LOCUS       NM_001370976            2143 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens La ribonucleoprotein 7, transcriptional regulator
            (LARP7), transcript variant 7, mRNA.
ACCESSION   NM_001370976
VERSION     NM_001370976.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2143)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2143)
  AUTHORS   Kao,T.L., Huang,Y.C., Chen,Y.H., Baumann,P. and Tseng,C.K.
  TITLE     LARP3, LARP7, and MePCE are involved in the early stage of human
            telomerase RNA biogenesis
  JOURNAL   Nat Commun 15 (1), 5955 (2024)
   PUBMED   39009594
  REMARK    GeneRIF: LARP3, LARP7, and MePCE are involved in the early stage of
            human telomerase RNA biogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2143)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 2143)
  AUTHORS   Zhang,J., Yu,R., Guo,X., Zou,Y., Chen,S., Zhou,K., Chen,Y., Li,Y.,
            Gao,S. and Wu,Y.
  TITLE     Identification of TYR, TYRP1, DCT and LARP7 as related biomarkers
            and immune infiltration characteristics of vitiligo via
            comprehensive strategies
  JOURNAL   Bioengineered 12 (1), 2214-2227 (2021)
   PUBMED   34107850
  REMARK    GeneRIF: Identification of TYR, TYRP1, DCT and LARP7 as related
            biomarkers and immune infiltration characteristics of vitiligo via
            comprehensive strategies.
REFERENCE   5  (bases 1 to 2143)
  AUTHORS   Yan,P., Li,Z., Xiong,J., Geng,Z., Wei,W., Zhang,Y., Wu,G.,
            Zhuang,T., Tian,X., Liu,Z., Liu,J., Sun,K., Chen,F., Zhang,Y.,
            Zeng,C., Huang,Y. and Zhang,B.
  TITLE     LARP7 ameliorates cellular senescence and aging by allosterically
            enhancing SIRT1 deacetylase activity
  JOURNAL   Cell Rep 37 (8), 110038 (2021)
   PUBMED   34818543
  REMARK    GeneRIF: LARP7 ameliorates cellular senescence and aging by
            allosterically enhancing SIRT1 deacetylase activity.
REFERENCE   6  (bases 1 to 2143)
  AUTHORS   Xue,Y., Yang,Z., Chen,R. and Zhou,Q.
  TITLE     A capping-independent function of MePCE in stabilizing 7SK snRNA
            and facilitating the assembly of 7SK snRNP
  JOURNAL   Nucleic Acids Res 38 (2), 360-369 (2010)
   PUBMED   19906723
REFERENCE   7  (bases 1 to 2143)
  AUTHORS   Markert,A., Grimm,M., Martinez,J., Wiesner,J., Meyerhans,A.,
            Meyuhas,O., Sickmann,A. and Fischer,U.
  TITLE     The La-related protein LARP7 is a component of the 7SK
            ribonucleoprotein and affects transcription of cellular and viral
            polymerase II genes
  JOURNAL   EMBO Rep 9 (6), 569-575 (2008)
   PUBMED   18483487
  REMARK    GeneRIF: Results suggest that LARP7 is a negative transcriptional
            regulator of polymerase II genes, acting by means of the 7SK RNP
            system.
REFERENCE   8  (bases 1 to 2143)
  AUTHORS   Krueger,B.J., Jeronimo,C., Roy,B.B., Bouchard,A., Barrandon,C.,
            Byers,S.A., Searcey,C.E., Cooper,J.J., Bensaude,O., Cohen,E.A.,
            Coulombe,B. and Price,D.H.
  TITLE     LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1
            and hnRNP A1 are reversibly associated
  JOURNAL   Nucleic Acids Res 36 (7), 2219-2229 (2008)
   PUBMED   18281698
  REMARK    GeneRIF: Results indicate LARP7 is a 7SK-binding protein.
REFERENCE   9  (bases 1 to 2143)
  AUTHORS   He,N., Jahchan,N.S., Hong,E., Li,Q., Bayfield,M.A., Maraia,R.J.,
            Luo,K. and Zhou,Q.
  TITLE     A La-related protein modulates 7SK snRNP integrity to suppress
            P-TEFb-dependent transcriptional elongation and tumorigenesis
  JOURNAL   Mol Cell 29 (5), 588-599 (2008)
   PUBMED   18249148
  REMARK    GeneRIF: Results identify PIP7S as a La-related protein stably
            associated with and required for 7SK snRNP integrity.
REFERENCE   10 (bases 1 to 2143)
  AUTHORS   Biewenga,P., Buist,M.R., Moerland,P.D., Ver Loren van Themaat,E.,
            van Kampen,A.H., ten Kate,F.J. and Baas,F.
  TITLE     Gene expression in early stage cervical cancer
  JOURNAL   Gynecol Oncol 108 (3), 520-526 (2008)
   PUBMED   18191186
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC106864.5.
            
            Summary: This gene encodes a protein which is found in the 7SK
            snRNP (small nuclear ribonucleoprotein). This snRNP complex
            inhibits a cyclin-dependent kinase, positive transcription
            elongation factor b, which is required for paused RNA polymerase II
            at a promoter to begin transcription elongation. A pseudogene of
            this gene is located on chromosome 3. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, May 2012].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372080.1459513.1,
                                           SRR14038194.4433134.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AC106864.5         233-329
            98-301              AC106864.5         7758-7961
            302-402             AC106864.5         9441-9541
            403-486             AC106864.5         9678-9761
            487-651             AC106864.5         9881-10045
            652-745             AC106864.5         10124-10217
            746-1093            AC106864.5         10292-10639
            1094-1277           AC106864.5         10741-10924
            1278-1429           AC106864.5         12625-12776
            1430-1551           AC106864.5         13551-13672
            1552-1711           AC106864.5         16167-16326
            1712-1803           AC106864.5         17158-17249
            1804-2143           AC106864.5         20337-20676
FEATURES             Location/Qualifiers
     source          1..2143
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q25"
     gene            1..2143
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /note="La ribonucleoprotein 7, transcriptional regulator"
                     /db_xref="GeneID:51574"
                     /db_xref="HGNC:HGNC:24912"
                     /db_xref="MIM:612026"
     exon            1..97
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            98..301
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1884
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /note="isoform 4 is encoded by transcript variant 7;
                     P-TEFb-interaction protein for 7SK stability; La-related
                     protein 7; La ribonucleoprotein domain family member 7"
                     /codon_start=1
                     /product="la-related protein 7 isoform 4"
                     /protein_id="NP_001357905.1"
                     /db_xref="CCDS:CCDS93569.1"
                     /db_xref="GeneID:51574"
                     /db_xref="HGNC:HGNC:24912"
                     /db_xref="MIM:612026"
                     /translation="METESGNQEKVMEEESTEKKKEVEKKKRSRVKQVLADIAKQVDF
                     WFGDANLHKDRFLREQIEKSRDGYVDISLLVSFNKMKKLTTDGKLIARALRSSAVVEL
                     DLEGTRIRRKKPLGERPKDEDERTVYVELLPKNVNHSWIERVFGKCGNVVYISIPHYK
                     STGDPKGFAFVEFETKEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEKK
                     KKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKKKK
                     KRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRAPC
                     LNGELFYLFQDIEISTEEEKDTGDLKDSSLLKTKRKHKKKHKERHKMGEEVIPLRVLS
                     KSEWMDLKKEYLALQKASMASLKKTISQIKSESEMETDSGVPQNTGMKNEKTANREEC
                     RTQEKVNATGPQFVSGVIVKIISTEPLPGRKQVRDTLAAISEVLYVDLLEGDTECHAR
                     FKTPEDAQAVINAYTEINKKHCWKLEILSGDHEQRYWQKILVDRQAKLNQPREKKRGT
                     EKLITKAEKIRLAKTQQASKHIRFSEYD"
     exon            302..402
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            403..486
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            487..651
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            652..745
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            746..1093
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1277
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1429
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1551
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..1711
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1803
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..2143
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2122..2127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /note="hexamer: AATAAA"
     polyA_site      2143
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /note="major polyA site"
ORIGIN      
        1 atcctatgac gcgaaagtaa ccgagactat caggatccgg agacggaaat gtccgaaggc
       61 cgcagtactt gaccctgtat tttgggagtc gaacggagaa tggaaactga aagtggaaat
      121 caggaaaagg taatggaaga agaaagcact gaaaagaaaa aagaagttga aaaaaagaaa
      181 cggtcacgag ttaaacaggt gcttgcagat attgctaagc aagtggactt ctggtttggg
      241 gatgcaaatc ttcacaagga tagatttctt cgagaacaga tagaaaaatc tagagatgga
      301 tatgttgata tatcactact tgtgtctttt aacaaaatga aaaaattgac tactgatggg
      361 aagttaattg ccagagcatt gagaagttca gctgttgtag agcttgattt ggaaggcacc
      421 agaatccgga ggaaaaaacc tctgggggaa agaccaaagg atgaggatga acgcacagtg
      481 tatgtggagt tacttcccaa aaatgttaat cacagctgga ttgaaagagt atttgggaaa
      541 tgtggcaatg ttgtttatat aagtatacca cattataagt ctactggaga tccaaaggga
      601 tttgcgtttg tggaatttga aacaaaagaa caagcagcaa aagcaattga gtttcttaac
      661 aacccaccag aagaagcacc aagaaaacct ggcatatttc ctaaaacagt gaaaaataag
      721 cccattccag ccttaagagt tgtggagaag aaaaagaaaa agaagaagaa aggccgaatg
      781 aaaaaggaag acaatatcca agccaaagaa gaaaacatgg acacaagcaa caccagcatc
      841 agtaaaatga aaagatccag acccacatct gagggctctg acattgagtc cactgaaccc
      901 caaaagcagt gctcaaagaa aaagaaaaaa cgggacagag ttgaagcatc tagcttacct
      961 gaagtcagaa cagggaagag gaagagaagc agctctgaag atgcagaatc cctagctccc
     1021 cgatcaaaag taaagaaaat tattcagaaa gacatcatta aggaagcatc agaagcttcc
     1081 aaggaaaata gagccccatg tcttaacgga gagctttttt atttatttca agatatagaa
     1141 atctctactg aagaggaaaa ggatactgga gatctaaaag atagctctct cttgaaaaca
     1201 aaaaggaaac ataagaaaaa acataaagag agacataaaa tgggagaaga agttatacca
     1261 ttaagagtgc tatcaaagag cgaatggatg gatttgaaaa aagagtattt agcgctacaa
     1321 aaagctagca tggcttcttt aaaaaaaaca atatcccaaa taaaatcaga gtcagaaatg
     1381 gaaacagaca gtggagtacc tcaaaacact ggaatgaaaa atgaaaaaac agccaacagg
     1441 gaagagtgtc gcacccagga gaaagttaat gcaacaggac cacagttcgt gagtggagtg
     1501 attgtgaaga tcattagcac agagcctcta cctggcagga aacaagtccg ggatactttg
     1561 gcagcaatct cagaagttct ttatgttgat ttgctagaag gggatacaga atgccatgct
     1621 agatttaaaa ctcctgagga tgctcaagca gtaataaatg cctatacaga aattaacaag
     1681 aaacactgct ggaaactcga gatcctttct ggtgatcacg aacaaaggta ttggcagaag
     1741 attttggttg atagacaggc aaaacttaat cagcctcggg aaaagaaaag aggcactgaa
     1801 aagttaatca ccaaagctga aaagattaga ctggcaaaga ctcaacaagc gagtaaacat
     1861 ataagatttt ctgaatatga ttgaaaaaaa aaacagttca cctcttaata cttcacaaga
     1921 tacttgagct gttcttggga gattcacttt tattatggta gcactgcata attaatgtgt
     1981 ttttaattaa aagaaatatc tttgttcctc aacttgtaaa taagactttt ttctagagac
     2041 aaatatgatg tataccacaa tttttcttaa acattttatt tgttgaaatt atcttagatg
     2101 tcagtgtcag gtgatttagt aaataaatgt gttttgaaca tta
//
