LOCUS       NM_006148               3910 bp    mRNA    linear   PRI 06-AUG-2024
DEFINITION  Homo sapiens LIM and SH3 protein 1 (LASP1), transcript variant 1,
            mRNA.
ACCESSION   NM_006148
VERSION     NM_006148.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3910)
  AUTHORS   Butt,E., Gunder,T., Sturzebecher,P., Kowalski,I., Schneider,P.,
            Buschmann,N., Schafer,S., Bender,A., Hermanns,H.M. and Zernecke,A.
  TITLE     Cholesterol uptake in the intestine is regulated by the
            LASP1-AKT-NPC1L1 signaling pathway
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 327 (1), G25-G35 (2024)
   PUBMED   38713618
  REMARK    GeneRIF: Cholesterol uptake in the intestine is regulated by the
            LASP1-AKT-NPC1L1 signaling pathway.
REFERENCE   2  (bases 1 to 3910)
  AUTHORS   Patterson,M.R., Meijers,A.S., Ryder,E.L., Wootton,L.M.,
            Scarth,J.A., Evans,D., Turner,A.L., Wasson,C.W., Darell,J.E.,
            Theobald,D.A., Cogan,J.A., James,C.D., Wang,M., Ladbury,J.E.,
            Morgan,I.M., Samson,A., Morgan,E.L. and Macdonald,A.
  TITLE     E7-mediated repression of miR-203 promotes LASP1-dependent
            proliferation in HPV-positive cervical cancer
  JOURNAL   Oncogene 43 (28), 2184-2198 (2024)
   PUBMED   38789663
  REMARK    GeneRIF: E7-mediated repression of miR-203 promotes LASP1-dependent
            proliferation in HPV-positive cervical cancer.
REFERENCE   3  (bases 1 to 3910)
  AUTHORS   Yang,C., Jin,X., Liu,X., Wu,G., Yang,W., Pang,B., Jiang,J., Liao,D.
            and Zhang,Y.
  TITLE     TRIM15 forms a regulatory loop with the AKT/FOXO1 axis and LASP1 to
            modulate the sensitivity of HCC cells to TKIs
  JOURNAL   Cell Death Dis 14 (1), 47 (2023)
   PUBMED   36670097
  REMARK    GeneRIF: TRIM15 forms a regulatory loop with the AKT/FOXO1 axis and
            LASP1 to modulate the sensitivity of HCC cells to TKIs.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3910)
  AUTHORS   Cai,Y., Huang,Y., Zhang,J., Liu,X., Zhao,F., Zhang,K., Xu,S.,
            Yang,Y., Huang,H. and Gao,Y.
  TITLE     LncRNA CBR3-AS1 predicts a poor prognosis and promotes cervical
            cancer progression through the miR-3163/LASP1 pathway
  JOURNAL   Neoplasma 69 (6), 1406-1417 (2022)
   PUBMED   36591804
  REMARK    GeneRIF: LncRNA CBR3-AS1 predicts a poor prognosis and promotes
            cervical cancer progression through the miR-3163/LASP1 pathway.
REFERENCE   5  (bases 1 to 3910)
  AUTHORS   Zhou,L., Zhang,L., Guan,X., Dong,Y.I. and Liu,T.
  TITLE     Long noncoding RNA PPP1R14B-AS1 imitates microRNA-134-3p to
            facilitate breast cancer progression by upregulating LIM and SH3
            protein 1
  JOURNAL   Oncol Res 29 (4), 251-262 (2022)
   PUBMED   37303940
  REMARK    GeneRIF: Long noncoding RNA PPP1R14B-AS1 imitates microRNA-134-3p
            to facilitate breast cancer progression by upregulating LIM and SH3
            protein 1.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3910)
  AUTHORS   Chew,C.S., Chen,X., Parente,J.A. Jr., Tarrer,S., Okamoto,C. and
            Qin,H.Y.
  TITLE     Lasp-1 binds to non-muscle F-actin in vitro and is localized within
            multiple sites of dynamic actin assembly in vivo
  JOURNAL   J Cell Sci 115 (Pt 24), 4787-4799 (2002)
   PUBMED   12432067
  REMARK    GeneRIF: In rabbits, lasp-1 localizes to sites of dynamic actin
            assembly, identifies sites that are phosphorylated by protein
            kinase A in vivo, and shows that the phosphorylation of these sites
            decreases F-actin-binding to lasp-1.
REFERENCE   7  (bases 1 to 3910)
  AUTHORS   Schreiber,V., Moog-Lutz,C., Regnier,C.H., Chenard,M.P., Boeuf,H.,
            Vonesch,J.L., Tomasetto,C. and Rio,M.C.
  TITLE     Lasp-1, a novel type of actin-binding protein accumulating in cell
            membrane extensions
  JOURNAL   Mol Med 4 (10), 675-687 (1998)
   PUBMED   9848085
REFERENCE   8  (bases 1 to 3910)
  AUTHORS   Chew,C.S., Parente,J.A. Jr., Zhou,C., Baranco,E. and Chen,X.
  TITLE     Lasp-1 is a regulated phosphoprotein within the cAMP signaling
            pathway in the gastric parietal cell
  JOURNAL   Am J Physiol 275 (1), C56-C67 (1998)
   PUBMED   9688835
  REMARK    GeneRIF: In rabbits, lasp-1 phosphorylation is increased by
            histamine H2 receptor activation and elevation of intracellular
            cAMP
REFERENCE   9  (bases 1 to 3910)
  AUTHORS   Tomasetto,C., Moog-Lutz,C., Regnier,C.H., Schreiber,V., Basset,P.
            and Rio,M.C.
  TITLE     Lasp-1 (MLN 50) defines a new LIM protein subfamily characterized
            by the association of LIM and SH3 domains
  JOURNAL   FEBS Lett 373 (3), 245-249 (1995)
   PUBMED   7589475
REFERENCE   10 (bases 1 to 3910)
  AUTHORS   Tomasetto,C., Regnier,C., Moog-Lutz,C., Mattei,M.G., Chenard,M.P.,
            Lidereau,R., Basset,P. and Rio,M.C.
  TITLE     Identification of four novel human genes amplified and
            overexpressed in breast carcinoma and localized to the q11-q21.3
            region of chromosome 17
  JOURNAL   Genomics 28 (3), 367-376 (1995)
   PUBMED   7490069
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC333179.1, X82456.1 and
            BC007560.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006148.3.
            
            Summary: This gene encodes a member of a subfamily of LIM proteins,
            characterized by a LIM motif and a domain of Src homology region 3,
            and also a member of the nebulin family of actin-binding proteins.
            The encoded protein is a cAMP and cGMP dependent signaling protein
            and binds to the actin cytoskeleton at extensions of the cell
            membrane. The encoded protein has been linked to metastatic breast
            cancer, hematopoetic tumors such as B-cell lymphomas, and
            colorectal cancer. [provided by RefSeq, Oct 2012].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X82456.1, ERR4643859.20637.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000318008.11/ ENSP00000325240.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                DC333179.1         200-256
            58-488              X82456.1           1-431
            489-569             BC007560.1         480-560
            570-923             X82456.1           513-866
            924-1175            BC007560.1         714-965
            1176-2251           X82456.1           1119-2194
            2252-2456           BC007560.1         2057-2261
            2457-3441           X82456.1           2401-3385
            3442-3910           BC007560.1         3173-3641
FEATURES             Location/Qualifiers
     source          1..3910
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..3910
                     /gene="LASP1"
                     /gene_synonym="Lasp-1; MLN50"
                     /note="LIM and SH3 protein 1"
                     /db_xref="GeneID:3927"
                     /db_xref="HGNC:HGNC:6513"
                     /db_xref="MIM:602920"
     exon            1..201
                     /gene="LASP1"
                     /gene_synonym="Lasp-1; MLN50"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..918
                     /gene="LASP1"
                     /gene_synonym="Lasp-1; MLN50"
                     /note="isoform a is encoded by transcript variant 1; LIM
                     and SH3 domain protein 1; metastatic lymph node gene 50
                     protein"
                     /codon_start=1
                     /product="LIM and SH3 domain protein 1 isoform a"
                     /protein_id="NP_006139.1"
                     /db_xref="CCDS:CCDS11331.1"
                     /db_xref="GeneID:3927"
                     /db_xref="HGNC:HGNC:6513"
                     /db_xref="MIM:602920"
                     /translation="MNPNCARCGKIVYPTEKVNCLDKFWHKACFHCETCKMTLNMKNY
                     KGYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQVRYKEEFEKNKGKGFSVVA
                     DTPELQRIKKTQDQISNIKYHEEFEKSRMGPSGGEGMEPERRDSQDGSSYRRPLEQQQ
                     PHHIPTSAPVYQQPQQQPVAQSYGGYKEPAAPVSIQRSAPGGGGKRYRAVYDYSAADE
                     DEVSFQDGDTIVNVQQIDDGWMYGTVERTGDTGMLPANYVEAI"
     exon            202..296
                     /gene="LASP1"
                     /gene_synonym="Lasp-1; MLN50"
                     /inference="alignment:Splign:2.1.0"
     exon            297..381
                     /gene="LASP1"
                     /gene_synonym="Lasp-1; MLN50"
                     /inference="alignment:Splign:2.1.0"
     exon            382..489
                     /gene="LASP1"
                     /gene_synonym="Lasp-1; MLN50"
                     /inference="alignment:Splign:2.1.0"
     exon            490..640
                     /gene="LASP1"
                     /gene_synonym="Lasp-1; MLN50"
                     /inference="alignment:Splign:2.1.0"
     exon            641..744
                     /gene="LASP1"
                     /gene_synonym="Lasp-1; MLN50"
                     /inference="alignment:Splign:2.1.0"
     exon            745..3910
                     /gene="LASP1"
                     /gene_synonym="Lasp-1; MLN50"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3884..3889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LASP1"
                     /gene_synonym="Lasp-1; MLN50"
                     /note="hexamer: AATAAA"
     polyA_site      3910
                     /gene="LASP1"
                     /gene_synonym="Lasp-1; MLN50"
                     /note="major polyA site"
ORIGIN      
        1 gccagttccc cagctccagc cgccgtcgct gctgcctgtg tagttgcagc cgcggccgcc
       61 tcccgccagc tcgcctcggg gaacaggacg cgcgtgagct caggcgtccc cgccccagct
      121 tttctcggaa ccatgaaccc caactgcgcc cggtgcggca agatcgtgta tcccacggag
      181 aaggtgaact gtctggataa gttctggcat aaagcatgct tccattgcga gacctgcaag
      241 atgacactga acatgaagaa ctacaagggc tacgagaaga agccctactg caacgcacac
      301 taccccaagc agtccttcac catggtggcg gacaccccgg aaaaccttcg cctcaagcaa
      361 cagagtgagc tccagagtca ggtgcgctac aaggaggagt ttgagaagaa caagggcaaa
      421 ggtttcagcg tagtggcaga cacgcccgag ctccagagaa tcaagaagac ccaggaccag
      481 atcagtaaca taaaatacca tgaggagttt gagaagagcc gcatgggccc tagcgggggc
      541 gagggcatgg agccagagcg tcgggattca caggacggca gcagctaccg gcggcccctg
      601 gagcagcagc agcctcacca catcccgacc agtgccccgg tttaccagca gccccagcag
      661 cagccggtgg cccagtccta tggtggctac aaggagcctg cagccccagt ctccatacag
      721 cgcagcgccc caggtggtgg cgggaagcgg taccgcgcgg tgtatgacta cagcgccgcc
      781 gacgaggacg aggtctcctt ccaggacggg gacaccatcg tcaacgtgca gcagatcgac
      841 gacggctgga tgtacgggac ggtggagcgc accggcgaca cggggatgct gccggccaac
      901 tacgtggagg ccatctgaac ccgcagcgcc cccatctgtc ttcagcacat tccacggcat
      961 cgcatccgtc ctgggcgtga cccgtccatt cttcagtgtc tctgtttttt aaaacctgcg
     1021 acagcttgtg attcctaccc ctcttccagc ttcttttgcc aactgaagcc ttcttctgcc
     1081 acttctgcgg gctccctcct ctggcaggct tcccccttga tcgacttctt ggttttctct
     1141 ctggatggaa cgggcatggg cctctctggg ggaggcaggg ctggaatggg agacctgttg
     1201 gcctgtgggc ctcacctgcc cctctgttct ctcccctcac atcctcctgc ccagctcctc
     1261 acatacccac acattccagg gctggggtga gcctgactgc caggacccca ggtcaggggc
     1321 tccctacatt ccccagagtg ggatccactt cttggttcct gggatggcga tggggactct
     1381 gccgctgtgt agggaccagt gggatgggct ctacctctct ttctcaaaga gggggctctg
     1441 cccacctggg gtctctctcc ctacctccct cctcaggggc aacaacagga gaatggggtt
     1501 cctgctgtgg ggcgaattca tcccctcccc gcgcgttcct tcgcacactg tgattttgcc
     1561 ctcctgccca cgcagacctg cagcgggcaa agagctcccg aggaagcaca gcttgggtca
     1621 ggttcttgcc tttcttaatt ttagggacag ctaccggaag gaggggaaca aggagttctc
     1681 ttccgcagcc cctttcccca cgcccacccc cagtctccag ggacccttgc ctgcctccta
     1741 ggctggaagc catggtcccg aagtgtaggg caagggtgcc tcaggacctt ttggtcttca
     1801 gcctccctca gcccccagga tctgggttag gtggccgctc ctccctgctc ctcatgggaa
     1861 gatgtctcag agccttccat gacctcccct ccccagccca atgccaagtg gacttggagc
     1921 tgcacaaagt cagcagggac cactaaatct ccaagacctg gtgtgcggag gcaggagcat
     1981 gtatgtctgc aggtgtctga cacgcaagtg tgtgagtgtg agtgtgagag atggggcggg
     2041 ggtgtgtctg taggtgtctc tgggcctgtg tgtgggtggg gttatgtgag ggtatgaaga
     2101 gctgtcttcc cctgagagtt tcctcagaac ccacagtgag aggggagggc tcctggggca
     2161 gagaagttcc ttaggttttc tttggaatga aattcctcct tccccccatc tctgagtgga
     2221 ggaagcccac caatctgccc tttgcagtgt gcagggtgga aggtaagagg ttggtgtgga
     2281 gttggggctg ccatagggtc tgcagcctgc tggggctaag cggtggagga aggctctgtc
     2341 actccaggca tatgtttccc catctctgtc tggggctaca gaatagggtg gcagaagtgt
     2401 caccctgtgg gtgtctccct cgggggctct tcccctagac ctccccctca cttacataaa
     2461 gctcccttga agcaagaaag agggtcccag ggctgcaaaa ctggaagcac agcctcgggg
     2521 atggggaggg aaagacggtg ctatatccag ttcctgctct ctgctcatgg gtggctgtga
     2581 caaccctggc ctcacttgat tcatctctgg ttttcttgcc accctctggg agtccccatc
     2641 ccattttcat cctgagccca accaggccct gccattggcc tcttgtccct tggcacactt
     2701 gtacccacag gtgaggggca ggacctgaag gtattggcct gttcaacaat cagtcatcat
     2761 gggtgttttt gtcaactgct tgttaattga tttggggatg tttgccccga atgagaggtt
     2821 gaggaaaaga ctgtgggtgg ggaggccctg cctgacccat cccttttcct ttctggcccc
     2881 agcctaggtg gaggcaagtg gaatatctta tattgggcga tttgggggct cggggaggca
     2941 gagaatctct tgggagtctt gggtggcgct ggtgcattct gtttcctctt gatctcaaag
     3001 cacaatgtgg atttggggac caaaggtcag ggacacatcc ccttagagga cctgagtttg
     3061 ggagagtggt gagtggaagg gaggagcagc aagaagcagc ctgttttcac tcagcttaat
     3121 tctccttccc agataaggca agccagtcat ggaatcttgc tgcaggccct ccctctactc
     3181 ttcctgtcct aaaaataggg gccgttttct tacacacccc cagagagagg agggactgtc
     3241 acactggtgc tgagtgaccg ggggctgctg ggcgtctgtt ctttaccaaa accatccatc
     3301 cctagaagag cacagagccc tgaggggctg ggctgggctg ggctgagccc ctggtcttct
     3361 ctacagttca cagaggtctt tcagctcatt taatcccagg aaagaggcat caaagctaga
     3421 atgtgaatat aacttttgtg gaccaatact aagaataaca agaagcccag tggtgaggaa
     3481 agtgcgttct cccagcactg cctcctgttt tctccctctc atgtccctcc agggaaaatg
     3541 actttattgc ttaatttctg cctttccccc ctcacacatg cacttttggg ccttttttta
     3601 tagctggaaa aaacaaaata ccaccctaca aacctgtatt taaaaagaaa cagaaatgac
     3661 cacgtgaaat ttgcctctgt ccaaacattt catccgtgtg tatgtgtatg tgtgtgagtg
     3721 tgtgaagccg ccagttcatc tttttatatg gggttgttgt ctcattttgg tctgttttgg
     3781 tcccctccct cgtgggcttg tgctcgggat caaacctttc tggcctgtta tgattctgaa
     3841 catttgactt gaaccacaag tgaatctttc tcctggtgac tcaaataaaa gtataatttt
     3901 tacctgcgga
//
