LOCUS       NM_004139               1825 bp    mRNA    linear   PRI 24-APR-2024
DEFINITION  Homo sapiens lipopolysaccharide binding protein (LBP), mRNA.
ACCESSION   NM_004139
VERSION     NM_004139.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1825)
  AUTHORS   Zhang,Q., Shen,X., Yuan,X., Huang,J., Zhu,Y., Zhu,T., Zhang,T.,
            Wu,H., Wu,Q., Fan,Y., Ni,J., Meng,L., He,A., Shi,C., Li,H., Hu,Q.,
            Wang,J., Chang,C., Huang,F., Li,F., Chen,M., Liu,A., Ye,S.,
            Zheng,M. and Fang,H.
  TITLE     Lipopolysaccharide binding protein resists hepatic oxidative stress
            by regulating lipid droplet homeostasis
  JOURNAL   Nat Commun 15 (1), 3213 (2024)
   PUBMED   38615060
  REMARK    GeneRIF: Lipopolysaccharide binding protein resists hepatic
            oxidative stress by regulating lipid droplet homeostasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1825)
  AUTHORS   Xie,L., Qiu,S., Lu,C., Gu,C., Wang,J., Lv,J., Fang,L., Chen,Z.,
            Li,Y., Jiang,T., Xia,Y., Wang,W., Li,B. and Xu,Z.
  TITLE     Gastric cancer-derived LBP promotes liver metastasis by driving
            intrahepatic fibrotic pre-metastatic niche formation
  JOURNAL   J Exp Clin Cancer Res 42 (1), 258 (2023)
   PUBMED   37789385
  REMARK    GeneRIF: Gastric cancer-derived LBP promotes liver metastasis by
            driving intrahepatic fibrotic pre-metastatic niche formation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1825)
  AUTHORS   Zhao,Y., Walker,D.I., Lill,C.M., Bloem,B.R., Darweesh,S.K.L.,
            Pinto-Pacheco,B., McNeil,B., Miller,G.W., Heath,A.K., Frissen,M.,
            Petrova,D., Sanchez,M.J., Chirlaque,M.D., Guevara,M., Zibetti,M.,
            Panico,S., Middleton,L., Katzke,V., Kaaks,R., Riboli,E., Masala,G.,
            Sieri,S., Zamora-Ros,R., Amiano,P., Jenab,M., Peters,S. and
            Vermeulen,R.
  TITLE     Lipopolysaccharide-binding protein and future Parkinson's disease
            risk: a European prospective cohort
  JOURNAL   J Neuroinflammation 20 (1), 170 (2023)
   PUBMED   37480114
  REMARK    GeneRIF: Lipopolysaccharide-binding protein and future Parkinson's
            disease risk: a European prospective cohort.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1825)
  AUTHORS   Futami,Y., Takeda,Y., Koba,T., Narumi,R., Nojima,Y., Ito,M.,
            Nakayama,M., Ishida,M., Yoshimura,H., Naito,Y., Fukushima,K.,
            Takimoto,T., Edahiro,R., Matsuki,T., Nojima,S., Hirata,H.,
            Koyama,S., Iwahori,K., Nagatomo,I., Shirai,Y., Suga,Y., Satoh,S.,
            Futami,S., Miyake,K., Shiroyama,T., Inoue,Y., Adachi,J.,
            Tomonaga,T., Ueda,K. and Kumanogoh,A.
  TITLE     Identification of CD14 and lipopolysaccharide-binding protein as
            novel biomarkers for sarcoidosis using proteomics of serum
            extracellular vesicles
  JOURNAL   Int Immunol 34 (6), 327-340 (2022)
   PUBMED   35294531
  REMARK    GeneRIF: Identification of CD14 and lipopolysaccharide-binding
            protein as novel biomarkers for sarcoidosis using proteomics of
            serum extracellular vesicles.
REFERENCE   5  (bases 1 to 1825)
  AUTHORS   Graham,R.L.J., McMullen,A.A., Moore,G., Dempsey-Hibbert,N.C.,
            Myers,B. and Graham,C.
  TITLE     SWATH-MS identification of CXCL7, LBP, TGFbeta1 and PDGFRbeta as
            novel biomarkers in human systemic mastocytosis
  JOURNAL   Sci Rep 12 (1), 5087 (2022)
   PUBMED   35332176
  REMARK    GeneRIF: SWATH-MS identification of CXCL7, LBP, TGFbeta1 and
            PDGFRbeta as novel biomarkers in human systemic mastocytosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1825)
  AUTHORS   Wilde,C.G., Seilhamer,J.J., McGrogan,M., Ashton,N., Snable,J.L.,
            Lane,J.C., Leong,S.R., Thornton,M.B., Miller,K.L., Scott,R.W. et
            al.
  TITLE     Bactericidal/permeability-increasing protein and lipopolysaccharide
            (LPS)-binding protein. LPS binding properties and effects on
            LPS-mediated cell activation
  JOURNAL   J Biol Chem 269 (26), 17411-17416 (1994)
   PUBMED   7517398
REFERENCE   7  (bases 1 to 1825)
  AUTHORS   Dentener,M.A., Von Asmuth,E.J., Francot,G.J., Marra,M.N. and
            Buurman,W.A.
  TITLE     Antagonistic effects of lipopolysaccharide binding protein and
            bactericidal/permeability-increasing protein on
            lipopolysaccharide-induced cytokine release by mononuclear
            phagocytes. Competition for binding to lipopolysaccharide
  JOURNAL   J Immunol 151 (8), 4258-4265 (1993)
   PUBMED   8409400
REFERENCE   8  (bases 1 to 1825)
  AUTHORS   Gray,P.W., Corcorran,A.E., Eddy,R.L. Jr., Byers,M.G. and Shows,T.B.
  TITLE     The genes for the lipopolysaccharide binding protein (LBP) and the
            bactericidal permeability increasing protein (BPI) are encoded in
            the same region of human chromosome 20
  JOURNAL   Genomics 15 (1), 188-190 (1993)
   PUBMED   8432532
REFERENCE   9  (bases 1 to 1825)
  AUTHORS   Schumann,R.R., Leong,S.R., Flaggs,G.W., Gray,P.W., Wright,S.D.,
            Mathison,J.C., Tobias,P.S. and Ulevitch,R.J.
  TITLE     Structure and function of lipopolysaccharide binding protein
  JOURNAL   Science 249 (4975), 1429-1431 (1990)
   PUBMED   2402637
REFERENCE   10 (bases 1 to 1825)
  AUTHORS   Wright,S.D., Tobias,P.S., Ulevitch,R.J. and Ramos,R.A.
  TITLE     Lipopolysaccharide (LPS) binding protein opsonizes LPS-bearing
            particles for recognition by a novel receptor on macrophages
  JOURNAL   J Exp Med 170 (4), 1231-1241 (1989)
   PUBMED   2477488
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL391095.6, AF105067.1 and
            BC022256.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004139.4.
            
            Summary: The protein encoded by this gene is involved in the
            acute-phase immunologic response to gram-negative bacterial
            infections. Gram-negative bacteria contain a glycolipid,
            lipopolysaccharide (LPS), on their outer cell wall. Together with
            bactericidal permeability-increasing protein (BPI), the encoded
            protein binds LPS and interacts with the CD14 receptor, probably
            playing a role in regulating LPS-dependent monocyte responses.
            Studies in mice suggest that the encoded protein is necessary for
            the rapid acute-phase response to LPS but not for the clearance of
            LPS from circulation. This protein is part of a family of
            structurally and functionally related proteins, including BPI,
            plasma cholesteryl ester transfer protein (CETP), and phospholipid
            transfer protein (PLTP). [provided by RefSeq, Apr 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189652.89550.1,
                                           SRR5189664.106705.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000217407.3/ ENSP00000217407.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AL391095.6         15603-15620
            19-178              AF105067.1         1-160
            179-179             AL391095.6         18688-18688
            180-646             BC022256.1         180-646
            647-647             AL391095.6         29848-29848
            648-1436            BC022256.1         648-1436
            1437-1825           AL391095.6         45746-46134
FEATURES             Location/Qualifiers
     source          1..1825
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.23"
     gene            1..1825
                     /gene="LBP"
                     /gene_synonym="BPIFD2"
                     /note="lipopolysaccharide binding protein"
                     /db_xref="GeneID:3929"
                     /db_xref="HGNC:HGNC:6517"
                     /db_xref="MIM:151990"
     exon            1..159
                     /gene="LBP"
                     /gene_synonym="BPIFD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1481
                     /gene="LBP"
                     /gene_synonym="BPIFD2"
                     /note="LPS-binding protein; BPI fold containing family D,
                     member 2"
                     /codon_start=1
                     /product="lipopolysaccharide-binding protein precursor"
                     /protein_id="NP_004130.2"
                     /db_xref="CCDS:CCDS13304.1"
                     /db_xref="GeneID:3929"
                     /db_xref="HGNC:HGNC:6517"
                     /db_xref="MIM:151990"
                     /translation="MGALARALPSILLALLLTSTPEALGANPGLVARITDKGLQYAAQ
                     EGLLALQSELLRITLPDFTGDLRIPHVGRGRYEFHSLNIHSCELLHSALRPVPGQGLS
                     LSISDSSIRVQGRWKVRKSFFKLQGSFDVSVKGISISVNLLLGSESSGRPTVTASSCS
                     SDIADVEVDMSGDLGWLLNLFHNQIESKFQKVLESRICEMIQKSVSSDLQPYLQTLPV
                     TTEIDSFADIDYSLVEAPRATAQMLEVMFKGEIFHRNHRSPVTLLAAVMSLPEEHNKM
                     VYFAISDYVFNTASLVYHEEGYLNFSITDDMIPPDSNIRLTTKSFRPFVPRLARLYPN
                     MNLELQGSVPSAPLLNFSPGNLSVDPYMEIDAFVLLPSSSKEPVFRLSVATNVSATLT
                     FNTSKITGFLKPGKVKVELKESKVGLFNAELLEALLNYYILNTFYPKFNDKLAEGFPL
                     PLLKRVQLYDLGLQIHKDFLFLGANVQYMRV"
     exon            160..274
                     /gene="LBP"
                     /gene_synonym="BPIFD2"
                     /inference="alignment:Splign:2.1.0"
     exon            275..403
                     /gene="LBP"
                     /gene_synonym="BPIFD2"
                     /inference="alignment:Splign:2.1.0"
     exon            404..559
                     /gene="LBP"
                     /gene_synonym="BPIFD2"
                     /inference="alignment:Splign:2.1.0"
     exon            560..623
                     /gene="LBP"
                     /gene_synonym="BPIFD2"
                     /inference="alignment:Splign:2.1.0"
     exon            624..687
                     /gene="LBP"
                     /gene_synonym="BPIFD2"
                     /inference="alignment:Splign:2.1.0"
     exon            688..779
                     /gene="LBP"
                     /gene_synonym="BPIFD2"
                     /inference="alignment:Splign:2.1.0"
     exon            780..956
                     /gene="LBP"
                     /gene_synonym="BPIFD2"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1016
                     /gene="LBP"
                     /gene_synonym="BPIFD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1184
                     /gene="LBP"
                     /gene_synonym="BPIFD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1252
                     /gene="LBP"
                     /gene_synonym="BPIFD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1295
                     /gene="LBP"
                     /gene_synonym="BPIFD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..1359
                     /gene="LBP"
                     /gene_synonym="BPIFD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..1436
                     /gene="LBP"
                     /gene_synonym="BPIFD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1825
                     /gene="LBP"
                     /gene_synonym="BPIFD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1803..1808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LBP"
                     /gene_synonym="BPIFD2"
                     /note="hexamer: AATAAA"
     polyA_site      1825
                     /gene="LBP"
                     /gene_synonym="BPIFD2"
                     /note="major polyA site"
ORIGIN      
        1 gggacagtcc tggcccactg cactgggaat ctaggatggg ggccttggcc agagccctgc
       61 cgtccatact gctggcattg ctgcttacgt ccaccccaga ggctctgggt gccaaccccg
      121 gcttggtcgc caggatcacc gacaagggac tgcagtatgc ggcccaggag gggctattag
      181 ctctgcagag tgagctgctc aggatcacgc tgcctgactt caccggggac ttgaggatcc
      241 cccacgtcgg ccgtgggcgc tatgagttcc acagcctgaa catccacagc tgtgagctgc
      301 ttcactctgc gctgaggcct gtccctggcc agggcctgag tctcagcatc tccgactcct
      361 ccatccgggt ccagggcagg tggaaggtgc gcaagtcatt cttcaaacta cagggctcct
      421 ttgatgtcag tgtcaagggc atcagcattt cggtcaacct cctgttgggc agcgagtcct
      481 ccgggaggcc cacagttact gcctccagct gcagcagtga catcgctgac gtggaggtgg
      541 acatgtcggg agacttgggg tggctgttga acctcttcca caaccagatt gagtccaagt
      601 tccagaaagt actggagagc aggatttgcg aaatgatcca gaaatcagtg tcctccgatc
      661 tacagcctta tctccaaact ctgccagtta caacagagat tgacagtttc gccgacattg
      721 attatagctt agtggaagcc cctcgggcaa cagcccagat gctggaggtg atgtttaagg
      781 gtgaaatctt tcatcgtaac caccgttctc cagttaccct ccttgctgca gtcatgagcc
      841 ttcctgagga acacaacaaa atggtctact ttgccatctc ggattatgtc ttcaacacgg
      901 ccagcctggt ttatcatgag gaaggatatc tgaacttctc catcacagat gacatgatac
      961 cgcctgactc taatatccga ctgaccacca agtccttccg acccttcgtc ccacggttag
     1021 ccaggctcta ccccaacatg aacctggaac tccagggatc agtgccctct gctccgctcc
     1081 tgaacttcag ccctgggaat ctgtctgtgg acccctatat ggagatagat gcctttgtgc
     1141 tcctgcccag ctccagcaag gagcctgtct tccggctcag tgtggccact aatgtgtccg
     1201 ccaccttgac cttcaatacc agcaagatca ctgggttcct gaagccagga aaggtaaaag
     1261 tggaactgaa agaatccaaa gttggactat tcaatgcaga gctgttggaa gcgctcctca
     1321 actattacat ccttaacacc ttctacccca agttcaatga taagttggcc gaaggcttcc
     1381 cccttcctct gctgaagcgt gttcagctct acgaccttgg gctgcagatc cataaggact
     1441 tcctgttctt gggtgccaat gtccaataca tgagagtttg aggacaagaa agatgaagct
     1501 tggaggtcac agctggatct gcttgttgca tttccagctg tgcagcacgt ctcagagatt
     1561 cttgaagaat gaagacattt ctgctctcag ctccgggggt gaggtgtgcc tggcctctgc
     1621 ctccaccctc ctcctcttca ccaggtgcat gcatgccctc tctgagtctg gactttgctt
     1681 cccctccagg agggaccacc ctccccgact ggcctgggat atctttacaa gcaggcactg
     1741 tattttttta ttcgccatct gatccccatg cctagcagag tgctggcact tagtaggtcc
     1801 tcaataaata tttattaaat gatga
//
