LOCUS       NM_001014987            1671 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens linker for activation of T cells (LAT), transcript
            variant 2, mRNA.
ACCESSION   NM_001014987
VERSION     NM_001014987.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1671)
  AUTHORS   Yu,J., Gao,W., Gao,S., Wen,S., Zhao,Y., Shang,Z., Wang,Y. and
            Niu,Y.
  TITLE     Identification of LAT/ZAP70 characterized immune subtypes of
            prostate cancer
  JOURNAL   World J Urol 40 (11), 2817-2824 (2022)
   PUBMED   36205741
  REMARK    GeneRIF: Identification of LAT/ZAP70 characterized immune subtypes
            of prostate cancer.
REFERENCE   2  (bases 1 to 1671)
  AUTHORS   Hayashi,K. and Anzai,N.
  TITLE     L-type amino acid transporter 1 as a target for inflammatory
            disease and cancer immunotherapy
  JOURNAL   J Pharmacol Sci 148 (1), 31-40 (2022)
   PUBMED   34924127
  REMARK    GeneRIF: L-type amino acid transporter 1 as a target for
            inflammatory disease and cancer immunotherapy.
            Review article
REFERENCE   3  (bases 1 to 1671)
  AUTHORS   Glatzova,D., Mavila,H., Saija,M.C., Chum,T., Cwiklik,L., Brdicka,T.
            and Cebecauer,M.
  TITLE     The role of prolines and glycine in the transmembrane domain of LAT
  JOURNAL   FEBS J 288 (13), 4039-4052 (2021)
   PUBMED   33458942
  REMARK    GeneRIF: The role of prolines and glycine in the transmembrane
            domain of LAT.
REFERENCE   4  (bases 1 to 1671)
  AUTHORS   Saez,J.J., Dogniaux,S., Shafaq-Zadah,M., Johannes,L., Hivroz,C. and
            Zucchetti,A.E.
  TITLE     Retrograde and Anterograde Transport of Lat-Vesicles during the
            Immunological Synapse Formation: Defining the Finely-Tuned
            Mechanism
  JOURNAL   Cells 10 (2), 359 (2021)
   PUBMED   33572370
  REMARK    GeneRIF: Retrograde and Anterograde Transport of Lat-Vesicles
            during the Immunological Synapse Formation: Defining the
            Finely-Tuned Mechanism.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1671)
  AUTHORS   Vico-Barranco,I., Arbulo-Echevarria,M.M., Serrano-Garcia,I.,
            Perez-Linaza,A., Miranda-Sayago,J.M., Miazek,A., Narbona-Sanchez,I.
            and Aguado,E.
  TITLE     A Novel, LAT/Lck Double Deficient T Cell Subline J.CaM1.7 for
            Combined Analysis of Early TCR Signaling
  JOURNAL   Cells 10 (2), 343 (2021)
   PUBMED   33562083
  REMARK    GeneRIF: A Novel, LAT/Lck Double Deficient T Cell Subline J.CaM1.7
            for Combined Analysis of Early TCR Signaling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1671)
  AUTHORS   Finco,T.S., Kadlecek,T., Zhang,W., Samelson,L.E. and Weiss,A.
  TITLE     LAT is required for TCR-mediated activation of PLCgamma1 and the
            Ras pathway
  JOURNAL   Immunity 9 (5), 617-626 (1998)
   PUBMED   9846483
  REMARK    GeneRIF: LAT is required for T cell activation.
REFERENCE   7  (bases 1 to 1671)
  AUTHORS   Zhang,W., Trible,R.P. and Samelson,L.E.
  TITLE     LAT palmitoylation: its essential role in membrane microdomain
            targeting and tyrosine phosphorylation during T cell activation
  JOURNAL   Immunity 9 (2), 239-246 (1998)
   PUBMED   9729044
REFERENCE   8  (bases 1 to 1671)
  AUTHORS   Weber,J.R., Orstavik,S., Torgersen,K.M., Danbolt,N.C., Berg,S.F.,
            Ryan,J.C., Tasken,K., Imboden,J.B. and Vaage,J.T.
  TITLE     Molecular cloning of the cDNA encoding pp36, a
            tyrosine-phosphorylated adaptor protein selectively expressed by T
            cells and natural killer cells
  JOURNAL   J Exp Med 187 (7), 1157-1161 (1998)
   PUBMED   9529333
REFERENCE   9  (bases 1 to 1671)
  AUTHORS   Zhang,W., Sloan-Lancaster,J., Kitchen,J., Trible,R.P. and
            Samelson,L.E.
  TITLE     LAT: the ZAP-70 tyrosine kinase substrate that links T cell
            receptor to cellular activation
  JOURNAL   Cell 92 (1), 83-92 (1998)
   PUBMED   9489702
REFERENCE   10 (bases 1 to 1671)
  AUTHORS   Trub,T., Frantz,J.D., Miyazaki,M., Band,H. and Shoelson,S.E.
  TITLE     The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in
            T cell receptor signaling
  JOURNAL   J Biol Chem 272 (2), 894-902 (1997)
   PUBMED   8995379
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC109460.3, BI769296.1,
            AJ223280.1 and BC011563.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001014987.1.
            
            Summary: The protein encoded by this gene is phosphorylated by
            ZAP-70/Syk protein tyrosine kinases following activation of the
            T-cell antigen receptor (TCR) signal transduction pathway. This
            transmembrane protein localizes to lipid rafts and acts as a
            docking site for SH2 domain-containing proteins. Upon
            phosphorylation, this protein recruits multiple adaptor proteins
            and downstream signaling molecules into multimolecular signaling
            complexes located near the site of TCR engagement. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 4. The resulting isoform (b) is
            shorter at the N-terminus compared to isoform d.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ223280.1, ERR279827.2531.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000395456.7/ ENSP00000378841.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC109460.3         117605-117618
            15-44               BI769296.1         3-32
            45-1660             AJ223280.1         1-1616
            1661-1670           BC011563.1         1439-1448
            1671-1671           AC109460.3         123337-123337
FEATURES             Location/Qualifiers
     source          1..1671
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..1671
                     /gene="LAT"
                     /gene_synonym="IMD52; LAT1; pp36"
                     /note="linker for activation of T cells"
                     /db_xref="GeneID:27040"
                     /db_xref="HGNC:HGNC:18874"
                     /db_xref="MIM:602354"
     exon            1..466
                     /gene="LAT"
                     /gene_synonym="IMD52; LAT1; pp36"
                     /inference="alignment:Splign:2.1.0"
     CDS             367..1068
                     /gene="LAT"
                     /gene_synonym="IMD52; LAT1; pp36"
                     /note="isoform b is encoded by transcript variant 2; 36
                     kDa phospho-tyrosine adaptor protein; linker for
                     activation of T-cells family member 1; p36-38; 36 kDa
                     phospho-tyrosine adapter protein; linker for activation of
                     T cells, transmembrane adaptor; 36 kDa phosphotyrosine
                     adapter protein"
                     /codon_start=1
                     /product="linker for activation of T-cells family member 1
                     isoform b"
                     /protein_id="NP_001014987.1"
                     /db_xref="CCDS:CCDS32425.1"
                     /db_xref="GeneID:27040"
                     /db_xref="HGNC:HGNC:18874"
                     /db_xref="MIM:602354"
                     /translation="MEEAILVPCVLGLLLLPILAMLMALCVHCHRLPGSYDSTSSDSL
                     YPRGIQFKRPHTVAPWPPAYPPVTSYPPLSQPDLLPIPRSPQPLGGSHRTPSSRRDSD
                     GANSVASYENEEPACEDADEDEDDYHNPGYLVVLPDSTPATSTAAPSAPALSTPGIRD
                     SAFSMESIDDYVNVPESGESAEASLDGSREYVNVSQELHPGAAKTEPAALSSQEAEEV
                     EEEGAPDYENLQELN"
     exon            467..494
                     /gene="LAT"
                     /gene_synonym="IMD52; LAT1; pp36"
                     /inference="alignment:Splign:2.1.0"
     exon            495..529
                     /gene="LAT"
                     /gene_synonym="IMD52; LAT1; pp36"
                     /inference="alignment:Splign:2.1.0"
     exon            530..611
                     /gene="LAT"
                     /gene_synonym="IMD52; LAT1; pp36"
                     /inference="alignment:Splign:2.1.0"
     exon            612..676
                     /gene="LAT"
                     /gene_synonym="IMD52; LAT1; pp36"
                     /inference="alignment:Splign:2.1.0"
     exon            677..706
                     /gene="LAT"
                     /gene_synonym="IMD52; LAT1; pp36"
                     /inference="alignment:Splign:2.1.0"
     exon            707..764
                     /gene="LAT"
                     /gene_synonym="IMD52; LAT1; pp36"
                     /inference="alignment:Splign:2.1.0"
     exon            765..859
                     /gene="LAT"
                     /gene_synonym="IMD52; LAT1; pp36"
                     /inference="alignment:Splign:2.1.0"
     exon            860..922
                     /gene="LAT"
                     /gene_synonym="IMD52; LAT1; pp36"
                     /inference="alignment:Splign:2.1.0"
     exon            923..988
                     /gene="LAT"
                     /gene_synonym="IMD52; LAT1; pp36"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1075
                     /gene="LAT"
                     /gene_synonym="IMD52; LAT1; pp36"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1671
                     /gene="LAT"
                     /gene_synonym="IMD52; LAT1; pp36"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1315..1320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAT"
                     /gene_synonym="IMD52; LAT1; pp36"
                     /note="hexamer: AATAAA"
     polyA_site      1342
                     /gene="LAT"
                     /gene_synonym="IMD52; LAT1; pp36"
                     /note="major polyA site"
     regulatory      1648..1653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LAT"
                     /gene_synonym="IMD52; LAT1; pp36"
                     /note="hexamer: AATAAA"
     polyA_site      1671
                     /gene="LAT"
                     /gene_synonym="IMD52; LAT1; pp36"
                     /note="major polyA site"
ORIGIN      
        1 acagcttcct gccgcaggcg ggcgggaggg cgggcacgga gaggcgggcg ccgaggaggg
       61 gcaggtaggg ctgggacgca ggggtaactg gatcccccga cttcagccca ggccctggtc
      121 tgaccaccct gggagcaggg actttccaca gtcagctgga cgcacactca gcccagtaaa
      181 agaggggacc catcccggga gccccgggga gggcacagct gcctcctccc gggctcccct
      241 gccacctggt gcctacctgc cccctgctcc ctgccgggtc cggtcctcac cccatcttca
      301 tctggccttg actctgccct tgaggggcct aggggtgcag ccagcctgct ccgagctccc
      361 ctgcagatgg aggaggccat cctggtcccc tgcgtgctgg ggctcctgct gctgcccatc
      421 ctggccatgt tgatggcact gtgtgtgcac tgccacagac tgccaggctc ctacgacagc
      481 acatcctcag atagtttgta tccaaggggc atccagttca aacggcctca cacggttgcc
      541 ccctggccac ctgcctaccc acctgtcacc tcctacccac ccctgagcca gccagacctg
      601 ctccccatcc caagatcccc gcagcccctt gggggctccc accggacgcc atcttcccgg
      661 cgggattctg atggtgccaa cagtgtggcg agctacgaga acgaggaacc agcctgtgag
      721 gatgcggatg aggatgagga cgactatcac aacccaggct acctggtggt gcttcctgac
      781 agcaccccgg ccactagcac tgctgcccca tcagctcctg cactcagcac ccctggcatc
      841 cgagacagtg ccttctccat ggagtccatt gatgattacg tgaacgttcc ggagagcggg
      901 gagagcgcag aagcgtctct ggatggcagc cgggagtatg tgaatgtgtc ccaggaactg
      961 catcctggag cggctaagac tgagcctgcc gccctgagtt cccaggaggc agaggaagtg
     1021 gaggaagagg gggctccaga ttacgagaat ctgcaggagc tgaactgagg gcctgtggag
     1081 gccgagtctg tcctggaacc aggcttgcct gggacggctg agctgggcag ctggaagtgg
     1141 ctctggggtc ctcacatggc gtcctgccct tgctccagcc tgacaacagc ctgagaaatc
     1201 cccccgtaac ttattatcac tttggggttc ggcctgtgtc ccccgaacgc tctgcacctt
     1261 ctgacgcagc ctgagaatga cctgccctgg ccccagccct actctgtgta atagaataaa
     1321 ggcctgcgtg tgtctgtgtt gagcgtgcgt ctgtgtgtgc ctgtgtgcga gtctgagtca
     1381 gagatttgga gatgtctctg tgtgtttgtg tgtatctgtg ggtctccatc ctccatgggg
     1441 gctcagccag gtgctgtgac accccccttc tgaatgaagc cttctgacct gggctggcac
     1501 tgctgggggt gaggacacat tgccccatga gacagtccca gaacacggca gctgctggct
     1561 gtgacaatgg tttcaccatc cttagaccaa gggatgggac ctgatgacct gggaggactc
     1621 tcttagttct taccttttgt ggttctcaat aaaacagaac ttaaaaaatt g
//
