LOCUS       NM_015454               2112 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens La ribonucleoprotein 7, transcriptional regulator
            (LARP7), transcript variant 2, mRNA.
ACCESSION   NM_015454
VERSION     NM_015454.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2112)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2112)
  AUTHORS   Kao,T.L., Huang,Y.C., Chen,Y.H., Baumann,P. and Tseng,C.K.
  TITLE     LARP3, LARP7, and MePCE are involved in the early stage of human
            telomerase RNA biogenesis
  JOURNAL   Nat Commun 15 (1), 5955 (2024)
   PUBMED   39009594
  REMARK    GeneRIF: LARP3, LARP7, and MePCE are involved in the early stage of
            human telomerase RNA biogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2112)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 2112)
  AUTHORS   Zhang,J., Yu,R., Guo,X., Zou,Y., Chen,S., Zhou,K., Chen,Y., Li,Y.,
            Gao,S. and Wu,Y.
  TITLE     Identification of TYR, TYRP1, DCT and LARP7 as related biomarkers
            and immune infiltration characteristics of vitiligo via
            comprehensive strategies
  JOURNAL   Bioengineered 12 (1), 2214-2227 (2021)
   PUBMED   34107850
  REMARK    GeneRIF: Identification of TYR, TYRP1, DCT and LARP7 as related
            biomarkers and immune infiltration characteristics of vitiligo via
            comprehensive strategies.
REFERENCE   5  (bases 1 to 2112)
  AUTHORS   Yan,P., Li,Z., Xiong,J., Geng,Z., Wei,W., Zhang,Y., Wu,G.,
            Zhuang,T., Tian,X., Liu,Z., Liu,J., Sun,K., Chen,F., Zhang,Y.,
            Zeng,C., Huang,Y. and Zhang,B.
  TITLE     LARP7 ameliorates cellular senescence and aging by allosterically
            enhancing SIRT1 deacetylase activity
  JOURNAL   Cell Rep 37 (8), 110038 (2021)
   PUBMED   34818543
  REMARK    GeneRIF: LARP7 ameliorates cellular senescence and aging by
            allosterically enhancing SIRT1 deacetylase activity.
REFERENCE   6  (bases 1 to 2112)
  AUTHORS   Xue,Y., Yang,Z., Chen,R. and Zhou,Q.
  TITLE     A capping-independent function of MePCE in stabilizing 7SK snRNA
            and facilitating the assembly of 7SK snRNP
  JOURNAL   Nucleic Acids Res 38 (2), 360-369 (2010)
   PUBMED   19906723
REFERENCE   7  (bases 1 to 2112)
  AUTHORS   Markert,A., Grimm,M., Martinez,J., Wiesner,J., Meyerhans,A.,
            Meyuhas,O., Sickmann,A. and Fischer,U.
  TITLE     The La-related protein LARP7 is a component of the 7SK
            ribonucleoprotein and affects transcription of cellular and viral
            polymerase II genes
  JOURNAL   EMBO Rep 9 (6), 569-575 (2008)
   PUBMED   18483487
  REMARK    GeneRIF: Results suggest that LARP7 is a negative transcriptional
            regulator of polymerase II genes, acting by means of the 7SK RNP
            system.
REFERENCE   8  (bases 1 to 2112)
  AUTHORS   Krueger,B.J., Jeronimo,C., Roy,B.B., Bouchard,A., Barrandon,C.,
            Byers,S.A., Searcey,C.E., Cooper,J.J., Bensaude,O., Cohen,E.A.,
            Coulombe,B. and Price,D.H.
  TITLE     LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1
            and hnRNP A1 are reversibly associated
  JOURNAL   Nucleic Acids Res 36 (7), 2219-2229 (2008)
   PUBMED   18281698
  REMARK    GeneRIF: Results indicate LARP7 is a 7SK-binding protein.
REFERENCE   9  (bases 1 to 2112)
  AUTHORS   He,N., Jahchan,N.S., Hong,E., Li,Q., Bayfield,M.A., Maraia,R.J.,
            Luo,K. and Zhou,Q.
  TITLE     A La-related protein modulates 7SK snRNP integrity to suppress
            P-TEFb-dependent transcriptional elongation and tumorigenesis
  JOURNAL   Mol Cell 29 (5), 588-599 (2008)
   PUBMED   18249148
  REMARK    GeneRIF: Results identify PIP7S as a La-related protein stably
            associated with and required for 7SK snRNP integrity.
REFERENCE   10 (bases 1 to 2112)
  AUTHORS   Biewenga,P., Buist,M.R., Moerland,P.D., Ver Loren van Themaat,E.,
            van Kampen,A.H., ten Kate,F.J. and Baas,F.
  TITLE     Gene expression in early stage cervical cancer
  JOURNAL   Gynecol Oncol 108 (3), 520-526 (2008)
   PUBMED   18191186
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN346208.1, BM979591.1,
            AL049996.1 and CA314598.1.
            
            On Aug 14, 2020 this sequence version replaced NM_015454.2.
            
            Summary: This gene encodes a protein which is found in the 7SK
            snRNP (small nuclear ribonucleoprotein). This snRNP complex
            inhibits a cyclin-dependent kinase, positive transcription
            elongation factor b, which is required for paused RNA polymerase II
            at a promoter to begin transcription elongation. A pseudogene of
            this gene is located on chromosome 3. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, May 2012].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            lacks a 5' exon compared to variant 3. These differences cause
            translation initiation at a downstream AUG and result in a protein
            (isoform 1) with a shorter N-terminus compared to isoform 2.
            Variants 1, 2, and 9 encode the same protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1603377.1,
                                           SRR14038197.1243082.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-456               CN346208.1         54-509
            457-980             BM979591.1         71-594
            981-1650            AL049996.1         2-671
            1651-2112           CA314598.1         18-479              c
FEATURES             Location/Qualifiers
     source          1..2112
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q25"
     gene            1..2112
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /note="La ribonucleoprotein 7, transcriptional regulator"
                     /db_xref="GeneID:51574"
                     /db_xref="HGNC:HGNC:24912"
                     /db_xref="MIM:612026"
     exon            1..102
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            103..306
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1853
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /note="isoform 1 is encoded by transcript variant 2;
                     P-TEFb-interaction protein for 7SK stability; La-related
                     protein 7; La ribonucleoprotein domain family member 7"
                     /codon_start=1
                     /product="la-related protein 7 isoform 1"
                     /protein_id="NP_056269.1"
                     /db_xref="CCDS:CCDS3701.2"
                     /db_xref="GeneID:51574"
                     /db_xref="HGNC:HGNC:24912"
                     /db_xref="MIM:612026"
                     /translation="METESGNQEKVMEEESTEKKKEVEKKKRSRVKQVLADIAKQVDF
                     WFGDANLHKDRFLREQIEKSRDGYVDISLLVSFNKMKKLTTDGKLIARALRSSAVVEL
                     DLEGTRIRRKKPLGERPKDEDERTVYVELLPKNVNHSWIERVFGKCGNVVYISIPHYK
                     STGDPKGFAFVEFETKEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEK
                     KKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKKK
                     KKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDI
                     EISTEEEKDTGDLKDSSLLKTKRKHKKKHKERHKMGEEVIPLRVLSKSEWMDLKKEYL
                     ALQKASMASLKKTISQIKSESEMETDSGVPQNTGMKNEKTANREECRTQEKVNATGPQ
                     FVSGVIVKIISTEPLPGRKQVRDTLAAISEVLYVDLLEGDTECHARFKTPEDAQAVIN
                     AYTEINKKHCWKLEILSGDHEQRYWQKILVDRQAKLNQPREKKRGTEKLITKAEKIRL
                     AKTQQASKHIRFSEYD"
     exon            307..407
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            408..491
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            492..656
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            657..750
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            751..1101
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1246
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1398
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1520
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            1521..1680
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1772
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            1773..2112
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2091..2096
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /note="hexamer: AATAAA"
     polyA_site      2112
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /note="major polyA site"
ORIGIN      
        1 gtccttgcgg aagtacgggt gccgagagaa gcagtagtca ataaagagag tgccgtattt
       61 cgcagattgg agctgagctg tggctgccag aagatagcga acgaatggaa actgaaagtg
      121 gaaatcagga aaaggtaatg gaagaagaaa gcactgaaaa gaaaaaagaa gttgaaaaaa
      181 agaaacggtc acgagttaaa caggtgcttg cagatattgc taagcaagtg gacttctggt
      241 ttggggatgc aaatcttcac aaggatagat ttcttcgaga acagatagaa aaatctagag
      301 atggatatgt tgatatatca ctacttgtgt cttttaacaa aatgaaaaaa ttgactactg
      361 atgggaagtt aattgccaga gcattgagaa gttcagctgt tgtagagctt gatttggaag
      421 gcaccagaat ccggaggaaa aaacctctgg gggaaagacc aaaggatgag gatgaacgca
      481 cagtgtatgt ggagttactt cccaaaaatg ttaatcacag ctggattgaa agagtatttg
      541 ggaaatgtgg caatgttgtt tatataagta taccacatta taagtctact ggagatccaa
      601 agggatttgc gtttgtggaa tttgaaacaa aagaacaagc agcaaaagca attgagtttc
      661 ttaacaaccc accagaagaa gcaccaagaa aacctggcat atttcctaaa acagtgaaaa
      721 ataagcccat tccagcctta agagttgtgg aagagaagaa aaagaaaaag aagaagaaag
      781 gccgaatgaa aaaggaagac aatatccaag ccaaagaaga aaacatggac acaagcaaca
      841 ccagcatcag taaaatgaaa agatccagac ccacatctga gggctctgac attgagtcca
      901 ctgaacccca aaagcagtgc tcaaagaaaa agaaaaaacg ggacagagtt gaagcatcta
      961 gcttacctga agtcagaaca gggaagagga agagaagcag ctctgaagat gcagaatccc
     1021 tagctccccg atcaaaagta aagaaaatta ttcagaaaga catcattaag gaagcatcag
     1081 aagcttccaa ggaaaataga gatatagaaa tctctactga agaggaaaag gatactggag
     1141 atctaaaaga tagctctctc ttgaaaacaa aaaggaaaca taagaaaaaa cataaagaga
     1201 gacataaaat gggagaagaa gttataccat taagagtgct atcaaagagc gaatggatgg
     1261 atttgaaaaa agagtattta gcgctacaaa aagctagcat ggcttcttta aaaaaaacaa
     1321 tatcccaaat aaaatcagag tcagaaatgg aaacagacag tggagtacct caaaacactg
     1381 gaatgaaaaa tgaaaaaaca gccaacaggg aagagtgtcg cacccaggag aaagttaatg
     1441 caacaggacc acagttcgtg agtggagtga ttgtgaagat cattagcaca gagcctctac
     1501 ctggcaggaa acaagtccgg gatactttgg cagcaatctc agaagttctt tatgttgatt
     1561 tgctagaagg ggatacagaa tgccatgcta gatttaaaac tcctgaggat gctcaagcag
     1621 taataaatgc ctatacagaa attaacaaga aacactgctg gaaactcgag atcctttctg
     1681 gtgatcacga acaaaggtat tggcagaaga ttttggttga tagacaggca aaacttaatc
     1741 agcctcggga aaagaaaaga ggcactgaaa agttaatcac caaagctgaa aagattagac
     1801 tggcaaagac tcaacaagcg agtaaacata taagattttc tgaatatgat tgaaaaaaaa
     1861 aacagttcac ctcttaatac ttcacaagat acttgagctg ttcttgggag attcactttt
     1921 attatggtag cactgcataa ttaatgtgtt tttaattaaa agaaatatct ttgttcctca
     1981 acttgtaaat aagacttttt tctagagaca aatatgatgt ataccacaat ttttcttaaa
     2041 cattttattt gttgaaatta tcttagatgt cagtgtcagg tgatttagta aataaatgtg
     2101 ttttgaacat ta
//
