LOCUS       NM_004690               7362 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens large tumor suppressor kinase 1 (LATS1), transcript
            variant 1, mRNA.
ACCESSION   NM_004690
VERSION     NM_004690.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7362)
  AUTHORS   Blakely,W.J., Hatterschide,J. and White,E.A.
  TITLE     HPV18 E7 inhibits LATS1 kinase and activates YAP1 by degrading
            PTPN14
  JOURNAL   mBio 15 (10), e0181124 (2024)
   PUBMED   39248565
  REMARK    GeneRIF: HPV18 E7 inhibits LATS1 kinase and activates YAP1 by
            degrading PTPN14.
REFERENCE   2  (bases 1 to 7362)
  AUTHORS   Nie,L., Fei,C., Fan,Y., Dang,F., Zhao,Z., Zhu,T., Wu,X., Dai,T.,
            Balasubramanian,A., Pan,J., Hu,Y., Luo,H.R., Wei,W. and Chen,J.
  TITLE     Consecutive palmitoylation and phosphorylation orchestrates NLRP3
            membrane trafficking and inflammasome activation
  JOURNAL   Mol Cell 84 (17), 3336-3353 (2024)
   PUBMED   39173637
REFERENCE   3  (bases 1 to 7362)
  AUTHORS   Zhang,Z., Zhou,X., Li,J., Meng,Q. and Zheng,P.
  TITLE     LncRNA HOTAIR promotes the migration and invasion of cervical
            cancer through DNMT3B/LATS1/ YAP1 pS127 axis
  JOURNAL   Reprod Biol 24 (2), 100893 (2024)
   PUBMED   38754347
  REMARK    GeneRIF: LncRNA HOTAIR promotes the migration and invasion of
            cervical cancer through DNMT3B/LATS1/ YAP1 pS127 axis.
REFERENCE   4  (bases 1 to 7362)
  AUTHORS   Wu,J., Yi,T., Zhuo,C., Wang,D., Zhang,M., Hu,R., Wu,D., Hou,G. and
            Xing,Y.
  TITLE     m6A-induced TRIB3 regulates Hippo pathway through interacting with
            LATS1 to promote the progression of lung adenocarcinoma
  JOURNAL   J Cell Physiol 239 (5), e31220 (2024)
   PUBMED   38372068
  REMARK    GeneRIF: m[6]A-induced TRIB3 regulates Hippo pathway through
            interacting with LATS1 to promote the progression of lung
            adenocarcinoma.
REFERENCE   5  (bases 1 to 7362)
  AUTHORS   Zhang,F., Issah,M.A., Fu,H.Y., Zhou,H.R., Liu,T.B. and Shen,J.Z.
  TITLE     LATS1 Promotes B-ALL Tumorigenesis by Regulating YAP1
            Phosphorylation and Subcellular Localization
  JOURNAL   Curr Med Sci 44 (1), 81-92 (2024)
   PUBMED   38277019
  REMARK    GeneRIF: LATS1 Promotes B-ALL Tumorigenesis by Regulating YAP1
            Phosphorylation and Subcellular Localization.
REFERENCE   6  (bases 1 to 7362)
  AUTHORS   Nishiyama,Y., Hirota,T., Morisaki,T., Hara,T., Marumoto,T.,
            Iida,S., Makino,K., Yamamoto,H., Hiraoka,T., Kitamura,N. and
            Saya,H.
  TITLE     A human homolog of Drosophila warts tumor suppressor, h-warts,
            localized to mitotic apparatus and specifically phosphorylated
            during mitosis
  JOURNAL   FEBS Lett 459 (2), 159-165 (1999)
   PUBMED   10518011
REFERENCE   7  (bases 1 to 7362)
  AUTHORS   St John,M.A., Tao,W., Fei,X., Fukumoto,R., Carcangiu,M.L.,
            Brownstein,D.G., Parlow,A.F., McGrath,J. and Xu,T.
  TITLE     Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian
            tumours and pituitary dysfunction
  JOURNAL   Nat Genet 21 (2), 182-186 (1999)
   PUBMED   9988269
REFERENCE   8  (bases 1 to 7362)
  AUTHORS   Tao,W., Zhang,S., Turenchalk,G.S., Stewart,R.A., St John,M.A.,
            Chen,W. and Xu,T.
  TITLE     Human homologue of the Drosophila melanogaster lats tumour
            suppressor modulates CDC2 activity
  JOURNAL   Nat Genet 21 (2), 177-181 (1999)
   PUBMED   9988268
REFERENCE   9  (bases 1 to 7362)
  AUTHORS   Xu,T., Wang,W., Zhang,S., Stewart,R.A. and Yu,W.
  TITLE     Identifying tumor suppressors in genetic mosaics: the Drosophila
            lats gene encodes a putative protein kinase
  JOURNAL   Development 121 (4), 1053-1063 (1995)
   PUBMED   7743921
REFERENCE   10 (bases 1 to 7362)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF104413.1, AL358852.5,
            BX276089.8 and AW021064.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004690.3.
            
            Summary: The protein encoded by this gene is a putative
            serine/threonine kinase that localizes to the mitotic apparatus and
            complexes with cell cycle controller CDC2 kinase in early mitosis.
            The protein is phosphorylated in a cell-cycle dependent manner,
            with late prophase phosphorylation remaining through metaphase. The
            N-terminal region of the protein binds CDC2 to form a complex
            showing reduced H1 histone kinase activity, indicating a role as a
            negative regulator of CDC2/cyclin A. In addition, the C-terminal
            kinase domain binds to its own N-terminal region, suggesting
            potential negative regulation through interference with complex
            formation via intramolecular binding. Biochemical and genetic data
            suggest a role as a tumor suppressor. This is supported by studies
            in knockout mice showing development of soft-tissue sarcomas,
            ovarian stromal cell tumors and a high sensitivity to carcinogenic
            treatments. [provided by RefSeq, Apr 2017].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.168479.1,
                                           SRR1660803.101506.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467150 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000543571.6/ ENSP00000437550.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                AF104413.1         156-244
            90-90               AL358852.5         12605-12605         c
            91-4147             AF104413.1         246-4302
            4148-6968           BX276089.8         35139-37959         c
            6969-7362           AW021064.1         72-465
FEATURES             Location/Qualifiers
     source          1..7362
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.1"
     gene            1..7362
                     /gene="LATS1"
                     /gene_synonym="WARTS; wts"
                     /note="large tumor suppressor kinase 1"
                     /db_xref="GeneID:9113"
                     /db_xref="HGNC:HGNC:6514"
                     /db_xref="MIM:603473"
     exon            1..253
                     /gene="LATS1"
                     /gene_synonym="WARTS; wts"
                     /inference="alignment:Splign:2.1.0"
     exon            254..741
                     /gene="LATS1"
                     /gene_synonym="WARTS; wts"
                     /inference="alignment:Splign:2.1.0"
     CDS             394..3786
                     /gene="LATS1"
                     /gene_synonym="WARTS; wts"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 1; LATS
                     (large tumor suppressor, Drosophila) homolog 1;
                     serine/threonine-protein kinase LATS1; h-warts; WARTS
                     protein kinase; large tumor suppressor homolog 1; LATS,
                     large tumor suppressor, homolog 1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase LATS1 isoform 1"
                     /protein_id="NP_004681.1"
                     /db_xref="CCDS:CCDS34551.1"
                     /db_xref="GeneID:9113"
                     /db_xref="HGNC:HGNC:6514"
                     /db_xref="MIM:603473"
                     /translation="MKRSEKPEGYRQMRPKTFPASNYTVSSRQMLQEIRESLRNLSKP
                     SDAAKAEHNMSKMSTEDPRQVRNPPKFGTHHKALQEIRNSLLPFANETNSSRSTSEVN
                     PQMLQDLQAAGFDEDMVIQALQKTNNRSIEAAIEFISKMSYQDPRREQMAAAAARPIN
                     ASMKPGNVQQSVNRKQSWKGSKESLVPQRHGPPLGESVAYHSESPNSQTDVGRPLSGS
                     GISAFVQAHPSNGQRVNPPPPPQVRSVTPPPPPRGQTPPPRGTTPPPPSWEPNSQTKR
                     YSGNMEYVISRISPVPPGAWQEGYPPPPLNTSPMNPPNQGQRGISSVPVGRQPIIMQS
                     SSKFNFPSGRPGMQNGTGQTDFMIHQNVVPAGTVNRQPPPPYPLTAANGQSPSALQTG
                     GSAAPSSYTNGSIPQSMMVPNRNSHNMELYNISVPGLQTNWPQSSSAPAQSSPSSGHE
                     IPTWQPNIPVRSNSFNNPLGNRASHSANSQPSATTVTAITPAPIQQPVKSMRVLKPEL
                     QTALAPTHPSWIPQPIQTVQPSPFPEGTASNVTVMPPVAEAPNYQGPPPPYPKHLLHQ
                     NPSVPPYESISKPSKEDQPSLPKEDESEKSYENVDSGDKEKKQITTSPITVRKNKKDE
                     ERRESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHRKKQLENEMMRVGLSQDAQDQMR
                     KMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKALYATKTLRKKD
                     VLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPGGDMMSLLIRMG
                     IFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCTGFRWT
                     HDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQRCLAHSLVGTP
                     NYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMKVINWQTSLHIP
                     PQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDLRQQSASYIPKI
                     THPTDTSNFDPVDPDKLWSDDNEEENVNDTLNGWYKNGKHPEHAFYEFTFRRFFDDNG
                     YPYNYPKPIEYEYINSQGSEQQSDEDDQNTGSEIKNRDLVYV"
     exon            742..889
                     /gene="LATS1"
                     /gene_synonym="WARTS; wts"
                     /inference="alignment:Splign:2.1.0"
     exon            890..2403
                     /gene="LATS1"
                     /gene_synonym="WARTS; wts"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2986
                     /gene="LATS1"
                     /gene_synonym="WARTS; wts"
                     /inference="alignment:Splign:2.1.0"
     exon            2987..3169
                     /gene="LATS1"
                     /gene_synonym="WARTS; wts"
                     /inference="alignment:Splign:2.1.0"
     exon            3170..3276
                     /gene="LATS1"
                     /gene_synonym="WARTS; wts"
                     /inference="alignment:Splign:2.1.0"
     exon            3277..7362
                     /gene="LATS1"
                     /gene_synonym="WARTS; wts"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7338..7343
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LATS1"
                     /gene_synonym="WARTS; wts"
                     /note="hexamer: AATAAA"
     polyA_site      7362
                     /gene="LATS1"
                     /gene_synonym="WARTS; wts"
                     /note="major polyA site"
ORIGIN      
        1 agcggagtgc ggcggcggcg acactgagtg gaaggcaaaa tggcggcggc ggcggcggtg
       61 gcctggtgtt aaggggagag ccaggtcctc acgacccctg ggacgggccg cgctggcccg
      121 cggcagcccc cccgttcgtc tccccgctct gccccaccag ggatacttgg ggttgctggg
      181 acggactctg gccgcctcag cgtccgccct caggcccgtg gccgctgtcc aggagctctg
      241 ctctcccctc cagagttaat tatttatatt gtaaagaatt ttaacagtcc tggggacttc
      301 cttgaaggat cattttcact tttgctcaga agaaagctct ggatctatca aataaagaag
      361 tccttcgtgt gggctacata tatagatgtt ttcatgaaga ggagtgaaaa gccagaagga
      421 tatagacaaa tgaggcctaa gacctttcct gccagtaact atactgtcag tagccggcaa
      481 atgttacaag aaattcggga atcccttagg aatttatcta aaccatctga tgctgctaag
      541 gctgagcata acatgagtaa aatgtcaacc gaagatcctc gacaagtcag aaatccaccc
      601 aaatttggga cgcatcataa agccttgcag gaaattcgaa actctctgct tccatttgca
      661 aatgaaacaa attcttctcg gagtacttca gaagttaatc cacaaatgct tcaagacttg
      721 caagctgctg gatttgatga ggatatggtt atacaagctc ttcagaaaac taacaacaga
      781 agtatagaag cagcaattga attcattagt aaaatgagtt accaagatcc tcgacgagag
      841 cagatggctg cagcagctgc cagacctatt aatgccagca tgaaaccagg gaatgtgcag
      901 caatcagtta accgcaaaca gagctggaaa ggttctaaag aatccttagt tcctcagagg
      961 catggcccgc cactaggaga aagtgtggcc tatcattctg agagtcccaa ctcacagaca
     1021 gatgtaggaa gacctttgtc tggatctggt atatcagcat ttgttcaagc tcaccctagc
     1081 aacggacaga gagtgaaccc cccaccacca cctcaagtaa ggagtgttac tcctccacca
     1141 cctccaagag gccagactcc ccctccaaga ggtacaactc cacctccccc ttcatgggaa
     1201 ccaaactctc aaacaaagcg ctattctgga aacatggaat acgtaatctc ccgaatctct
     1261 cctgtcccac ctggggcatg gcaagagggc tatcctccac cacctctcaa cacttccccc
     1321 atgaatcctc ctaatcaagg acagagaggc attagttctg ttcctgttgg cagacaacca
     1381 atcatcatgc agagttctag caaatttaac tttccatcag ggagacctgg aatgcagaat
     1441 ggtactggac aaactgattt catgatacac caaaatgttg tccctgctgg cactgtgaat
     1501 cggcagccac cacctccata tcctctgaca gcagctaatg gacaaagccc ttctgcttta
     1561 caaacagggg gatctgctgc tccttcgtca tatacaaatg gaagtattcc tcagtctatg
     1621 atggtgccaa acagaaatag tcataacatg gaactatata acattagtgt acctggactg
     1681 caaacaaatt ggcctcagtc atcttctgct ccagcccagt catccccgag cagtgggcat
     1741 gaaatcccta catggcaacc taacatacca gtgaggtcaa attcttttaa taacccatta
     1801 ggaaatagag caagtcactc tgctaattct cagccttctg ctacaacagt cactgcaatt
     1861 acaccagctc ctattcaaca gcctgtgaaa agtatgcgtg tattaaaacc agagctacag
     1921 actgctttag cacctacaca cccttcttgg ataccacagc caattcaaac tgttcaaccc
     1981 agtccttttc ctgagggaac cgcttcaaat gtgactgtga tgccacctgt tgctgaagct
     2041 ccaaactatc aaggaccacc accaccctac ccaaaacatc tgctgcacca aaacccatct
     2101 gttcctccat acgagtcaat cagtaagcct agcaaagagg atcagccaag cttgcccaag
     2161 gaagatgaga gtgaaaagag ttatgaaaat gttgatagtg gggataaaga aaagaaacag
     2221 attacaactt cacctattac tgttaggaaa aacaagaaag atgaagagcg aagggaatct
     2281 cgtattcaaa gttattctcc tcaagcattt aaattcttta tggagcaaca tgtagaaaat
     2341 gtactcaaat ctcatcagca gcgtctacat cgtaaaaaac aattagagaa tgaaatgatg
     2401 cgggttggat tatctcaaga tgcccaggat caaatgagaa agatgctttg ccaaaaagaa
     2461 tctaattaca tccgtcttaa aagggctaaa atggacaagt ctatgtttgt gaagataaag
     2521 acactaggaa taggagcatt tggtgaagtc tgtctagcaa gaaaagtaga tactaaggct
     2581 ttgtatgcaa caaaaactct tcgaaagaaa gatgttcttc ttcgaaatca agtcgctcat
     2641 gttaaggctg agagagatat cctggctgaa gctgacaatg aatgggtagt tcgtctatat
     2701 tattcattcc aagataagga caatttatac tttgtaatgg actacattcc tgggggtgat
     2761 atgatgagcc tattaattag aatgggcatc tttccagaaa gtctggcacg attctacata
     2821 gcagaactta cctgtgcagt tgaaagtgtt cataaaatgg gttttattca tagagatatt
     2881 aaacctgata atattttgat tgatcgtgat ggtcatatta aattgactga ctttggcctc
     2941 tgcactggct tcagatggac acacgattct aagtactatc agagtggtga ccatccacgg
     3001 caagatagca tggatttcag taatgaatgg ggggatccct caagctgtcg atgtggagac
     3061 agactgaagc cattagagcg gagagctgca cgccagcacc agcgatgtct agcacattct
     3121 ttggttggga ctcccaatta tattgcacct gaagtgttgc tacgaacagg atacacacag
     3181 ttgtgtgatt ggtggagtgt tggtgttatt ctttttgaaa tgttggtggg acaacctcct
     3241 ttcttggcac aaacaccatt agaaacacaa atgaaggtta tcaactggca aacatctctt
     3301 cacattccac cacaagctaa actcagtcct gaagcttctg atcttattat taaactttgc
     3361 cgaggacccg aagatcgctt aggcaagaat ggtgctgatg aaataaaagc tcatccattt
     3421 tttaaaacaa ttgacttctc cagtgacctg agacagcagt ctgcttcata cattcctaaa
     3481 atcacacacc caacagatac atcaaatttt gatcctgttg atcctgataa attatggagt
     3541 gatgataacg aggaagaaaa tgtaaatgac actctcaatg gatggtataa aaatggaaag
     3601 catcctgaac atgcattcta tgaatttacc ttccgaaggt tttttgatga caatggctac
     3661 ccatataatt atccgaagcc tattgaatat gaatacatta attcacaagg ctcagagcag
     3721 cagtcggatg aagatgatca aaacacaggc tcagagatta aaaatcgcga tctagtatat
     3781 gtttaacaca ctagtaaata aatgtaatga ggatttgtaa aagggcctga aatgcgaggt
     3841 gttttgaggt tctgagagta aaattatgca aatatgacag agctatatat gtgtgctctg
     3901 tgtacaatat tttattttcc taaattatgg gaaatccttt taaaatgtta atttattcca
     3961 gccgtttaaa tcagtattta gaaaaaaatt gttataagga aagtaaatta tgaactgaat
     4021 attatagtca gttcttggta cttaaagtac ttaaaataag tagtgctttg tttaaaagga
     4081 gaaacctggt atctatttgt atatatgcta aataatttta aaatacaaga gtttttgaaa
     4141 tttttttgaa agacagtttt agttttatct tgctttaacc aaatatgaaa cataccccct
     4201 attttacaga gctctttttt cccctcataa ccttgttttt ggtagaaaat aagctagaga
     4261 aattaagcca tcgtgttggt gagtgttcct aggctaatga taatctgtat aattcacatc
     4321 ctgaaactaa ggaatacagg gttgaaaaaa tattaatatg tttgtcagaa ggaaaaataa
     4381 tgcatttatc ttccccccca ccccccgccc catggaatat ttaatctatt taatcttctt
     4441 gcatttattt ctcaagaatt actggcttta aaagaagcca aagcactact agcttttttt
     4501 ccatattggt atttttgatg ctgcttccaa ttttaaaagg gaacaaagct gccataaatc
     4561 gaaatgttca atactaaaag ctaaaatatt tctcaccatc ctaagcagat aattatttta
     4621 attttcatat acttttcctg tatagtaact attttgatta tatcatcaat gttacctgtt
     4681 tcctctttca gaacagtgct gcatatacag attgttattg gcaaaggaaa atctggctat
     4741 ctggcaatat tttacctaag cgcagattaa ttggtgaaaa aattaactct taagatggcc
     4801 attaataatt aggaaagttt acagagtggt cttagtagaa aattcaagtc ctcctaattt
     4861 atttaaggtt caataatgcg ttcaacatgc ctgttatgta taacgcttag gttctaagga
     4921 agattaaggt ttcataccaa aatacatgta gcttatcttt taggaagggg aaaaaggctc
     4981 cattttgacc atagtaaaat ttgtgttgtg ttttatttcc ttttcttaag ctccactgat
     5041 aagggattgt ttttatcaaa agttactatt tgtagattgg aggcataatt ttagtgattt
     5101 tcatactttt agctttcttc gcataaaagc taattgaaac cgtatatgta gtaaaattaa
     5161 aggcagagct gttgcagttg aattggagag ttagggcaaa gaacacttat tagcccacac
     5221 ttcccacctt tctacaggtg gtcctttcag agctcagcct gaaaacccac tactgtgtta
     5281 tcgtgcgtct tttggggtta gtggttcttt tgagaatctg aaggaagctg tggactcttc
     5341 ctagaaaaaa aaaccacaca tacacataca atgttgcatg cagtttcaag ggattttgga
     5401 catattgaaa cctatcacag gctgtaggtt atggacctct gtgccatgag aaaattgata
     5461 cattaaacta agaactttgt ttttaactta ccaatcacta ctcagcacat cttatataag
     5521 ctgataattt gtgatggaaa aggtctgtag catgtgatat aaggtgacct tatgaatgcc
     5581 tctcttgctg gtacattaag ttgttttaat atatcatttg gaggggactg aaatgttagg
     5641 ctcattacaa gcttgataca gaaatatttc tgaaggattt ctaatcagaa ttgtaaaaca
     5701 atgtgctatc atgaaatcgc agtcttcacc tcatggttca tggaacattt ggttagtccc
     5761 ataaaatcct atgcaaaaca aagtagttca agaattttta ggtgggtagt cacatttata
     5821 aggtattcct cttactcttt gggctttttc agtctgattt atttaaattt tcatttagtt
     5881 gttttacttt tggactaagg tgcaatacag tagaagataa ctttgttaca tttatgttgt
     5941 aggaaaacta aggtgctgtc tcctccccct tcccttccca caaaatctgt attcccccta
     6001 ttgctgaaat gtaacagaca ctacaaattt tgtattcttt ttttgttttt tgttttgaga
     6061 cagggtctca ctctgtcacc caggctggag ggcagtggcg cttcacagct cactgcatcc
     6121 tcaaccttgg gggctcacgc agtcctcccg cctcagcctc ccaagtagct gggcatgcgc
     6181 caccaagccc agctaatttt tgtatcttta gtagagatgg ggtttcgcca tgttgcccag
     6241 gttggtgtgg aattcctggg ctccagttat atgcccacct cagcctccca aagtgctggg
     6301 attacagacg tgacccaccg cgcctggcgc aaatatgtat tcttttaaaa tttcctctga
     6361 tactataagc tttttgcatt tatctgaagc agtatacatg cctttggtat cagcaatttt
     6421 aacagtttgg atatacttat cagctatctt attccaaaac tacatctact tcttccagta
     6481 tagaatctgg tgcttcctga ccaaaaagat gagaaaaaca atgttaaaaa tatagatgct
     6541 ttccattgaa atggagtgaa aacattggtt ctatatgttt tcttttaaaa taattttctt
     6601 attaaaaact tgctgtcttt attatactta ccctttttat gcatatcaat agtatttata
     6661 agatgtgttc tataattatg taattgtaga tactgttatg cattgtccag tgacatcata
     6721 aggcaggccc tactgctgta tcttttctac cttcttattt gtaatagaaa ctatagaatg
     6781 tatgactaaa aagtcacttt gagattgact tttttaaaaa gttattacct tctgctgttg
     6841 caaagtgcaa aactgtgagt ggaattgttt tattctgact taatgtgtta gaaattagag
     6901 aatacagtgg gaggattttt agacattgct gctgctgtta cccaaggtat tttagataaa
     6961 aaatttttaa taaacatccc tttggtattt aaagtggaac atttagcctg ttcattttaa
     7021 tctaaagcaa aaagtaattt gggtcaaaat attggtatat ttgtaaagcg ccttaatata
     7081 tccctttgtg gaaggcacta cacagtttac ttttatattg tattgtgtat ataagtattt
     7141 tgtattaaaa ttgaatcagt ggcaacatta aagttttata aaatcatgct ttgttagaaa
     7201 aagaattaca gctttgcaat ataactaatt gtttcgcata attctgaatg taatagatat
     7261 gaataatcag cctgtgtttt taatgaactt atttgtattt tcccaatcat tttctctagt
     7321 gtaatgtttg ctgggataat aaaaaaaatt caaatctttc aa
//
