LOCUS       NM_014572               5546 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens large tumor suppressor kinase 2 (LATS2), mRNA.
ACCESSION   NM_014572
VERSION     NM_014572.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5546)
  AUTHORS   Nie,L., Fei,C., Fan,Y., Dang,F., Zhao,Z., Zhu,T., Wu,X., Dai,T.,
            Balasubramanian,A., Pan,J., Hu,Y., Luo,H.R., Wei,W. and Chen,J.
  TITLE     Consecutive palmitoylation and phosphorylation orchestrates NLRP3
            membrane trafficking and inflammasome activation
  JOURNAL   Mol Cell 84 (17), 3336-3353 (2024)
   PUBMED   39173637
REFERENCE   2  (bases 1 to 5546)
  AUTHORS   Cao,L., Han,R., Zhao,Y., Qin,X., Li,Q., Xiong,H., Kong,Y., Liu,Z.,
            Li,Z., Dong,F., Li,T., Zhao,X., Lei,L., Zhao,Q., Liu,D., Wang,B.
            and Wu,X.
  TITLE     A LATS2 and ALKBH5 positive feedback loop supports their oncogenic
            roles
  JOURNAL   Cell Rep 43 (4), 114032 (2024)
   PUBMED   38568805
  REMARK    GeneRIF: A LATS2 and ALKBH5 positive feedback loop supports their
            oncogenic roles.
REFERENCE   3  (bases 1 to 5546)
  AUTHORS   Yu,H., Xu,X., Zhu,L., Chen,S. and He,J.
  TITLE     MELK aggravates lung adenocarcinoma by regulating EZH2
            ubiquitination and H3K27me3 histone methylation of LATS2
  JOURNAL   J Cell Mol Med 28 (8), e18216 (2024)
   PUBMED   38652219
  REMARK    GeneRIF: MELK aggravates lung adenocarcinoma by regulating EZH2
            ubiquitination and H3K27me3 histone methylation of LATS2.
REFERENCE   4  (bases 1 to 5546)
  AUTHORS   Li,Y., Zeng,S. and Cao,L.
  TITLE     Mir-629 Repressed LATS2 Expression and Promoted the Proliferation
            of Prostate Cancer Cells
  JOURNAL   Horm Metab Res 55 (8), 573-579 (2023)
   PUBMED   36990459
  REMARK    GeneRIF: Mir-629 Repressed LATS2 Expression and Promoted the
            Proliferation of Prostate Cancer Cells.
REFERENCE   5  (bases 1 to 5546)
  AUTHORS   Sun,Q., Lu,H., Zhang,W., Du,Y., Liang,Q., Zhang,Y., Wu,J. and
            Zhong,M.
  TITLE     RNF106 aggravates esophageal squamous cell carcinoma progression
            through LATS2/YAP axis
  JOURNAL   Arch Biochem Biophys 742, 109640 (2023)
   PUBMED   37207933
  REMARK    GeneRIF: RNF106 aggravates esophageal squamous cell carcinoma
            progression through LATS2/YAP axis.
REFERENCE   6  (bases 1 to 5546)
  AUTHORS   Powzaniuk,M., McElwee-Witmer,S., Vogel,R.L., Hayami,T.,
            Rutledge,S.J., Chen,F., Harada,S., Schmidt,A., Rodan,G.A.,
            Freedman,L.P. and Bai,C.
  TITLE     The LATS2/KPM tumor suppressor is a negative regulator of the
            androgen receptor
  JOURNAL   Mol Endocrinol 18 (8), 2011-2023 (2004)
   PUBMED   15131260
  REMARK    GeneRIF: LATS2 may play a role in androgen receptor-mediated
            transcription and contribute to the development of prostate cancer
REFERENCE   7  (bases 1 to 5546)
  AUTHORS   Toji,S., Yabuta,N., Hosomi,T., Nishihara,S., Kobayashi,T.,
            Suzuki,S., Tamai,K. and Nojima,H.
  TITLE     The centrosomal protein Lats2 is a phosphorylation target of
            Aurora-A kinase
  JOURNAL   Genes Cells 9 (5), 383-397 (2004)
   PUBMED   15147269
  REMARK    GeneRIF: S83 of Lats2 is a phosphorylation target of Aurora-A and
            this phosphorylation plays a role of the centrosomal localization
            of Lats2
REFERENCE   8  (bases 1 to 5546)
  AUTHORS   Li,Y., Pei,J., Xia,H., Ke,H., Wang,H. and Tao,W.
  TITLE     Lats2, a putative tumor suppressor, inhibits G1/S transition
  JOURNAL   Oncogene 22 (28), 4398-4405 (2003)
   PUBMED   12853976
  REMARK    GeneRIF: of mammalian Lats2 and Lats1 control cell proliferation by
            negatively regulating different cell cycle check points.
REFERENCE   9  (bases 1 to 5546)
  AUTHORS   Hori,T., Takaori-Kondo,A., Kamikubo,Y. and Uchiyama,T.
  TITLE     Molecular cloning of a novel human protein kinase, kpm, that is
            homologous to warts/lats, a Drosophila tumor suppressor
  JOURNAL   Oncogene 19 (27), 3101-3109 (2000)
   PUBMED   10871863
REFERENCE   10 (bases 1 to 5546)
  AUTHORS   Yabuta,N., Fujii,T., Copeland,N.G., Gilbert,D.J., Jenkins,N.A.,
            Nishiguchi,H., Endo,Y., Toji,S., Tanaka,H., Nishimune,Y. and
            Nojima,H.
  TITLE     Structure, expression, and chromosome mapping of LATS2, a mammalian
            homologue of the Drosophila tumor suppressor gene lats/warts
  JOURNAL   Genomics 63 (2), 263-270 (2000)
   PUBMED   10673337
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL161613.23, DB452765.1,
            AF207547.1, AL356285.9 and BQ774580.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014572.2.
            
            Summary: This gene encodes a serine/threonine protein kinase
            belonging to the LATS tumor suppressor family. The protein
            localizes to centrosomes during interphase, and early and late
            metaphase. It interacts with the centrosomal proteins aurora-A and
            ajuba and is required for accumulation of gamma-tubulin and spindle
            formation at the onset of mitosis. It also interacts with a
            negative regulator of p53 and may function in a positive feedback
            loop with p53 that responds to cytoskeleton damage. Additionally,
            it can function as a co-repressor of androgen-responsive gene
            expression. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF207547.1, DRR138518.685317.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382592.5/ ENSP00000372035.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AL161613.23        35820-35822         c
            4-71                DB452765.1         1-68
            72-1531             AF207547.1         1-1460
            1532-1532           AL356285.9         144527-144527       c
            1533-2576           AF207547.1         1462-2505
            2577-2577           AL356285.9         139408-139408       c
            2578-3949           AF207547.1         2507-3878
            3950-5067           AL356285.9         129349-130466       c
            5068-5546           BQ774580.1         16-494              c
FEATURES             Location/Qualifiers
     source          1..5546
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.11"
     gene            1..5546
                     /gene="LATS2"
                     /gene_synonym="KPM"
                     /note="large tumor suppressor kinase 2"
                     /db_xref="GeneID:26524"
                     /db_xref="HGNC:HGNC:6515"
                     /db_xref="MIM:604861"
     exon            1..241
                     /gene="LATS2"
                     /gene_synonym="KPM"
                     /inference="alignment:Splign:2.1.0"
     exon            242..787
                     /gene="LATS2"
                     /gene_synonym="KPM"
                     /inference="alignment:Splign:2.1.0"
     CDS             446..3712
                     /gene="LATS2"
                     /gene_synonym="KPM"
                     /EC_number="2.7.11.1"
                     /note="LATS (large tumor suppressor, Drosophila) homolog
                     2; serine/threonine kinase KPM; kinase phosphorylated
                     during mitosis protein; warts-like kinase; large tumor
                     suppressor homolog 2; serine/threonine-protein kinase kpm;
                     LATS, large tumor suppressor, homolog 2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase LATS2"
                     /protein_id="NP_055387.2"
                     /db_xref="CCDS:CCDS9294.1"
                     /db_xref="GeneID:26524"
                     /db_xref="HGNC:HGNC:6515"
                     /db_xref="MIM:604861"
                     /translation="MRPKTFPATTYSGNSRQRLQEIREGLKQPSKSSVQGLPAGPNSD
                     TSLDAKVLGSKDATRQQQQMRATPKFGPYQKALREIRYSLLPFANESGTSAAAEVNRQ
                     MLQELVNAGCDQEMAGRALKQTGSRSIEAALEYISKMGYLDPRNEQIVRVIKQTSPGK
                     GLMPTPVTRRPSFEGTGDSFASYHQLSGTPYEGPSFGADGPTALEEMPRPYVDYLFPG
                     VGPHGPGHQHQHPPKGYGASVEAAGAHFPLQGAHYGRPHLLVPGEPLGYGVQRSPSFQ
                     SKTPPETGGYASLPTKGQGGPPGAGLAFPPPAAGLYVPHPHHKQAGPAAHQLHVLGSR
                     SQVFASDSPPQSLLTPSRNSLNVDLYELGSTSVQQWPAATLARRDSLQKPGLEAPPRA
                     HVAFRPDCPVPSRTNSFNSHQPRPGPPGKAEPSLPAPNTVTAVTAAHILHPVKSVRVL
                     RPEPQTAVGPSHPAWVPAPAPAPAPAPAPAAEGLDAKEEHALALGGAGAFPLDVEYGG
                     PDRRCPPPPYPKHLLLRSKSEQYDLDSLCAGMEQSLRAGPNEPEGGDKSRKSAKGDKG
                     GKDKKQIQTSPVPVRKNSRDEEKRESRIKSYSPYAFKFFMEQHVENVIKTYQQKVNRR
                     LQLEQEMAKAGLCEAEQEQMRKILYQKESNYNRLKRAKMDKSMFVKIKTLGIGAFGEV
                     CLACKVDTHALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEWVVKLYYSFQDKDS
                     LYFVMDYIPGGDMMSLLIRMEVFPEHLARFYIAELTLAIESVHKMGFIHRDIKPDNIL
                     IDLDGHIKLTDFGLCTGFRWTHNSKYYQKGSHVRQDSMEPSDLWDDVSNCRCGDRLKT
                     LEQRARKQHQRCLAHSLVGTPNYIAPEVLLRKGYTQLCDWWSVGVILFEMLVGQPPFL
                     APTPTETQLKVINWENTLHIPAQVKLSPEARDLITKLCCSADHRLGRNGADDLKAHPF
                     FSAIDFSSDIRKQPAPYVPTISHPMDTSNFDPVDEESPWNDASEGSTKAWDTLTSPNN
                     KHPEHAFYEFTFRRFFDDNGYPFRCPKPSGAEASQAESSDLESSDLVDQTEGCQPVYV
                     "
     exon            788..920
                     /gene="LATS2"
                     /gene_synonym="KPM"
                     /inference="alignment:Splign:2.1.0"
     exon            921..2344
                     /gene="LATS2"
                     /gene_synonym="KPM"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2927
                     /gene="LATS2"
                     /gene_synonym="KPM"
                     /inference="alignment:Splign:2.1.0"
     exon            2928..3110
                     /gene="LATS2"
                     /gene_synonym="KPM"
                     /inference="alignment:Splign:2.1.0"
     exon            3111..3217
                     /gene="LATS2"
                     /gene_synonym="KPM"
                     /inference="alignment:Splign:2.1.0"
     exon            3218..5546
                     /gene="LATS2"
                     /gene_synonym="KPM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5527..5532
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LATS2"
                     /gene_synonym="KPM"
                     /note="hexamer: ATTAAA"
     polyA_site      5546
                     /gene="LATS2"
                     /gene_synonym="KPM"
                     /note="major polyA site"
ORIGIN      
        1 gacgcccgtg gaatgccaac aatgtagcga atgtcccact tgggtctgcg ctttggaacc
       61 gcggcgtgag cgccccggga agatggagca gtcgccgtcc acgccaccgc cgccgcccgg
      121 ggctcccccg tccctgcggg gccagcagca gctccagcca ccagtgcccg gtctcccggc
      181 gcgagaggcc cgggagccgc cggccaggac gcccccgagg gtgtagaccg cgcccctgga
      241 gagagtgata atcttcaaaa tgaagacttt ggaaaatttt aggttctcta taggaactac
      301 aaaaatggaa ggaaagaaca ttttcaaaag gaaattattt tgaaagtatg tttacaacaa
      361 actgatacta ttgacagttt ttttttttaa ataataaaac actttaagaa gattgtattt
      421 atggtaaaag gaaactggac taacaatgag gccaaagact tttcctgcca cgacttattc
      481 tggaaatagc cggcagcgac tgcaagagat tcgtgagggg ttaaaacagc catccaagtc
      541 ttcggttcag gggctacccg caggaccaaa cagtgacact tccctggatg ccaaagtcct
      601 ggggagcaaa gatgccacca ggcagcagca gcagatgaga gccaccccaa agttcggacc
      661 ttatcagaaa gccttgaggg aaatcagata ttccttgttg ccttttgcta atgaatcggg
      721 cacctctgca gctgcagaag tgaaccggca aatgctgcag gaactggtga acgcaggatg
      781 cgaccaggag atggctggcc gagctctcaa gcagactggc agcaggagca tcgaggccgc
      841 cctggagtac atcagcaaga tgggctacct ggacccgagg aatgagcaga ttgtgcgggt
      901 cattaagcag acctccccag gaaaggggct catgccaacc ccagtgacgc ggaggcccag
      961 cttcgaagga accggcgatt cgtttgcgtc ctaccaccag ctgagcggta ccccctacga
     1021 gggcccaagc ttcggcgctg acggccccac ggcgctggag gagatgccgc ggccgtacgt
     1081 ggactacctt ttccccggag tcggccccca cgggcccggc caccagcacc agcacccacc
     1141 caagggctac ggtgccagcg tagaggcagc aggggcacac ttcccgctgc agggcgcgca
     1201 ctacgggcgg ccgcacctgc tggtgcctgg ggaacccctg ggctacggag tgcagcgcag
     1261 cccctccttc cagagcaaga cgccgccgga gaccgggggt tacgccagcc tgcccacgaa
     1321 gggccaggga ggaccgccag gcgccggcct cgctttccca ccccctgccg ccgggctcta
     1381 cgtgccgcac ccacaccaca agcaggccgg tcccgcggcc caccagctgc atgtgctggg
     1441 ctcccgcagc caggtgttcg ccagcgacag ccccccgcag agcctgctca ctccctcgcg
     1501 gaacagcctc aacgtggacc tgtatgaatt gggcagcacc tccgtccagc agtggccggc
     1561 tgccaccctg gcccgccggg actccctgca gaagccgggc ctggaggcgc cgccgcgcgc
     1621 gcacgtggcc ttccggcctg actgcccagt gcccagcagg accaactcct tcaacagcca
     1681 ccagccgcgg cccggtccgc ctggcaaggc cgagccctcc ctgcccgccc ccaacaccgt
     1741 gacggctgtc acggccgcgc acatcttgca cccggtgaag agcgtgcgtg tgctgaggcc
     1801 ggagccgcag acggctgtgg ggccctcgca ccccgcctgg gtgcccgcgc ctgccccggc
     1861 ccccgccccc gcccccgccc cggctgcgga gggcttggac gccaaggagg agcatgccct
     1921 ggcgctgggc ggcgcaggcg ccttcccgct ggacgtggag tacggaggcc cagaccggag
     1981 gtgcccgcct ccgccctacc cgaagcacct gctgctgcgc agcaagtcgg agcagtacga
     2041 cctggacagc ctgtgcgcag gcatggagca gagcctccgt gcgggcccca acgagcccga
     2101 gggcggcgac aagagccgca aaagcgccaa gggggacaaa ggcggaaagg ataaaaagca
     2161 gattcagacc tctcccgttc ccgtccgcaa aaacagcaga gacgaagaga agagagagtc
     2221 acgcatcaag agctactcgc catacgcctt taagttcttc atggagcagc acgtggagaa
     2281 tgtcatcaaa acctaccagc agaaggttaa ccggaggctg cagctggagc aagaaatggc
     2341 caaagctgga ctctgtgaag ctgagcagga gcagatgcgg aagatcctct accagaaaga
     2401 gtctaattac aacaggttaa agagggccaa gatggacaag tctatgtttg tcaagatcaa
     2461 aaccctgggg atcggtgcct ttggagaagt gtgccttgct tgtaaggtgg acactcacgc
     2521 cctgtacgcc atgaagaccc taaggaaaaa ggatgtcctg aaccggaatc aggtggccca
     2581 cgtcaaggcc gagagggaca tcctggccga ggcagacaat gagtgggtgg tcaaactcta
     2641 ctactccttc caagacaaag acagcctgta ctttgtgatg gactacatcc ctggtgggga
     2701 catgatgagc ctgctgatcc ggatggaggt cttccctgag cacctggccc ggttctacat
     2761 cgcagagctg actttggcca ttgagagtgt ccacaagatg ggcttcatcc accgagacat
     2821 caagcctgat aacattttga tagatctgga tggtcacatt aaactcacag atttcggcct
     2881 ctgcactggg ttcaggtgga ctcacaattc caaatattac cagaaaggga gccatgtcag
     2941 acaggacagc atggagccca gcgacctctg ggatgatgtg tctaactgtc ggtgtgggga
     3001 caggctgaag accctagagc agagggcgcg gaagcagcac cagaggtgcc tggcacattc
     3061 actggtgggg actccaaact acatcgcacc cgaggtgctc ctccgcaaag ggtacactca
     3121 actctgtgac tggtggagtg ttggagtgat tctcttcgag atgctggtgg ggcagccgcc
     3181 ctttttggca cctactccca cagaaaccca gctgaaggtg atcaactggg agaacacgct
     3241 ccacattcca gcccaggtga agctgagccc tgaggccagg gacctcatca ccaagctgtg
     3301 ctgctccgca gaccaccgcc tggggcggaa tggggccgat gacctgaagg cccacccctt
     3361 cttcagcgcc attgacttct ccagtgacat ccggaagcag ccagccccct acgttcccac
     3421 catcagccac cccatggaca cctcgaattt cgaccccgta gatgaagaaa gcccttggaa
     3481 cgatgccagc gaaggtagca ccaaggcctg ggacacactc acctcgccca ataacaagca
     3541 tcctgagcac gcattttacg aattcacctt ccgaaggttc tttgatgaca atggctaccc
     3601 ctttcgatgc ccaaagcctt caggagcaga agcttcacag gctgagagct cagatttaga
     3661 aagctctgat ctggtggatc agactgaagg ctgccagcct gtgtacgtgt agatgggggc
     3721 caggcacccc caccactcgc tgcctcccag gtcagggtcc cggagccggt gccctcacag
     3781 gccaataggg aagccgaggg ctgttttgtt ttaaattagt ccgtcgatta cttcacttga
     3841 aattctgctc ttcaccaaga aaacccaaac aggacacttt tgaaaacagg actcagcatc
     3901 gctttcaata ggcttttcag gaccttcact gcattaaaac aatatttttg aaaatttagt
     3961 acagtttaga aagagcactt attttgttta tatccatttt ttcttactaa attataggga
     4021 ttaactttga caaatcatgc tgctgttatt ttctacattt gtattttatc catagcactt
     4081 attcacattt aggaaaagac ataaaaactg aagaacattg atgagaaatc tctgtgcaat
     4141 aatgtaaaaa aaaaaaaaga taacactctg ctcaatgtca cggagaccat tttatccaca
     4201 caatggtttt tgttttttat tttttcccat gtttcaaaat tgtgatataa tgatataatg
     4261 ttaaaagctg ctttttttgg ctttttgcat atctagtata ataggaagtg tgagcaaggt
     4321 gatgatgtgg ctgtgatttc cgacgtctgg tgtgtggaga gtactgcatg agcagagttc
     4381 ttctattata aaattaccat atcttgccat tcacagcagg tcctgtgaat acgtttttac
     4441 tgagtgtctt taaatgaggt gttctagaca gtgtgctgat aatgtattgt gcgggtgacc
     4501 tcttcgctat gattgtatct cttactgttt tgttaaagaa atgcagatgt gtaactgaga
     4561 agtgatttgt gtgtgtgtct tggttgtgat tggattcttt gggggggggg aactgaaaca
     4621 tttgtcatat actgaactta tatacatcaa aagggattaa tacagcgatg ccaaaaagtt
     4681 taatcacgga cacatgtccg tttctgtagt ccgtatgctc tttcattctt ggtagagctg
     4741 gtatgtggaa tgccatacct ctgaccctac tacttacctt tttactgaca gactgcccac
     4801 actgaaagct tcagtgaatg ttcttagtcc tgttttcttc tgttactgtc aggaaactga
     4861 gtgatctaat ggttctctca cttttttttt gttcttttag tgtactttga agtatcaaat
     4921 cttaacttgg tttaaacaat acatattcct aacctttgta aaaaagcaaa gattcttcaa
     4981 aatgacattg aaataaaaag taagccatac gtattttctt agaagtatag atgtatgtgc
     5041 gtgtatacac acacacacac acacacagag ataaacacaa tattccttat ttcaaattag
     5101 tatgattcct atttaaagtg atttatattt gagtaaaaag ttcaattctt ttttgctttt
     5161 taaaaaatct gatgcttcat aattttcatt atattattcc acatattttt ccttgaagtt
     5221 cttagcataa tgtatccatt acttagtata tatctaggca acaacactta gaagtttatc
     5281 agtgtttaaa ctaaaaaaat aaagattcct gtgtactggt ttacatttgt gtgagtggca
     5341 tactcaagtc tgctgtgcct gtcgtcgtga ctgtcagtat tctcgctatt ttatagtcgt
     5401 gccatgttgt tactcacagc gctctgacat actttcatgt ggtaggttct ttctcaggaa
     5461 ctcagtttaa ctattattta ttgatatatc attacctttg aaaagcttct actggcacaa
     5521 tttattatta aaattttgaa tccaaa
//
