LOCUS       NM_001414697            3243 bp    mRNA    linear   PRI 10-APR-2024
DEFINITION  Homo sapiens LASP1 neighbor (LASP1NB), mRNA.
ACCESSION   NM_001414697
VERSION     NM_001414697.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3243)
  AUTHORS   Li,W., Li,H., Zhang,L., Hu,M., Li,F., Deng,J., An,M., Wu,S., Ma,R.,
            Lu,J. and Zhou,Y.
  TITLE     Long non-coding RNA LINC00672 contributes to p53 protein-mediated
            gene suppression and promotes endometrial cancer chemosensitivity
  JOURNAL   J Biol Chem 292 (14), 5801-5813 (2017)
   PUBMED   28232485
  REMARK    GeneRIF: These findings indicate that LINC00672 can influence LASP1
            expression as a locus-restricted cofactor for p53-mediated gene
            suppression, thus impacting endometrial cancer and chemosensitivity
            to paclitaxel.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006441.13.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK090935.1, SRR1660807.73327.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000583195.3/ ENSP00000490930.1
            NMD candidate          :: translation inferred from conservation
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-278               AC006441.13        99398-99675         c
            279-3243            AC006441.13        95908-98872         c
FEATURES             Location/Qualifiers
     source          1..3243
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..3243
                     /gene="LASP1NB"
                     /gene_synonym="LINC00672"
                     /note="LASP1 neighbor"
                     /db_xref="GeneID:100505576"
                     /db_xref="HGNC:HGNC:44353"
                     /db_xref="MIM:617544"
     exon            1..278
                     /gene="LASP1NB"
                     /gene_synonym="LINC00672"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..158
                     /gene="LASP1NB"
                     /gene_synonym="LINC00672"
                     /note="long intergenic non-protein coding RNA 672"
                     /codon_start=1
                     /product="LASP1 neighbor protein"
                     /protein_id="NP_001401626.1"
                     /db_xref="GeneID:100505576"
                     /db_xref="HGNC:HGNC:44353"
                     /db_xref="MIM:617544"
                     /translation="MLDIFILMFFAIIGLVILSYIIYLL"
     exon            279..3243
                     /gene="LASP1NB"
                     /gene_synonym="LINC00672"
                     /inference="alignment:Splign:2.1.0"
     regulatory      510..515
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LASP1NB"
                     /gene_synonym="LINC00672"
                     /note="hexamer: ATTAAA"
     polyA_site      540
                     /gene="LASP1NB"
                     /gene_synonym="LINC00672"
                     /note="major polyA site"
     regulatory      2995..3000
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LASP1NB"
                     /gene_synonym="LINC00672"
                     /note="hexamer: AATACA"
     polyA_site      3014
                     /gene="LASP1NB"
                     /gene_synonym="LINC00672"
     regulatory      3220..3225
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LASP1NB"
                     /gene_synonym="LINC00672"
                     /note="hexamer: AATAAA"
     polyA_site      3243
                     /gene="LASP1NB"
                     /gene_synonym="LINC00672"
                     /note="major polyA site"
ORIGIN      
        1 ctctccaccg actgcaacct ccgtgctcac agctcacggt tcaccagaat ccaggggctt
       61 ggtcggccta ggaatccaca atgctggata ttttcatcct gatgttcttt gccatcatag
      121 gcctggtcat tctgtcctac attatctatc tgctctagtg gcctggagct gcggccggag
      181 cctgctggag aacagctcag aaggaaggat ggagatgaat ggccgagtgc cctgcttgct
      241 gacgcaccgg tggatttttg cttctgctgt tatctcggct cctggtctct ccagtccaac
      301 aagaggcctc tcatccacag aagcagtcct actgcccagc agacctcttt cagagccttc
      361 cagacatggc tgacccctgg caagcaaggg gctttttgag ctgagaggca cttggctggg
      421 acttcaggaa ttcatggaca gggctggcag atactgcata tgtttgagct gtagatggga
      481 ttgagaacag aaagttgaaa tggagactta ttaaagttac cgtggagaac tgctcaaaaa
      541 ttcattttga attaaggaaa cttaaattca ttttaagttt ccttagatct aaatgcaact
      601 gcacattaca ctcaaatatg ttccttcctt ctcacacaca ggactccctt gtgaaactca
      661 aggggaagtt caagttgtcc atcttcatct atgaagtagt cactttatca ctgtctttac
      721 agattgcaca gtctggggtt ttgtggtttc tcttgtctca ctctccagcc aggaagaact
      781 tgtcatttga gtttttaaaa tgtatcattt cttccccacc tcaaaccact tgtatcccag
      841 tttctcattt aaagggagaa atggttatat agtcctctct ttgcacctga ttgaattata
      901 aatgatagaa acaagatggc tatacttatt taggaaaaat ctcttacccc aaaatgagtg
      961 tgtgtgtgtg tgtgtgtgtg cgtgtgtgtg tgtgtgtgtg ttttaatcaa agatcttttc
     1021 tggaaaaaac tttccacata gttctctgac ccattagagt tgaagaaact atgtattttg
     1081 ggattcagag tagaattggc ctgcaaatct ggggtgttta ttccttttac aagtctatca
     1141 taattgttct acatttaatt ttcctttctt gcttaaaagt aaacaaggag agtcaggagt
     1201 ggtggctcat gcctgtaatc ccagcactct gggaggccga ggcggatgga tcacctgagg
     1261 tcaggagttg gagaccagcc tggccaacac ggtgaaaccc cgtctctact aaaaatacaa
     1321 aaattagtca ggcacagtag tgcgcgcctg tagtcccagc tacccgggag gctgaggccg
     1381 aagaattgct tgaacccggg aggcagaggt tgtagtgagc cgacatcatg tcactgcact
     1441 ccagcctggg agacatagcg agattccgtc tcaaataaaa taaaataaat aaataaataa
     1501 acaaggagaa agattagttt ttagtaataa cattgtgtcc aatttccatg ttttaaaaca
     1561 aaaattgagg cattatatgt cacaactgaa atggaaaagt tgtgtttaaa aattatggac
     1621 aaggccgggc acggtggctc acgcctggaa tcccagcact ttgggaggct caggcaggag
     1681 gatcacttga ggtcgggagt ttgagaccag tctgaccaac gtggtgaaac cctgtctcta
     1741 ctaaaaatac aaaaattagc tggtgtggtg gcaggtgcct gtaatcccag ctactcagga
     1801 ggctgaggca ggagaatcgc ttgaacctgg gaggcagagg ttgcagtgag ccgagatcac
     1861 acctctgcac tccagcctag gtgacacagc aagaccccat ctcaaaaaaa aataataata
     1921 aaaacataaa aattatggac aagaaaaaac actattctgg aagctttgtt ttggcaacaa
     1981 attatatgac ctgacctttc ataagtcatt taaactttag ggctaggcca ggtgctatgg
     2041 cgcatgccta taatcccagc atttagggaa gtagaagcag gaggatagct tgaggccaag
     2101 aattccagac cagcccaggc aatatagcga gacccccgtc tccacaaaaa taaaaaataa
     2161 aataaaaata aataaataca taaactttag gtcctctgtt tattctgtca aatgaaagtg
     2221 ttaggccaag gtcgcattat ctctttggaa actacatcga gaacagaatt cccatggaac
     2281 gaactcttaa tagttcactg gtagtccccc ttttctgaat attcttccca acatgacact
     2341 ttataacaaa aatttaactg caaaactctt tttttttcac caacagccag attttgatga
     2401 gaaaatggcc atatttattt actccaaata tatattatgt ctgtgataat ttgcctaaac
     2461 tgtttaagga atattaacaa gtatgatact gcatcgtggt atgtagcaaa aagataggta
     2521 atctgacata catggatgca agcagcatgg ctgtgaacct ggatatattt agaaatgatc
     2581 ttcagtggag tccttgatgt gacattttcc actaaaacat tcttctaact ctggtatatc
     2641 ttagtgtttc gaactataat ttccgtcttc aagccaagac agcagctcta catccttacc
     2701 taggtaattc aggcatgcgc cagtattttg gaggggtcca aattagagtt agttatgatg
     2761 gtatagatct ttaaagtata gtctaaccaa gcttgctctg gtcttttgtg acatcaaggc
     2821 ttctcagtct gtattcacat aaagttgaaa caactaatca attcagtgaa aaaaaatcag
     2881 cagatttcac tcatacactg gtgatatata ccactggtat tgggtacaat gtaaggagag
     2941 aggattaccc atctcttcag ttacttgtaa aatatgattt taaaaaaata aatcaataca
     3001 ttttggaaaa attatatgac tttgtgctta tatttatgca acaatatgct agcttataac
     3061 agggttttac tgtgttattt tgatagttgt ttaaatttta catttaaact atttgtattt
     3121 tggcatccca aaacataata aaacactgca aaaagttacc tctgtaatat aagattttgt
     3181 ataaatttta taaatttgtg tcatagggta attttgtcca ataaaatgtc aatgagataa
     3241 aaa
//
