggaagtcc tgtgcagctt agcactgccc gaaggcgctc cagatcccgg cctctgcctc
      601 ggccctgccg gccctgactc ccggccccac ctgtcagacg aggagataca ggtggacgat
      661 tgaagacaaa gccgccgcca atcctgggct ctggggccct ggactcctca cctcgcgctc
      721 tgcctctggc cagagttcca gggtggagga aggaggtcca cttgggcctc ttccggccca
      781 cagtccagac gctcaccttt cccggttttt ttgtaagttt gttttgttgt ctgagacagg
      841 gcctcgctct gtcgcccagg ctggagtgcc gtggagcgat caccgctcac tgcagtcgcg
      901 acctcctggg ctcaagcgat cctcctgcct caacctcccg actagctggc attacaggcg
      961 tgcagcacca ccccaggcta atttaaaaaa cttttttttt tagagaggag gtcccgctat
     1021 gttgtccagg ctactttccc aatatttgag aataaagtcg agactctgcc gca
//
