LOCUS       NM_024099               1818 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens LBH domain containing 1 (LBHD1), transcript variant 2,
            mRNA.
ACCESSION   NM_024099
VERSION     NM_024099.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1818)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1818)
  AUTHORS   Michel,A.M., Choudhury,K.R., Firth,A.E., Ingolia,N.T., Atkins,J.F.
            and Baranov,P.V.
  TITLE     Observation of dually decoded regions of the human genome using
            ribosome profiling data
  JOURNAL   Genome Res 22 (11), 2219-2229 (2012)
   PUBMED   22593554
REFERENCE   3  (bases 1 to 1818)
  AUTHORS   Oyama,M., Kozuka-Hata,H., Suzuki,Y., Semba,K., Yamamoto,T. and
            Sugano,S.
  TITLE     Diversity of translation start sites may define increased
            complexity of the human short ORFeome
  JOURNAL   Mol Cell Proteomics 6 (6), 1000-1006 (2007)
   PUBMED   17317662
REFERENCE   4  (bases 1 to 1818)
  AUTHORS   Weber,M.J.
  TITLE     Mammalian small nucleolar RNAs are mobile genetic elements
  JOURNAL   PLoS Genet 2 (12), e205 (2006)
   PUBMED   17154719
  REMARK    Erratum:[PLoS Genet. 2007 Feb;3(2):e36]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001458.6.
            
            On Apr 28, 2021 this sequence version replaced NM_024099.4.
            
            Summary: This gene shares three exons in common with another gene,
            chromosome 11 open reading frame 98 (GeneID:102288414), but the
            encoded protein uses a reading frame that is different from that of
            the chromosome 11 open reading frame 98 gene. [provided by RefSeq,
            Nov 2017].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            segment compared to variant 1. The resulting isoform (b) has the
            same N- and C-termini but is shorter compared to isoform a.
            Variants 2, 3, and 8-10 all encode the same isoform (b).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001434.2, SRR14038192.2864228.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000354588.8/ ENSP00000346600.3
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-704               AP001458.6         78831-79534         c
            705-864             AP001458.6         77149-77308         c
            865-1027            AP001458.6         76908-77070         c
            1028-1252           AP001458.6         74790-75014         c
            1253-1377           AP001458.6         72116-72240         c
            1378-1475           AP001458.6         70503-70600         c
            1476-1818           AP001458.6         70084-70426         c
FEATURES             Location/Qualifiers
     source          1..1818
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.3"
     gene            1..1818
                     /gene="LBHD1"
                     /gene_synonym="C11orf48"
                     /note="LBH domain containing 1"
                     /db_xref="GeneID:79081"
                     /db_xref="HGNC:HGNC:28351"
     exon            1..704
                     /gene="LBHD1"
                     /gene_synonym="C11orf48"
                     /inference="alignment:Splign:2.1.0"
     exon            705..864
                     /gene="LBHD1"
                     /gene_synonym="C11orf48"
                     /inference="alignment:Splign:2.1.0"
     CDS             715..1506
                     /gene="LBHD1"
                     /gene_synonym="C11orf48"
                     /note="isoform b is encoded by transcript variant 2; LBH
                     domain-containing protein 1"
                     /codon_start=1
                     /product="LBH domain-containing protein 1 isoform b"
                     /protein_id="NP_077004.2"
                     /db_xref="CCDS:CCDS8028.1"
                     /db_xref="GeneID:79081"
                     /db_xref="HGNC:HGNC:28351"
                     /translation="MALVPGRSKEDGLWTRNSPGSSQHPESPRLPNPLWDRGKIGKVE
                     GHQHIQDFSQKSHLPSIVVESSEVNEESGDLHLPHEELLLLTDGEEEDAEAFFQDQSE
                     EPGWAWSPQDPRSPLRTFNAGLSWGQDQDEEDACWILEDTACLEATNHCPFWDSTGSR
                     VCRSGFVEYSHLLPPNSFEGAEEEAVQTPAGVESGAASEAPGGRGCDRPRADHAAPPQ
                     EAGVQCTCQHYTVREEAQKTPPADPACPEREDSHGSGSPFKASQD"
     exon            865..1027
                     /gene="LBHD1"
                     /gene_synonym="C11orf48"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1252
                     /gene="LBHD1"
                     /gene_synonym="C11orf48"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1377
                     /gene="LBHD1"
                     /gene_synonym="C11orf48"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1475
                     /gene="LBHD1"
                     /gene_synonym="C11orf48"
                     /inference="alignment:Splign:2.1.0"
     exon            1476..1818
                     /gene="LBHD1"
                     /gene_synonym="C11orf48"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1798..1803
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LBHD1"
                     /gene_synonym="C11orf48"
                     /note="hexamer: AATAAA"
     polyA_site      1818
                     /gene="LBHD1"
                     /gene_synonym="C11orf48"
                     /note="major polyA site"
ORIGIN      
        1 aaacgtgctc acccgacggc agctcacagg accccggaga gtcctggcat ggtatctcgg
       61 tccggactct ccgctgggcc cacgaaggag aaaggctgcc tcggattcct gcgcccaagc
      121 caaggtccgg cgcccacgga ggcaagtccg gtctcacggt gacctcccgc cggcgccgcc
      181 ttcgccgcca accatccagt tcttcctcca ggccacgttc tcctgcgtgg tcgctgcctc
      241 ctgcagagtg gccagcaata gctgctgggt cctggccgcc tcctccctgc tccttgggtc
      301 ctgcagtggc atctcctgag ggcaggaagg ggagttcgca ggagctccag tccggggctc
      361 tccacccgcc cacccttcct cgggactacc agttgcttct acctttagca tttcctgctt
      421 ccgccgctct cccggggtca cgataacgag gagcgcgtag cccacgccag cccctgcgcc
      481 cagcattgcg actgagatca gcattttccg caaggaatcc atggccgcct gcacagccag
      541 cggagcgccc acgggagctc cccgcagccg caagctgttg ccgcgcggtc tcactacccc
      601 ttggcgcagg ctagagcgcc ctatagcaga aaccatagat aagcggccgg ctagagagga
      661 cctgctcgag gaaacgtttg gaatccggag cgcttggatc tcagaatcac caccatggcc
      721 cttgtgccag ggagaagcaa ggaggatggg ctttggacta gaaatagccc aggctcctcc
      781 cagcatccag aaagtcccag gctgcccaac cctctctggg acagaggaaa aattggcaag
      841 gttgaaggtc accagcacat tcaggatttc tctcaaaagt cccatctgcc gtctattgtg
      901 gtggaatcca gtgaggtgaa tgaagagagt ggggatctcc atttgcccca tgaggagctg
      961 ctgctgctca ctgatggtga ggaagaggat gctgaggcct tcttccaaga ccaaagtgaa
     1021 gagccaggct gggcttggag cccacaggac cctagaagtc ctttaagaac atttaacgct
     1081 ggactcagct gggggcagga ccaggatgaa gaagatgctt gttggattct tgaggacaca
     1141 gcatgtctgg aagccaccaa ccactgtccc ttctgggact caacaggctc ccgtgtttgt
     1201 agaagtggct ttgtggaata ttcccatctc ctgcctccta atagctttga gggagctgaa
     1261 gaagaagctg ttcaaacgcc ggcgggtgtt gaatcgggag cggcgtctga ggcaccgggt
     1321 ggtcggggct gtgatagacc aagggctgat cacgcggcac cacctcaaga agcgggcgtc
     1381 cagtgcacgt gccaacatta cactgtcagg gaagaagcgc agaaaactcc tccagcagat
     1441 ccggcttgcc cagaaagaga agacagccat ggaagtggaa gccccttcaa agccagccag
     1501 gactagtgaa ccacagctca aaaggcaaaa gaagacaaaa gccccccagg atgtagaaat
     1561 gaaggacctt gaagatgaga gctaaacctc ttccactaga agattctcaa ctggagccag
     1621 ccttcagact cagtggttgt ttcagaggac tttgacaaaa gcaaggcccc ttttcactct
     1681 ccagatttcc tcctacctaa tggcctactg acctccccta gagggatgtc tttgggaggg
     1741 aagaaggtac agaagaaaga ttggagaagg gcctctctag cagtcaactc catttgtaat
     1801 aaagccctag cactctga
//
