LOCUS       NP_060827                491 aa            linear   PRI 28-APR-2025
DEFINITION  la-related protein 6 isoform 1 [Homo sapiens].
ACCESSION   NP_060827
VERSION     NP_060827.2
DBSOURCE    REFSEQ: accession NM_018357.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 491)
  AUTHORS   Long,X., Liu,X., Deng,T., Chen,J., Lan,J., Zhang,S., Zhou,M.,
            Guo,D. and Zhou,J.
  TITLE     LARP6 suppresses colorectal cancer progression through
            ZNF267/SGMS2-mediated imbalance of sphingomyelin synthesis
  JOURNAL   J Exp Clin Cancer Res 42 (1), 33 (2023)
   PUBMED   36691044
  REMARK    GeneRIF: LARP6 suppresses colorectal cancer progression through
            ZNF267/SGMS2-mediated imbalance of sphingomyelin synthesis.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 491)
  AUTHORS   Chen,L., Su,Y., Yin,B., Li,S., Cheng,X., He,Y. and Jia,C.
  TITLE     LARP6 Regulates Keloid Fibroblast Proliferation, Invasion, and
            Ability to Synthesize Collagen
  JOURNAL   J Invest Dermatol 142 (9), 2395-2405 (2022)
   PUBMED   35176288
  REMARK    GeneRIF: LARP6 Regulates Keloid Fibroblast Proliferation, Invasion,
            and Ability to Synthesize Collagen.
REFERENCE   3  (residues 1 to 491)
  AUTHORS   Stefanovic,L., Gordon,B.H., Silvers,R. and Stefanovic,B.
  TITLE     Characterization of Sequence-Specific Binding of LARP6 to the 5'
            Stem-Loop of Type I Collagen mRNAs and Implications for Rational
            Design of Antifibrotic Drugs
  JOURNAL   J Mol Biol 434 (2), 167394 (2022)
   PUBMED   34896113
  REMARK    GeneRIF: Characterization of Sequence-Specific Binding of LARP6 to
            the 5' Stem-Loop of Type I Collagen mRNAs and Implications for
            Rational Design of Antifibrotic Drugs.
REFERENCE   4  (residues 1 to 491)
  AUTHORS   Maraia,R.J., Mattijssen,S., Cruz-Gallardo,I. and Conte,M.R.
  TITLE     The La and related RNA-binding proteins (LARPs): structures,
            functions, and evolving perspectives
  JOURNAL   Wiley Interdiscip Rev RNA 8 (6) (2017)
   PUBMED   28782243
  REMARK    GeneRIF: A cytoplasmic isoform of La protein as well as LARPs 6, 4,
            and 1 function in mRNA metabolism and translation in distinct but
            similar ways, sometimes with the poly(A)-binding protein, and in
            some cases by direct binding to poly(A)-RNA.
            Review article
REFERENCE   5  (residues 1 to 491)
  AUTHORS   Zhang,Y. and Stefanovic,B.
  TITLE     mTORC1 phosphorylates LARP6 to stimulate type I collagen expression
  JOURNAL   Sci Rep 7, 41173 (2017)
   PUBMED   28112218
  REMARK    GeneRIF: Study shows that mTORC1 phosphorylates La
            ribonucleoprotein domain family, member 6 to stimulate type I
            collagen expression.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 491)
  AUTHORS   Shao,R., Scully,S.J. Jr., Yan,W., Bentley,B., Mueller,J., Brown,C.,
            Bigelow,C. and Schwartz,L.M.
  TITLE     The novel lupus antigen related protein acheron enhances the
            development of human breast cancer
  JOURNAL   Int J Cancer 130 (3), 544-554 (2012)
   PUBMED   21387291
  REMARK    GeneRIF: Achn enhances human breast tumor growth and
            vascularization and that this activity is dependent on nuclear
            localization.
REFERENCE   7  (residues 1 to 491)
  AUTHORS   Cai,L., Fritz,D., Stefanovic,L. and Stefanovic,B.
  TITLE     Nonmuscle myosin-dependent synthesis of type I collagen
  JOURNAL   J Mol Biol 401 (4), 564-578 (2010)
   PUBMED   20603131
  REMARK    Erratum:[J Mol Biol. 2016 Oct 9;428(20):4242-4243. doi:
            10.1016/j.jmb.2016.07.011. PMID: 27485541]
REFERENCE   8  (residues 1 to 491)
  AUTHORS   Cai,L., Fritz,D., Stefanovic,L. and Stefanovic,B.
  TITLE     Binding of LARP6 to the conserved 5' stem-loop regulates
            translation of mRNAs encoding type I collagen
  JOURNAL   J Mol Biol 395 (2), 309-326 (2010)
   PUBMED   19917293
  REMARK    GeneRIF: LARP6 has a distinctive bipartite RNA binding domain not
            found in other members of the La superfamily. LARP6 interacts with
            the two single-stranded regions of the 5' stem-loop.
REFERENCE   9  (residues 1 to 491)
  AUTHORS   Glenn,H.L., Wang,Z. and Schwartz,L.M.
  TITLE     Acheron, a Lupus antigen family member, regulates integrin
            expression, adhesion, and motility in differentiating myoblasts
  JOURNAL   Am J Physiol Cell Physiol 298 (1), C46-C55 (2010)
   PUBMED   19889961
  REMARK    GeneRIF: Acheron may influence differentiation in part via its
            control of cell adhesion dynamics.
REFERENCE   10 (residues 1 to 491)
  AUTHORS   Valavanis,C., Wang,Z., Sun,D., Vaine,M. and Schwartz,L.M.
  TITLE     Acheron, a novel member of the Lupus Antigen family, is induced
            during the programmed cell death of skeletal muscles in the moth
            Manduca sexta
  JOURNAL   Gene 393 (1-2), 101-109 (2007)
   PUBMED   17383118
  REMARK    GeneRIF: These data define Achn as a newly discovered regulatory
            molecule that presumably mediates a variety of developmental and
            homeostatic processes in animals.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DN992782.1, AL833876.1, AI376944.1 and AC009269.6.
            
            On Oct 7, 2003 this sequence version replaced NP_060827.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.108123.1,
                                           SRR1660805.195089.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2152568, SAMEA2155974
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299213.10/ ENSP00000299213.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q23"
     Protein         1..491
                     /product="la-related protein 6 isoform 1"
                     /note="la-related protein 6; acheron; death-associated LA
                     motif protein; La ribonucleoprotein domain family member
                     6"
                     /calculated_mol_wt=54606
     Region          1..87
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BRS8.1)"
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine.
                     /evidence=ECO:0007744|PubMed:19413330; propagated from
                     UniProtKB/Swiss-Prot (Q9BRS8.1)"
     Site            56
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163; propagated from
                     UniProtKB/Swiss-Prot (Q9BRS8.1)"
     Site            58
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q8BN59; propagated from
                     UniProtKB/Swiss-Prot (Q9BRS8.1)"
     Region          93..169
                     /region_name="LARP_6"
                     /note="La RNA-binding domain of La-related protein 6;
                     cd08033"
                     /db_xref="CDD:153402"
     Site            order(99,102..103,108,111..112,114,135..137)
                     /site_type="other"
                     /note="RNA binding site [nucleotide binding]"
                     /db_xref="CDD:153402"
     Region          184..292
                     /region_name="RRM_LARP6"
                     /note="RNA recognition motif (RRM) found in La-related
                     protein 6 (LARP6) and similar proteins; cd12289"
                     /db_xref="CDD:409731"
     Region          186..193
                     /region_name="Nuclear export signal"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BRS8.1)"
     Region          293..403
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BRS8.1)"
     Region          296..302
                     /region_name="Nuclear localization signal"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BRS8.1)"
     Region          423..491
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9BRS8.1)"
     Region          452..482
                     /region_name="SUZ-C"
                     /note="SUZ-C motif; pfam12901"
                     /db_xref="CDD:463745"
     CDS             1..491
                     /gene="LARP6"
                     /gene_synonym="ACHN"
                     /coded_by="NM_018357.4:70..1545"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS32281.1"
                     /db_xref="GeneID:55323"
                     /db_xref="HGNC:HGNC:24012"
                     /db_xref="MIM:611300"
ORIGIN      
        1 maqsggearp gpktavqirv aiqeaedvde ledeeegaet rgagdparyl spgwgsasee
       61 epsrghsgtt asggenered leqewkppde elikklvdqi efyfsdenle kdafllkhvr
      121 rnklgyvsvk lltsfkkvkh ltrdwrttah alkysvvlel nedhrkvrrt tpvplfpnen
      181 lpskmllvyd lylspklwal atpqkngrvq ekvmehllkl fgtfgvissv rilkpgrelp
      241 pdirrissry sqvgtqecai vefeeveaai kahefmites qgkenmkavl igmkppkkkp
      301 akdknhdeep tasihlnksl nkrveelqym gdessansss dpesnptspm agrrhaatnk
      361 lspsghqnlf lspnaspcts pwssplaqrk gvsrksplae egrlncstsp eifrkcmdys
      421 sdssvtpsgs pwvrrrrqae mgtqekspgt spllsrkmqt adglpvgvlr lprgpdntrg
      481 fhghersrac v
//
