LOCUS       NM_001370982            2004 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens La ribonucleoprotein 7, transcriptional regulator
            (LARP7), transcript variant 4, mRNA.
ACCESSION   NM_001370982 NR_049768
VERSION     NM_001370982.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2004)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2004)
  AUTHORS   Kao,T.L., Huang,Y.C., Chen,Y.H., Baumann,P. and Tseng,C.K.
  TITLE     LARP3, LARP7, and MePCE are involved in the early stage of human
            telomerase RNA biogenesis
  JOURNAL   Nat Commun 15 (1), 5955 (2024)
   PUBMED   39009594
  REMARK    GeneRIF: LARP3, LARP7, and MePCE are involved in the early stage of
            human telomerase RNA biogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2004)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 2004)
  AUTHORS   Zhang,J., Yu,R., Guo,X., Zou,Y., Chen,S., Zhou,K., Chen,Y., Li,Y.,
            Gao,S. and Wu,Y.
  TITLE     Identification of TYR, TYRP1, DCT and LARP7 as related biomarkers
            and immune infiltration characteristics of vitiligo via
            comprehensive strategies
  JOURNAL   Bioengineered 12 (1), 2214-2227 (2021)
   PUBMED   34107850
  REMARK    GeneRIF: Identification of TYR, TYRP1, DCT and LARP7 as related
            biomarkers and immune infiltration characteristics of vitiligo via
            comprehensive strategies.
REFERENCE   5  (bases 1 to 2004)
  AUTHORS   Yan,P., Li,Z., Xiong,J., Geng,Z., Wei,W., Zhang,Y., Wu,G.,
            Zhuang,T., Tian,X., Liu,Z., Liu,J., Sun,K., Chen,F., Zhang,Y.,
            Zeng,C., Huang,Y. and Zhang,B.
  TITLE     LARP7 ameliorates cellular senescence and aging by allosterically
            enhancing SIRT1 deacetylase activity
  JOURNAL   Cell Rep 37 (8), 110038 (2021)
   PUBMED   34818543
  REMARK    GeneRIF: LARP7 ameliorates cellular senescence and aging by
            allosterically enhancing SIRT1 deacetylase activity.
REFERENCE   6  (bases 1 to 2004)
  AUTHORS   Xue,Y., Yang,Z., Chen,R. and Zhou,Q.
  TITLE     A capping-independent function of MePCE in stabilizing 7SK snRNA
            and facilitating the assembly of 7SK snRNP
  JOURNAL   Nucleic Acids Res 38 (2), 360-369 (2010)
   PUBMED   19906723
REFERENCE   7  (bases 1 to 2004)
  AUTHORS   Markert,A., Grimm,M., Martinez,J., Wiesner,J., Meyerhans,A.,
            Meyuhas,O., Sickmann,A. and Fischer,U.
  TITLE     The La-related protein LARP7 is a component of the 7SK
            ribonucleoprotein and affects transcription of cellular and viral
            polymerase II genes
  JOURNAL   EMBO Rep 9 (6), 569-575 (2008)
   PUBMED   18483487
  REMARK    GeneRIF: Results suggest that LARP7 is a negative transcriptional
            regulator of polymerase II genes, acting by means of the 7SK RNP
            system.
REFERENCE   8  (bases 1 to 2004)
  AUTHORS   Krueger,B.J., Jeronimo,C., Roy,B.B., Bouchard,A., Barrandon,C.,
            Byers,S.A., Searcey,C.E., Cooper,J.J., Bensaude,O., Cohen,E.A.,
            Coulombe,B. and Price,D.H.
  TITLE     LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1
            and hnRNP A1 are reversibly associated
  JOURNAL   Nucleic Acids Res 36 (7), 2219-2229 (2008)
   PUBMED   18281698
  REMARK    GeneRIF: Results indicate LARP7 is a 7SK-binding protein.
REFERENCE   9  (bases 1 to 2004)
  AUTHORS   He,N., Jahchan,N.S., Hong,E., Li,Q., Bayfield,M.A., Maraia,R.J.,
            Luo,K. and Zhou,Q.
  TITLE     A La-related protein modulates 7SK snRNP integrity to suppress
            P-TEFb-dependent transcriptional elongation and tumorigenesis
  JOURNAL   Mol Cell 29 (5), 588-599 (2008)
   PUBMED   18249148
  REMARK    GeneRIF: Results identify PIP7S as a La-related protein stably
            associated with and required for 7SK snRNP integrity.
REFERENCE   10 (bases 1 to 2004)
  AUTHORS   Biewenga,P., Buist,M.R., Moerland,P.D., Ver Loren van Themaat,E.,
            van Kampen,A.H., ten Kate,F.J. and Baas,F.
  TITLE     Gene expression in early stage cervical cancer
  JOURNAL   Gynecol Oncol 108 (3), 520-526 (2008)
   PUBMED   18191186
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC106864.5.
            
            On Jun 19, 2019 this sequence version replaced NR_049768.1.
            
            Summary: This gene encodes a protein which is found in the 7SK
            snRNP (small nuclear ribonucleoprotein). This snRNP complex
            inhibits a cyclin-dependent kinase, positive transcription
            elongation factor b, which is required for paused RNA polymerase II
            at a promoter to begin transcription elongation. A pseudogene of
            this gene is located on chromosome 3. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, May 2012].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX647100.1, SRR14038197.2582505.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AC106864.5         233-329
            98-198              AC106864.5         7758-7858
            199-299             AC106864.5         9441-9541
            300-383             AC106864.5         9678-9761
            384-548             AC106864.5         9881-10045
            549-642             AC106864.5         10124-10217
            643-993             AC106864.5         10289-10639
            994-1138            AC106864.5         10780-10924
            1139-1290           AC106864.5         12625-12776
            1291-1412           AC106864.5         13551-13672
            1413-1572           AC106864.5         16167-16326
            1573-1664           AC106864.5         17158-17249
            1665-2004           AC106864.5         20337-20676
FEATURES             Location/Qualifiers
     source          1..2004
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q25"
     gene            1..2004
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /note="La ribonucleoprotein 7, transcriptional regulator"
                     /db_xref="GeneID:51574"
                     /db_xref="HGNC:HGNC:24912"
                     /db_xref="MIM:612026"
     exon            1..97
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            98..198
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            199..299
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..1745
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /note="isoform 6 is encoded by transcript variant 4;
                     P-TEFb-interaction protein for 7SK stability; La-related
                     protein 7; La ribonucleoprotein domain family member 7"
                     /codon_start=1
                     /product="la-related protein 7 isoform 6"
                     /protein_id="NP_001357911.1"
                     /db_xref="CCDS:CCDS93571.1"
                     /db_xref="GeneID:51574"
                     /db_xref="HGNC:HGNC:24912"
                     /db_xref="MIM:612026"
                     /translation="MKKLTTDGKLIARALRSSAVVELDLEGTRIRRKKPLGERPKDED
                     ERTVYVELLPKNVNHSWIERVFGKCGNVVYISIPHYKSTGDPKGFAFVEFETKEQAAK
                     AIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKKKGRMKKEDNIQAKEE
                     NMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKKKKKRDRVEASSLPEVRTGKRKR
                     SSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRDIEISTEEEKDTGDLKDSSLLKT
                     KRKHKKKHKERHKMGEEVIPLRVLSKSEWMDLKKEYLALQKASMASLKKTISQIKSES
                     EMETDSGVPQNTGMKNEKTANREECRTQEKVNATGPQFVSGVIVKIISTEPLPGRKQV
                     RDTLAAISEVLYVDLLEGDTECHARFKTPEDAQAVINAYTEINKKHCWKLEILSGDHE
                     QRYWQKILVDRQAKLNQPREKKRGTEKLITKAEKIRLAKTQQASKHIRFSEYD"
     exon            300..383
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            384..548
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            549..642
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            643..993
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1138
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1290
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1412
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1572
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1664
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            1665..2004
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1983..1988
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /note="hexamer: AATAAA"
     polyA_site      2004
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /note="major polyA site"
ORIGIN      
        1 atcctatgac gcgaaagtaa ccgagactat caggatccgg agacggaaat gtccgaaggc
       61 cgcagtactt gaccctgtat tttgggagtc gaacggagaa tggaaactga aagtggaaat
      121 caggaaaagg taatggaaga agaaagcact gaaaagaaaa aagaagttga aaaaaagaaa
      181 cggtcacgag ttaaacagat gttgatatat cactacttgt gtcttttaac aaaatgaaaa
      241 aattgactac tgatgggaag ttaattgcca gagcattgag aagttcagct gttgtagagc
      301 ttgatttgga aggcaccaga atccggagga aaaaacctct gggggaaaga ccaaaggatg
      361 aggatgaacg cacagtgtat gtggagttac ttcccaaaaa tgttaatcac agctggattg
      421 aaagagtatt tgggaaatgt ggcaatgttg tttatataag tataccacat tataagtcta
      481 ctggagatcc aaagggattt gcgtttgtgg aatttgaaac aaaagaacaa gcagcaaaag
      541 caattgagtt tcttaacaac ccaccagaag aagcaccaag aaaacctggc atatttccta
      601 aaacagtgaa aaataagccc attccagcct taagagttgt ggaagagaag aaaaagaaaa
      661 agaagaagaa aggccgaatg aaaaaggaag acaatatcca agccaaagaa gaaaacatgg
      721 acacaagcaa caccagcatc agtaaaatga aaagatccag acccacatct gagggctctg
      781 acattgagtc cactgaaccc caaaagcagt gctcaaagaa aaagaaaaaa cgggacagag
      841 ttgaagcatc tagcttacct gaagtcagaa cagggaagag gaagagaagc agctctgaag
      901 atgcagaatc cctagctccc cgatcaaaag taaagaaaat tattcagaaa gacatcatta
      961 aggaagcatc agaagcttcc aaggaaaata gagatataga aatctctact gaagaggaaa
     1021 aggatactgg agatctaaaa gatagctctc tcttgaaaac aaaaaggaaa cataagaaaa
     1081 aacataaaga gagacataaa atgggagaag aagttatacc attaagagtg ctatcaaaga
     1141 gcgaatggat ggatttgaaa aaagagtatt tagcgctaca aaaagctagc atggcttctt
     1201 taaaaaaaac aatatcccaa ataaaatcag agtcagaaat ggaaacagac agtggagtac
     1261 ctcaaaacac tggaatgaaa aatgaaaaaa cagccaacag ggaagagtgt cgcacccagg
     1321 agaaagttaa tgcaacagga ccacagttcg tgagtggagt gattgtgaag atcattagca
     1381 cagagcctct acctggcagg aaacaagtcc gggatacttt ggcagcaatc tcagaagttc
     1441 tttatgttga tttgctagaa ggggatacag aatgccatgc tagatttaaa actcctgagg
     1501 atgctcaagc agtaataaat gcctatacag aaattaacaa gaaacactgc tggaaactcg
     1561 agatcctttc tggtgatcac gaacaaaggt attggcagaa gattttggtt gatagacagg
     1621 caaaacttaa tcagcctcgg gaaaagaaaa gaggcactga aaagttaatc accaaagctg
     1681 aaaagattag actggcaaag actcaacaag cgagtaaaca tataagattt tctgaatatg
     1741 attgaaaaaa aaaacagttc acctcttaat acttcacaag atacttgagc tgttcttggg
     1801 agattcactt ttattatggt agcactgcat aattaatgtg tttttaatta aaagaaatat
     1861 ctttgttcct caacttgtaa ataagacttt tttctagaga caaatatgat gtataccaca
     1921 atttttctta aacattttat ttgttgaaat tatcttagat gtcagtgtca ggtgatttag
     1981 taaataaatg tgttttgaac atta
//
