LOCUS       NM_001350340            7457 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens large tumor suppressor kinase 1 (LATS1), transcript
            variant 5, mRNA.
ACCESSION   NM_001350340 XM_017011478
VERSION     NM_001350340.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7457)
  AUTHORS   Blakely,W.J., Hatterschide,J. and White,E.A.
  TITLE     HPV18 E7 inhibits LATS1 kinase and activates YAP1 by degrading
            PTPN14
  JOURNAL   mBio 15 (10), e0181124 (2024)
   PUBMED   39248565
  REMARK    GeneRIF: HPV18 E7 inhibits LATS1 kinase and activates YAP1 by
            degrading PTPN14.
REFERENCE   2  (bases 1 to 7457)
  AUTHORS   Nie,L., Fei,C., Fan,Y., Dang,F., Zhao,Z., Zhu,T., Wu,X., Dai,T.,
            Balasubramanian,A., Pan,J., Hu,Y., Luo,H.R., Wei,W. and Chen,J.
  TITLE     Consecutive palmitoylation and phosphorylation orchestrates NLRP3
            membrane trafficking and inflammasome activation
  JOURNAL   Mol Cell 84 (17), 3336-3353 (2024)
   PUBMED   39173637
REFERENCE   3  (bases 1 to 7457)
  AUTHORS   Zhang,Z., Zhou,X., Li,J., Meng,Q. and Zheng,P.
  TITLE     LncRNA HOTAIR promotes the migration and invasion of cervical
            cancer through DNMT3B/LATS1/ YAP1 pS127 axis
  JOURNAL   Reprod Biol 24 (2), 100893 (2024)
   PUBMED   38754347
  REMARK    GeneRIF: LncRNA HOTAIR promotes the migration and invasion of
            cervical cancer through DNMT3B/LATS1/ YAP1 pS127 axis.
REFERENCE   4  (bases 1 to 7457)
  AUTHORS   Wu,J., Yi,T., Zhuo,C., Wang,D., Zhang,M., Hu,R., Wu,D., Hou,G. and
            Xing,Y.
  TITLE     m6A-induced TRIB3 regulates Hippo pathway through interacting with
            LATS1 to promote the progression of lung adenocarcinoma
  JOURNAL   J Cell Physiol 239 (5), e31220 (2024)
   PUBMED   38372068
  REMARK    GeneRIF: m[6]A-induced TRIB3 regulates Hippo pathway through
            interacting with LATS1 to promote the progression of lung
            adenocarcinoma.
REFERENCE   5  (bases 1 to 7457)
  AUTHORS   Zhang,F., Issah,M.A., Fu,H.Y., Zhou,H.R., Liu,T.B. and Shen,J.Z.
  TITLE     LATS1 Promotes B-ALL Tumorigenesis by Regulating YAP1
            Phosphorylation and Subcellular Localization
  JOURNAL   Curr Med Sci 44 (1), 81-92 (2024)
   PUBMED   38277019
  REMARK    GeneRIF: LATS1 Promotes B-ALL Tumorigenesis by Regulating YAP1
            Phosphorylation and Subcellular Localization.
REFERENCE   6  (bases 1 to 7457)
  AUTHORS   Nishiyama,Y., Hirota,T., Morisaki,T., Hara,T., Marumoto,T.,
            Iida,S., Makino,K., Yamamoto,H., Hiraoka,T., Kitamura,N. and
            Saya,H.
  TITLE     A human homolog of Drosophila warts tumor suppressor, h-warts,
            localized to mitotic apparatus and specifically phosphorylated
            during mitosis
  JOURNAL   FEBS Lett 459 (2), 159-165 (1999)
   PUBMED   10518011
REFERENCE   7  (bases 1 to 7457)
  AUTHORS   St John,M.A., Tao,W., Fei,X., Fukumoto,R., Carcangiu,M.L.,
            Brownstein,D.G., Parlow,A.F., McGrath,J. and Xu,T.
  TITLE     Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian
            tumours and pituitary dysfunction
  JOURNAL   Nat Genet 21 (2), 182-186 (1999)
   PUBMED   9988269
REFERENCE   8  (bases 1 to 7457)
  AUTHORS   Tao,W., Zhang,S., Turenchalk,G.S., Stewart,R.A., St John,M.A.,
            Chen,W. and Xu,T.
  TITLE     Human homologue of the Drosophila melanogaster lats tumour
            suppressor modulates CDC2 activity
  JOURNAL   Nat Genet 21 (2), 177-181 (1999)
   PUBMED   9988268
REFERENCE   9  (bases 1 to 7457)
  AUTHORS   Xu,T., Wang,W., Zhang,S., Stewart,R.A. and Yu,W.
  TITLE     Identifying tumor suppressors in genetic mosaics: the Drosophila
            lats gene encodes a putative protein kinase
  JOURNAL   Development 121 (4), 1053-1063 (1995)
   PUBMED   7743921
REFERENCE   10 (bases 1 to 7457)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL358852.5, AL583963.12 and
            BX276089.8.
            
            On Jun 1, 2019 this sequence version replaced NM_001350340.1.
            
            Summary: The protein encoded by this gene is a putative
            serine/threonine kinase that localizes to the mitotic apparatus and
            complexes with cell cycle controller CDC2 kinase in early mitosis.
            The protein is phosphorylated in a cell-cycle dependent manner,
            with late prophase phosphorylation remaining through metaphase. The
            N-terminal region of the protein binds CDC2 to form a complex
            showing reduced H1 histone kinase activity, indicating a role as a
            negative regulator of CDC2/cyclin A. In addition, the C-terminal
            kinase domain binds to its own N-terminal region, suggesting
            potential negative regulation through interference with complex
            formation via intramolecular binding. Biochemical and genetic data
            suggest a role as a tumor suppressor. This is supported by studies
            in knockout mice showing development of soft-tissue sarcomas,
            ovarian stromal cell tumors and a high sensitivity to carcinogenic
            treatments. [provided by RefSeq, Apr 2017].
            
            Transcript Variant: This variant (5) encodes isoform 4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.3067085.1,
                                           SRR14038194.3316673.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-253               AL358852.5         12442-12694         c
            254-741             AL583963.12        26097-26584         c
            742-836             AL583963.12        21410-21504         c
            837-984             AL583963.12        19392-19539         c
            985-2498            AL583963.12        7397-8910           c
            2499-3081           AL583963.12        4193-4775           c
            3082-3264           BX276089.8         53147-53329         c
            3265-3371           BX276089.8         52852-52958         c
            3372-7457           BX276089.8         34745-38830         c
FEATURES             Location/Qualifiers
     source          1..7457
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.1"
     gene            1..7457
                     /gene="LATS1"
                     /gene_synonym="WARTS; wts"
                     /note="large tumor suppressor kinase 1"
                     /db_xref="GeneID:9113"
                     /db_xref="HGNC:HGNC:6514"
                     /db_xref="MIM:603473"
     exon            1..253
                     /gene="LATS1"
                     /gene_synonym="WARTS; wts"
                     /inference="alignment:Splign:2.1.0"
     exon            254..741
                     /gene="LATS1"
                     /gene_synonym="WARTS; wts"
                     /inference="alignment:Splign:2.1.0"
     exon            742..836
                     /gene="LATS1"
                     /gene_synonym="WARTS; wts"
                     /inference="alignment:Splign:2.1.0"
     CDS             804..3881
                     /gene="LATS1"
                     /gene_synonym="WARTS; wts"
                     /EC_number="2.7.11.1"
                     /note="isoform 4 is encoded by transcript variant 5; LATS
                     (large tumor suppressor, Drosophila) homolog 1;
                     serine/threonine-protein kinase LATS1; h-warts; WARTS
                     protein kinase; large tumor suppressor homolog 1; LATS,
                     large tumor suppressor, homolog 1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase LATS1 isoform 4"
                     /protein_id="NP_001337269.1"
                     /db_xref="GeneID:9113"
                     /db_xref="HGNC:HGNC:6514"
                     /db_xref="MIM:603473"
                     /translation="MSFEILNPLGQDMVIQALQKTNNRSIEAAIEFISKMSYQDPRRE
                     QMAAAAARPINASMKPGNVQQSVNRKQSWKGSKESLVPQRHGPPLGESVAYHSESPNS
                     QTDVGRPLSGSGISAFVQAHPSNGQRVNPPPPPQVRSVTPPPPPRGQTPPPRGTTPPP
                     PSWEPNSQTKRYSGNMEYVISRISPVPPGAWQEGYPPPPLNTSPMNPPNQGQRGISSV
                     PVGRQPIIMQSSSKFNFPSGRPGMQNGTGQTDFMIHQNVVPAGTVNRQPPPPYPLTAA
                     NGQSPSALQTGGSAAPSSYTNGSIPQSMMVPNRNSHNMELYNISVPGLQTNWPQSSSA
                     PAQSSPSSGHEIPTWQPNIPVRSNSFNNPLGNRASHSANSQPSATTVTAITPAPIQQP
                     VKSMRVLKPELQTALAPTHPSWIPQPIQTVQPSPFPEGTASNVTVMPPVAEAPNYQGP
                     PPPYPKHLLHQNPSVPPYESISKPSKEDQPSLPKEDESEKSYENVDSGDKEKKQITTS
                     PITVRKNKKDEERRESRIQSYSPQAFKFFMEQHVENVLKSHQQRLHRKKQLENEMMRV
                     GLSQDAQDQMRKMLCQKESNYIRLKRAKMDKSMFVKIKTLGIGAFGEVCLARKVDTKA
                     LYATKTLRKKDVLLRNQVAHVKAERDILAEADNEWVVRLYYSFQDKDNLYFVMDYIPG
                     GDMMSLLIRMGIFPESLARFYIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLT
                     DFGLCTGFRWTHDSKYYQSGDHPRQDSMDFSNEWGDPSSCRCGDRLKPLERRAARQHQ
                     RCLAHSLVGTPNYIAPEVLLRTGYTQLCDWWSVGVILFEMLVGQPPFLAQTPLETQMK
                     VINWQTSLHIPPQAKLSPEASDLIIKLCRGPEDRLGKNGADEIKAHPFFKTIDFSSDL
                     RQQSASYIPKITHPTDTSNFDPVDPDKLWSDDNEEENVNDTLNGWYKNGKHPEHAFYE
                     FTFRRFFDDNGYPYNYPKPIEYEYINSQGSEQQSDEDDQNTGSEIKNRDLVYV"
     exon            837..984
                     /gene="LATS1"
                     /gene_synonym="WARTS; wts"
                     /inference="alignment:Splign:2.1.0"
     exon            985..2498
                     /gene="LATS1"
                     /gene_synonym="WARTS; wts"
                     /inference="alignment:Splign:2.1.0"
     exon            2499..3081
                     /gene="LATS1"
                     /gene_synonym="WARTS; wts"
                     /inference="alignment:Splign:2.1.0"
     exon            3082..3264
                     /gene="LATS1"
                     /gene_synonym="WARTS; wts"
                     /inference="alignment:Splign:2.1.0"
     exon            3265..3371
                     /gene="LATS1"
                     /gene_synonym="WARTS; wts"
                     /inference="alignment:Splign:2.1.0"
     exon            3372..7457
                     /gene="LATS1"
                     /gene_synonym="WARTS; wts"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7433..7438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LATS1"
                     /gene_synonym="WARTS; wts"
                     /note="hexamer: AATAAA"
     polyA_site      7457
                     /gene="LATS1"
                     /gene_synonym="WARTS; wts"
                     /note="major polyA site"
ORIGIN      
        1 agcggagtgc ggcggcggcg acactgagtg gaaggcaaaa tggcggcggc ggcggcggtg
       61 gcctggtgtt aaggggagag ccaggtcctc acgacccctg ggacgggccg cgctggcccg
      121 cggcagcccc cccgttcgtc tccccgctct gccccaccag ggatacttgg ggttgctggg
      181 acggactctg gccgcctcag cgtccgccct caggcccgtg gccgctgtcc aggagctctg
      241 ctctcccctc cagagttaat tatttatatt gtaaagaatt ttaacagtcc tggggacttc
      301 cttgaaggat cattttcact tttgctcaga agaaagctct ggatctatca aataaagaag
      361 tccttcgtgt gggctacata tatagatgtt ttcatgaaga ggagtgaaaa gccagaagga
      421 tatagacaaa tgaggcctaa gacctttcct gccagtaact atactgtcag tagccggcaa
      481 atgttacaag aaattcggga atcccttagg aatttatcta aaccatctga tgctgctaag
      541 gctgagcata acatgagtaa aatgtcaacc gaagatcctc gacaagtcag aaatccaccc
      601 aaatttggga cgcatcataa agccttgcag gaaattcgaa actctctgct tccatttgca
      661 aatgaaacaa attcttctcg gagtacttca gaagttaatc cacaaatgct tcaagacttg
      721 caagctgctg gatttgatga ggaggatcat ctgtcagtag cctgttcacc cattagtctt
      781 actaagccat ttctcattta aaaatgtcgt ttgaaatact gaatcctcta ggacaagata
      841 tggttataca agctcttcag aaaactaaca acagaagtat agaagcagca attgaattca
      901 ttagtaaaat gagttaccaa gatcctcgac gagagcagat ggctgcagca gctgccagac
      961 ctattaatgc cagcatgaaa ccagggaatg tgcagcaatc agttaaccgc aaacagagct
     1021 ggaaaggttc taaagaatcc ttagttcctc agaggcatgg cccgccacta ggagaaagtg
     1081 tggcctatca ttctgagagt cccaactcac agacagatgt aggaagacct ttgtctggat
     1141 ctggtatatc agcatttgtt caagctcacc ctagcaacgg acagagagtg aaccccccac
     1201 caccacctca agtaaggagt gttactcctc caccacctcc aagaggccag actccccctc
     1261 caagaggtac aactccacct cccccttcat gggaaccaaa ctctcaaaca aagcgctatt
     1321 ctggaaacat ggaatacgta atctcccgaa tctctcctgt cccacctggg gcatggcaag
     1381 agggctatcc tccaccacct ctcaacactt cccccatgaa tcctcctaat caaggacaga
     1441 gaggcattag ttctgttcct gttggcagac aaccaatcat catgcagagt tctagcaaat
     1501 ttaactttcc atcagggaga cctggaatgc agaatggtac tggacaaact gatttcatga
     1561 tacaccaaaa tgttgtccct gctggcactg tgaatcggca gccaccacct ccatatcctc
     1621 tgacagcagc taatggacaa agcccttctg ctttacaaac agggggatct gctgctcctt
     1681 cgtcatatac aaatggaagt attcctcagt ctatgatggt gccaaacaga aatagtcata
     1741 acatggaact atataacatt agtgtacctg gactgcaaac aaattggcct cagtcatctt
     1801 ctgctccagc ccagtcatcc ccgagcagtg ggcatgaaat ccctacatgg caacctaaca
     1861 taccagtgag gtcaaattct tttaataacc cattaggaaa tagagcaagt cactctgcta
     1921 attctcagcc ttctgctaca acagtcactg caattacacc agctcctatt caacagcctg
     1981 tgaaaagtat gcgtgtatta aaaccagagc tacagactgc tttagcacct acacaccctt
     2041 cttggatacc acagccaatt caaactgttc aacccagtcc ttttcctgag ggaaccgctt
     2101 caaatgtgac tgtgatgcca cctgttgctg aagctccaaa ctatcaagga ccaccaccac
     2161 cctacccaaa acatctgctg caccaaaacc catctgttcc tccatacgag tcaatcagta
     2221 agcctagcaa agaggatcag ccaagcttgc ccaaggaaga tgagagtgaa aagagttatg
     2281 aaaatgttga tagtggggat aaagaaaaga aacagattac aacttcacct attactgtta
     2341 ggaaaaacaa gaaagatgaa gagcgaaggg aatctcgtat tcaaagttat tctcctcaag
     2401 catttaaatt ctttatggag caacatgtag aaaatgtact caaatctcat cagcagcgtc
     2461 tacatcgtaa aaaacaatta gagaatgaaa tgatgcgggt tggattatct caagatgccc
     2521 aggatcaaat gagaaagatg ctttgccaaa aagaatctaa ttacatccgt cttaaaaggg
     2581 ctaaaatgga caagtctatg tttgtgaaga taaagacact aggaatagga gcatttggtg
     2641 aagtctgtct agcaagaaaa gtagatacta aggctttgta tgcaacaaaa actcttcgaa
     2701 agaaagatgt tcttcttcga aatcaagtcg ctcatgttaa ggctgagaga gatatcctgg
     2761 ctgaagctga caatgaatgg gtagttcgtc tatattattc attccaagat aaggacaatt
     2821 tatactttgt aatggactac attcctgggg gtgatatgat gagcctatta attagaatgg
     2881 gcatctttcc agaaagtctg gcacgattct acatagcaga acttacctgt gcagttgaaa
     2941 gtgttcataa aatgggtttt attcatagag atattaaacc tgataatatt ttgattgatc
     3001 gtgatggtca tattaaattg actgactttg gcctctgcac tggcttcaga tggacacacg
     3061 attctaagta ctatcagagt ggtgaccatc cacggcaaga tagcatggat ttcagtaatg
     3121 aatgggggga tccctcaagc tgtcgatgtg gagacagact gaagccatta gagcggagag
     3181 ctgcacgcca gcaccagcga tgtctagcac attctttggt tgggactccc aattatattg
     3241 cacctgaagt gttgctacga acaggataca cacagttgtg tgattggtgg agtgttggtg
     3301 ttattctttt tgaaatgttg gtgggacaac ctcctttctt ggcacaaaca ccattagaaa
     3361 cacaaatgaa ggttatcaac tggcaaacat ctcttcacat tccaccacaa gctaaactca
     3421 gtcctgaagc ttctgatctt attattaaac tttgccgagg acccgaagat cgcttaggca
     3481 agaatggtgc tgatgaaata aaagctcatc cattttttaa aacaattgac ttctccagtg
     3541 acctgagaca gcagtctgct tcatacattc ctaaaatcac acacccaaca gatacatcaa
     3601 attttgatcc tgttgatcct gataaattat ggagtgatga taacgaggaa gaaaatgtaa
     3661 atgacactct caatggatgg tataaaaatg gaaagcatcc tgaacatgca ttctatgaat
     3721 ttaccttccg aaggtttttt gatgacaatg gctacccata taattatccg aagcctattg
     3781 aatatgaata cattaattca caaggctcag agcagcagtc ggatgaagat gatcaaaaca
     3841 caggctcaga gattaaaaat cgcgatctag tatatgttta acacactagt aaataaatgt
     3901 aatgaggatt tgtaaaaggg cctgaaatgc gaggtgtttt gaggttctga gagtaaaatt
     3961 atgcaaatat gacagagcta tatatgtgtg ctctgtgtac aatattttat tttcctaaat
     4021 tatgggaaat ccttttaaaa tgttaattta ttccagccgt ttaaatcagt atttagaaaa
     4081 aaattgttat aaggaaagta aattatgaac tgaatattat agtcagttct tggtacttaa
     4141 agtacttaaa ataagtagtg ctttgtttaa aaggagaaac ctggtatcta tttgtatata
     4201 tgctaaataa ttttaaaata caagagtttt tgaaattttt ttgaaagaca gttttagttt
     4261 tatcttgctt taaccaaata tgaaacatac cccctatttt acagagctct tttttcccct
     4321 cataaccttg tttttggtag aaaataagct agagaaatta agccatcgtg ttggtgagtg
     4381 ttcctaggct aatgataatc tgtataattc acatcctgaa actaaggaat acagggttga
     4441 aaaaatatta atatgtttgt cagaaggaaa aataatgcat ttatcttccc ccccaccccc
     4501 cgccccatgg aatatttaat ctatttaatc ttcttgcatt tatttctcaa gaattactgg
     4561 ctttaaaaga agccaaagca ctactagctt tttttccata ttggtatttt tgatgctgct
     4621 tccaatttta aaagggaaca aagctgccat aaatcgaaat gttcaatact aaaagctaaa
     4681 atatttctca ccatcctaag cagataatta ttttaatttt catatacttt tcctgtatag
     4741 taactatttt gattatatca tcaatgttac ctgtttcctc tttcagaaca gtgctgcata
     4801 tacagattgt tattggcaaa ggaaaatctg gctatctggc aatattttac ctaagcgcag
     4861 attaattggt gaaaaaatta actcttaaga tggccattaa taattaggaa agtttacaga
     4921 gtggtcttag tagaaaattc aagtcctcct aatttattta aggttcaata atgcgttcaa
     4981 catgcctgtt atgtataacg cttaggttct aaggaagatt aaggtttcat accaaaatac
     5041 atgtagctta tcttttagga aggggaaaaa ggctccattt tgaccatagt aaaatttgtg
     5101 ttgtgtttta tttccttttc ttaagctcca ctgataaggg attgttttta tcaaaagtta
     5161 ctatttgtag attggaggca taattttagt gattttcata cttttagctt tcttcgcata
     5221 aaagctaatt gaaaccgtat atgtagtaaa attaaaggca gagctgttgc agttgaattg
     5281 gagagttagg gcaaagaaca cttattagcc cacacttccc acctttctac aggtggtcct
     5341 ttcagagctc agcctgaaaa cccactactg tgttatcgtg cgtcttttgg ggttagtggt
     5401 tcttttgaga atctgaagga agctgtggac tcttcctaga aaaaaaaacc acacatacac
     5461 atacaatgtt gcatgcagtt tcaagggatt ttggacatat tgaaacctat cacaggctgt
     5521 aggttatgga cctctgtgcc atgagaaaat tgatacatta aactaagaac tttgttttta
     5581 acttaccaat cactactcag cacatcttat ataagctgat aatttgtgat ggaaaaggtc
     5641 tgtagcatgt gatataaggt gaccttatga atgcctctct tgctggtaca ttaagttgtt
     5701 ttaatatatc atttggaggg gactgaaatg ttaggctcat tacaagcttg atacagaaat
     5761 atttctgaag gatttctaat cagaattgta aaacaatgtg ctatcatgaa atcgcagtct
     5821 tcacctcatg gttcatggaa catttggtta gtcccataaa atcctatgca aaacaaagta
     5881 gttcaagaat ttttaggtgg gtagtcacat ttataaggta ttcctcttac tctttgggct
     5941 ttttcagtct gatttattta aattttcatt tagttgtttt acttttggac taaggtgcaa
     6001 tacagtagaa gataactttg ttacatttat gttgtaggaa aactaaggtg ctgtctcctc
     6061 ccccttccct tcccacaaaa tctgtattcc ccctattgct gaaatgtaac agacactaca
     6121 aattttgtat tctttttttg ttttttgttt tgagacaggg tctcactctg tcacccaggc
     6181 tggagggcag tggcgcttca cagctcactg catcctcaac cttgggggct cacgcagtcc
     6241 tcccgcctca gcctcccaag tagctgggca tgcgccacca agcccagcta atttttgtat
     6301 ctttagtaga gatggggttt cgccatgttg cccaggttgg tgtggaattc ctgggctcca
     6361 gttatatgcc cacctcagcc tcccaaagtg ctgggattac agacgtgacc caccgcgcct
     6421 ggcgcaaata tgtattcttt taaaatttcc tctgatacta taagcttttt gcatttatct
     6481 gaagcagtat acatgccttt ggtatcagca attttaacag tttggatata cttatcagct
     6541 atcttattcc aaaactacat ctacttcttc cagtatagaa tctggtgctt cctgaccaaa
     6601 aagatgagaa aaacaatgtt aaaaatatag atgctttcca ttgaaatgga gtgaaaacat
     6661 tggttctata tgttttcttt taaaataatt ttcttattaa aaacttgctg tctttattat
     6721 acttaccctt tttatgcata tcaatagtat ttataagatg tgttctataa ttatgtaatt
     6781 gtagatactg ttatgcattg tccagtgaca tcataaggca ggccctactg ctgtatcttt
     6841 tctaccttct tatttgtaat agaaactata gaatgtatga ctaaaaagtc actttgagat
     6901 tgactttttt aaaaagttat taccttctgc tgttgcaaag tgcaaaactg tgagtggaat
     6961 tgttttattc tgacttaatg tgttagaaat tagagaatac agtgggagga tttttagaca
     7021 ttgctgctgc tgttacccaa ggtattttag ataaaaaatt tttaataaac atccctttgg
     7081 tatttaaagt ggaacattta gcctgttcat tttaatctaa agcaaaaagt aatttgggtc
     7141 aaaatattgg tatatttgta aagcgcctta atatatccct ttgtggaagg cactacacag
     7201 tttactttta tattgtattg tgtatataag tattttgtat taaaattgaa tcagtggcaa
     7261 cattaaagtt ttataaaatc atgctttgtt agaaaaagaa ttacagcttt gcaatataac
     7321 taattgtttc gcataattct gaatgtaata gatatgaata atcagcctgt gtttttaatg
     7381 aacttatttg tattttccca atcattttct ctagtgtaat gtttgctggg ataataaaaa
     7441 aaattcaaat ctttcaa
//
