LOCUS       NM_001352316            6317 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens La ribonucleoprotein 4 (LARP4), transcript variant 20,
            mRNA.
ACCESSION   NM_001352316 XM_017018758
VERSION     NM_001352316.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6317)
  AUTHORS   Zhang,J., Yang,Y., Song,X., Xing,K. and Chen,Y.
  TITLE     Biological functions of Circular RNA_LARP4/ Upstream frameshift 1
            in development of gastric cancer
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (4), 176-180 (2024)
   PUBMED   38678610
  REMARK    GeneRIF: Biological functions of Circular RNA_LARP4/ Upstream
            frameshift 1 in development of gastric cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6317)
  AUTHORS   Lewis,B.M., Cho,C.Y., Her,H.L., Mizrahi,O., Hunter,T. and Yeo,G.W.
  TITLE     LARP4 is an RNA-binding protein that binds nuclear-encoded
            mitochondrial mRNAs to promote mitochondrial function
  JOURNAL   RNA 30 (3), 223-239 (2024)
   PUBMED   38164626
  REMARK    GeneRIF: LARP4 is an RNA-binding protein that binds nuclear-encoded
            mitochondrial mRNAs to promote mitochondrial function.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6317)
  AUTHORS   Lu,M., Gong,B., Wang,Y. and Li,J.
  TITLE     CircBNC2 affects epithelial ovarian cancer progression through the
            miR-223-3p/ LARP4 axis
  JOURNAL   Anticancer Drugs 34 (3), 384-394 (2023)
   PUBMED   36730544
  REMARK    GeneRIF: CircBNC2 affects epithelial ovarian cancer progression
            through the miR-223-3p/ LARP4 axis.
REFERENCE   4  (bases 1 to 6317)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 6317)
  AUTHORS   Mattijssen,S., Iben,J.R., Li,T., Coon,S.L. and Maraia,R.J.
  TITLE     Single molecule poly(A) tail-seq shows LARP4 opposes deadenylation
            throughout mRNA lifespan with most impact on short tails
  JOURNAL   Elife 9, e59186 (2020)
   PUBMED   32744499
  REMARK    GeneRIF: Single molecule poly(A) tail-seq shows LARP4 opposes
            deadenylation throughout mRNA lifespan with most impact on short
            tails.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6317)
  AUTHORS   Bai,S.W., Herrera-Abreu,M.T., Rohn,J.L., Racine,V., Tajadura,V.,
            Suryavanshi,N., Bechtel,S., Wiemann,S., Baum,B. and Ridley,A.J.
  TITLE     Identification and characterization of a set of conserved and new
            regulators of cytoskeletal organization, cell morphology and
            migration
  JOURNAL   BMC Biol 9, 54 (2011)
   PUBMED   21834987
  REMARK    Erratum:[BMC Biol. 2024 Oct 10;22(1):228. doi:
            10.1186/s12915-024-02036-3.. PMID: 39390519]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6317)
  AUTHORS   Yang,R., Gaidamakov,S.A., Xie,J., Lee,J., Martino,L., Kozlov,G.,
            Crawford,A.K., Russo,A.N., Conte,M.R., Gehring,K. and Maraia,R.J.
  TITLE     La-related protein 4 binds poly(A), interacts with the
            poly(A)-binding protein MLLE domain via a variant PAM2w motif, and
            can promote mRNA stability
  JOURNAL   Mol Cell Biol 31 (3), 542-556 (2011)
   PUBMED   21098120
  REMARK    GeneRIF: LARP4 activity is integrated with other PAM2 protein
            activities by PABP as part of mRNA homeostasis.
REFERENCE   8  (bases 1 to 6317)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   9  (bases 1 to 6317)
  AUTHORS   Puigdecanet,E., Espinet,B., Villa,O., Florensa,L., Besses,C.,
            Serrano,S. and Sole,F.
  TITLE     Detection of abnormalities of PRV-1, TPO, and c-MPL genes detected
            by fluorescence in situ hybridization in essential thrombocythemia
  JOURNAL   Cancer Genet Cytogenet 167 (1), 39-42 (2006)
   PUBMED   16682284
  REMARK    GeneRIF: FISH study showed no cytogenetic abnormalities in any of
            the analyzed cases.
REFERENCE   10 (bases 1 to 6317)
  AUTHORS   Kralovics,R. and Skoda,R.C.
  TITLE     Molecular pathogenesis of Philadelphia chromosome negative
            myeloproliferative disorders
  JOURNAL   Blood Rev 19 (1), 1-13 (2005)
   PUBMED   15572213
  REMARK    GeneRIF: The c-MPL protein altered expression provide an
            opportunity to diagnose and identify subpopulations of MPD
            patients.
            Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090058.21.
            
            On May 31, 2019 this sequence version replaced NM_001352316.1.
            
            Transcript Variant: This variant (20), as well as variant 21,
            encodes isoform o.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.40991.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               AC090058.21        63296-63439
            145-233             AC090058.21        78757-78845
            234-381             AC090058.21        90173-90320
            382-537             AC090058.21        91346-91501
            538-613             AC090058.21        92906-92981
            614-750             AC090058.21        97899-98035
            751-854             AC090058.21        100146-100249
            855-965             AC090058.21        102850-102960
            966-1019            AC090058.21        104001-104054
            1020-1123           AC090058.21        116725-116828
            1124-1336           AC090058.21        123546-123758
            1337-1385           AC090058.21        124993-125041
            1386-1547           AC090058.21        129370-129531
            1548-1669           AC090058.21        135826-135947
            1670-1838           AC090058.21        136410-136578
            1839-6317           AC090058.21        137937-142415
FEATURES             Location/Qualifiers
     source          1..6317
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..6317
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /note="La ribonucleoprotein 4"
                     /db_xref="GeneID:113251"
                     /db_xref="HGNC:HGNC:24320"
                     /db_xref="MIM:618657"
     exon            1..144
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            145..233
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            234..381
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            382..537
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     CDS             426..2177
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /note="isoform o is encoded by transcript variant 20;
                     c-Mpl binding protein; La-related protein 4; La
                     ribonucleoprotein domain family member 4"
                     /codon_start=1
                     /product="la-related protein 4 isoform o"
                     /protein_id="NP_001339245.1"
                     /db_xref="GeneID:113251"
                     /db_xref="HGNC:HGNC:24320"
                     /db_xref="MIM:618657"
                     /translation="MYSSSCETTRNTTGIEESTDGMILGPEDLSYQIYDVSGESNSAV
                     STEDLKECLKKQLEFCFSRENLSKDLYLISQMDSDQFIPIWTVANMEEIKKLTTDPDL
                     ILEVLRSSPMVQVDEKGEKVRPSHKRCIVILREIPETTPIEEVKGLFKSENCPKVISC
                     EFAHNSNWYITFQSDTDAQQAFKYLREEVKTFQGKPIMAPFPNGSFVNGFNSPGSYKT
                     NAAAMNMGRPFQKNRVKPQFRSSGGSEHSTEGSVSLGDGQLNRYSSRNFPAERHNPTV
                     TGHQEQTYLQKETSTLQVEQNGDYGRGRRTLFRGRRRREDDRISRPHPSTAESKAPTP
                     KFDLLASNFPPLPGSSSRMPGELVLENRMSDVVKGVYKEKDNEELTISCPVPADEQTE
                     CTSAQQLNMSTSSPCAAELTALSTTQQEKDLIEDSSVQKDGLNQTTIPVSPPSTTKPS
                     RASTASPCNNNINAATAVALQEPRKLSYAEVCQKPPKEPSSVLVQPLRELRSNVVSPT
                     KNEDNGAPENSVEKPHEKPEARASKDYSGFRGNIIPRGAAGKIREQRRQFSHRAIPQG
                     VTRRNGKEQYVPPRSPK"
     exon            538..613
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            614..750
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            751..854
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            855..965
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1019
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1123
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1336
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1385
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1547
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1669
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1838
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..6317
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4268..4273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /note="hexamer: AATAAA"
     polyA_site      4289
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /note="major polyA site"
     regulatory      6298..6303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /note="hexamer: AATAAA"
     polyA_site      6317
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /note="major polyA site"
ORIGIN      
        1 agccgggtcc actgccgggt ggaggggcaa ggcgagtgtg tgtccttatc ctagcaattg
       61 gggcgcgggc ctgtgagcca gttggagttg cggcggcggg aacgattggg ctgagcagag
      121 gacgacatgt tgcttttcgt ggagtgagaa tcagagcgtc tactgcacct ttcagatgac
      181 cgggtgccgt ggctcaacac ctataatccc agcacttggg atgggaggct aagcaggtag
      241 catctaaagg aactggttta aatcctaatg ccaaagtatg gcaagaaatt gctcctggaa
      301 atactgatgc caccccagta actcatggaa ctgaaagctc ttggcatgaa atagcagcta
      361 catcaggtgc tcatcctgag ggtaatgcag agctctcaga agatatatgt aaagaatatg
      421 aagtaatgta ttcttcatct tgtgaaacca caagaaatac tacaggcatt gaagaatcaa
      481 ctgatgggat gattttagga ccagaagatc tgagttacca aatatatgat gtttccggag
      541 aaagcaattc agcagtttct acagaagacc taaaagaatg tctgaagaaa caattagaat
      601 tctgtttttc acgagaaaat ttgtcaaagg atctttactt gatatctcaa atggatagtg
      661 atcagttcat cccaatttgg acagttgcca acatggaaga aataaaaaag ttgactacag
      721 accctgatct aattcttgaa gtgttaagat cttctcccat ggtacaagtt gatgagaagg
      781 gtgagaaagt gagaccaagt cataagcgtt gtattgtaat tcttagagag attcctgaaa
      841 caacaccaat agaggaagtg aaaggtttgt tcaaaagtga aaactgcccc aaagtgataa
      901 gctgtgagtt tgcacacaat agcaactggt atatcacttt ccagtcagac acagatgcac
      961 aacaggcttt taaatactta agagaagaag ttaaaacatt tcagggcaag ccaattatgg
     1021 ctccctttcc caatggtagt tttgtgaatg gctttaattc gccaggatct tataaaacaa
     1081 atgctgctgc tatgaatatg ggtcgaccat tccaaaaaaa tcgtgtgaag cctcagttta
     1141 ggtcatctgg tggttcagaa cactcaacag agggctctgt atccttgggg gatggacagt
     1201 tgaacagata tagttcaaga aactttccag ctgaacggca taaccccaca gtaactgggc
     1261 atcaggagca aacttacctt cagaaggaga cttccacttt gcaggtggaa cagaatgggg
     1321 actatggtag gggcaggaga actctcttca gaggtcgaag acgacgagaa gatgacagga
     1381 tctcaagacc tcatccttca acagctgaat caaaggctcc aacaccaaag tttgacttat
     1441 tagcctcaaa ttttccacct ttacctggaa gttcatcaag aatgccaggt gaactcgttt
     1501 tggagaatag gatgtctgat gttgttaaag gtgtctacaa agaaaaggat aatgaagagt
     1561 tgacaattag ttgcccagtg cctgcagatg agcagacaga atgcacttct gcccagcaac
     1621 tcaatatgag taccagttct ccatgtgctg ctgagcttac tgcattaagc acaactcagc
     1681 aagaaaagga tctaatagaa gattcctctg ttcagaagga tggtctcaat cagacaacta
     1741 taccagtttc tcctccaagt actacaaagc catcgagggc aagtactgct tcaccatgta
     1801 ataataacat aaatgcagct acagctgtgg ctctacagga accccgaaag ttaagttatg
     1861 ctgaagtgtg ccagaagccc cctaaagagc catcttcagt tcttgtgcag ccactacggg
     1921 aacttcgctc caatgtggtg tctcccacca aaaatgaaga caatggagct cctgagaact
     1981 ccgttgagaa accacatgag aagccagaag caagggctag taaggattat tctggcttcc
     2041 gaggcaatat aatccccagg ggagcagcag gaaaaatcag ggaacagaga cgccagttta
     2101 gccatagggc tatacctcag ggagtgactc gacgtaatgg caaagagcaa tatgtgccac
     2161 ccagatcacc aaagtaaaaa acaacaaaac tattcaaaaa cttcactctc ttcccattaa
     2221 acttgaactg tggctatatt gaactgtttt ggaggggagg gggtagccag gaaggaaaca
     2281 agagaaagta cgtccatttc attatggatt ttggagttgt gagtgatagg atcccaaaat
     2341 tcatctctaa tgtggttttt aaatgctgga ggattccaat caatataaat atatatatat
     2401 atatacacac acatatataa aaagtataat ttttctattt ttgtttttgg ttttaatttg
     2461 cagagatttg ctgccaggaa tcaattttga gggttcagat ttagcttgga agaaaaaaaa
     2521 gaaacataca tccttcagta taggagatga gggaatgaga gaaaatattt tttgaagaag
     2581 catttctgta aaattagaaa ttactttttt taatctattt aaagtttggc ttgaagaatg
     2641 ccatctctga ctatatggcc ttgtattgca aagcggatca gtggctgggg tgcctgttgt
     2701 gggtgtgagt gtgtacaaga gcgattgaag ccaaatctgt tgtcatgtta gtaaatgatt
     2761 tgaaaactga atgtaatact tgagtagatt tttttttcta gtttgaaatt tagtctgtct
     2821 ttttgacctt actaatattt catttaacaa gttgtaaaac tctgattgta cttagagatg
     2881 tgactaccaa tcagtttgat actcaaggaa agggggttat tcaagaaatt gaaaatttca
     2941 tcttggacct cagtgcatag gtcaaatgga tttcagaggt ttaaacttcc ctgtgattcc
     3001 cccgaatacc cccaaaatga gaaacaaaat tttttttctt actccatttg ttactctctg
     3061 ttctttgact gcccacccac agaaaagcaa aataaccaac tacctactca attgtgtgtt
     3121 tgtaattgct ttgagcagtc tagtcaaatc atataaattg ttctaaattt cagaattgaa
     3181 cattgaagta ttaactcttc tgttcacaca tttagaattt tagctcccaa gatggtaggg
     3241 cagactgacc gtacagtaat ttatttgtcg ttagtgttaa agattaagca tagtaactga
     3301 ctcttaagtg ttaaataatg tagaagtaaa aaaatttttt ttaaaggctt aatttgggag
     3361 gggggactta tttctgttta cagtgtatta ccttccttcc ctcctcttct ccccccacac
     3421 ccaacaaaat acagtttgga attcactgaa acagtaccag caagtcatga gattttttag
     3481 taaagatgag aaagatggtt gaagaaaatt agtgcataat ttctcagtga ataaagttgt
     3541 agctctcata tactaaatag acaagtttac atgctgttat ttagaaaatg actaaaatat
     3601 taaaaaccgt gttgtgttaa tctgttttaa gtcataccat gttcagagtt ctatgtaagg
     3661 tgggttttat ttttctttta agggatagtt tgtaatagta agaactgtcc catatgttag
     3721 taaattacat atgtacaaat tgaaactgta aattgtgaac actggaaagc accattgtga
     3781 catagagtaa acatcttagt aatatattaa agtgaatgta aatggtggtt aaaattacat
     3841 tactgtgaaa ttcatcttcc aactctaagt taagctttgg agatacatgt tagtggttaa
     3901 ctgttaagag ctttgaaaac actgcacata tctgtacaag ccagaattac tatttctttg
     3961 acttattatt agcttggcag ttgcttttga tttgattgtt ttatgacatg gtatactact
     4021 atatttactc agtttgaaac tattcatttc tacacactat ttttaaaaat tgcctactag
     4081 gtgaaacata acaataaaac tacctgtgct gaaatttggg ggaagtttag gtcctttaaa
     4141 aaaacatatt aatcattgac tacatctatg ataaaagtgc ttattttggt ttactaagat
     4201 aatgcagttg gtggaaatga taaacgtttt aagtgttaac atcctttgaa tgcgttggat
     4261 ttcagagaat aaacattttg taaaaatcac ttggtaagga ttataaactt aattactgca
     4321 cttaaaatga aacattactt tttttaaaca atgtgtcaca aatgtaggtc tgtattactt
     4381 gtatgcttgt gtgacttact gttagtccag ctctaaaaat ttaaaggttg taattgaaat
     4441 acaagaaaag agccttcttt tagaagaaag caagtatatt tttgctttta cttcaaatgt
     4501 tatttaaagt agaaatttaa tttgtagata taacctttaa aaattttctc attaagacaa
     4561 tgtttttaat ttaatttgcc tcattacatc taatagttcc catttgatgg catgtatagg
     4621 gaagagtgag agagtgtgtg tgtgtgtatg tgtgtgtaat atttatatat attcacagta
     4681 tgtatttagc atttatttta ttacagcaga tttaaagttt gtatctaaat aatgcctatg
     4741 agttgtgtga agctcttggc ttttttccaa cgttactttg taactaatga gggtggatgt
     4801 tcattgtagt ttatttattt ggttctttag atggaggaat ttaaaaaatc aaatttttct
     4861 cttcaccttt atgacttgac atttccttga tctgttggag gctaaaagta ggtataaatg
     4921 atattgaatg ttgggtatag tgatactctg ccatagttct tactgcatga agagaacaag
     4981 agtcacacaa gttcaccact ttgcacttca tagagaaggt acatagagac attgcaaaac
     5041 ctgtctccat ttgctatcct gataattaag gttttcataa tacctagggc ctgtctctga
     5101 gtaattttaa ttttgccaaa tacactgaca tttaaaatag tgatccatct aaattttttt
     5161 cagctgggtt ttgaggaata taagagcttt caatgataaa ggtttgttgt agttgtctta
     5221 tgtgctgaat ttgcagatga tcagatgctg tgcagaattc tgatttattt ttgtttccta
     5281 aaattaagat agcttgaata ttatttcaca ttcctttttc ttttttaaat aaacaggttt
     5341 gctttggaaa ggcttaatga tggaatgtta gcatcttcac tagggtaaag aagaacaaaa
     5401 agaatgttgc tggaacgtaa aatagtattt aaaagttaat gaacacttct ctagttttct
     5461 tagttatggc cttaataatt agtctcttgg cttaaatgtc cactggtttt actttgacac
     5521 agttgaacaa cactggggtt aagtctctgg tatttaggct ggcaatatat atattaacca
     5581 tattttaaaa gtaccaattt tgtttttaca gaaaagataa aactcaaaag agaacagtgt
     5641 attccttctg aggggctttt ataaattatt aactataata tatgatggat tttttcctaa
     5701 ttttttatat ttccttacaa ttttggtggc cattaattta actttaggct tttgggcata
     5761 tgctagtctg agcttccgaa aagatacata tatgtttccc ttttcattag ctgaatgagg
     5821 atattttaag aagttgaaag agaatttatt ttcaagttgt gagtaaatcc tcctttgaaa
     5881 ttcacctgat tattagataa cttaaagttt atttttaaaa gctgacaact ttttatgaat
     5941 cttcgagttg acagttccta aaagcgtaac tcagatatta atgggctgtg tattaaatgg
     6001 ttttattttc agttttgcag cacagaacac tgttgaaata tccatatcaa cttgattttt
     6061 ttaacctaat tcaggtgtcc tttgcatctc ttaaatgttg ggggtggggg tcagagccag
     6121 ttatccggct tctgttttgt cgattgctta gatttgttcc tgttgtcaaa actgttaccc
     6181 ccaaaattgg tgtgacacat gctcatgcat aaaatgttaa aatgagtaca tccttgtatt
     6241 tgtatttgtt ttcaacatcg ccaaggtgct atgggaaatt aacaaaatta gaaaaaaaat
     6301 aaaattatta aaaagca
//
