LOCUS       NM_018357               4467 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens La ribonucleoprotein 6, translational regulator
            (LARP6), transcript variant 1, mRNA.
ACCESSION   NM_018357
VERSION     NM_018357.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4467)
  AUTHORS   Long,X., Liu,X., Deng,T., Chen,J., Lan,J., Zhang,S., Zhou,M.,
            Guo,D. and Zhou,J.
  TITLE     LARP6 suppresses colorectal cancer progression through
            ZNF267/SGMS2-mediated imbalance of sphingomyelin synthesis
  JOURNAL   J Exp Clin Cancer Res 42 (1), 33 (2023)
   PUBMED   36691044
  REMARK    GeneRIF: LARP6 suppresses colorectal cancer progression through
            ZNF267/SGMS2-mediated imbalance of sphingomyelin synthesis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4467)
  AUTHORS   Chen,L., Su,Y., Yin,B., Li,S., Cheng,X., He,Y. and Jia,C.
  TITLE     LARP6 Regulates Keloid Fibroblast Proliferation, Invasion, and
            Ability to Synthesize Collagen
  JOURNAL   J Invest Dermatol 142 (9), 2395-2405 (2022)
   PUBMED   35176288
  REMARK    GeneRIF: LARP6 Regulates Keloid Fibroblast Proliferation, Invasion,
            and Ability to Synthesize Collagen.
REFERENCE   3  (bases 1 to 4467)
  AUTHORS   Stefanovic,L., Gordon,B.H., Silvers,R. and Stefanovic,B.
  TITLE     Characterization of Sequence-Specific Binding of LARP6 to the 5'
            Stem-Loop of Type I Collagen mRNAs and Implications for Rational
            Design of Antifibrotic Drugs
  JOURNAL   J Mol Biol 434 (2), 167394 (2022)
   PUBMED   34896113
  REMARK    GeneRIF: Characterization of Sequence-Specific Binding of LARP6 to
            the 5' Stem-Loop of Type I Collagen mRNAs and Implications for
            Rational Design of Antifibrotic Drugs.
REFERENCE   4  (bases 1 to 4467)
  AUTHORS   Maraia,R.J., Mattijssen,S., Cruz-Gallardo,I. and Conte,M.R.
  TITLE     The La and related RNA-binding proteins (LARPs): structures,
            functions, and evolving perspectives
  JOURNAL   Wiley Interdiscip Rev RNA 8 (6) (2017)
   PUBMED   28782243
  REMARK    GeneRIF: A cytoplasmic isoform of La protein as well as LARPs 6, 4,
            and 1 function in mRNA metabolism and translation in distinct but
            similar ways, sometimes with the poly(A)-binding protein, and in
            some cases by direct binding to poly(A)-RNA.
            Review article
REFERENCE   5  (bases 1 to 4467)
  AUTHORS   Zhang,Y. and Stefanovic,B.
  TITLE     mTORC1 phosphorylates LARP6 to stimulate type I collagen expression
  JOURNAL   Sci Rep 7, 41173 (2017)
   PUBMED   28112218
  REMARK    GeneRIF: Study shows that mTORC1 phosphorylates La
            ribonucleoprotein domain family, member 6 to stimulate type I
            collagen expression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4467)
  AUTHORS   Shao,R., Scully,S.J. Jr., Yan,W., Bentley,B., Mueller,J., Brown,C.,
            Bigelow,C. and Schwartz,L.M.
  TITLE     The novel lupus antigen related protein acheron enhances the
            development of human breast cancer
  JOURNAL   Int J Cancer 130 (3), 544-554 (2012)
   PUBMED   21387291
  REMARK    GeneRIF: Achn enhances human breast tumor growth and
            vascularization and that this activity is dependent on nuclear
            localization.
REFERENCE   7  (bases 1 to 4467)
  AUTHORS   Cai,L., Fritz,D., Stefanovic,L. and Stefanovic,B.
  TITLE     Nonmuscle myosin-dependent synthesis of type I collagen
  JOURNAL   J Mol Biol 401 (4), 564-578 (2010)
   PUBMED   20603131
  REMARK    Erratum:[J Mol Biol. 2016 Oct 9;428(20):4242-4243. doi:
            10.1016/j.jmb.2016.07.011.. PMID: 27485541]
REFERENCE   8  (bases 1 to 4467)
  AUTHORS   Cai,L., Fritz,D., Stefanovic,L. and Stefanovic,B.
  TITLE     Binding of LARP6 to the conserved 5' stem-loop regulates
            translation of mRNAs encoding type I collagen
  JOURNAL   J Mol Biol 395 (2), 309-326 (2010)
   PUBMED   19917293
  REMARK    GeneRIF: LARP6 has a distinctive bipartite RNA binding domain not
            found in other members of the La superfamily. LARP6 interacts with
            the two single-stranded regions of the 5' stem-loop.
REFERENCE   9  (bases 1 to 4467)
  AUTHORS   Glenn,H.L., Wang,Z. and Schwartz,L.M.
  TITLE     Acheron, a Lupus antigen family member, regulates integrin
            expression, adhesion, and motility in differentiating myoblasts
  JOURNAL   Am J Physiol Cell Physiol 298 (1), C46-C55 (2010)
   PUBMED   19889961
  REMARK    GeneRIF: Acheron may influence differentiation in part via its
            control of cell adhesion dynamics.
REFERENCE   10 (bases 1 to 4467)
  AUTHORS   Valavanis,C., Wang,Z., Sun,D., Vaine,M. and Schwartz,L.M.
  TITLE     Acheron, a novel member of the Lupus Antigen family, is induced
            during the programmed cell death of skeletal muscles in the moth
            Manduca sexta
  JOURNAL   Gene 393 (1-2), 101-109 (2007)
   PUBMED   17383118
  REMARK    GeneRIF: These data define Achn as a newly discovered regulatory
            molecule that presumably mediates a variety of developmental and
            homeostatic processes in animals.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DN992782.1, AL833876.1, AI376944.1 and AC009269.6.
            
            On May 17, 2019 this sequence version replaced NM_018357.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.108123.1,
                                           SRR1660805.195089.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2152568, SAMEA2155974
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299213.10/ ENSP00000299213.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                DN992782.1         114-151
            39-2047             AL833876.1         1-2009
            2048-2073           AI376944.1         7-32                c
            2074-4467           AC009269.6         18027-20420
FEATURES             Location/Qualifiers
     source          1..4467
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q23"
     gene            1..4467
                     /gene="LARP6"
                     /gene_synonym="ACHN"
                     /note="La ribonucleoprotein 6, translational regulator"
                     /db_xref="GeneID:55323"
                     /db_xref="HGNC:HGNC:24012"
                     /db_xref="MIM:611300"
     exon            1..269
                     /gene="LARP6"
                     /gene_synonym="ACHN"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..1545
                     /gene="LARP6"
                     /gene_synonym="ACHN"
                     /note="isoform 1 is encoded by transcript variant 1;
                     la-related protein 6; acheron; death-associated LA motif
                     protein; La ribonucleoprotein domain family member 6"
                     /codon_start=1
                     /product="la-related protein 6 isoform 1"
                     /protein_id="NP_060827.2"
                     /db_xref="CCDS:CCDS32281.1"
                     /db_xref="GeneID:55323"
                     /db_xref="HGNC:HGNC:24012"
                     /db_xref="MIM:611300"
                     /translation="MAQSGGEARPGPKTAVQIRVAIQEAEDVDELEDEEEGAETRGAG
                     DPARYLSPGWGSASEEEPSRGHSGTTASGGENEREDLEQEWKPPDEELIKKLVDQIEF
                     YFSDENLEKDAFLLKHVRRNKLGYVSVKLLTSFKKVKHLTRDWRTTAHALKYSVVLEL
                     NEDHRKVRRTTPVPLFPNENLPSKMLLVYDLYLSPKLWALATPQKNGRVQEKVMEHLL
                     KLFGTFGVISSVRILKPGRELPPDIRRISSRYSQVGTQECAIVEFEEVEAAIKAHEFM
                     ITESQGKENMKAVLIGMKPPKKKPAKDKNHDEEPTASIHLNKSLNKRVEELQYMGDES
                     SANSSSDPESNPTSPMAGRRHAATNKLSPSGHQNLFLSPNASPCTSPWSSPLAQRKGV
                     SRKSPLAEEGRLNCSTSPEIFRKCMDYSSDSSVTPSGSPWVRRRRQAEMGTQEKSPGT
                     SPLLSRKMQTADGLPVGVLRLPRGPDNTRGFHGHERSRACV"
     exon            270..480
                     /gene="LARP6"
                     /gene_synonym="ACHN"
                     /inference="alignment:Splign:2.1.0"
     exon            481..4467
                     /gene="LARP6"
                     /gene_synonym="ACHN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2027..2032
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LARP6"
                     /gene_synonym="ACHN"
                     /note="hexamer: AATAAA"
     regulatory      2034..2039
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LARP6"
                     /gene_synonym="ACHN"
                     /note="hexamer: AATAAA"
     polyA_site      2044
                     /gene="LARP6"
                     /gene_synonym="ACHN"
     polyA_site      2047
                     /gene="LARP6"
                     /gene_synonym="ACHN"
                     /note="major polyA site"
ORIGIN      
        1 agtcgctgcc gaccggctgg ctgggccttg cggcgtgagg accccggcgg cgccgcagtc
       61 ccgcgagcca tggcccagtc cggcggggag gctcggcccg ggcccaagac ggcggtgcag
      121 atccgcgtcg ccatccagga ggccgaggac gtggacgagt tggaggacga ggaggagggg
      181 gcggagactc ggggcgccgg ggacccggcc cggtacctca gccccggctg gggcagcgcg
      241 agcgaggagg agccgagccg cgggcacagt ggcaccactg caagtggagg tgagaacgag
      301 cgtgaggacc tggagcagga gtggaagccc ccggatgagg agttgatcaa gaaactggtg
      361 gatcagatcg aattctactt ttctgatgaa aacctggaga aggacgcctt tttgctaaaa
      421 cacgtgagga ggaacaagct gggatatgtg agcgttaagc tactcacatc cttcaaaaag
      481 gtgaaacatc ttacacggga ctggagaacc acagcacatg ctttgaagta ttcagtggtc
      541 cttgagttga atgaggacca ccggaaggtg aggaggacca cccccgtccc actgttcccc
      601 aacgagaacc tccccagcaa gatgctcctg gtctatgatc tctacttgtc tcctaagctg
      661 tgggctctgg ccacccccca gaagaatgga agggtgcaag agaaggtgat ggaacacctg
      721 ctcaagcttt ttgggacttt tggagtcatc tcatcagtgc ggatcctcaa acctgggaga
      781 gagctgcccc ctgacatccg gaggatcagc agccgctaca gccaagtggg gacccaggag
      841 tgcgccatcg tggagttcga ggaggtggaa gcagccatca aagcccatga gttcatgatc
      901 acagaatctc agggcaaaga gaacatgaaa gctgtcctga ttggtatgaa gccacccaaa
      961 aagaaacctg ccaaagacaa aaatcatgac gaggagccca ctgcgagcat ccacctgaac
     1021 aagtccctga acaagagagt cgaggagctt cagtacatgg gtgatgagtc ttctgccaac
     1081 agctcctctg accccgagag caaccccaca tcccctatgg cgggccgacg gcacgcggcc
     1141 accaacaagc tcagcccgtc tggccaccag aatctctttc tgagtccaaa tgcctccccg
     1201 tgcacaagtc cttggagcag ccccttggcc caacgcaaag gcgtttccag aaagtcccca
     1261 ctggcggagg aaggtagact gaactgcagc accagccctg agatcttccg caagtgtatg
     1321 gattattcct ctgacagcag cgtcactccc tctggcagcc cctgggtccg gaggcgtcgc
     1381 caagccgaga tggggaccca ggagaaaagc cccggtacga gtcccctgct ctcccggaag
     1441 atgcagactg cagatgggct acccgtaggg gtgctgaggt tgcccagggg tcctgacaac
     1501 accagaggat ttcatggcca tgagaggagc agggcctgtg tataaatacc ttctattttt
     1561 aatacaagct ccactgaaaa ccaccttcgt tttcaaggtt ctgacaaaca cctggcatga
     1621 cagaatggaa ttcgttcccc tttgagagat tttttattca tgtagacctc ttaatttatc
     1681 tatctgtaat atacataaat cggtacgcca tggtttgaag accaccttct agttcaggac
     1741 tcctgttctt cccagcatgg ccactatttt gatgatggct gatgtgtgtg agtgtgatgg
     1801 ccctgaaggg ctgtaggacg gaggttccct gggggaagtc tgttctttgg tatggaattt
     1861 ttctctcttc tttggtatgg aatttttccc ttcagtgact gagctgtcct cgataggcca
     1921 tgcaagggct tcctgagagt tcaggaaagt tctcttgtgc aacagcaagt agctaagcct
     1981 atagcatggt gtcttgtagg accaaatcga tgttacctgt caagtaaata aataataaaa
     2041 cacccaactg ggagtgctga ctttgaggtt atagattgtg cctgacaaaa gtctgtgcct
     2101 gtctgacaga gctgtgggtg gtatgtcatg aggccctgag gagcttagca gagacatctt
     2161 tcttttcttt aagagaacat ttaaaaattt ttttatttgt acacatttat gggctacatg
     2221 agaaactttg ttacatgttt ataatgcata gtgatcaagt cagggcattt agggtttctc
     2281 actgtacccc agggcagccc cagggctctc cttgggcttc tggcagcctg agtggtgtct
     2341 catcacaggg aattttactg agcaaaggca gcttggcgta tactgagggt gtacagtcca
     2401 ggacccacag cattgatctc acctgggaac ttattagaaa tccagattct caggccaacc
     2461 ctaggcccac tgaattagaa agtctgggag aaaggcctgg aatttgggtt ttaacaaacg
     2521 ctgcaggtga ttctgatgca cgctggagaa ccactggatg gacaaaggct gcaggacttg
     2581 aggtcagtcc atttgacccc caatctctca ctattttgtg accttgggaa ggttactaag
     2641 ccccgtgaac ctcatcatct ccctgtgaat tgctttgtta cgatgtccat gtctggaatg
     2701 cagctggccc tccataaatg ttagctctct ttccttctca cttgggttaa tgtttgttat
     2761 catcaggagc tgccttggtg tagcagaaag agcattggcc tagattccag tgttggctta
     2821 tgctctggct atttggcagg atttaataga gcttgttaat aattattgaa cagtgattag
     2881 gtgccaggga ctatgctaag agctttccat gcattatctc atttaatctg cccaaaaact
     2941 acaagagaaa tgttcaggta ttatctctat tttattccag aaaaaaacag actttacttg
     3001 ggtaattaac ttgtctaagg cttaacagct aaattggtag agttgggctt gaaactagtg
     3061 gtctggcttt ggagcccaca ctgtttaacc actaagtggt actcaacatt tctgatcttt
     3121 actatccata ttcaaaaaag aatccaccat aaaaggtgct aatatttatt cagcaccttc
     3181 ctacgtgcta ggcattgggt tagacacatt tcacttactc tcagtgtcca tcataaggaa
     3241 ttattatgcc agtatcacac atgcagctgc tgaagtagga aaataatatc ccaaacttgt
     3301 gaaaatggac aaagatagta tatcctaaat gatatggctc tatacaaatt agcaggtgat
     3361 tgtgatctgg atagtaagat gctttgtccc ttaagatgca gaagagttcg tgttaactgg
     3421 caaatgcctc cagcaatgtt ctggatttgc catttccagc actaccagct gtaggtagcc
     3481 tgaaggcttg tgcctagacc accaggactc ctgaccttgg gcaatgtcag ggccccctcc
     3541 agccccgccc tatgcttccc tccctgactc tgctcccatc accccctgcc tgctccttcc
     3601 ctgcagccac tccacctgct ccttggccat cgggccatct gggcttcacc agctcttctt
     3661 ggcctgtgac attcaaggct gttccaccct attatgcctg ttacacaagt cacagctcta
     3721 tttttagatt aaccctcgtg gatcatagtt acttttaaaa atacctacac cctcaccttt
     3781 acatgtgaat acagatgaac ttggccttcc tttggtcgta ttgccctgtg tgacattata
     3841 aaagaaccct gaagtggggg tcagcagatc tgaggtcgag tcgtggcttt tctactaagc
     3901 aactgtgacc ttcagcaagt catttatttt attggttcac agttcttccc acaaaccagt
     3961 ggataacaag aagatgttcc ttaaataagg tcatatatgt gcaagtgctt tctgaatgga
     4021 aaagtgcttt gcaggcatta gtcactactt atcctgctgt ctgatcatca cctccaaagg
     4081 caagcctcct tttgctgcaa ttcttaaccc tggcctcaca ttagagtcac ctaaagagct
     4141 tttaaaaact gcctatgggg ctgggcacgg tggctcacgc ctgtaatccc agcacttcag
     4201 gagactgagg cgggcagatc atgaggtcag gagattgaga ctatcctggc taatgtggta
     4261 aaaccctgtc tctactaaaa atacaaaaaa attagccggg catggtggca cgcacctgta
     4321 atcccagcta cttgggaggc ggaggcagga gaattgcttg aacctgggag gcggaggttg
     4381 cagtgagccg agatcacgcc gctgcattcc agcctgggca acagaatgag actccatctc
     4441 aaaaaaataa aaataaaaat aaacaaa
//
