LOCUS       NM_001370975            2151 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens La ribonucleoprotein 7, transcriptional regulator
            (LARP7), transcript variant 6, mRNA.
ACCESSION   NM_001370975 XM_024454081
VERSION     NM_001370975.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2151)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2151)
  AUTHORS   Kao,T.L., Huang,Y.C., Chen,Y.H., Baumann,P. and Tseng,C.K.
  TITLE     LARP3, LARP7, and MePCE are involved in the early stage of human
            telomerase RNA biogenesis
  JOURNAL   Nat Commun 15 (1), 5955 (2024)
   PUBMED   39009594
  REMARK    GeneRIF: LARP3, LARP7, and MePCE are involved in the early stage of
            human telomerase RNA biogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2151)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 2151)
  AUTHORS   Zhang,J., Yu,R., Guo,X., Zou,Y., Chen,S., Zhou,K., Chen,Y., Li,Y.,
            Gao,S. and Wu,Y.
  TITLE     Identification of TYR, TYRP1, DCT and LARP7 as related biomarkers
            and immune infiltration characteristics of vitiligo via
            comprehensive strategies
  JOURNAL   Bioengineered 12 (1), 2214-2227 (2021)
   PUBMED   34107850
  REMARK    GeneRIF: Identification of TYR, TYRP1, DCT and LARP7 as related
            biomarkers and immune infiltration characteristics of vitiligo via
            comprehensive strategies.
REFERENCE   5  (bases 1 to 2151)
  AUTHORS   Yan,P., Li,Z., Xiong,J., Geng,Z., Wei,W., Zhang,Y., Wu,G.,
            Zhuang,T., Tian,X., Liu,Z., Liu,J., Sun,K., Chen,F., Zhang,Y.,
            Zeng,C., Huang,Y. and Zhang,B.
  TITLE     LARP7 ameliorates cellular senescence and aging by allosterically
            enhancing SIRT1 deacetylase activity
  JOURNAL   Cell Rep 37 (8), 110038 (2021)
   PUBMED   34818543
  REMARK    GeneRIF: LARP7 ameliorates cellular senescence and aging by
            allosterically enhancing SIRT1 deacetylase activity.
REFERENCE   6  (bases 1 to 2151)
  AUTHORS   Xue,Y., Yang,Z., Chen,R. and Zhou,Q.
  TITLE     A capping-independent function of MePCE in stabilizing 7SK snRNA
            and facilitating the assembly of 7SK snRNP
  JOURNAL   Nucleic Acids Res 38 (2), 360-369 (2010)
   PUBMED   19906723
REFERENCE   7  (bases 1 to 2151)
  AUTHORS   Markert,A., Grimm,M., Martinez,J., Wiesner,J., Meyerhans,A.,
            Meyuhas,O., Sickmann,A. and Fischer,U.
  TITLE     The La-related protein LARP7 is a component of the 7SK
            ribonucleoprotein and affects transcription of cellular and viral
            polymerase II genes
  JOURNAL   EMBO Rep 9 (6), 569-575 (2008)
   PUBMED   18483487
  REMARK    GeneRIF: Results suggest that LARP7 is a negative transcriptional
            regulator of polymerase II genes, acting by means of the 7SK RNP
            system.
REFERENCE   8  (bases 1 to 2151)
  AUTHORS   Krueger,B.J., Jeronimo,C., Roy,B.B., Bouchard,A., Barrandon,C.,
            Byers,S.A., Searcey,C.E., Cooper,J.J., Bensaude,O., Cohen,E.A.,
            Coulombe,B. and Price,D.H.
  TITLE     LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1
            and hnRNP A1 are reversibly associated
  JOURNAL   Nucleic Acids Res 36 (7), 2219-2229 (2008)
   PUBMED   18281698
  REMARK    GeneRIF: Results indicate LARP7 is a 7SK-binding protein.
REFERENCE   9  (bases 1 to 2151)
  AUTHORS   He,N., Jahchan,N.S., Hong,E., Li,Q., Bayfield,M.A., Maraia,R.J.,
            Luo,K. and Zhou,Q.
  TITLE     A La-related protein modulates 7SK snRNP integrity to suppress
            P-TEFb-dependent transcriptional elongation and tumorigenesis
  JOURNAL   Mol Cell 29 (5), 588-599 (2008)
   PUBMED   18249148
  REMARK    GeneRIF: Results identify PIP7S as a La-related protein stably
            associated with and required for 7SK snRNP integrity.
REFERENCE   10 (bases 1 to 2151)
  AUTHORS   Biewenga,P., Buist,M.R., Moerland,P.D., Ver Loren van Themaat,E.,
            van Kampen,A.H., ten Kate,F.J. and Baas,F.
  TITLE     Gene expression in early stage cervical cancer
  JOURNAL   Gynecol Oncol 108 (3), 520-526 (2008)
   PUBMED   18191186
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC106864.5.
            
            On Jun 19, 2019 this sequence version replaced XM_024454081.1.
            
            Summary: This gene encodes a protein which is found in the 7SK
            snRNP (small nuclear ribonucleoprotein). This snRNP complex
            inhibits a cyclin-dependent kinase, positive transcription
            elongation factor b, which is required for paused RNA polymerase II
            at a promoter to begin transcription elongation. A pseudogene of
            this gene is located on chromosome 3. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, May 2012].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.2944920.1,
                                           SRR14038194.3905125.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-102               AC106864.5         592-693
            103-306             AC106864.5         7758-7961
            307-407             AC106864.5         9441-9541
            408-491             AC106864.5         9678-9761
            492-656             AC106864.5         9881-10045
            657-750             AC106864.5         10124-10217
            751-1101            AC106864.5         10289-10639
            1102-1285           AC106864.5         10741-10924
            1286-1437           AC106864.5         12625-12776
            1438-1559           AC106864.5         13551-13672
            1560-1719           AC106864.5         16167-16326
            1720-1811           AC106864.5         17158-17249
            1812-2151           AC106864.5         20337-20676
FEATURES             Location/Qualifiers
     source          1..2151
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q25"
     gene            1..2151
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /note="La ribonucleoprotein 7, transcriptional regulator"
                     /db_xref="GeneID:51574"
                     /db_xref="HGNC:HGNC:24912"
                     /db_xref="MIM:612026"
     exon            1..102
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            103..306
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..1892
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /note="isoform 3 is encoded by transcript variant 6;
                     P-TEFb-interaction protein for 7SK stability; La-related
                     protein 7; La ribonucleoprotein domain family member 7"
                     /codon_start=1
                     /product="la-related protein 7 isoform 3"
                     /protein_id="NP_001357904.1"
                     /db_xref="CCDS:CCDS93568.1"
                     /db_xref="GeneID:51574"
                     /db_xref="HGNC:HGNC:24912"
                     /db_xref="MIM:612026"
                     /translation="METESGNQEKVMEEESTEKKKEVEKKKRSRVKQVLADIAKQVDF
                     WFGDANLHKDRFLREQIEKSRDGYVDISLLVSFNKMKKLTTDGKLIARALRSSAVVEL
                     DLEGTRIRRKKPLGERPKDEDERTVYVELLPKNVNHSWIERVFGKCGNVVYISIPHYK
                     STGDPKGFAFVEFETKEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEK
                     KKKKKKKGRMKKEDNIQAKEENMDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKKK
                     KKRDRVEASSLPEVRTGKRKRSSSEDAESLAPRSKVKKIIQKDIIKEASEASKENRAP
                     CLNGELFYLFQDIEISTEEEKDTGDLKDSSLLKTKRKHKKKHKERHKMGEEVIPLRVL
                     SKSEWMDLKKEYLALQKASMASLKKTISQIKSESEMETDSGVPQNTGMKNEKTANREE
                     CRTQEKVNATGPQFVSGVIVKIISTEPLPGRKQVRDTLAAISEVLYVDLLEGDTECHA
                     RFKTPEDAQAVINAYTEINKKHCWKLEILSGDHEQRYWQKILVDRQAKLNQPREKKRG
                     TEKLITKAEKIRLAKTQQASKHIRFSEYD"
     exon            307..407
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            408..491
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            492..656
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            657..750
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            751..1101
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1285
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1437
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1559
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1719
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            1720..1811
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..2151
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2130..2135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /note="hexamer: AATAAA"
     polyA_site      2151
                     /gene="LARP7"
                     /gene_synonym="ALAZS; HDCMA18P; hLARP7; PIP7S"
                     /note="major polyA site"
ORIGIN      
        1 gtccttgcgg aagtacgggt gccgagagaa gcagtagtca ataaagagag tgccgtattt
       61 cgcagattgg agctgagctg tggctgccag aagatagcga acgaatggaa actgaaagtg
      121 gaaatcagga aaaggtaatg gaagaagaaa gcactgaaaa gaaaaaagaa gttgaaaaaa
      181 agaaacggtc acgagttaaa caggtgcttg cagatattgc taagcaagtg gacttctggt
      241 ttggggatgc aaatcttcac aaggatagat ttcttcgaga acagatagaa aaatctagag
      301 atggatatgt tgatatatca ctacttgtgt cttttaacaa aatgaaaaaa ttgactactg
      361 atgggaagtt aattgccaga gcattgagaa gttcagctgt tgtagagctt gatttggaag
      421 gcaccagaat ccggaggaaa aaacctctgg gggaaagacc aaaggatgag gatgaacgca
      481 cagtgtatgt ggagttactt cccaaaaatg ttaatcacag ctggattgaa agagtatttg
      541 ggaaatgtgg caatgttgtt tatataagta taccacatta taagtctact ggagatccaa
      601 agggatttgc gtttgtggaa tttgaaacaa aagaacaagc agcaaaagca attgagtttc
      661 ttaacaaccc accagaagaa gcaccaagaa aacctggcat atttcctaaa acagtgaaaa
      721 ataagcccat tccagcctta agagttgtgg aagagaagaa aaagaaaaag aagaagaaag
      781 gccgaatgaa aaaggaagac aatatccaag ccaaagaaga aaacatggac acaagcaaca
      841 ccagcatcag taaaatgaaa agatccagac ccacatctga gggctctgac attgagtcca
      901 ctgaacccca aaagcagtgc tcaaagaaaa agaaaaaacg ggacagagtt gaagcatcta
      961 gcttacctga agtcagaaca gggaagagga agagaagcag ctctgaagat gcagaatccc
     1021 tagctccccg atcaaaagta aagaaaatta ttcagaaaga catcattaag gaagcatcag
     1081 aagcttccaa ggaaaataga gccccatgtc ttaacggaga gcttttttat ttatttcaag
     1141 atatagaaat ctctactgaa gaggaaaagg atactggaga tctaaaagat agctctctct
     1201 tgaaaacaaa aaggaaacat aagaaaaaac ataaagagag acataaaatg ggagaagaag
     1261 ttataccatt aagagtgcta tcaaagagcg aatggatgga tttgaaaaaa gagtatttag
     1321 cgctacaaaa agctagcatg gcttctttaa aaaaaacaat atcccaaata aaatcagagt
     1381 cagaaatgga aacagacagt ggagtacctc aaaacactgg aatgaaaaat gaaaaaacag
     1441 ccaacaggga agagtgtcgc acccaggaga aagttaatgc aacaggacca cagttcgtga
     1501 gtggagtgat tgtgaagatc attagcacag agcctctacc tggcaggaaa caagtccggg
     1561 atactttggc agcaatctca gaagttcttt atgttgattt gctagaaggg gatacagaat
     1621 gccatgctag atttaaaact cctgaggatg ctcaagcagt aataaatgcc tatacagaaa
     1681 ttaacaagaa acactgctgg aaactcgaga tcctttctgg tgatcacgaa caaaggtatt
     1741 ggcagaagat tttggttgat agacaggcaa aacttaatca gcctcgggaa aagaaaagag
     1801 gcactgaaaa gttaatcacc aaagctgaaa agattagact ggcaaagact caacaagcga
     1861 gtaaacatat aagattttct gaatatgatt gaaaaaaaaa acagttcacc tcttaatact
     1921 tcacaagata cttgagctgt tcttgggaga ttcactttta ttatggtagc actgcataat
     1981 taatgtgttt ttaattaaaa gaaatatctt tgttcctcaa cttgtaaata agactttttt
     2041 ctagagacaa atatgatgta taccacaatt tttcttaaac attttatttg ttgaaattat
     2101 cttagatgtc agtgtcaggt gatttagtaa ataaatgtgt tttgaacatt a
//
