LOCUS       NM_001352308            6246 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens La ribonucleoprotein 4 (LARP4), transcript variant 12,
            mRNA.
ACCESSION   NM_001352308 XM_017018750
VERSION     NM_001352308.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6246)
  AUTHORS   Zhang,J., Yang,Y., Song,X., Xing,K. and Chen,Y.
  TITLE     Biological functions of Circular RNA_LARP4/ Upstream frameshift 1
            in development of gastric cancer
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (4), 176-180 (2024)
   PUBMED   38678610
  REMARK    GeneRIF: Biological functions of Circular RNA_LARP4/ Upstream
            frameshift 1 in development of gastric cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6246)
  AUTHORS   Lewis,B.M., Cho,C.Y., Her,H.L., Mizrahi,O., Hunter,T. and Yeo,G.W.
  TITLE     LARP4 is an RNA-binding protein that binds nuclear-encoded
            mitochondrial mRNAs to promote mitochondrial function
  JOURNAL   RNA 30 (3), 223-239 (2024)
   PUBMED   38164626
  REMARK    GeneRIF: LARP4 is an RNA-binding protein that binds nuclear-encoded
            mitochondrial mRNAs to promote mitochondrial function.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6246)
  AUTHORS   Lu,M., Gong,B., Wang,Y. and Li,J.
  TITLE     CircBNC2 affects epithelial ovarian cancer progression through the
            miR-223-3p/ LARP4 axis
  JOURNAL   Anticancer Drugs 34 (3), 384-394 (2023)
   PUBMED   36730544
  REMARK    GeneRIF: CircBNC2 affects epithelial ovarian cancer progression
            through the miR-223-3p/ LARP4 axis.
REFERENCE   4  (bases 1 to 6246)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 6246)
  AUTHORS   Mattijssen,S., Iben,J.R., Li,T., Coon,S.L. and Maraia,R.J.
  TITLE     Single molecule poly(A) tail-seq shows LARP4 opposes deadenylation
            throughout mRNA lifespan with most impact on short tails
  JOURNAL   Elife 9, e59186 (2020)
   PUBMED   32744499
  REMARK    GeneRIF: Single molecule poly(A) tail-seq shows LARP4 opposes
            deadenylation throughout mRNA lifespan with most impact on short
            tails.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6246)
  AUTHORS   Bai,S.W., Herrera-Abreu,M.T., Rohn,J.L., Racine,V., Tajadura,V.,
            Suryavanshi,N., Bechtel,S., Wiemann,S., Baum,B. and Ridley,A.J.
  TITLE     Identification and characterization of a set of conserved and new
            regulators of cytoskeletal organization, cell morphology and
            migration
  JOURNAL   BMC Biol 9, 54 (2011)
   PUBMED   21834987
  REMARK    Erratum:[BMC Biol. 2024 Oct 10;22(1):228. doi:
            10.1186/s12915-024-02036-3.. PMID: 39390519]
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6246)
  AUTHORS   Yang,R., Gaidamakov,S.A., Xie,J., Lee,J., Martino,L., Kozlov,G.,
            Crawford,A.K., Russo,A.N., Conte,M.R., Gehring,K. and Maraia,R.J.
  TITLE     La-related protein 4 binds poly(A), interacts with the
            poly(A)-binding protein MLLE domain via a variant PAM2w motif, and
            can promote mRNA stability
  JOURNAL   Mol Cell Biol 31 (3), 542-556 (2011)
   PUBMED   21098120
  REMARK    GeneRIF: LARP4 activity is integrated with other PAM2 protein
            activities by PABP as part of mRNA homeostasis.
REFERENCE   8  (bases 1 to 6246)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   9  (bases 1 to 6246)
  AUTHORS   Puigdecanet,E., Espinet,B., Villa,O., Florensa,L., Besses,C.,
            Serrano,S. and Sole,F.
  TITLE     Detection of abnormalities of PRV-1, TPO, and c-MPL genes detected
            by fluorescence in situ hybridization in essential thrombocythemia
  JOURNAL   Cancer Genet Cytogenet 167 (1), 39-42 (2006)
   PUBMED   16682284
  REMARK    GeneRIF: FISH study showed no cytogenetic abnormalities in any of
            the analyzed cases.
REFERENCE   10 (bases 1 to 6246)
  AUTHORS   Kralovics,R. and Skoda,R.C.
  TITLE     Molecular pathogenesis of Philadelphia chromosome negative
            myeloproliferative disorders
  JOURNAL   Blood Rev 19 (1), 1-13 (2005)
   PUBMED   15572213
  REMARK    GeneRIF: The c-MPL protein altered expression provide an
            opportunity to diagnose and identify subpopulations of MPD
            patients.
            Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090058.21.
            
            On May 31, 2019 this sequence version replaced NM_001352308.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.120309.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-144               AC090058.21        63296-63439
            145-292             AC090058.21        90173-90320
            293-466             AC090058.21        91328-91501
            467-542             AC090058.21        92906-92981
            543-679             AC090058.21        97899-98035
            680-783             AC090058.21        100146-100249
            784-894             AC090058.21        102850-102960
            895-948             AC090058.21        104001-104054
            949-1052            AC090058.21        116725-116828
            1053-1265           AC090058.21        123546-123758
            1266-1314           AC090058.21        124993-125041
            1315-1476           AC090058.21        129370-129531
            1477-1598           AC090058.21        135826-135947
            1599-1767           AC090058.21        136410-136578
            1768-6246           AC090058.21        137937-142415
FEATURES             Location/Qualifiers
     source          1..6246
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..6246
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /note="La ribonucleoprotein 4"
                     /db_xref="GeneID:113251"
                     /db_xref="HGNC:HGNC:24320"
                     /db_xref="MIM:618657"
     exon            1..144
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..2106
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /note="isoform l is encoded by transcript variant 12;
                     c-Mpl binding protein; La-related protein 4; La
                     ribonucleoprotein domain family member 4"
                     /codon_start=1
                     /product="la-related protein 4 isoform l"
                     /protein_id="NP_001339237.1"
                     /db_xref="GeneID:113251"
                     /db_xref="HGNC:HGNC:24320"
                     /db_xref="MIM:618657"
                     /translation="MLLFVEQVASKGTGLNPNAKVWQEIAPGNTDATPVTHGTESSWH
                     EIAATSGAHPEVSVFNTGNAELSEDICKEYEVMYSSSCETTRNTTGIEESTDGMILGP
                     EDLSYQIYDVSGESNSAVSTEDLKECLKKQLEFCFSRENLSKDLYLISQMDSDQFIPI
                     WTVANMEEIKKLTTDPDLILEVLRSSPMVQVDEKGEKVRPSHKRCIVILREIPETTPI
                     EEVKGLFKSENCPKVISCEFAHNSNWYITFQSDTDAQQAFKYLREEVKTFQGKPIMAP
                     FPNGSFVNGFNSPGSYKTNAAAMNMGRPFQKNRVKPQFRSSGGSEHSTEGSVSLGDGQ
                     LNRYSSRNFPAERHNPTVTGHQEQTYLQKETSTLQVEQNGDYGRGRRTLFRGRRRRED
                     DRISRPHPSTAESKAPTPKFDLLASNFPPLPGSSSRMPGELVLENRMSDVVKGVYKEK
                     DNEELTISCPVPADEQTECTSAQQLNMSTSSPCAAELTALSTTQQEKDLIEDSSVQKD
                     GLNQTTIPVSPPSTTKPSRASTASPCNNNINAATAVALQEPRKLSYAEVCQKPPKEPS
                     SVLVQPLRELRSNVVSPTKNEDNGAPENSVEKPHEKPEARASKDYSGFRGNIIPRGAA
                     GKIREQRRQFSHRAIPQGVTRRNGKEQYVPPRSPK"
     exon            145..292
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            293..466
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            467..542
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            543..679
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            680..783
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            784..894
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            895..948
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1052
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1265
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1314
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1476
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1598
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1767
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..6246
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4197..4202
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /note="hexamer: AATAAA"
     polyA_site      4218
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /note="major polyA site"
     regulatory      6227..6232
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /note="hexamer: AATAAA"
     polyA_site      6246
                     /gene="LARP4"
                     /gene_synonym="PP13296"
                     /note="major polyA site"
ORIGIN      
        1 agccgggtcc actgccgggt ggaggggcaa ggcgagtgtg tgtccttatc ctagcaattg
       61 gggcgcgggc ctgtgagcca gttggagttg cggcggcggg aacgattggg ctgagcagag
      121 gacgacatgt tgcttttcgt ggagcaggta gcatctaaag gaactggttt aaatcctaat
      181 gccaaagtat ggcaagaaat tgctcctgga aatactgatg ccaccccagt aactcatgga
      241 actgaaagct cttggcatga aatagcagct acatcaggtg ctcatcctga ggtgtctgtc
      301 tttaatacag gtaatgcaga gctctcagaa gatatatgta aagaatatga agtaatgtat
      361 tcttcatctt gtgaaaccac aagaaatact acaggcattg aagaatcaac tgatgggatg
      421 attttaggac cagaagatct gagttaccaa atatatgatg tttccggaga aagcaattca
      481 gcagtttcta cagaagacct aaaagaatgt ctgaagaaac aattagaatt ctgtttttca
      541 cgagaaaatt tgtcaaagga tctttacttg atatctcaaa tggatagtga tcagttcatc
      601 ccaatttgga cagttgccaa catggaagaa ataaaaaagt tgactacaga ccctgatcta
      661 attcttgaag tgttaagatc ttctcccatg gtacaagttg atgagaaggg tgagaaagtg
      721 agaccaagtc ataagcgttg tattgtaatt cttagagaga ttcctgaaac aacaccaata
      781 gaggaagtga aaggtttgtt caaaagtgaa aactgcccca aagtgataag ctgtgagttt
      841 gcacacaata gcaactggta tatcactttc cagtcagaca cagatgcaca acaggctttt
      901 aaatacttaa gagaagaagt taaaacattt cagggcaagc caattatggc tccctttccc
      961 aatggtagtt ttgtgaatgg ctttaattcg ccaggatctt ataaaacaaa tgctgctgct
     1021 atgaatatgg gtcgaccatt ccaaaaaaat cgtgtgaagc ctcagtttag gtcatctggt
     1081 ggttcagaac actcaacaga gggctctgta tccttggggg atggacagtt gaacagatat
     1141 agttcaagaa actttccagc tgaacggcat aaccccacag taactgggca tcaggagcaa
     1201 acttaccttc agaaggagac ttccactttg caggtggaac agaatgggga ctatggtagg
     1261 ggcaggagaa ctctcttcag aggtcgaaga cgacgagaag atgacaggat ctcaagacct
     1321 catccttcaa cagctgaatc aaaggctcca acaccaaagt ttgacttatt agcctcaaat
     1381 tttccacctt tacctggaag ttcatcaaga atgccaggtg aactcgtttt ggagaatagg
     1441 atgtctgatg ttgttaaagg tgtctacaaa gaaaaggata atgaagagtt gacaattagt
     1501 tgcccagtgc ctgcagatga gcagacagaa tgcacttctg cccagcaact caatatgagt
     1561 accagttctc catgtgctgc tgagcttact gcattaagca caactcagca agaaaaggat
     1621 ctaatagaag attcctctgt tcagaaggat ggtctcaatc agacaactat accagtttct
     1681 cctccaagta ctacaaagcc atcgagggca agtactgctt caccatgtaa taataacata
     1741 aatgcagcta cagctgtggc tctacaggaa ccccgaaagt taagttatgc tgaagtgtgc
     1801 cagaagcccc ctaaagagcc atcttcagtt cttgtgcagc cactacggga acttcgctcc
     1861 aatgtggtgt ctcccaccaa aaatgaagac aatggagctc ctgagaactc cgttgagaaa
     1921 ccacatgaga agccagaagc aagggctagt aaggattatt ctggcttccg aggcaatata
     1981 atccccaggg gagcagcagg aaaaatcagg gaacagagac gccagtttag ccatagggct
     2041 atacctcagg gagtgactcg acgtaatggc aaagagcaat atgtgccacc cagatcacca
     2101 aagtaaaaaa caacaaaact attcaaaaac ttcactctct tcccattaaa cttgaactgt
     2161 ggctatattg aactgttttg gaggggaggg ggtagccagg aaggaaacaa gagaaagtac
     2221 gtccatttca ttatggattt tggagttgtg agtgatagga tcccaaaatt catctctaat
     2281 gtggttttta aatgctggag gattccaatc aatataaata tatatatata tatacacaca
     2341 catatataaa aagtataatt tttctatttt tgtttttggt tttaatttgc agagatttgc
     2401 tgccaggaat caattttgag ggttcagatt tagcttggaa gaaaaaaaag aaacatacat
     2461 ccttcagtat aggagatgag ggaatgagag aaaatatttt ttgaagaagc atttctgtaa
     2521 aattagaaat tacttttttt aatctattta aagtttggct tgaagaatgc catctctgac
     2581 tatatggcct tgtattgcaa agcggatcag tggctggggt gcctgttgtg ggtgtgagtg
     2641 tgtacaagag cgattgaagc caaatctgtt gtcatgttag taaatgattt gaaaactgaa
     2701 tgtaatactt gagtagattt ttttttctag tttgaaattt agtctgtctt tttgacctta
     2761 ctaatatttc atttaacaag ttgtaaaact ctgattgtac ttagagatgt gactaccaat
     2821 cagtttgata ctcaaggaaa gggggttatt caagaaattg aaaatttcat cttggacctc
     2881 agtgcatagg tcaaatggat ttcagaggtt taaacttccc tgtgattccc ccgaataccc
     2941 ccaaaatgag aaacaaaatt ttttttctta ctccatttgt tactctctgt tctttgactg
     3001 cccacccaca gaaaagcaaa ataaccaact acctactcaa ttgtgtgttt gtaattgctt
     3061 tgagcagtct agtcaaatca tataaattgt tctaaatttc agaattgaac attgaagtat
     3121 taactcttct gttcacacat ttagaatttt agctcccaag atggtagggc agactgaccg
     3181 tacagtaatt tatttgtcgt tagtgttaaa gattaagcat agtaactgac tcttaagtgt
     3241 taaataatgt agaagtaaaa aaattttttt taaaggctta atttgggagg ggggacttat
     3301 ttctgtttac agtgtattac cttccttccc tcctcttctc cccccacacc caacaaaata
     3361 cagtttggaa ttcactgaaa cagtaccagc aagtcatgag attttttagt aaagatgaga
     3421 aagatggttg aagaaaatta gtgcataatt tctcagtgaa taaagttgta gctctcatat
     3481 actaaataga caagtttaca tgctgttatt tagaaaatga ctaaaatatt aaaaaccgtg
     3541 ttgtgttaat ctgttttaag tcataccatg ttcagagttc tatgtaaggt gggttttatt
     3601 tttcttttaa gggatagttt gtaatagtaa gaactgtccc atatgttagt aaattacata
     3661 tgtacaaatt gaaactgtaa attgtgaaca ctggaaagca ccattgtgac atagagtaaa
     3721 catcttagta atatattaaa gtgaatgtaa atggtggtta aaattacatt actgtgaaat
     3781 tcatcttcca actctaagtt aagctttgga gatacatgtt agtggttaac tgttaagagc
     3841 tttgaaaaca ctgcacatat ctgtacaagc cagaattact atttctttga cttattatta
     3901 gcttggcagt tgcttttgat ttgattgttt tatgacatgg tatactacta tatttactca
     3961 gtttgaaact attcatttct acacactatt tttaaaaatt gcctactagg tgaaacataa
     4021 caataaaact acctgtgctg aaatttgggg gaagtttagg tcctttaaaa aaacatatta
     4081 atcattgact acatctatga taaaagtgct tattttggtt tactaagata atgcagttgg
     4141 tggaaatgat aaacgtttta agtgttaaca tcctttgaat gcgttggatt tcagagaata
     4201 aacattttgt aaaaatcact tggtaaggat tataaactta attactgcac ttaaaatgaa
     4261 acattacttt ttttaaacaa tgtgtcacaa atgtaggtct gtattacttg tatgcttgtg
     4321 tgacttactg ttagtccagc tctaaaaatt taaaggttgt aattgaaata caagaaaaga
     4381 gccttctttt agaagaaagc aagtatattt ttgcttttac ttcaaatgtt atttaaagta
     4441 gaaatttaat ttgtagatat aacctttaaa aattttctca ttaagacaat gtttttaatt
     4501 taatttgcct cattacatct aatagttccc atttgatggc atgtataggg aagagtgaga
     4561 gagtgtgtgt gtgtgtatgt gtgtgtaata tttatatata ttcacagtat gtatttagca
     4621 tttattttat tacagcagat ttaaagtttg tatctaaata atgcctatga gttgtgtgaa
     4681 gctcttggct tttttccaac gttactttgt aactaatgag ggtggatgtt cattgtagtt
     4741 tatttatttg gttctttaga tggaggaatt taaaaaatca aatttttctc ttcaccttta
     4801 tgacttgaca tttccttgat ctgttggagg ctaaaagtag gtataaatga tattgaatgt
     4861 tgggtatagt gatactctgc catagttctt actgcatgaa gagaacaaga gtcacacaag
     4921 ttcaccactt tgcacttcat agagaaggta catagagaca ttgcaaaacc tgtctccatt
     4981 tgctatcctg ataattaagg ttttcataat acctagggcc tgtctctgag taattttaat
     5041 tttgccaaat acactgacat ttaaaatagt gatccatcta aatttttttc agctgggttt
     5101 tgaggaatat aagagctttc aatgataaag gtttgttgta gttgtcttat gtgctgaatt
     5161 tgcagatgat cagatgctgt gcagaattct gatttatttt tgtttcctaa aattaagata
     5221 gcttgaatat tatttcacat tcctttttct tttttaaata aacaggtttg ctttggaaag
     5281 gcttaatgat ggaatgttag catcttcact agggtaaaga agaacaaaaa gaatgttgct
     5341 ggaacgtaaa atagtattta aaagttaatg aacacttctc tagttttctt agttatggcc
     5401 ttaataatta gtctcttggc ttaaatgtcc actggtttta ctttgacaca gttgaacaac
     5461 actggggtta agtctctggt atttaggctg gcaatatata tattaaccat attttaaaag
     5521 taccaatttt gtttttacag aaaagataaa actcaaaaga gaacagtgta ttccttctga
     5581 ggggctttta taaattatta actataatat atgatggatt ttttcctaat tttttatatt
     5641 tccttacaat tttggtggcc attaatttaa ctttaggctt ttgggcatat gctagtctga
     5701 gcttccgaaa agatacatat atgtttccct tttcattagc tgaatgagga tattttaaga
     5761 agttgaaaga gaatttattt tcaagttgtg agtaaatcct cctttgaaat tcacctgatt
     5821 attagataac ttaaagttta tttttaaaag ctgacaactt tttatgaatc ttcgagttga
     5881 cagttcctaa aagcgtaact cagatattaa tgggctgtgt attaaatggt tttattttca
     5941 gttttgcagc acagaacact gttgaaatat ccatatcaac ttgatttttt taacctaatt
     6001 caggtgtcct ttgcatctct taaatgttgg gggtgggggt cagagccagt tatccggctt
     6061 ctgttttgtc gattgcttag atttgttcct gttgtcaaaa ctgttacccc caaaattggt
     6121 gtgacacatg ctcatgcata aaatgttaaa atgagtacat ccttgtattt gtatttgttt
     6181 tcaacatcgc caaggtgcta tgggaaatta acaaaattag aaaaaaaata aaattattaa
     6241 aaagca
//
