LOCUS       NM_001351277            8651 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens La ribonucleoprotein 4B (LARP4B), transcript variant
            2, mRNA.
ACCESSION   NM_001351277 XM_005252432
VERSION     NM_001351277.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8651)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 8651)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   3  (bases 1 to 8651)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 8651)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 8651)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 8651)
  AUTHORS   Wang,J., Huo,K., Ma,L., Tang,L., Li,D., Huang,X., Yuan,Y., Li,C.,
            Wang,W., Guan,W., Chen,H., Jin,C., Wei,J., Zhang,W., Yang,Y.,
            Liu,Q., Zhou,Y., Zhang,C., Wu,Z., Xu,W., Zhang,Y., Liu,T., Yu,D.,
            Zhang,Y., Chen,L., Zhu,D., Zhong,X., Kang,L., Gan,X., Yu,X., Ma,Q.,
            Yan,J., Zhou,L., Liu,Z., Zhu,Y., Zhou,T., He,F. and Yang,X.
  TITLE     Toward an understanding of the protein interaction network of the
            human liver
  JOURNAL   Mol Syst Biol 7, 536 (2011)
   PUBMED   21988832
  REMARK    Erratum:[Mol Syst Biol. 2017 Dec 18;13(12):965. doi:
            10.15252/msb.20178107.. PMID: 29254952]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 8651)
  AUTHORS   Schaffler,K., Schulz,K., Hirmer,A., Wiesner,J., Grimm,M.,
            Sickmann,A. and Fischer,U.
  TITLE     A stimulatory role for the La-related protein 4B in translation
  JOURNAL   RNA 16 (8), 1488-1499 (2010)
   PUBMED   20573744
REFERENCE   8  (bases 1 to 8651)
  AUTHORS   Bayfield,M.A., Yang,R. and Maraia,R.J.
  TITLE     Conserved and divergent features of the structure and function of
            La and La-related proteins (LARPs)
  JOURNAL   Biochim Biophys Acta 1799 (5-6), 365-378 (2010)
   PUBMED   20138158
  REMARK    Review article
REFERENCE   9  (bases 1 to 8651)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   10 (bases 1 to 8651)
  AUTHORS   Bousquet-Antonelli,C. and Deragon,J.M.
  TITLE     A comprehensive analysis of the La-motif protein superfamily
  JOURNAL   RNA 15 (5), 750-764 (2009)
   PUBMED   19299548
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY013410.1, BC152443.1,
            AU132926.1, AL157709.17 and BM684990.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001351277.1.
            
            Summary: This gene encodes a member of an evolutionarily conserved
            protein family implicated in RNA metabolism and translation.
            Members of this family are characterized by the presence of an La
            motif, which is often located adjacent to one or more RNA
            recognition motifs (RRM). Together, the two motifs constitute the
            functional region of the protein and enable its interaction with
            the RNA substrate. This protein family is divided into five
            sub-families: the genuine La proteins and four La-related protein
            (LARP) sub-families. The protein encoded by this gene belongs to
            LARP sub-family 4. It is a cytoplasmic protein that may play a
            stimulatory role in translation. [provided by RefSeq, Oct 2012].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the 3' coding region, compared to variant 1. The
            encoded isoform (2) is longer than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.129814.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-508               HY013410.1         1-508
            509-1621            BC152443.1         233-1345
            1622-2405           AU132926.1         1-784
            2406-5179           BC152443.1         2025-4798
            5180-8620           AL157709.17        119875-123315       c
            8621-8651           BM684990.1         19-49               c
FEATURES             Location/Qualifiers
     source          1..8651
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p15.3"
     gene            1..8651
                     /gene="LARP4B"
                     /gene_synonym="KIAA0217; LARP5"
                     /note="La ribonucleoprotein 4B"
                     /db_xref="GeneID:23185"
                     /db_xref="HGNC:HGNC:28987"
                     /db_xref="MIM:616513"
     exon            1..278
                     /gene="LARP4B"
                     /gene_synonym="KIAA0217; LARP5"
                     /inference="alignment:Splign:2.1.0"
     exon            279..398
                     /gene="LARP4B"
                     /gene_synonym="KIAA0217; LARP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             318..2639
                     /gene="LARP4B"
                     /gene_synonym="KIAA0217; LARP5"
                     /note="isoform 2 is encoded by transcript variant 2; La
                     ribonucleoprotein domain family, member 5; la-related
                     protein 4B; la-related protein 5; La ribonucleoprotein
                     domain family member 4B"
                     /codon_start=1
                     /product="la-related protein 4B isoform 2"
                     /protein_id="NP_001338206.1"
                     /db_xref="GeneID:23185"
                     /db_xref="HGNC:HGNC:28987"
                     /db_xref="MIM:616513"
                     /translation="MTSDQDAKVVAEPQTQRVQEGKDSAHLMNGPISQTTSQTSSIPP
                     LSQVPATKVSELNPNAEVWGAPVLHLEASSAADGVSAAWEEVAGHHADRGPQGSDANG
                     DGDQGHENAALPDPQESDPADMNALALGPSEYDSLPENSETGGNESQPDSQEDPREVL
                     KKTLEFCLSRENLASDMYLISQMDSDQYVPITTVANLDHIKKLSTDVDLIVEVLRSLP
                     LVQVDEKGEKVRPNQNRCIVILREISESTPVEEVEALFKGDNLPKFINCEFAYNDNWF
                     ITFETEADAQQAYKYLREEVKTFQGKPIKARIKAKAIAINTFLPKNGFRPLDVSLYAQ
                     QRYATSFYFPPMYSPQQQFPLYSLITPQTWSATHSYLDPPLVTPFPNTGFINGFTSPA
                     FKPAASPLTSLRQYPPRSRNPSKSHLRHAIPSAERGPGLLESPSIFNFTADRLINGVR
                     SPQTRQAGQTRTRIQNPSAYAKREAGPGRVEPGSLESSPGLGRGRKNSFGYRKKREEK
                     FTSSQTQSPTPPKPPSPSFELGLSSFPPLPGAAGNLKTEDLFENRLSSLIIGPSKERT
                     LSADASVNTLPVVVSREPSVPASCAVSATYERSPSPAHLPDDPKVAEKQRETHSVDRL
                     PSALTATACKSVQVNGAATVRTSCLPSCTTAARLWCEQTLRTPAPARFLITSNLELRK
                     PSYAEICQRTSKEPPSSPLQPQKEQKPNTVGCGKEEKKLAEPAERYREPPALKSTPGA
                     PRDQRRPAGGRPSPSAMGKRLSREQSTPPKSPQ"
     exon            399..458
                     /gene="LARP4B"
                     /gene_synonym="KIAA0217; LARP5"
                     /inference="alignment:Splign:2.1.0"
     exon            459..606
                     /gene="LARP4B"
                     /gene_synonym="KIAA0217; LARP5"
                     /inference="alignment:Splign:2.1.0"
     exon            607..747
                     /gene="LARP4B"
                     /gene_synonym="KIAA0217; LARP5"
                     /inference="alignment:Splign:2.1.0"
     exon            748..826
                     /gene="LARP4B"
                     /gene_synonym="KIAA0217; LARP5"
                     /inference="alignment:Splign:2.1.0"
     exon            827..963
                     /gene="LARP4B"
                     /gene_synonym="KIAA0217; LARP5"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1067
                     /gene="LARP4B"
                     /gene_synonym="KIAA0217; LARP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1178
                     /gene="LARP4B"
                     /gene_synonym="KIAA0217; LARP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..1232
                     /gene="LARP4B"
                     /gene_synonym="KIAA0217; LARP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1442
                     /gene="LARP4B"
                     /gene_synonym="KIAA0217; LARP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1549
                     /gene="LARP4B"
                     /gene_synonym="KIAA0217; LARP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1801
                     /gene="LARP4B"
                     /gene_synonym="KIAA0217; LARP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1847
                     /gene="LARP4B"
                     /gene_synonym="KIAA0217; LARP5"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..2012
                     /gene="LARP4B"
                     /gene_synonym="KIAA0217; LARP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2137
                     /gene="LARP4B"
                     /gene_synonym="KIAA0217; LARP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2138..2351
                     /gene="LARP4B"
                     /gene_synonym="KIAA0217; LARP5"
                     /inference="alignment:Splign:2.1.0"
     exon            2352..8651
                     /gene="LARP4B"
                     /gene_synonym="KIAA0217; LARP5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6000..6005
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LARP4B"
                     /gene_synonym="KIAA0217; LARP5"
                     /note="hexamer: AATAAA"
     polyA_site      6023
                     /gene="LARP4B"
                     /gene_synonym="KIAA0217; LARP5"
                     /note="major polyA site"
     regulatory      6046..6051
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LARP4B"
                     /gene_synonym="KIAA0217; LARP5"
                     /note="hexamer: ATTAAA"
     polyA_site      6068
                     /gene="LARP4B"
                     /gene_synonym="KIAA0217; LARP5"
     regulatory      6693..6698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LARP4B"
                     /gene_synonym="KIAA0217; LARP5"
                     /note="hexamer: AGTAAA"
     polyA_site      6712
                     /gene="LARP4B"
                     /gene_synonym="KIAA0217; LARP5"
     regulatory      8630..8635
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LARP4B"
                     /gene_synonym="KIAA0217; LARP5"
                     /note="hexamer: ATTACA"
     polyA_site      8651
                     /gene="LARP4B"
                     /gene_synonym="KIAA0217; LARP5"
ORIGIN      
        1 gagctgtgtg ttctcatgcg aacgggaagg agcgttgggg atctggagtc ccggggttga
       61 gacattttcg ggcccgaaag gggaagaatc cgccgccgcc gccgccgcca gctcgcgccc
      121 gccctctccc ctacctccgg cccggcccgg cccggccgcg ccgcctctcc ctgccgtctc
      181 tctcctcgcc gtccccgcgt gtggcgcggc cgccgggccc cggggttgag gcgaggagcc
      241 cgcgggcggc cggtcgggcg gggcggcggc gctgacagca tcctgaggtt agcattacac
      301 ttctcccagt ggagcccatg acttctgatc aggacgctaa ggttgtggct gaaccgcaga
      361 cgcagagagt ccaggagggc aaggacagcg ctcatctgat gaatggtcct atatctcaaa
      421 ccacttctca gacaagttcc atcccacctt tgagtcaggt accagcaact aaggtttcag
      481 agctgaaccc taatgcagaa gtgtgggggg ctcctgtgtt acatctggaa gcaagcagtg
      541 ctgctgacgg tgtgagtgct gcatgggagg aggtggctgg ccaccacgca gaccgtggcc
      601 cgcagggatc ggatgccaat ggtgatggtg accagggcca tgagaatgcc gcattgccag
      661 acccgcagga gtcggaccca gcagacatga acgctctcgc tctgggtccc tcagaatatg
      721 actctctgcc tgaaaatagc gagacaggag gaaatgagtc tcaaccagac agccaggaag
      781 acccccgaga agtacttaaa aaaacattgg aattctgctt atctagggag aaccttgcta
      841 gtgacatgta tcttatatca cagatggata gtgaccagta tgtgccaatc acaacggtgg
      901 ctaacctcga ccacatcaag aagctcagca ctgatgtgga cttgattgtg gaagtgctaa
      961 gatctttacc tttagtccaa gtggatgaaa agggagaaaa agtaaggcca aatcaaaatc
     1021 gctgcatagt aatattgcgt gaaatatctg aatctacccc cgtggaagaa gtagaagcac
     1081 tatttaaagg agataattta ccaaaattta taaactgtga atttgcatat aatgataatt
     1141 ggtttattac atttgaaaca gaagctgatg cacaacaggc ttacaaatac cttcgagaag
     1201 aagtcaaaac ttttcaagga aaaccaatta aggcacggat aaaagcaaag gcaatagcta
     1261 taaacacatt tttgccaaag aatggattta gacccctgga cgtgagcctg tatgcccagc
     1321 agcgctacgc gacgtcgttc tacttccctc ccatgtacag cccccagcag cagttccccc
     1381 tgtacagcct gatcactccc cagacgtggt cagcaacgca cagctatctt gacccaccct
     1441 tggtaactcc atttccaaat actggattta taaatgggtt tacgtctcca gcgttcaagc
     1501 ctgcggcgtc tcctctgact tctctcagac agtatcctcc tcgaagcagg aatcctagta
     1561 aatctcatct gcggcatgcg attcctagtg cagagagggg acctgggtta ttagaaagtc
     1621 cttcaatatt taacttcact gcagatcgat taattaatgg tgtccggagt ccacaaacaa
     1681 ggcaagcagg tcaaactaga acacggattc aaaacccttc agcatatgcc aagagagagg
     1741 ctgggcctgg gcgtgtggag ccaggcagtc tcgaatcctc tcctggttta gggaggggaa
     1801 ggaagaattc ctttggctac cggaagaaaa gggaggagaa gtttacaagc agccagacac
     1861 agtctccaac gccaccaaag cctccgtcgc caagcttcga gctggggctg tccagcttcc
     1921 ctccattacc tggagctgcc ggcaatttga agacagagga cttgtttgaa aacaggctat
     1981 ctagcttgat aataggacca tccaaagaaa ggaccctcag tgcagacgca agcgtgaaca
     2041 cccttcctgt agtggtctcc agagagccct cggtgccggc ttcttgtgct gtatcagcaa
     2101 cgtacgagcg atccccctcc ccagctcatt tacccgatga tcccaaggtg gcggagaaac
     2161 agagggaaac ccacagtgtg gacagacttc cttccgccct cactgcgacc gcgtgtaaat
     2221 cggtgcaggt gaacggagcc gccacggtac gtacctcgtg cctgccttcc tgcacgacag
     2281 ccgcgaggct ctggtgtgaa cagacgctgc gcactcctgc acctgctcgt tttttaatca
     2341 catctaattt ggaattgcga aagcccagct acgcagagat ttgtcagaga acgagtaaag
     2401 agcctccttc ttccccattg caaccccaaa aagaacaaaa gccaaacact gttggttgtg
     2461 ggaaggagga aaagaagctg gcagagcccg cagagagata ccgggagccc ccagccctca
     2521 agtccacacc tggagccccc agagaccaga ggcggccggc ggggggccgg ccctcgccct
     2581 cggccatggg gaagcgtctc agccgagagc agagcactcc ccccaagtct cctcagtgaa
     2641 aaccgtacgt ctgggagggg tcgcagagcg ctgtgttaac cacaaacgag acactctccc
     2701 actcagtgcg agggcgagcc gctggttagg agcttgcagt gtctgaggcc tgtgggatcc
     2761 tcaagttggt tttcttctgt gagttggatt ctccccctct tgaaaaaaaa tcgatttttc
     2821 aggatttaat taatacaaac cttattttag gttggtgctt aactggaggt gatgcataag
     2881 tctgattttt ttttccaaga tagaaaaagc atttatccta acaaattggt attttttatt
     2941 aagcctccat gtggctctga atgcaagcta tatatagtga gtttttctaa attaagggaa
     3001 ctctgctttt tttttttttt tttaagtaac tggtctgtaa gtgcatatct ctagaacgtc
     3061 cccgcagatg aatgagggcc agtggccttg gcagaggcag gtgtggcctc gtagaggcag
     3121 tgctggccgc gccagggcat cagtgctgat gtgggagctg tgcttccacc taagccgttg
     3181 gtaggggact gtggcattta agaatgtaga gagcgcatcc tttttgatct cctgggcgga
     3241 gtgaacctgc aggggccacc ccagaaacct tggttctgat gcactgcaag caagtaacca
     3301 gcttctcact ccagtttcaa gtggctatta tgtaatataa attcaaagca cattgtgaat
     3361 agaacctaca tgaaaacata cactttgttg cccactgaca tgttaccaga agttgtacca
     3421 tgatgttgtt ttgacccctg tgagctgatg gccccggccc tgctctgtgc acatttctgt
     3481 ccgtgttccc cagcactctg gttggagaga gtccacatct tcagctccgt gtggacatct
     3541 ccctgtacct ctgcatcagc acatggattt aagagttatg taatcgtgag agaatggtgt
     3601 ttgtggtttt tccccctctt tggctggtgg aggataaagt tcctgctctt ttacctccaa
     3661 gacgagggcc tcattgattc acttccagaa gtgctgcact tctgaagaac aaggatgcac
     3721 taaagttagc aagtttataa taaagttaaa tataaattat tttgttttaa aatgcctcaa
     3781 atttttcttt attctaagca gcaaacatta aaataagaat atttcctgct aaatgtaacc
     3841 atacacttta ttccacaaaa tgttatttaa caagactgag ggtttttttt aagaaaaaat
     3901 tatttccatc caatatttaa agacttgaat tttatttaaa cttgaaaatg actttgcctt
     3961 aacttttgta taagacagct tagagtccat ggagcccggc cctgggttgg cgtgagtggg
     4021 tcagagttac tcagttactg cgtggatctc ctgtcgctag ttttactgag taagcatact
     4081 gtagtacaag agctagtagt agtttttgta atatacctta aagatcttca acagttgatc
     4141 ttttttcaga atgttggaaa atcctgtaaa tgcaaatagt caatactgta ttaaatacgt
     4201 gcacttggag tgtgcttcgc ttgtacagtt gtaaataatc agaacatatg aaaaaggtac
     4261 cctacagaga aaattctgat acagattatt gatatattat aaatgttgct gttgagcggg
     4321 atgtagataa actaaatgtt gtggtttgaa tattattttg atttgttgag attttctttt
     4381 ttctcttaca tcggtgtgtt gaactgattc tgcctctttg ctgcaaaagg gaattggaaa
     4441 gtcttattaa aagcctccag atgttttcat actcttttaa aatgtatgta aatgcatact
     4501 aatcatatct aatgtgaaag agttttaaag tatatagaga gcaaaaactg gcaggatcgt
     4561 aagtgaaggt gactagtaat ctaatttaaa tcacctgcag ctaagcatga ttgaccctgc
     4621 cagaggaaaa catgcctatt tgaccatttc ctttaaagca gttgccatta ttcaaataca
     4681 gagaaatagc cacagggcta gtgtttttca aatgcatttt aaagaacatg gggatttttt
     4741 tttgtagttg tcagttcact gaccaaaaaa aaaaaaaaaa tcagaaataa ttgatctgtg
     4801 aaacccaaac tctcaatact cagaaagctg ggaggcaacc tcgaggcctg ggcctacgag
     4861 ctgcatcttc gctacggaag ggccagggcg ccatcagcca ttcccaaaac acaaggcctg
     4921 cccgtccgcc agtgagtcct tggtttttaa taatgagaag tcctttcccc caaggtgtga
     4981 gcattgcagc gcagtgtgtg tgtgtggtta gagccagctt agtccttcac tttgtcgacc
     5041 gaagtgggag ctcaacagct gcatgaggag ggcagcgcgt gcattagcca gtcgccactg
     5101 gagggctctg ctgccctccg gtcaatacac tgtagttact gcctagccag cagcagtctt
     5161 ctgcatcaag aactgaaacg ttgctcggag gtgattttta tagcatcctt tttaattaaa
     5221 ggtgaaatac agattgctat ataatgtctg aaaaaacctg atactacttc aagagtttct
     5281 gctcagaaga aaatgagagt tatcataata ggaagctgtg gcggtccatg ccaactgtgc
     5341 tgtgtcacat acagcgatga gagtggcttt catacttttt ttttttttaa gttaacaccc
     5401 tcctttaccc ccagcagtat ctcaggttat agaatcagag atgcagcagt gacaaatggc
     5461 attttaactt gtaaaatcgt gtgatgatgc ttatcatttt gaaatagaag aataaaaacc
     5521 tggtcccgtt tcaccagaca tgaatttcaa gtggagtcgt cgttctctga gagtgagtgt
     5581 cttgacattt tcacccaggc cctcctgtca tcacatcacc ggctgtcact ggcgggtggc
     5641 cgtaaacgtc ctgcgttgct atattaggat ctctgcagtt caggcttcaa aaccagttca
     5701 gtgtatccgg gcgacgggta gtggtggtgc atgcctgtct gtgtgccccg ctggcgagct
     5761 gtagttgcgg cttgcgtgcc tcgcggccca ctacagggct gcagacaatc gaggcgaggg
     5821 cgctggccgc cagcagctca cagcgcgggg gtcatgtggt cgctcctcga gggtttcgtt
     5881 tttgttctgc ttcattaaga ctggaatcaa gcttacatgt aaactattgg taatttaagt
     5941 ttccttttgt gtcattcagt gtaaaactgt ctaatttgaa aaaaaatgta ggttatgaaa
     6001 ataaagattt aggcactgtt caatttttct tttgattttt tttaaattaa aatttcttca
     6061 ataatgcatc ttttctaaac atagtttttt gtctgttccc ataagtgcat gagaaagaaa
     6121 cacgggcctc atatatgatt ggatcctaaa gccttctcac ctacgtgggg gctggctgtg
     6181 gcacacgggg ctcacccttt gtgttttagt ggttcagagt gagcattaac atcagatgct
     6241 catgcggaga cagccattac tgtgactgcc aagatgtact gcaaaaatac atgttcctgt
     6301 atcaggactt tgattttgtt aaaatggcac tctctccaaa gctgtgtcca tgaagctgtt
     6361 tggagctaac gttgggtctt catggtgatg gactcatcct taggcagcag tgatgtctgc
     6421 actaggaaga ggctggcggg aggcggggcc cctcctgtgc caggcaccga gtggatgggg
     6481 gactgattaa catgttgctg ccttcctcct ctgtgcattg ccttttcatg tcgtcttccc
     6541 atttttactc tttttctgat ggaattaata ttcttgatct gttaaggcta ttaatccttt
     6601 gtcatatatg ttacaaatat tttctttcaa tctaccattt gtcttaactc tttatttaga
     6661 atagtatctt ttacggtgtt taattattgt gtagtaaaat ctatcaatct tctcctttgt
     6721 tgagtgtctt ggacttgctt aagaagcctt tccctactcc agggtcataa agttaatagt
     6781 gtgtgtgtat gtgtgcgtgt gtgtgtgtgt gtgcgtgcac acgcacacac acacacacac
     6841 gcttttaatc cagctgggcc taatcgtgtg tgtggtgtgc gtgcttaggc aggaacccag
     6901 ttttacttta tgccatgtgg aaagtttctt tttccagtat caccagtgag ttcactgtct
     6961 ctccactggt ctgcagtgct gcttctgtta cttgcagact tcccacgtgt gcatggatct
     7021 ccacctgggg tctctagggt ctctattcta cactgcctat ttccctttct gtcctaacac
     7081 catagcattt aactcacccg tcatcctgtg ttgctgagaa tttccttcat agaactcatc
     7141 aaagtatgat taactgtgct ccctgagggc aggaattatg ccatctggat caccagcctc
     7201 tcccttgtcc ttagcacgcc atctgcaaat tagcagatac tcggtaaatg tgtattaact
     7261 cgaagtatat tttgtgtctt ctctgtgcac agcactgccc tgggaagaac taggatgagg
     7321 tattgacttg ctgttgccac ataacaaacc ctgccagaac tccctggatg gaagtgacca
     7381 ccgtgtatct gtggattgtc tgcagggctc tgctggggtc agcaggtccc acaagagagc
     7441 cagggctcgg tctcctcatg gctgtcagag gtttacgtat tccgcctcca cccaccaaag
     7501 tctgaagttg ttgtattcca ttccttgcta tatccacatc ttttaataat gctaaaatcc
     7561 cgtgtttctc taaagcattg gattgaacca actgaagaag gaccacgtgt gttgctgggc
     7621 ctgcttgggc acaagccgtt tccgatccaa gtcaactgct ggtctgctta gacgaaggtg
     7681 tgtgggtgtc tccaccacgg agaggaggga cagcaggtga gaccataggc caggaaggaa
     7741 gggcacagcc taagcgtgca gtggcttagc cagagaccct cgtgcaccag ccttcaggtg
     7801 cttatggaac ttatgtcagc ccaggccata tccaagtgtg tgatgtctcg gagcatatat
     7861 gccaggccag ccggagaggc ttagccctgc cctggtggag ctggagggcc gcagggccgc
     7921 ccggtggggt caggaggttg tgaagaggat cctgatacag gctgggcctc cctgcaggcg
     7981 tgagccccgg agcacggggt gagcagctcc acccagaggg gcttgcagga ccaagctggg
     8041 acagcaacca ccaggccctg gggcagatca gtgagcgtcc aggagatgca gatgcagaag
     8101 acagccaaat tcattcacct ctgcgtgggc ctgtgagggc ccacagagat gcattttcat
     8161 tcacgaccag gatttcctcg gccggagcag ccgcttttcc cagccgaagc tcactgtgtt
     8221 tactacatag gatgtgagtg tatagaaaga ctctctctaa cgttagctac gcgtgcagaa
     8281 atgtggggcg cttacaagtg tgggcagccg cagcctgttc ctcacccctg tcctaacggg
     8341 acatactcca cgcatgcaca tttaggatca ccgtgtcttc tcgttggact gatctgtcat
     8401 taggaccctg gacccaagta attgtctttg ctctgaagtt ttgacagtaa caaaggcatt
     8461 ccagctcttt ctttttcact cctgtcggtg taacgtgccg tttttcatcc tttgactttt
     8521 agcccgcctg tgccctgtct gaagggagtt gtctgtggac agcacggagt ggtgggtgtt
     8581 tgtaatccac tctgccagcc tcagtcttct aactgttgcg tatggaccaa ttacatctgc
     8641 cctttctctt c
//
