LOCUS       NM_018078               4847 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens La ribonucleoprotein 1B (LARP1B), transcript variant
            1, mRNA.
ACCESSION   NM_018078
VERSION     NM_018078.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4847)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4847)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 4847)
  AUTHORS   Gao,T., Nie,Y. and Guo,J.
  TITLE     Hypermethylation of the gene LARP2 for noninvasive prenatal
            diagnosis of beta-thalassemia based on DNA methylation profile
  JOURNAL   Mol Biol Rep 39 (6), 6591-6598 (2012)
   PUBMED   22327645
  REMARK    GeneRIF: The promoter of the gene of La ribonucleoprotein domain
            family (LARP2) was significantly hypermethylated in
            beta-thalassemia, and the expression of LARP2 was significantly
            lower in beta-thalassemia.
REFERENCE   4  (bases 1 to 4847)
  AUTHORS   Orvedahl,A., Sumpter,R. Jr., Xiao,G., Ng,A., Zou,Z., Tang,Y.,
            Narimatsu,M., Gilpin,C., Sun,Q., Roth,M., Forst,C.V., Wrana,J.L.,
            Zhang,Y.E., Luby-Phelps,K., Xavier,R.J., Xie,Y. and Levine,B.
  TITLE     Image-based genome-wide siRNA screen identifies selective autophagy
            factors
  JOURNAL   Nature 480 (7375), 113-117 (2011)
   PUBMED   22020285
REFERENCE   5  (bases 1 to 4847)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   6  (bases 1 to 4847)
  AUTHORS   Wolin,S.L. and Cedervall,T.
  TITLE     The La protein
  JOURNAL   Annu Rev Biochem 71, 375-403 (2002)
   PUBMED   12045101
  REMARK    GeneRIF: Review discusses the La motif, found in this protein.
            Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA181086.1, DB230609.1,
            AK092764.1, AL137759.1, AK027164.1, AI374914.1 and AC096898.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_018078.3.
            
            Summary: This gene encodes a protein containing domains found in
            the La related protein of Drosophila melanogaster. La
            motif-containing proteins are thought to be RNA-binding proteins,
            where the La motif and adjacent amino acids fold into an RNA
            recognition motif. The La motif is also found in proteins unrelated
            to the La protein. Alternative splicing has been observed at this
            locus and multiple variants, encoding distinct isoforms, are
            described. Additional splice variation has been identified but the
            full-length nature of these transcripts has not been determined.
            [provided by RefSeq, Jun 2013].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA1970526 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000326639.11/ ENSP00000321997.6
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-521               DA181086.1         47-567
            522-588             DB230609.1         525-591
            589-981             AK092764.1         448-840
            982-1551            AL137759.1         762-1331
            1552-1584           AK092764.1         1411-1443
            1585-1633           AL137759.1         1365-1413
            1634-1815           AK092764.1         1493-1674
            1816-2145           AL137759.1         1596-1925
            2146-2191           AK027164.1         159-204
            2192-3993           AL137759.1         1972-3773
            3994-4002           AI374914.1         6-14                c
            4003-4847           AC096898.6         16069-16913
FEATURES             Location/Qualifiers
     source          1..4847
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q28.2"
     gene            1..4847
                     /gene="LARP1B"
                     /gene_synonym="LARP2"
                     /note="La ribonucleoprotein 1B"
                     /db_xref="GeneID:55132"
                     /db_xref="HGNC:HGNC:24704"
                     /db_xref="MIM:620467"
     exon            1..90
                     /gene="LARP1B"
                     /gene_synonym="LARP2"
                     /inference="alignment:Splign:2.1.0"
     exon            91..149
                     /gene="LARP1B"
                     /gene_synonym="LARP2"
                     /inference="alignment:Splign:2.1.0"
     exon            150..209
                     /gene="LARP1B"
                     /gene_synonym="LARP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..2912
                     /gene="LARP1B"
                     /gene_synonym="LARP2"
                     /note="isoform 1 is encoded by transcript variant 1; La
                     ribonucleoprotein domain family, member 2; la-related
                     protein 1B; La ribonucleoprotein domain family member 1B;
                     la-related protein 2"
                     /codon_start=1
                     /product="la-related protein 1B isoform 1"
                     /protein_id="NP_060548.2"
                     /db_xref="CCDS:CCDS3738.1"
                     /db_xref="GeneID:55132"
                     /db_xref="HGNC:HGNC:24704"
                     /db_xref="MIM:620467"
                     /translation="MENWPTPSELVNTGFQSVLSQGNKKPQNRKEKEEKVEKRSNSDS
                     KENRETKLNGPGENVSEDEAQSSNQRKRANKHKWVPLHLDVVRSESQERPGSRNSSRC
                     QPEANKPTHNNRRNDTRSWKRDREKRDDQDDVSSVRSEGGNIRGSFRGRGRGRGRGRG
                     RGRGNPRLNFDYSYGYQEHGERTDQPFQTELNTSMMYYYDDGTGVQVYPVEEALLKEY
                     IKRQIEYYFSVENLERDFFLRGKMDEQGFLPISLIAGFQRVQALTTNLNLILEALKDS
                     TEVEIVDEKMRKKIEPEKWPIPGPPPRSVPPTDFSQLIDCPEFVPGQAFCSHTESAPN
                     SPRIGSPLSPKKNSETSILQAMSRGLSTSLPDLDSEPWIEVKKRHQPAPVKLRESVSV
                     PEGSLNQLCSSEEPEQEELDFLFDEEIEQIGRKNTFTDWSDNDSDYEIDDQDLNKILI
                     VTQTPPYVKKHPGGDRTGTHMSRAKITSELAKVINDGLYYYEQDLWMEEDENKHTAIK
                     QEVENFKKLNLISKEQFENLTPELPFEPNQEVPVAPSQSRQGGVQGVLHIPKKDLTDE
                     LAQKLFDVSEITSAAMVHSLPTAVPESPRIHPTRTPKTPRTPRLQDPNKTPRFYPVVK
                     EPKAIDVKSPRKRKTRHSTNPPLECHVGWVMDSRDRGPGTSSVSTSNASPSEGAPLAG
                     SYGCTPHSFPKFQHPSHELLKENGFTQQVYHKYRRRCLSERKRLGIGQSQEMNTLFRF
                     WSFFLRDHFNKKMYEEFRQLAWEDAKENYRYGLECLFRFYSYGLEKKFRREIFQDFQE
                     ETKKDYESGQLYGLEKFWAYLKYSQSKTQSIDPKLQEYLCSFKRLEDFRVDPPISDEF
                     GRKRHSSTSGEESNRHRLPPNSSTKPPNAAKPTSTSELQVPINSPRRNISPESSDNSH
                     "
     exon            210..384
                     /gene="LARP1B"
                     /gene_synonym="LARP2"
                     /inference="alignment:Splign:2.1.0"
     exon            385..525
                     /gene="LARP1B"
                     /gene_synonym="LARP2"
                     /inference="alignment:Splign:2.1.0"
     exon            526..669
                     /gene="LARP1B"
                     /gene_synonym="LARP2"
                     /inference="alignment:Splign:2.1.0"
     exon            670..835
                     /gene="LARP1B"
                     /gene_synonym="LARP2"
                     /inference="alignment:Splign:2.1.0"
     exon            836..980
                     /gene="LARP1B"
                     /gene_synonym="LARP2"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1155
                     /gene="LARP1B"
                     /gene_synonym="LARP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1328
                     /gene="LARP1B"
                     /gene_synonym="LARP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1691
                     /gene="LARP1B"
                     /gene_synonym="LARP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1815
                     /gene="LARP1B"
                     /gene_synonym="LARP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1851
                     /gene="LARP1B"
                     /gene_synonym="LARP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..2063
                     /gene="LARP1B"
                     /gene_synonym="LARP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2170
                     /gene="LARP1B"
                     /gene_synonym="LARP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2331
                     /gene="LARP1B"
                     /gene_synonym="LARP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2476
                     /gene="LARP1B"
                     /gene_synonym="LARP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2477..2586
                     /gene="LARP1B"
                     /gene_synonym="LARP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..2714
                     /gene="LARP1B"
                     /gene_synonym="LARP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2715..4847
                     /gene="LARP1B"
                     /gene_synonym="LARP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3974..3979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LARP1B"
                     /gene_synonym="LARP2"
                     /note="hexamer: AATAAA"
     polyA_site      3993
                     /gene="LARP1B"
                     /gene_synonym="LARP2"
                     /note="major polyA site"
     regulatory      4695..4700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LARP1B"
                     /gene_synonym="LARP2"
                     /note="hexamer: AATGAA"
     polyA_site      4710
                     /gene="LARP1B"
                     /gene_synonym="LARP2"
     regulatory      4825..4830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LARP1B"
                     /gene_synonym="LARP2"
                     /note="hexamer: TATAAA"
     polyA_site      4847
                     /gene="LARP1B"
                     /gene_synonym="LARP2"
ORIGIN      
        1 agttaccagc tttggctgct cgcgcctccc caactcgggt aaagctcctc ggcctcggcg
       61 tgctgcgcct ccgcggctgc cctgcgccag aattcggttc cctcaaaatt ataaaggcag
      121 gaaagctcaa gacaaagaaa tccaacaagg ctagtgattt cagtgatatg gagaattggc
      181 caacaccaag tgaattagtg aacactggat ttcagagcgt cctcagccaa ggaaataaaa
      241 agccacaaaa tagaaaagaa aaagaagaga aggttgaaaa gagaagtaac agtgacagca
      301 aagaaaaccg ggaaacaaaa ttaaatggtc ctggtgaaaa cgtcagtgag gatgaggctc
      361 agtcaagtaa tcaacgtaag agagctaata agcacaagtg ggtaccactc cacttagatg
      421 ttgtaagatc agagagtcaa gaaagacctg gatcccggaa cagctcaaga tgtcaacctg
      481 aagcaaataa accaacacat aacaatagga gaaatgatac acgaagttgg aagcgagata
      541 gagaaaaaag ggatgatcaa gatgacgttt ccagtgtgag aagtgagggt ggtaatatcc
      601 gaggttcctt tagaggtcga ggaagaggcc gaggacgggg aagaggacga ggcagaggaa
      661 atcctcgatt gaactttgat tattcatatg gttatcaaga acatggtgaa aggactgatc
      721 aaccatttca aacagaactt aataccagta tgatgtatta ctatgatgat ggtacaggtg
      781 tacaggtgta tcctgtggaa gaagcattgc ttaaagagta tattaagcgt caaattgaat
      841 attacttcag tgtagaaaat ttggaacgag acttctttct tcggggaaag atggatgaac
      901 aaggtttctt gcctatttcc ctgattgctg gttttcagcg tgttcaggct ctcactacaa
      961 accttaatct catcttagag gcactgaagg atagcacaga agtagaaatt gtggatgaga
     1021 aaatgagaaa aaagatagaa ccagaaaaat ggccaattcc aggccctcct ccacgcagtg
     1081 tgccaccaac agacttctct caactgattg attgtccaga gtttgtacca ggccaagcct
     1141 tttgctcaca tacagagtct gccccaaatt ctccaagaat tggaagccca ttgagcccaa
     1201 agaaaaacag tgaaacaagt attcttcaag caatgtctag aggtttgtct accagtttgc
     1261 ctgacttgga ctcagaacct tggatagaag ttaaaaaaag acatcagcca gccccagtga
     1321 aattgaggga atcagtgtct gtccctgaag ggtcattaaa tcagctatgt tcttcagaag
     1381 aaccagaaca agaagaactt gattttttgt ttgatgaaga gattgaacaa ataggacgaa
     1441 aaaacacatt tactgattgg tctgataatg attcagatta tgaaattgat gaccaagact
     1501 taaacaagat tttgattgta actcagacac caccttatgt gaaaaaacat cctggaggag
     1561 atcgaacagg cacccacatg tctcgggcaa aaatcacatc tgaacttgct aaagttatca
     1621 atgatggctt atactattat gaacaggatc tatggatgga agaagatgaa aacaaacaca
     1681 cagccataaa gcaagaagtt gagaacttta agaagctaaa tctcattagt aaagagcagt
     1741 ttgaaaacct aacacctgaa cttccttttg agccaaacca agaagttcct gtagcacctt
     1801 cacagtccag gcaaggaggt gttcaaggag tgcttcacat tcccaagaaa gatttgactg
     1861 atgaattagc tcagaagtta tttgatgttt cagaaataac ttcagcagca atggttcatt
     1921 cgttgcctac agcagttcca gaatctccta gaattcatcc tacaagaaca cccaaaacac
     1981 ctcgaacacc taggttacaa gatcctaaca aaacaccaag attttatcct gttgttaaag
     2041 aaccaaaagc cattgatgta aagagtccaa gaaagagaaa aacaaggcat agcacaaatc
     2101 cccctctaga gtgtcatgtt ggttgggtaa tggattccag agaccgtggg ccaggaacat
     2161 cctctgtcag cacttcaaat gcttcacctt cagaaggcgc accactagca ggaagttatg
     2221 gatgtactcc tcattcattc ccaaagttcc agcatccttc tcatgaactt ttgaaggaaa
     2281 atggctttac ccaacaagtg taccacaagt atcgtcgaag atgcctaagt gagagaaaac
     2341 gcttgggaat tggtcagtcc caagaaatga ataccctctt tcgtttctgg tcctttttcc
     2401 tcagagatca cttcaataaa aaaatgtatg aggaatttag acaacttgct tgggaagatg
     2461 caaaagaaaa ttacaggtat gggttagaat gtctgttcag gttttatagt tatggactgg
     2521 aaaaaaaatt caggcgagaa atttttcagg atttccaaga agaaaccaaa aaagactacg
     2581 aatctggtca gctgtatgga ctagaaaagt tttgggctta tttgaaatat tctcaatcta
     2641 agacacagtc tattgaccca aaacttcagg aatacctctg tagttttaag aggttagaag
     2701 acttccgtgt tgatccccct attagtgatg aatttggaag aaaaagacat tcctctactt
     2761 ctggtgagga gagtaatcgt catagacttc cacctaattc ctctacaaag ccaccaaatg
     2821 ctgctaaacc tacatctacc agtgagcttc aggtaccaat aaactctccc agaaggaata
     2881 tttcaccgga gtccagtgac aattcacatt aaacagtgct gcctgtgtcc tgtggtctca
     2941 agaaatggtg aaatgcctga gaaatagact cttatgaaag ttctttgtcc ttgaagtcaa
     3001 catttacatc agtatttatt tggggaaaat cttctggtgt ttaattgtga taataagaaa
     3061 gaagaaaaag aaagaaaagt ggtagcattt tttctaacaa gataaattct aaaaatgttt
     3121 tccctgattt cacaaacaag gatagtcttg gtgacctttt atagagatct tctagtaatg
     3181 tattttgatc tcagatttct ttttcaaagc catggtttta caaaaacagc attccttaaa
     3241 tatatttaaa aaacaataca aggaatgcct aacatttcag ctcatacttc ttaaagaaga
     3301 tatagtatgt tgtattctct tcttagagct ttcttaaaga atccacaatc caattacccc
     3361 actgtcaatt catatttgaa cttaccaaaa caaaggagga ttacgtatat gttttttaaa
     3421 ttcaaaaaag aatatgaaat tataccttta gtatcccttt gagacatata gtttaaagaa
     3481 aacttttttt aaaacaaaag taggaatata tagtaagatt gtagttacaa tgagtatatg
     3541 cacttttgat gctaggtttt gcttttctcc ccccagtcat atctcatgat ttccacagtt
     3601 gttgtattgg tgtggagttt tctgaattgg ctataagctg attacatatt agaggtttat
     3661 ttttatgatt ctatataaac gtgcacgagt aatttaaaac ctgcattggg attgattgga
     3721 atattgtcct aaattaatta aatcttgcac tgttttgaat gcatctgcta tttatacatc
     3781 tgcaagtggg tatgtcataa ggagtcagat tatctttaat ttaaaatgaa tacttagttt
     3841 tacctttttg tttatttttt gtttaatttt gtttttataa atgttttcaa gagttatagc
     3901 aaattgattt ctaattttta ttgctattac aactgatgta aatggtagtt tcagtttttg
     3961 tgagatttaa aaaaataaag cacttattct gaattttttg aattgatttt taattatttt
     4021 tatttagaat atagttgaaa agctgtaata ttcagttttg ctagtaaaag accatttttt
     4081 tgtgtgaatg aagtttcaat tataaactta cattcacttt attgagcact acataattta
     4141 cagatatttt gttgtattgg caaaagcaag tggtttccat atgctaaatt aattgtattt
     4201 tctttttgag cagattggat atcttgttct tataaattat aatattgaaa tacatataat
     4261 ctttggatgg atgggctgtt aatttgtaaa taggttttca ttaagttatt tctcatgata
     4321 agtaataatc agcagtttta taatatttac tatttggagg gtcattttga tgctttaaat
     4381 tgcagaaata gtcaaatttg aatattcaga aaataaattt atttagatat attgtaaaga
     4441 gggtgcaaaa caagcaatgg gttagaataa tagatcttca agtcttttct taaatggggt
     4501 atgtagttcc agcttttcag tgagaaattt ccaaaccgtg cttattagct ttaaatggtc
     4561 tcttgaaatg atcataaatt tttctcagtg tcctttttgt gttgaacaca tatatctgaa
     4621 acctgtattt aaccagatat ttctactcaa ctgaatatac aagtgtaaat ttgattggaa
     4681 aattgtatat tataaatgaa aatacaataa tcaggagttt tgtggtttgt attaattagt
     4741 agttttatca tatttttatt ataaaagtaa tacatgtaca ttgggaaatt tagaaaagca
     4801 caaagaagaa aataaagtac ttgttataaa aagaagaaaa accaaaa
//
