LOCUS       NM_001352320            6217 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens La ribonucleoprotein 4 (LARP4), transcript variant 24,
            mRNA.
ACCESSION   NM_001352320
VERSION     NM_001352320.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6217)
  AUTHORS   Zhang,J., Yang,Y., Song,X., Xing,K. and Chen,Y.
  TITLE     Biological functions of Circular RNA_LARP4/ Upstream frameshift 1
            in development of gastric cancer
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (4), 176-180 (2024)
   PUBMED   38678610
  REMARK    GeneRIF: Biological functions of Circular RNA_LARP4/ Upstream
            frameshift 1 in development of gastric cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6217)
  AUTHORS   Lewis,B.M., Cho,C.Y., Her,H.L., Mizrahi,O., Hunter,T. and Yeo,G.W.
  TITLE     LARP4 is an RNA-binding protein that binds nuclear-encoded
            mitochondrial mRNAs to promote mitochondrial function
  JOURNAL   RNA 30 (3), 223-239 (2024)
   PUBMED   38164626
  REMARK    GeneRIF: LARP4 is an RNA-binding protein that binds nuclear-encoded
            mitochondrial mRNAs to promote mitochondrial function.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6217)
  AUTHORS   Lu,M., Gong,B., Wang,Y. and Li,J.
  TITLE     CircBNC2 affects epithelial ovarian cancer progression through the
            miR-223-3p/ LARP4 axis
  JOURNAL   Anticancer Drugs 34 (3), 384-394 (2023)
   PUBMED   36730544
  REMARK    GeneRIF: CircBNC2 affects epithelial ovarian cancer progression
            through the miR-223-3p/ LARP4 axis.
REFERENCE   4  (bases 1 to 6217)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 6217)
  AUTHORS   Mattijssen,S., Iben,J.R., Li,T., Coon,S.L. and Maraia,R.J.
  TITLE     Single molecule poly(A) tail-seq shows LARP4 opposes deadenylation
            throughout mRNA lifespan with most impact on short tails
  JOURNAL   Elife 9, e59186 (2020)
   PUBMED   32744499
  REMARK    GeneRIF: Single molecule poly(A) tail-seq shows LARP4 opposes
            deadenylation throughout mRNA lifespan with most impact on short
            tails.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6217)
  AUTHORS   Bai,S.W., Herrera-Abreu,M.T., Rohn,J.L., Racine,V., Tajadura,V.,
            Suryavanshi,N., Bechtel,S., Wiemann,S., Baum,B. and Ridley,A.J.
  TITLE     Identification and characterization of a set of conserved and new
            regulators of cytoskeletal organization, cell morphology and
            migration
  JOURNAL   BMC Biol 9, 54 (2011)
   PUBMED   21834987
  REMARK    Erratum:[BMC Biol. 2024 Oct 10;22(1):228. doi:
            10.1186/s12915-024-02036-3.. PMID: 39390519]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6217)
  AUTHORS   Yang,R., Gaidamakov,S.A., Xie,J., Lee,J., Martino,L., Kozlov,G.,
            Crawford,A.K., Russo,A.N., Conte,M.R., Gehring,K. and Maraia,R.J.
  TITLE     La-related protein 4 binds poly(A), interacts with the
            poly(A)-binding protein MLLE domain via a variant PAM2w motif, and
            can promote mRNA stability
  JOURNAL   Mol Cell Biol 31 (3), 542-556 (2011)
   PUBMED   21098120
  REMARK    GeneRIF: LARP4 activity is integrated with other PAM2 protein
            activities by PABP as part of mRNA homeostasis.
REFERENCE   8  (bases 1 to 6217)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   9  (bases 1 to 6217)
  AUTHORS   Puigdecanet,E., Espinet,B., Villa,O., Florensa,L., Besses,C.,
            Serrano,S. and Sole,F.
  TITLE     Detection of abnormalities of PRV-1, TPO, and c-MPL genes detected
            by fluorescence in situ hybridization in essential thrombocythemia
  JOURNAL   Cancer Genet Cytogenet 167 (1), 39-42 (2006)
   PUBMED   16682284
  REMARK    GeneRIF: FISH study showed no cytogenetic abnormalities in any of
            the analyzed cases.
REFERENCE   10 (bases 1 to 6217)
  AUTHORS   Kralovics,R. and Skoda,R.C.
  TITLE     Molecular pathogenesis of Philadelphia chromosome negative
            myeloproliferative disorders
  JOURNAL   Blood Rev 19 (1), 1-13 (2005)
   PUBMED   15572213
  REMARK    GeneRIF: The c-MPL protein altered expression provide an
            opportunity to diagnose and identify subpopulations of MPD
            patients.
            Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090058.21.
            
            On May 31, 2019 this sequence version replaced NM_001352320.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.133074.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               AC090058.21        63296-63439
            145-193             AC090058.21        74816-74864
            194-341             AC090058.21        90173-90320
            342-497             AC090058.21        91346-91501
            498-573             AC090058.21        92906-92981
            574-710             AC090058.21        97899-98035
            711-814             AC090058.21        100146-100249
            815-925             AC090058.21        102850-102960
            926-979             AC090058.21        104001-104054
            980-1083            AC090058.21        116725-116828
            1084-1296           AC090058.21        123546-123758
            1297-1345           AC090058.21        124993-125041
            1346-1507           AC090058.21        129370-129531
            1508-1629           AC090058.21        135826-135947
            1630-1738           AC090058.21        136410-136518
            1739-6217           AC090058.21        137937-142415
FEATURES             Location/Qualifiers
     source          1..6217
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..6217
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /note="La ribonucleoprotein 4"
                     /db_xref="GeneID:113251"
                     /db_xref="HGNC:HGNC:24320"
                     /db_xref="MIM:618657"
     exon            1..144
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            145..193
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            194..341
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            342..497
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     CDS             386..2077
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /note="isoform r is encoded by transcript variant 24;
                     c-Mpl binding protein; La-related protein 4; La
                     ribonucleoprotein domain family member 4"
                     /codon_start=1
                     /product="la-related protein 4 isoform r"
                     /protein_id="NP_001339249.1"
                     /db_xref="GeneID:113251"
                     /db_xref="HGNC:HGNC:24320"
                     /db_xref="MIM:618657"
                     /translation="MYSSSCETTRNTTGIEESTDGMILGPEDLSYQIYDVSGESNSAV
                     STEDLKECLKKQLEFCFSRENLSKDLYLISQMDSDQFIPIWTVANMEEIKKLTTDPDL
                     ILEVLRSSPMVQVDEKGEKVRPSHKRCIVILREIPETTPIEEVKGLFKSENCPKVISC
                     EFAHNSNWYITFQSDTDAQQAFKYLREEVKTFQGKPIMAPFPNGSFVNGFNSPGSYKT
                     NAAAMNMGRPFQKNRVKPQFRSSGGSEHSTEGSVSLGDGQLNRYSSRNFPAERHNPTV
                     TGHQEQTYLQKETSTLQVEQNGDYGRGRRTLFRGRRRREDDRISRPHPSTAESKAPTP
                     KFDLLASNFPPLPGSSSRMPGELVLENRMSDVVKGVYKEKDNEELTISCPVPADEQTE
                     CTSAQQLNMSTSSPCAAELTALSTTQQEKDLIEDSSVQKDGLNQTTIPVSPPSTTKPS
                     REPRKLSYAEVCQKPPKEPSSVLVQPLRELRSNVVSPTKNEDNGAPENSVEKPHEKPE
                     ARASKDYSGFRGNIIPRGAAGKIREQRRQFSHRAIPQGVTRRNGKEQYVPPRSPK"
     exon            498..573
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            574..710
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            711..814
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            815..925
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            926..979
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1083
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1296
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1345
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1507
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1629
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            1630..1738
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..6217
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4168..4173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /note="hexamer: AATAAA"
     polyA_site      4189
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /note="major polyA site"
     regulatory      6198..6203
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /note="hexamer: AATAAA"
     polyA_site      6217
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /note="major polyA site"
ORIGIN      
        1 agccgggtcc actgccgggt ggaggggcaa ggcgagtgtg tgtccttatc ctagcaattg
       61 gggcgcgggc ctgtgagcca gttggagttg cggcggcggg aacgattggg ctgagcagag
      121 gacgacatgt tgcttttcgt ggagcattta tggggttaag tggcatggga tttctgtttc
      181 tgatagtaaa tagcaggtag catctaaagg aactggttta aatcctaatg ccaaagtatg
      241 gcaagaaatt gctcctggaa atactgatgc caccccagta actcatggaa ctgaaagctc
      301 ttggcatgaa atagcagcta catcaggtgc tcatcctgag ggtaatgcag agctctcaga
      361 agatatatgt aaagaatatg aagtaatgta ttcttcatct tgtgaaacca caagaaatac
      421 tacaggcatt gaagaatcaa ctgatgggat gattttagga ccagaagatc tgagttacca
      481 aatatatgat gtttccggag aaagcaattc agcagtttct acagaagacc taaaagaatg
      541 tctgaagaaa caattagaat tctgtttttc acgagaaaat ttgtcaaagg atctttactt
      601 gatatctcaa atggatagtg atcagttcat cccaatttgg acagttgcca acatggaaga
      661 aataaaaaag ttgactacag accctgatct aattcttgaa gtgttaagat cttctcccat
      721 ggtacaagtt gatgagaagg gtgagaaagt gagaccaagt cataagcgtt gtattgtaat
      781 tcttagagag attcctgaaa caacaccaat agaggaagtg aaaggtttgt tcaaaagtga
      841 aaactgcccc aaagtgataa gctgtgagtt tgcacacaat agcaactggt atatcacttt
      901 ccagtcagac acagatgcac aacaggcttt taaatactta agagaagaag ttaaaacatt
      961 tcagggcaag ccaattatgg ctccctttcc caatggtagt tttgtgaatg gctttaattc
     1021 gccaggatct tataaaacaa atgctgctgc tatgaatatg ggtcgaccat tccaaaaaaa
     1081 tcgtgtgaag cctcagttta ggtcatctgg tggttcagaa cactcaacag agggctctgt
     1141 atccttgggg gatggacagt tgaacagata tagttcaaga aactttccag ctgaacggca
     1201 taaccccaca gtaactgggc atcaggagca aacttacctt cagaaggaga cttccacttt
     1261 gcaggtggaa cagaatgggg actatggtag gggcaggaga actctcttca gaggtcgaag
     1321 acgacgagaa gatgacagga tctcaagacc tcatccttca acagctgaat caaaggctcc
     1381 aacaccaaag tttgacttat tagcctcaaa ttttccacct ttacctggaa gttcatcaag
     1441 aatgccaggt gaactcgttt tggagaatag gatgtctgat gttgttaaag gtgtctacaa
     1501 agaaaaggat aatgaagagt tgacaattag ttgcccagtg cctgcagatg agcagacaga
     1561 atgcacttct gcccagcaac tcaatatgag taccagttct ccatgtgctg ctgagcttac
     1621 tgcattaagc acaactcagc aagaaaagga tctaatagaa gattcctctg ttcagaagga
     1681 tggtctcaat cagacaacta taccagtttc tcctccaagt actacaaagc catcgaggga
     1741 accccgaaag ttaagttatg ctgaagtgtg ccagaagccc cctaaagagc catcttcagt
     1801 tcttgtgcag ccactacggg aacttcgctc caatgtggtg tctcccacca aaaatgaaga
     1861 caatggagct cctgagaact ccgttgagaa accacatgag aagccagaag caagggctag
     1921 taaggattat tctggcttcc gaggcaatat aatccccagg ggagcagcag gaaaaatcag
     1981 ggaacagaga cgccagttta gccatagggc tatacctcag ggagtgactc gacgtaatgg
     2041 caaagagcaa tatgtgccac ccagatcacc aaagtaaaaa acaacaaaac tattcaaaaa
     2101 cttcactctc ttcccattaa acttgaactg tggctatatt gaactgtttt ggaggggagg
     2161 gggtagccag gaaggaaaca agagaaagta cgtccatttc attatggatt ttggagttgt
     2221 gagtgatagg atcccaaaat tcatctctaa tgtggttttt aaatgctgga ggattccaat
     2281 caatataaat atatatatat atatacacac acatatataa aaagtataat ttttctattt
     2341 ttgtttttgg ttttaatttg cagagatttg ctgccaggaa tcaattttga gggttcagat
     2401 ttagcttgga agaaaaaaaa gaaacataca tccttcagta taggagatga gggaatgaga
     2461 gaaaatattt tttgaagaag catttctgta aaattagaaa ttactttttt taatctattt
     2521 aaagtttggc ttgaagaatg ccatctctga ctatatggcc ttgtattgca aagcggatca
     2581 gtggctgggg tgcctgttgt gggtgtgagt gtgtacaaga gcgattgaag ccaaatctgt
     2641 tgtcatgtta gtaaatgatt tgaaaactga atgtaatact tgagtagatt tttttttcta
     2701 gtttgaaatt tagtctgtct ttttgacctt actaatattt catttaacaa gttgtaaaac
     2761 tctgattgta cttagagatg tgactaccaa tcagtttgat actcaaggaa agggggttat
     2821 tcaagaaatt gaaaatttca tcttggacct cagtgcatag gtcaaatgga tttcagaggt
     2881 ttaaacttcc ctgtgattcc cccgaatacc cccaaaatga gaaacaaaat tttttttctt
     2941 actccatttg ttactctctg ttctttgact gcccacccac agaaaagcaa aataaccaac
     3001 tacctactca attgtgtgtt tgtaattgct ttgagcagtc tagtcaaatc atataaattg
     3061 ttctaaattt cagaattgaa cattgaagta ttaactcttc tgttcacaca tttagaattt
     3121 tagctcccaa gatggtaggg cagactgacc gtacagtaat ttatttgtcg ttagtgttaa
     3181 agattaagca tagtaactga ctcttaagtg ttaaataatg tagaagtaaa aaaatttttt
     3241 ttaaaggctt aatttgggag gggggactta tttctgttta cagtgtatta ccttccttcc
     3301 ctcctcttct ccccccacac ccaacaaaat acagtttgga attcactgaa acagtaccag
     3361 caagtcatga gattttttag taaagatgag aaagatggtt gaagaaaatt agtgcataat
     3421 ttctcagtga ataaagttgt agctctcata tactaaatag acaagtttac atgctgttat
     3481 ttagaaaatg actaaaatat taaaaaccgt gttgtgttaa tctgttttaa gtcataccat
     3541 gttcagagtt ctatgtaagg tgggttttat ttttctttta agggatagtt tgtaatagta
     3601 agaactgtcc catatgttag taaattacat atgtacaaat tgaaactgta aattgtgaac
     3661 actggaaagc accattgtga catagagtaa acatcttagt aatatattaa agtgaatgta
     3721 aatggtggtt aaaattacat tactgtgaaa ttcatcttcc aactctaagt taagctttgg
     3781 agatacatgt tagtggttaa ctgttaagag ctttgaaaac actgcacata tctgtacaag
     3841 ccagaattac tatttctttg acttattatt agcttggcag ttgcttttga tttgattgtt
     3901 ttatgacatg gtatactact atatttactc agtttgaaac tattcatttc tacacactat
     3961 ttttaaaaat tgcctactag gtgaaacata acaataaaac tacctgtgct gaaatttggg
     4021 ggaagtttag gtcctttaaa aaaacatatt aatcattgac tacatctatg ataaaagtgc
     4081 ttattttggt ttactaagat aatgcagttg gtggaaatga taaacgtttt aagtgttaac
     4141 atcctttgaa tgcgttggat ttcagagaat aaacattttg taaaaatcac ttggtaagga
     4201 ttataaactt aattactgca cttaaaatga aacattactt tttttaaaca atgtgtcaca
     4261 aatgtaggtc tgtattactt gtatgcttgt gtgacttact gttagtccag ctctaaaaat
     4321 ttaaaggttg taattgaaat acaagaaaag agccttcttt tagaagaaag caagtatatt
     4381 tttgctttta cttcaaatgt tatttaaagt agaaatttaa tttgtagata taacctttaa
     4441 aaattttctc attaagacaa tgtttttaat ttaatttgcc tcattacatc taatagttcc
     4501 catttgatgg catgtatagg gaagagtgag agagtgtgtg tgtgtgtatg tgtgtgtaat
     4561 atttatatat attcacagta tgtatttagc atttatttta ttacagcaga tttaaagttt
     4621 gtatctaaat aatgcctatg agttgtgtga agctcttggc ttttttccaa cgttactttg
     4681 taactaatga gggtggatgt tcattgtagt ttatttattt ggttctttag atggaggaat
     4741 ttaaaaaatc aaatttttct cttcaccttt atgacttgac atttccttga tctgttggag
     4801 gctaaaagta ggtataaatg atattgaatg ttgggtatag tgatactctg ccatagttct
     4861 tactgcatga agagaacaag agtcacacaa gttcaccact ttgcacttca tagagaaggt
     4921 acatagagac attgcaaaac ctgtctccat ttgctatcct gataattaag gttttcataa
     4981 tacctagggc ctgtctctga gtaattttaa ttttgccaaa tacactgaca tttaaaatag
     5041 tgatccatct aaattttttt cagctgggtt ttgaggaata taagagcttt caatgataaa
     5101 ggtttgttgt agttgtctta tgtgctgaat ttgcagatga tcagatgctg tgcagaattc
     5161 tgatttattt ttgtttccta aaattaagat agcttgaata ttatttcaca ttcctttttc
     5221 ttttttaaat aaacaggttt gctttggaaa ggcttaatga tggaatgtta gcatcttcac
     5281 tagggtaaag aagaacaaaa agaatgttgc tggaacgtaa aatagtattt aaaagttaat
     5341 gaacacttct ctagttttct tagttatggc cttaataatt agtctcttgg cttaaatgtc
     5401 cactggtttt actttgacac agttgaacaa cactggggtt aagtctctgg tatttaggct
     5461 ggcaatatat atattaacca tattttaaaa gtaccaattt tgtttttaca gaaaagataa
     5521 aactcaaaag agaacagtgt attccttctg aggggctttt ataaattatt aactataata
     5581 tatgatggat tttttcctaa ttttttatat ttccttacaa ttttggtggc cattaattta
     5641 actttaggct tttgggcata tgctagtctg agcttccgaa aagatacata tatgtttccc
     5701 ttttcattag ctgaatgagg atattttaag aagttgaaag agaatttatt ttcaagttgt
     5761 gagtaaatcc tcctttgaaa ttcacctgat tattagataa cttaaagttt atttttaaaa
     5821 gctgacaact ttttatgaat cttcgagttg acagttccta aaagcgtaac tcagatatta
     5881 atgggctgtg tattaaatgg ttttattttc agttttgcag cacagaacac tgttgaaata
     5941 tccatatcaa cttgattttt ttaacctaat tcaggtgtcc tttgcatctc ttaaatgttg
     6001 ggggtggggg tcagagccag ttatccggct tctgttttgt cgattgctta gatttgttcc
     6061 tgttgtcaaa actgttaccc ccaaaattgg tgtgacacat gctcatgcat aaaatgttaa
     6121 aatgagtaca tccttgtatt tgtatttgtt ttcaacatcg ccaaggtgct atgggaaatt
     6181 aacaaaatta gaaaaaaaat aaaattatta aaaagca
//
