LOCUS       NM_016648               2107 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens La ribonucleoprotein 7, transcriptional regulator
            (LARP7), transcript variant 1, mRNA.
ACCESSION   NM_016648
VERSION     NM_016648.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2107)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2107)
  AUTHORS   Kao,T.L., Huang,Y.C., Chen,Y.H., Baumann,P. and Tseng,C.K.
  TITLE     LARP3, LARP7, and MePCE are involved in the early stage of human
            telomerase RNA biogenesis
  JOURNAL   Nat Commun 15 (1), 5955 (2024)
   PUBMED   39009594
  REMARK    GeneRIF: LARP3, LARP7, and MePCE are involved in the early stage of
            human telomerase RNA biogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2107)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 2107)
  AUTHORS   Zhang,J., Yu,R., Guo,X., Zou,Y., Chen,S., Zhou,K., Chen,Y., Li,Y.,
            Gao,S. and Wu,Y.
  TITLE     Identification of TYR, TYRP1, DCT and LARP7 as related biomarkers
            and immune infiltration characteristics of vitiligo via
            comprehensive strategies
  JOURNAL   Bioengineered 12 (1), 2214-2227 (2021)
   PUBMED   34107850
  REMARK    GeneRIF: Identification of TYR, TYRP1, DCT and LARP7 as related
            biomarkers and immune infiltration characteristics of vitiligo via
            comprehensive strategies.
REFERENCE   5  (bases 1 to 2107)
  AUTHORS   Yan,P., Li,Z., Xiong,J., Geng,Z., Wei,W., Zhang,Y., Wu,G.,
            Zhuang,T., Tian,X., Liu,Z., Liu,J., Sun,K., Chen,F., Zhang,Y.,
            Zeng,C., Huang,Y. and Zhang,B.
  TITLE     LARP7 ameliorates cellular senescence and aging by allosterically
            enhancing SIRT1 deacetylase activity
  JOURNAL   Cell Rep 37 (8), 110038 (2021)
   PUBMED   34818543
  REMARK    GeneRIF: LARP7 ameliorates cellular senescence and aging by
            allosterically enhancing SIRT1 deacetylase activity.
REFERENCE   6  (bases 1 to 2107)
  AUTHORS   Xue,Y., Yang,Z., Chen,R. and Zhou,Q.
  TITLE     A capping-independent function of MePCE in stabilizing 7SK snRNA
            and facilitating the assembly of 7SK snRNP
  JOURNAL   Nucleic Acids Res 38 (2), 360-369 (2010)
   PUBMED   19906723
REFERENCE   7  (bases 1 to 2107)
  AUTHORS   Markert,A., Grimm,M., Martinez,J., Wiesner,J., Meyerhans,A.,
            Meyuhas,O., Sickmann,A. and Fischer,U.
  TITLE     The La-related protein LARP7 is a component of the 7SK
            ribonucleoprotein and affects transcription of cellular and viral
            polymerase II genes
  JOURNAL   EMBO Rep 9 (6), 569-575 (2008)
   PUBMED   18483487
  REMARK    GeneRIF: Results suggest that LARP7 is a negative transcriptional
            regulator of polymerase II genes, acting by means of the 7SK RNP
            system.
REFERENCE   8  (bases 1 to 2107)
  AUTHORS   Krueger,B.J., Jeronimo,C., Roy,B.B., Bouchard,A., Barrandon,C.,
            Byers,S.A., Searcey,C.E., Cooper,J.J., Bensaude,O., Cohen,E.A.,
            Coulombe,B. and Price,D.H.
  TITLE     LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1
            and hnRNP A1 are reversibly associated
  JOURNAL   Nucleic Acids Res 36 (7), 2219-2229 (2008)
   PUBMED   18281698
  REMARK    GeneRIF: Results indicate LARP7 is a 7SK-binding protein.
REFERENCE   9  (bases 1 to 2107)
  AUTHORS   He,N., Jahchan,N.S., Hong,E., Li,Q., Bayfield,M.A., Maraia,R.J.,
            Luo,K. and Zhou,Q.
  TITLE     A La-related protein modulates 7SK snRNP integrity to suppress
            P-TEFb-dependent transcriptional elongation and tumorigenesis
  JOURNAL   Mol Cell 29 (5), 588-599 (2008)
   PUBMED   18249148
  REMARK    GeneRIF: Results identify PIP7S as a La-related protein stably
            associated with and required for 7SK snRNP integrity.
REFERENCE   10 (bases 1 to 2107)
  AUTHORS   Biewenga,P., Buist,M.R., Moerland,P.D., Ver Loren van Themaat,E.,
            van Kampen,A.H., ten Kate,F.J. and Baas,F.
  TITLE     Gene expression in early stage cervical cancer
  JOURNAL   Gynecol Oncol 108 (3), 520-526 (2008)
   PUBMED   18191186
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB270203.1, AK000274.1,
            AL049996.1 and AC106864.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_016648.3.
            
            Summary: This gene encodes a protein which is found in the 7SK
            snRNP (small nuclear ribonucleoprotein). This snRNP complex
            inhibits a cyclin-dependent kinase, positive transcription
            elongation factor b, which is required for paused RNA polymerase II
            at a promoter to begin transcription elongation. A pseudogene of
            this gene is located on chromosome 3. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, May 2012].
            
            Transcript Variant: This variant (1) lacks two 5' exons compared to
            variant 3. These differences cause translation initiation at a
            downstream AUG and result in a protein (isoform 1) with a shorter
            N-terminus compared to isoform 2. Variants 1, 2, and 9 encode the
            same protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.80557.1,
                                           SRR1803612.16172.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000344442.10/ ENSP00000344950.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DB270203.1         180-192
            14-1689             AK000274.1         3-1678
            1690-1776           AL049996.1         716-802
            1777-2024           AC106864.5         20346-20593
            2025-2107           AK000274.1         2008-2090
FEATURES             Location/Qualifiers
     source          1..2107
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q25"
     gene            1..2107
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /note="La ribonucleoprotein 7, transcriptional regulator"
                     /db_xref="GeneID:51574"
                     /db_xref="HGNC:HGNC:24912"
                     /db_xref="MIM:612026"
     exon            1..97
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            98..301
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1848
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /note="isoform 1 is encoded by transcript variant 1;
                     P-TEFb-interaction protein for 7SK stability; La-related
                     protein 7; La ribonucleoprotein domain family member 7"
                     /codon_start=1
                     /product="la-related protein 7 isoform 1"
                     /protein_id="NP_057732.2"
                     /db_xref="CCDS:CCDS3701.2"
                     /db_xref="GeneID:51574"
                     /db_xref="HGNC:HGNC:24912"
                     /db_xref="MIM:612026"
                     /translation="METESGNQEKVMEEESTEKKKEVEKKKRSRVKQVLADIAKQVDF
                     WFGDANLHKDRFLREQIEKSRDGYVDISLLVSFNKMKKLTTDGKLIARALRSSAVVEL
                     DLEGTRIRRKKPLGERPKDEDERTVYVELLPKNVNHSWIERVFGKCGNVVYISIPHYK
                     STGDPKGFAFVEFETKEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEK
                     KKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKKK
                     KKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDI
                     EISTEEEKDTGDLKDSSLLKTKRKHKKKHKERHKMGEEVIPLRVLSKSEWMDLKKEYL
                     ALQKASMASLKKTISQIKSESEMETDSGVPQNTGMKNEKTANREECRTQEKVNATGPQ
                     FVSGVIVKIISTEPLPGRKQVRDTLAAISEVLYVDLLEGDTECHARFKTPEDAQAVIN
                     AYTEINKKHCWKLEILSGDHEQRYWQKILVDRQAKLNQPREKKRGTEKLITKAEKIRL
                     AKTQQASKHIRFSEYD"
     exon            302..402
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            403..486
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            487..651
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            652..745
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            746..1096
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1241
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1393
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1515
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1675
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1767
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..2107
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2086..2091
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /note="hexamer: AATAAA"
     polyA_site      2107
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /note="major polyA site"
ORIGIN      
        1 atcctatgac gcgaaagtaa ccgagactat caggatccgg agacggaaat gtccgaaggc
       61 cgcagtactt gaccctgtat tttgggagtc gaacggagaa tggaaactga aagtggaaat
      121 caggaaaagg taatggaaga agaaagcact gaaaagaaaa aagaagttga aaaaaagaaa
      181 cggtcacgag ttaaacaggt gcttgcagat attgctaagc aagtggactt ctggtttggg
      241 gatgcaaatc ttcacaagga tagatttctt cgagaacaga tagaaaaatc tagagatgga
      301 tatgttgata tatcactact tgtgtctttt aacaaaatga aaaaattgac tactgatggg
      361 aagttaattg ccagagcatt gagaagttca gctgttgtag agcttgattt ggaaggcacc
      421 agaatccgga ggaaaaaacc tctgggggaa agaccaaagg atgaggatga acgcacagtg
      481 tatgtggagt tacttcccaa aaatgttaat cacagctgga ttgaaagagt atttgggaaa
      541 tgtggcaatg ttgtttatat aagtatacca cattataagt ctactggaga tccaaaggga
      601 tttgcgtttg tggaatttga aacaaaagaa caagcagcaa aagcaattga gtttcttaac
      661 aacccaccag aagaagcacc aagaaaacct ggcatatttc ctaaaacagt gaaaaataag
      721 cccattccag ccttaagagt tgtggaagag aagaaaaaga aaaagaagaa gaaaggccga
      781 atgaaaaagg aagacaatat ccaagccaaa gaagaaaaca tggacacaag caacaccagc
      841 atcagtaaaa tgaaaagatc cagacccaca tctgagggct ctgacattga gtccactgaa
      901 ccccaaaagc agtgctcaaa gaaaaagaaa aaacgggaca gagttgaagc atctagctta
      961 cctgaagtca gaacagggaa gaggaagaga agcagctctg aagatgcaga atccctagct
     1021 ccccgatcaa aagtaaagaa aattattcag aaagacatca ttaaggaagc atcagaagct
     1081 tccaaggaaa atagagatat agaaatctct actgaagagg aaaaggatac tggagatcta
     1141 aaagatagct ctctcttgaa aacaaaaagg aaacataaga aaaaacataa agagagacat
     1201 aaaatgggag aagaagttat accattaaga gtgctatcaa agagcgaatg gatggatttg
     1261 aaaaaagagt atttagcgct acaaaaagct agcatggctt ctttaaaaaa aacaatatcc
     1321 caaataaaat cagagtcaga aatggaaaca gacagtggag tacctcaaaa cactggaatg
     1381 aaaaatgaaa aaacagccaa cagggaagag tgtcgcaccc aggagaaagt taatgcaaca
     1441 ggaccacagt tcgtgagtgg agtgattgtg aagatcatta gcacagagcc tctacctggc
     1501 aggaaacaag tccgggatac tttggcagca atctcagaag ttctttatgt tgatttgcta
     1561 gaaggggata cagaatgcca tgctagattt aaaactcctg aggatgctca agcagtaata
     1621 aatgcctata cagaaattaa caagaaacac tgctggaaac tcgagatcct ttctggtgat
     1681 cacgaacaaa ggtattggca gaagattttg gttgatagac aggcaaaact taatcagcct
     1741 cgggaaaaga aaagaggcac tgaaaagtta atcaccaaag ctgaaaagat tagactggca
     1801 aagactcaac aagcgagtaa acatataaga ttttctgaat atgattgaaa aaaaaaacag
     1861 ttcacctctt aatacttcac aagatacttg agctgttctt gggagattca cttttattat
     1921 ggtagcactg cataattaat gtgtttttaa ttaaaagaaa tatctttgtt cctcaacttg
     1981 taaataagac ttttttctag agacaaatat gatgtatacc acaatttttc ttaaacattt
     2041 tatttgttga aattatctta gatgtcagtg tcaggtgatt tagtaaataa atgtgttttg
     2101 aacatta
//
