LOCUS       NM_015340               4781 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens leucyl-tRNA synthetase 2, mitochondrial (LARS2),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_015340
VERSION     NM_015340.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4781)
  AUTHORS   Idyahia,A., Redouan,S., Amalou,G., Charoute,H., Harmak,H.,
            Bonnet,C., Petit,C., Benrahma,H. and Barakat,A.
  TITLE     Exome sequencing reveals pathogenic mutations in the LARS2 and
            HSD17B4 genes associated with Perrault syndrome and D-bifunctional
            protein deficiency in Moroccan families
  JOURNAL   Mol Biol Rep 51 (1), 850 (2024)
   PUBMED   39052101
  REMARK    GeneRIF: Exome sequencing reveals pathogenic mutations in the LARS2
            and HSD17B4 genes associated with Perrault syndrome and
            D-bifunctional protein deficiency in Moroccan families.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4781)
  AUTHORS   Lei,Y.B., Sun,S.P., Mao,L., Xu,H.E., Tang,W.X., Pan,Z.Y. and Lu,W.
  TITLE     [Analysis of perrault syndrome caused by pathogenic variants in
            LARS2 and HARS2 genes]
  JOURNAL   Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 58 (12), 1191-1197
            (2023)
   PUBMED   38186093
  REMARK    GeneRIF: [Analysis of perrault syndrome caused by pathogenic
            variants in LARS2 and HARS2 genes].
REFERENCE   3  (bases 1 to 4781)
  AUTHORS   Chen,J. and Liu,W.
  TITLE     Lin28a induced mitochondrial dysfunction in human granulosa cells
            via suppressing LARS2 expression
  JOURNAL   Cell Signal 103, 110536 (2023)
   PUBMED   36436798
  REMARK    GeneRIF: Lin28a induced mitochondrial dysfunction in human
            granulosa cells via suppressing LARS2 expression.
REFERENCE   4  (bases 1 to 4781)
  AUTHORS   De Paepe,B., Smet,J., Kopajtich,R., Prokisch,H., Van Coster,R. and
            Vanlander,A.
  TITLE     Neonatal lactic acidosis explained by LARS2 defect
  JOURNAL   Pediatr Res 93 (4), 740-743 (2023)
   PUBMED   35750896
  REMARK    GeneRIF: Neonatal lactic acidosis explained by LARS2 defect.
REFERENCE   5  (bases 1 to 4781)
  AUTHORS   Wang,Z., Lu,Z., Lin,S., Xia,J., Zhong,Z., Xie,Z., Xing,Y., Qie,J.,
            Jiao,M., Li,Y., Wen,H., Zhao,P., Zhang,D., Zhou,P., Qian,J.,
            Luo,F., Wang,L., Yu,H., Liu,J., Gu,J., Liu,R. and Chu,Y.
  TITLE     Leucine-tRNA-synthase-2-expressing B cells contribute to colorectal
            cancer immunoevasion
  JOURNAL   Immunity 55 (6), 1067-1081 (2022)
   PUBMED   35659337
  REMARK    GeneRIF: Leucine-tRNA-synthase-2-expressing B cells contribute to
            colorectal cancer immunoevasion.
            Erratum:[Immunity. 2022 Sep 13;55(9):1748. doi:
            10.1016/j.immuni.2022.07.017.. PMID: 36103860]
REFERENCE   6  (bases 1 to 4781)
  AUTHORS   Bullard,J.M., Cai,Y.C. and Spremulli,L.L.
  TITLE     Expression and characterization of the human mitochondrial
            leucyl-tRNA synthetase
  JOURNAL   Biochim Biophys Acta 1490 (3), 245-258 (2000)
   PUBMED   10684970
REFERENCE   7  (bases 1 to 4781)
  AUTHORS   Kiss,H., Kedra,D., Yang,Y., Kost-Alimova,M., Kiss,C., O'Brien,K.P.,
            Fransson,I., Klein,G., Imreh,S. and Dumanski,J.P.
  TITLE     A novel gene containing LIM domains (LIMD1) is located within the
            common eliminated region 1 (C3CER1) in 3p21.3
  JOURNAL   Hum Genet 105 (6), 552-559 (1999)
   PUBMED   10647888
REFERENCE   8  (bases 1 to 4781)
  AUTHORS   Szeles,A., Yang,Y., Sandlund,A.M., Kholodnyuk,I., Kiss,H.,
            Kost-Alimova,M., Zabarovsky,E.R., Stanbridge,E., Klein,G. and
            Imreh,S.
  TITLE     Human/mouse microcell hybrid based elimination test reduces the
            putative tumor suppressor region at 3p21.3 to 1.6 cM
  JOURNAL   Genes Chromosomes Cancer 20 (4), 329-336 (1997)
   PUBMED   9408748
REFERENCE   9  (bases 1 to 4781)
  AUTHORS   Newman,W.G., Friedman,T.B., Conway,G.S. and Demain,L.A.M.
  TITLE     Perrault Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   25254289
REFERENCE   10 (bases 1 to 4781)
  AUTHORS   Olsson,P. and Wennberg,A.L.
  TITLE     [Midwife and research. Conference report]
  JOURNAL   Jordemodern 104 (11), 408-409 (1991)
   PUBMED   1684970
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC006515.7, BI463427.1,
            D21851.1 and AC099539.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_015340.3.
            
            Summary: This gene encodes a class 1 aminoacyl-tRNA synthetase,
            mitochondrial leucyl-tRNA synthetase. Each of the twenty
            aminoacyl-tRNA synthetases catalyzes the aminoacylation of a
            specific tRNA or tRNA isoaccepting family with the cognate amino
            acid. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025989.2, D21851.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000645846.2/
                                                  ENSP00000495093.1
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AC006515.7         190418-190424
            8-283               BI463427.1         10-285
            284-4210            D21851.1           277-4203
            4211-4781           AC099539.2         69157-69727         c
FEATURES             Location/Qualifiers
     source          1..4781
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.31"
     gene            1..4781
                     /gene="LARS2"
                     /gene_synonym="HLASA; LEURS; mtLeuRS; PRLTS4"
                     /note="leucyl-tRNA synthetase 2, mitochondrial"
                     /db_xref="GeneID:23395"
                     /db_xref="HGNC:HGNC:17095"
                     /db_xref="MIM:604544"
     exon            1..105
                     /gene="LARS2"
                     /gene_synonym="HLASA; LEURS; mtLeuRS; PRLTS4"
                     /inference="alignment:Splign:2.1.0"
     exon            106..171
                     /gene="LARS2"
                     /gene_synonym="HLASA; LEURS; mtLeuRS; PRLTS4"
                     /inference="alignment:Splign:2.1.0"
     exon            172..426
                     /gene="LARS2"
                     /gene_synonym="HLASA; LEURS; mtLeuRS; PRLTS4"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..2904
                     /gene="LARS2"
                     /gene_synonym="HLASA; LEURS; mtLeuRS; PRLTS4"
                     /EC_number="6.1.1.4"
                     /note="leucine tRNA ligase 2, mitocondrial; leucine
                     translase; probable leucyl-tRNA synthetase, mitochondrial;
                     probable leucine--tRNA ligase, mitochondrial; leucine tRNA
                     ligase 2, mitochondrial"
                     /codon_start=1
                     /product="leucine--tRNA ligase, mitochondrial"
                     /protein_id="NP_056155.1"
                     /db_xref="CCDS:CCDS2728.1"
                     /db_xref="GeneID:23395"
                     /db_xref="HGNC:HGNC:17095"
                     /db_xref="MIM:604544"
                     /translation="MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSAT
                     GKWTKEYTLQTRKDVEKWWHQRIKEQASKISEADKSKPKFYVLSMFPYPSGKLHMGHV
                     RVYTISDTIARFQKMRGMQVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHMRKQ
                     LDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANE
                     QVDEHGCSWRSGAKVEQKYLRQWFIKTTAYAKAMQDALADLPEWYGIKGMQAHWIGDC
                     VGCHLDFTLKVHGQATGEKLTAYTATPEAIYGTSHVAISPSHRLLHGHSSLKEALRMA
                     LVPGKDCLTPVMAVNMLTQQEVPVVILAKADLEGSLDSKIGIPSTSSEDTILAQTLGL
                     AYSEVIETLPDGTERLSSSAEFTGMTRQDAFLALTQKARGKRVGGDVTSDKLKDWLIS
                     RQRYWGTPIPIVHCPVCGPTPVPLEDLPVTLPNIASFTGKGGPPLAMASEWVNCSCPR
                     CKGAAKRETDTMDTFVDSAWYYFRYTDPHNPHSPFNTAVADYWMPVDLYIGGKEHAVM
                     HLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIKGQTFRLPSGQYLQREEVDLTGSVP
                     VHAKTKEKLEVTWEKMSKSKHNGVDPEEVVEQYGIDTIRLYILFAAPPEKDILWDVKT
                     DALPGVLRWQQRLWTLTTRFIEARASGKSPQPQLLSNKEKAEARKLWEYKNSVISQVT
                     THFTEDFSLNSAISQLMGLSNALSQASQSVILHSPEFEDALCALMVMAAPLAPHVTSE
                     IWAGLALVPRKLCAHYTWDASVLLQAWPAVDPEFLQQPEVVQMAVLINNKACGKIPVP
                     QQVARDQDKVHEFVLQSELGVRLLQGRSIKKSFLSPRTALINFLVQD"
     exon            427..555
                     /gene="LARS2"
                     /gene_synonym="HLASA; LEURS; mtLeuRS; PRLTS4"
                     /inference="alignment:Splign:2.1.0"
     exon            556..647
                     /gene="LARS2"
                     /gene_synonym="HLASA; LEURS; mtLeuRS; PRLTS4"
                     /inference="alignment:Splign:2.1.0"
     exon            648..708
                     /gene="LARS2"
                     /gene_synonym="HLASA; LEURS; mtLeuRS; PRLTS4"
                     /inference="alignment:Splign:2.1.0"
     exon            709..798
                     /gene="LARS2"
                     /gene_synonym="HLASA; LEURS; mtLeuRS; PRLTS4"
                     /inference="alignment:Splign:2.1.0"
     exon            799..942
                     /gene="LARS2"
                     /gene_synonym="HLASA; LEURS; mtLeuRS; PRLTS4"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1050
                     /gene="LARS2"
                     /gene_synonym="HLASA; LEURS; mtLeuRS; PRLTS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1210
                     /gene="LARS2"
                     /gene_synonym="HLASA; LEURS; mtLeuRS; PRLTS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1315
                     /gene="LARS2"
                     /gene_synonym="HLASA; LEURS; mtLeuRS; PRLTS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1431
                     /gene="LARS2"
                     /gene_synonym="HLASA; LEURS; mtLeuRS; PRLTS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1715
                     /gene="LARS2"
                     /gene_synonym="HLASA; LEURS; mtLeuRS; PRLTS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1814
                     /gene="LARS2"
                     /gene_synonym="HLASA; LEURS; mtLeuRS; PRLTS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1952
                     /gene="LARS2"
                     /gene_synonym="HLASA; LEURS; mtLeuRS; PRLTS4"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2053
                     /gene="LARS2"
                     /gene_synonym="HLASA; LEURS; mtLeuRS; PRLTS4"
                     /inference="alignment:Splign:2.1.0"
     exon            2054..2236
                     /gene="LARS2"
                     /gene_synonym="HLASA; LEURS; mtLeuRS; PRLTS4"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2406
                     /gene="LARS2"
                     /gene_synonym="HLASA; LEURS; mtLeuRS; PRLTS4"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2484
                     /gene="LARS2"
                     /gene_synonym="HLASA; LEURS; mtLeuRS; PRLTS4"
                     /inference="alignment:Splign:2.1.0"
     exon            2485..2596
                     /gene="LARS2"
                     /gene_synonym="HLASA; LEURS; mtLeuRS; PRLTS4"
                     /inference="alignment:Splign:2.1.0"
     exon            2597..2724
                     /gene="LARS2"
                     /gene_synonym="HLASA; LEURS; mtLeuRS; PRLTS4"
                     /inference="alignment:Splign:2.1.0"
     exon            2725..4781
                     /gene="LARS2"
                     /gene_synonym="HLASA; LEURS; mtLeuRS; PRLTS4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4189..4194
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LARS2"
                     /gene_synonym="HLASA; LEURS; mtLeuRS; PRLTS4"
                     /note="hexamer: AATAAA"
     polyA_site      4211
                     /gene="LARS2"
                     /gene_synonym="HLASA; LEURS; mtLeuRS; PRLTS4"
                     /note="major polyA site"
     regulatory      4762..4767
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LARS2"
                     /gene_synonym="HLASA; LEURS; mtLeuRS; PRLTS4"
                     /note="hexamer: AATATA"
     polyA_site      4781
                     /gene="LARS2"
                     /gene_synonym="HLASA; LEURS; mtLeuRS; PRLTS4"
ORIGIN      
        1 gctgttttga caacatggcg gcgcccatgg tccgtggccc ggcagtgctc gcctaaaggt
       61 ggagaacgag gagtagagga gccgcaggcc agagcctgtg agcagatcca gacctacaga
      121 taaaaaacat tatttaatct atctgggatt tactccggct tatgatttga gggccttctc
      181 accttctgaa gaatggcttc tgtttggcag agattgggtt tttatgcctc tcttctgaaa
      241 agacagctaa atggtgggcc agatgtcatc aagtgggaaa ggagagtaat tcccggatgt
      301 accagaagca tctacagtgc cacgggaaag tggacaaaag agtatacatt gcagacaaga
      361 aaggatgttg agaaatggtg gcatcaacga ataaaagaac aggcctccaa aatttcagaa
      421 gctgataaat cgaagccaaa attttacgtg ctttccatgt tcccttatcc ttctggtaag
      481 ctgcacatgg gccatgtgcg tgtctacacc atcagcgaca ccatagcacg gttccagaag
      541 atgagaggga tgcaggtcat caaccccatg ggatgggatg cttttggatt gcctgctgaa
      601 aatgccgcag tcgagaggaa tctacatcca caaagttgga cacaaagtaa tattaaacac
      661 atgaggaaac agcttgatcg tctgggcctg tgtttcagct gggataggga aataactacg
      721 tgtttgccag attactacaa gtggactcag tatctcttta ttaaactgta tgaggctggg
      781 ctggcctatc aaaaggaggc cctggttaac tgggacccag tggatcaaac agtgcttgcc
      841 aatgagcagg tggatgaaca tggctgttca tggcgttctg gagcaaaggt ggaacagaag
      901 tacctcagac aatggtttat taagacaacc gcttatgcaa aggccatgca ggacgcgttg
      961 gcagaccttc cagaatggta tggaataaaa ggcatgcaag cccactggat tggggactgt
     1021 gtgggctgcc acctggactt cacattaaag gttcatgggc aagccacggg cgaaaagctg
     1081 actgcctata cggccacccc tgaagccatt tatggcacct cccacgtggc catctcgccc
     1141 agccacagac tcctacatgg gcacagctct ctgaaggaag ccttgaggat ggcccttgtc
     1201 cctggcaaag attgcctcac gcctgtaatg gctgtgaaca tgcttaccca gcaggaggtc
     1261 cctgtcgtta ttttggccaa agctgacttg gaaggctctc tggattcaaa aataggaatt
     1321 cccagtacta gctcagagga caccatctta gcccaaaccc tgggcctggc ctactctgaa
     1381 gtcattgaaa ctttgccaga tggcacagag agactgagca gctctgctga gttcacaggt
     1441 atgacccggc aggatgcttt tctagccctg actcagaaag cccgggggaa gagagtgggt
     1501 ggagacgtga caagtgataa actgaaagac tggctgattt cacggcagcg gtactggggc
     1561 acaccaatcc ccattgtcca ctgcccagtc tgtggcccca cacctgtgcc cctggaggac
     1621 ttgcctgtga ccctgcccaa catcgcgtct ttcactggca agggaggccc cccactggcc
     1681 atggcttcag agtgggtgaa ctgctcctgc ccaaggtgca agggagcagc caagagagag
     1741 acagacacga tggatacctt tgttgattct gcttggtact acttcagata cactgaccct
     1801 cataatccac acagcccttt taacacagca gtggccgatt actggatgcc tgtggatttg
     1861 tacattggag ggaaagaaca tgccgtcatg cacttgttct atgcaagatt ctttagtcat
     1921 ttttgccatg atcaaaaaat ggttaaacat agggagcctt ttcataagct gctggcccaa
     1981 ggccttatca aggggcagac attccgccta ccatctggac agtatctaca gagagaggaa
     2041 gtggatctca caggttccgt tcctgttcat gcaaaaacga aagagaagtt agaggtgacg
     2101 tgggagaaga tgagtaagtc caaacacaac ggggtggacc cagaggaagt tgtggagcag
     2161 tatgggatcg acacgattcg gctctacatc ctttttgctg cccctcctga gaaggatatc
     2221 ttgtgggatg tgaaaactga tgctctccct ggggtgctga gatggcaaca acgactgtgg
     2281 accttgacaa ctcggtttat tgaggccagg gcttctggga agtctcccca gcctcagctg
     2341 ctgagtaaca aggagaaagc tgaggccagg aagctctggg agtacaagaa ctccgtcatc
     2401 tctcaggtga ccacccattt cacagaggac ttctcactga attctgcaat ttctcagctg
     2461 atgggactca gcaatgccct ctcgcaagcc tctcagagcg tcattctcca cagccccgag
     2521 tttgaggatg ctttgtgtgc cctgatggta atggctgctc cactggcccc tcatgtaacc
     2581 tcagagatct gggcaggcct ggcgctggtg ccgaggaagc tctgtgccca ctacacttgg
     2641 gatgccagtg tgctgctcca ggcatggcct gctgtggacc cggagttcct gcagcagcct
     2701 gaggttgtcc agatggcagt tctgatcaac aataaagctt gtggcaaaat tcctgtgccc
     2761 caacaagttg cccgggacca ggacaaagtc cacgaatttg ttcttcaaag cgagctgggt
     2821 gtcaggcttt tgcaaggacg aagcatcaag aagtccttcc tttccccgag aactgccctc
     2881 atcaacttcc tggtgcaaga ttgacagcca ggaggctgca gctaccacga gggcctctga
     2941 ggaacctcct tccaggcctg ggatgagggg gcgatgtctg ctggcccagg ggaagggaaa
     3001 agacaaatgt cttgactgtt gacctcggtc ctgtggcaga ctgcagtcaa cagtgtgcct
     3061 ctgtagtgtg gcctggtgct ggggtgaagg tgagctgggc aaaggagaaa tatgagctac
     3121 tgaggagggg gttggacatc ctgcccctca ccccccaccc acactgcagg tagaggaggc
     3181 catctgatcc catgggaagc catcagagac actgctggtg ggagcaggaa ggagcagtgc
     3241 ccctcgagca gccaggaagc ctgcggatct gggaaatggc tctgccttag gcacttctcg
     3301 ggaatttgag gccagcctga ggaactgcag gactcaggtg caatgtgcca gccacttgga
     3361 actgctaact gagcctccag atggtagtga atggtctctt tgccttcagg ctggatgagg
     3421 aagtcattta ggaaatgttc aaataaccaa tatgtggaaa tggacacagg gatcttctga
     3481 agttgctttg aatcaaaagg caggcagtgc tggttcctct gcctgtgtcc ccaccactcc
     3541 ccagctctgt catgcaggcc tgtcctcccc aaccccagct ggatgtgcct cccaggcctg
     3601 ctgtggttct gacacacagg atcccaggca aggcaccact tcctcacatg aatgaggagc
     3661 agcaagtcat aaccactccc ttgggtatac aatttgctgt gtagtgaagt ggaaccaggc
     3721 tcaggctgct ggtcccaacc tcagagcccc accgcagccc agtagggatg cagcacgccc
     3781 cagagggctc atgtgggccc cagatggcaa tgccaccatt gttgatgtga ctccagagcc
     3841 agttattagg aagagcaagc tcaccacaga ggagtggaac tgaggccccc cagatgttgc
     3901 ctccggtgtc caagccacag cggtctggct gttgggaaga tggccaggaa tggactcata
     3961 ccattggcac attaggctaa tcctggtttt atgtgaagtc agcaattaag tgttcccact
     4021 agaactgacc taagccactg attaatattt aatgagggaa ggtaggggag aatctagcca
     4081 ttttataatg ccagaaatct atatatgtta tctgatgcca tttttctgaa gtagcctcac
     4141 atgtggtccc cctgcagttc agcagttaac agatgacttt tttagtgtaa taaaatgttt
     4201 atcatctatg acttcaggac atatgtgtga tcctggaata caccatattc caatttcaga
     4261 gttaattaca aacagattga ggtattccat catcatcgga agcattggct gtgtgtctga
     4321 ctccacatgg aatgctataa agtgggatac atgtggttct tcttgttcca gaacttacag
     4381 tccatggtag acaacactga tacaggcaaa ctagcaacag caattaagtc actggttctc
     4441 agacttaata ctctgcctgg tcctcatgcc cagatattcc aatttaattg gtccatggtg
     4501 tggcttgaac accaggaatc tttaaaactc cacaagtgat tctaatgggc agcaaagttt
     4561 gagaatcact ggacacattg atgcacttga gccatcattt ctatctagtt cttcctcttc
     4621 ctaatcttca ggttagcggg gataagtttg gtccaggacc aagagttgga ccaaaaggga
     4681 agacaggggc cagaagtcta gagtgctaga gccgacttga atgtactcag tctcattgca
     4741 catggcagtg aatatggatt aaatataagc ccatgaaaat a
//
