LOCUS       NM_030915               2930 bp    mRNA    linear   PRI 23-MAR-2024
DEFINITION  Homo sapiens LBH regulator of WNT signaling pathway (LBH), mRNA.
ACCESSION   NM_030915 XM_940997 XM_944921 XM_944924
VERSION     NM_030915.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2930)
  AUTHORS   Garikapati,K., Young,I.C., Hong,S., Rai,P., Jain,C. and
            Briegel,K.J.
  TITLE     Blocking LBH expression causes replication stress and sensitizes
            triple-negative breast cancer cells to ATR inhibitor treatment
  JOURNAL   Oncogene 43 (12), 851-865 (2024)
   PUBMED   38297083
  REMARK    GeneRIF: Blocking LBH expression causes replication stress and
            sensitizes triple-negative breast cancer cells to ATR inhibitor
            treatment.
REFERENCE   2  (bases 1 to 2930)
  AUTHORS   Young,I.C., Brabletz,T., Lindley,L.E., Abreu,M., Nagathihalli,N.,
            Zaika,A. and Briegel,K.J.
  TITLE     Multi-cancer analysis reveals universal association of oncogenic
            LBH expression with DNA hypomethylation and WNT-Integrin signaling
            pathways
  JOURNAL   Cancer Gene Ther 30 (9), 1234-1248 (2023)
   PUBMED   37268816
  REMARK    GeneRIF: Multi-cancer analysis reveals universal association of
            oncogenic LBH expression with DNA hypomethylation and WNT-Integrin
            signaling pathways.
REFERENCE   3  (bases 1 to 2930)
  AUTHORS   Wu,A., Luo,N., Xu,Y., Du,N., Li,L. and Liu,Q.
  TITLE     Exosomal LBH inhibits epithelial-mesenchymal transition and
            angiogenesis in nasopharyngeal carcinoma via downregulating VEGFA
            signaling
  JOURNAL   Int J Biol Sci 18 (1), 242-260 (2022)
   PUBMED   34975330
  REMARK    GeneRIF: Exosomal LBH inhibits epithelial-mesenchymal transition
            and angiogenesis in nasopharyngeal carcinoma via downregulating
            VEGFA signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2930)
  AUTHORS   Wu,A., Zhang,L., Luo,N., Zhang,L., Li,L. and Liu,Q.
  TITLE     Limb-bud and heart (LBH) inhibits cellular migration, invasion and
            epithelial-mesenchymal transition in nasopharyngeal carcinoma via
            downregulating alphaB-crystallin expression
  JOURNAL   Cell Signal 85, 110045 (2021)
   PUBMED   34000384
  REMARK    GeneRIF: Limb-bud and heart (LBH) inhibits cellular migration,
            invasion and epithelial-mesenchymal transition in nasopharyngeal
            carcinoma via downregulating alphaB-crystallin expression.
REFERENCE   5  (bases 1 to 2930)
  AUTHORS   Chang,K.W., Hung,W.W., Chou,C.H., Tu,H.F., Chang,S.R., Liu,Y.C.,
            Liu,C.J. and Lin,S.C.
  TITLE     LncRNA MIR31HG Drives Oncogenicity by Inhibiting the Limb-Bud and
            Heart Development Gene (LBH) during Oral Carcinoma
  JOURNAL   Int J Mol Sci 22 (16), 8383 (2021)
   PUBMED   34445087
  REMARK    GeneRIF: LncRNA MIR31HG Drives Oncogenicity by Inhibiting the
            Limb-Bud and Heart Development Gene (LBH) during Oral Carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2930)
  AUTHORS   Ai,J., Wang,Y., Tan,K., Deng,Y., Luo,N., Yuan,W., Wang,Z., Li,Y.,
            Wang,Y., Mo,X., Zhu,C., Yin,Z., Liu,M. and Wu,X.
  TITLE     A human homolog of mouse Lbh gene, hLBH, expresses in heart and
            activates SRE and AP-1 mediated MAPK signaling pathway
  JOURNAL   Mol Biol Rep 35 (2), 179-187 (2008)
   PUBMED   17390236
  REMARK    GeneRIF: These results suggest that hLBH proteins may act as a
            transcriptional activator in mitogen-activated protein kinase
            signaling pathway to mediate cellular functions.
REFERENCE   7  (bases 1 to 2930)
  AUTHORS   Macaulay,I.C., Tijssen,M.R., Thijssen-Timmer,D.C., Gusnanto,A.,
            Steward,M., Burns,P., Langford,C.F., Ellis,P.D., Dudbridge,F.,
            Zwaginga,J.J., Watkins,N.A., van der Schoot,C.E. and Ouwehand,W.H.
  TITLE     Comparative gene expression profiling of in vitro differentiated
            megakaryocytes and erythroblasts identifies novel activatory and
            inhibitory platelet membrane proteins
  JOURNAL   Blood 109 (8), 3260-3269 (2007)
   PUBMED   17192395
REFERENCE   8  (bases 1 to 2930)
  AUTHORS   Tao,W.A., Wollscheid,B., O'Brien,R., Eng,J.K., Li,X.J.,
            Bodenmiller,B., Watts,J.D., Hood,L. and Aebersold,R.
  TITLE     Quantitative phosphoproteome analysis using a dendrimer conjugation
            chemistry and tandem mass spectrometry
  JOURNAL   Nat Methods 2 (8), 591-598 (2005)
   PUBMED   16094384
REFERENCE   9  (bases 1 to 2930)
  AUTHORS   Briegel,K.J., Baldwin,H.S., Epstein,J.A. and Joyner,A.L.
  TITLE     Congenital heart disease reminiscent of partial trisomy 2p syndrome
            in mice transgenic for the transcription factor Lbh
  JOURNAL   Development 132 (14), 3305-3316 (2005)
   PUBMED   15958514
  REMARK    GeneRIF: LBH is implicated as a candidate gene for congenital heart
            disease associated with partial trisomy 2p syndrome
            Erratum:[Development. 2005 Sep;132(17):4015]
REFERENCE   10 (bases 1 to 2930)
  AUTHORS   Briegel,K.J. and Joyner,A.L.
  TITLE     Identification and characterization of Lbh, a novel conserved
            nuclear protein expressed during early limb and heart development
  JOURNAL   Dev Biol 233 (2), 291-304 (2001)
   PUBMED   11336496
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC109376.1, BC130415.1, CN485291.1 and AI302040.1.
            
            On Nov 23, 2018 this sequence version replaced NM_030915.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK027232.1, BC109376.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395323.9/ ENSP00000378733.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                BC109376.1         8-32
            26-2193             BC130415.1         1-2168
            2194-2693           CN485291.1         62-561
            2694-2930           AI302040.1         2-238               c
FEATURES             Location/Qualifiers
     source          1..2930
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.1"
     gene            1..2930
                     /gene="LBH"
                     /note="LBH regulator of WNT signaling pathway"
                     /db_xref="GeneID:81606"
                     /db_xref="HGNC:HGNC:29532"
                     /db_xref="MIM:611763"
     exon            1..231
                     /gene="LBH"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..523
                     /gene="LBH"
                     /note="hLBH; limb bud and heart development homolog; limb
                     bud and heart development protein homolog"
                     /codon_start=1
                     /product="protein LBH"
                     /protein_id="NP_112177.2"
                     /db_xref="CCDS:CCDS33173.1"
                     /db_xref="GeneID:81606"
                     /db_xref="HGNC:HGNC:29532"
                     /db_xref="MIM:611763"
                     /translation="MSIYFPIHCPDYLRSAKMTEVMMNTQPMEEIGLSPRKDGLSYQI
                     FPDPSDFDRCCKLKDRLPSIVVEPTEGEVESGELRWPPEEFLVQEDEQDNCEETAKEN
                     KEQ"
     exon            232..334
                     /gene="LBH"
                     /inference="alignment:Splign:2.1.0"
     exon            335..2930
                     /gene="LBH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2907..2912
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LBH"
                     /note="hexamer: AATAAA"
     polyA_site      2930
                     /gene="LBH"
                     /note="major polyA site"
ORIGIN      
        1 gctgagtgct cagtggagag cggggagttg tgtccacctt gccgacgtcg ctagccgtgg
       61 ggctgtcctg ggaaggcgga cggcgagcgc ccggtgtccg cactcggccg cctgccgtgc
      121 ccgtctgcgc ccgtgtcatc ctcactcggg acgcagggac cgtttttaaa tcacaggggc
      181 gtgtgtcagc ctgccctagg acttcatgtc tatatatttc cccattcact gccccgacta
      241 tctgagatcg gccaagatga ctgaggtgat gatgaacacc cagcccatgg aggagatcgg
      301 cctcagcccc cgcaaggatg gcctttccta ccagatcttc ccagacccgt cagattttga
      361 ccgctgctgc aaactgaagg accgtctgcc ctccatagtg gtggaaccca cagaagggga
      421 ggtggagagc ggggagctcc ggtggccccc tgaggagttc ctggtccagg aggatgagca
      481 agataactgc gaagagacag cgaaagaaaa taaagagcag tagagtccct gtggactccc
      541 atgggtcata ccagccagca tctgttcctg aactgtgttt ttcccatcat gacggaagaa
      601 gagagtgagc cgcaattgtt ctgaaaatgt caaacgaggc ttctgttttg cacctgcaga
      661 tcaccgagtt ggttttcttt tcttttcttg cctttttttt tttttgaaat ttgccgagca
      721 gtggagccct ctgacaattt gcaaggccct ctgagaaagg aagctgctta gagccagggg
      781 gttagtgggt gaggggagcg agtgctgttt ttgagatcat tatctgaact caggcagcct
      841 agtagaggca gtggtgggat tccaatgggt cttggtgggt gggaggtggg gcatgtgcaa
      901 agcaagcaag gaacatttgg ggtaagaaaa caaacatgag gcaaaagaaa aaatacatgt
      961 ttttaagaaa acattgagca gagaactgca gccaggatgc gctcagcaga cattcactct
     1021 ggctgctggg acatcagaaa acaaagtctt catctctctc tccagtttca cccaccccac
     1081 cctttgcttt catttcaggt gtgttggtct atatgacagg gaggagagta aaggagagca
     1141 ggagcaattg gctgcctgca aagccagctg gaggtgaagt gcaggaaagg aaaggtcacc
     1201 ccattctact ccatggcctc tctgctccca gctgtggtag gctcacatag ccagtgtgat
     1261 cggtttttaa gaggcagtgc ttttcagctt ttctccctga tatatccatt ttgcttccca
     1321 gcacttttta ggagtagtga gagcacttcc tgcccttgtt ggaagcccca gggtggacac
     1381 tcagcacgaa ggtctctccc ttaactgctg cccttccaag acttgctccc gagatggagt
     1441 gggcgtggtc ttccaggctg gcccttcctt ctcctcaccg ccaccttccc tgccccagcc
     1501 ccagcagcca tgggtacatg ggtccccagc tcacctatgg attcccgcca gtctgcccag
     1561 ctgcagtact cacgccccat gggggatctt ggtctgtttt tcttgtggga gcctagtgga
     1621 gagcagacgt ggctttttat gtgtcttgtt ggggaggtga cttgcatggt ggggacaagg
     1681 ctgtcgtggc aaccttggga tcgagtttga gactaaagga tgtcatgaga tccctggctt
     1741 ctccccatgt tgttcccgga caagggcaga agggaggcat ggcaagggac ctctgctgtc
     1801 cttactcaac agtggtcctc atccctcccc acctcccact gcttcctgca agggcaccag
     1861 ttgtatgaga aagttggcct ttggacttag gatttcttat tgtagctaag agccatctga
     1921 agcagcaggt tgcaggacaa atgcttcagt ccgccgagag cagtaccgtg tggccaagag
     1981 gtggactcag agccttcctt gagctaaact cggccaacca aggcacgcag catgtcccct
     2041 caggtctcca gtcagtccag gttgaccctc agttctggac gtgtgtatat agctgtattt
     2101 aatacctcaa ggtcattgtg gctctgggga tgccggggca ggaggacgag ggtgcgctgt
     2161 ggacacagca gtccgcggaa ttccgttctg ggaagccaat ggtcgccggc accccttgct
     2221 tcctccctct gttgtctgcc tgtgtgacac acatcaatgg caataacttc ttccaactcc
     2281 tcgcagaagt gggagaggcc ggcagcctgc accgagaggg gctttcctct ctcttgctcc
     2341 ccgcttcgtt ctgttttggc tgcagagagt ggttcatcca tactctcatt ccctcgcctc
     2401 cccttgtgga cgggggtctt gccttttcaa ttcctgtgtt ttggtgtctt cccttatctg
     2461 ctaccctgaa tcacctgtcc tggtcttgct gtgtgatggg aacatgcttg taaactgcgt
     2521 aacaaatcta ctttgtgtat gtgtctgttt atgggggtgg tttattattt ttgctggtcc
     2581 ctagaccact ttgtatgacc gtttgcagtc tgagcaggcc aggggctgac agctaatgtc
     2641 aggaccctca gcggtggagc ctgctggggg gacccagctg ctcttggaca agtggctgag
     2701 ctcctatctg gcctcctctt tttttttttt tcaagtaatt tgtgtgtatt tctaactgat
     2761 tgtattgaaa aaattcctag tatttcagta aaaatgcctg ttgtgagatg aacctcctgt
     2821 aacttctatc tgttcttttt tgaggctcag ggagaaacta gcattttttt ttttccaaac
     2881 tactttttgt cactgtgaca gttgtaaata aagtttgaaa atgctttcca
//
