LOCUS       NM_033551               7181 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens La ribonucleoprotein 1, translational regulator
            (LARP1), transcript variant 2, mRNA.
ACCESSION   NM_033551 XM_005268404
VERSION     NM_033551.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7181)
  AUTHORS   Ma,J., Dong,D., Qi,H., Li,J., Yu,H., Hu,X., Sun,L. and Shen,L.
  TITLE     LARP1, an RNA-binding protein, participates in ovarian cancer cell
            survival by regulating mitochondrial oxidative phosphorylation in
            response to the influence of the PI3K/mTOR pathway
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (8), 167453 (2024)
   PUBMED   39111634
  REMARK    GeneRIF: LARP1, an RNA-binding protein, participates in ovarian
            cancer cell survival by regulating mitochondrial oxidative
            phosphorylation in response to the influence of the PI3K/mTOR
            pathway.
REFERENCE   2  (bases 1 to 7181)
  AUTHORS   Chettle,J., Louie,R.J., Larner,O., Best,R., Chen,K., Morris,J.,
            Dedeic,Z., Childers,A., Rogers,R.C., DuPont,B.R., Skinner,C.,
            Kury,S., Uguen,K., Planes,M., Monteil,D., Li,M., Eliyahu,A.,
            Greenbaum,L., Mor,N., Besnard,T., Isidor,B., Cogne,B., Blesson,A.,
            Comi,A., Wentzensen,I.M., Vuocolo,B., Lalani,S.R., Sierra,R.,
            Berry,L., Carter,K., Sanders,S.J. and Blagden,S.P.
  TITLE     LARP1 haploinsufficiency is associated with an autosomal dominant
            neurodevelopmental disorder
  JOURNAL   HGG Adv 5 (4), 100345 (2024)
   PUBMED   39182167
  REMARK    GeneRIF: LARP1 haploinsufficiency is associated with an autosomal
            dominant neurodevelopmental disorder.
REFERENCE   3  (bases 1 to 7181)
  AUTHORS   Smith,B.C. and Silvers,R.
  TITLE     1H, 13C, and 15N resonance assignments of the La Motif of the human
            La-related protein 1
  JOURNAL   Biomol NMR Assign 18 (1), 111-118 (2024)
   PUBMED   38691336
  REMARK    GeneRIF: [1]H, [13]C, and [15]N resonance assignments of the La
            Motif of the human La-related protein 1.
REFERENCE   4  (bases 1 to 7181)
  AUTHORS   Bley,H., Krisp,C., Schobel,A., Hehner,J., Schneider,L., Becker,M.,
            Stegmann,C., Heidenfels,E., Nguyen-Dinh,V., Schluter,H., Gerold,G.
            and Herker,E.
  TITLE     Proximity labeling of host factor ANXA3 in HCV infection reveals a
            novel LARP1 function in viral entry
  JOURNAL   J Biol Chem 300 (5), 107286 (2024)
   PUBMED   38636657
  REMARK    GeneRIF: Proximity labeling of host factor ANXA3 in HCV infection
            reveals a novel LARP1 function in viral entry.
REFERENCE   5  (bases 1 to 7181)
  AUTHORS   Kozlov,G., Jiang,J., Rutherford,T., Noronha,A.M., Wilds,C.J. and
            Gehring,K.
  TITLE     Enhanced binding of guanylated poly(A) RNA by the LaM domain of
            LARP1
  JOURNAL   RNA Biol 21 (1), 7-16 (2024)
   PUBMED   39016322
  REMARK    GeneRIF: Enhanced binding of guanylated poly(A) RNA by the LaM
            domain of LARP1.
REFERENCE   6  (bases 1 to 7181)
  AUTHORS   McKnight,N.C., Jefferies,H.B., Alemu,E.A., Saunders,R.E.,
            Howell,M., Johansen,T. and Tooze,S.A.
  TITLE     Genome-wide siRNA screen reveals amino acid starvation-induced
            autophagy requires SCOC and WAC
  JOURNAL   EMBO J 31 (8), 1931-1946 (2012)
   PUBMED   22354037
REFERENCE   7  (bases 1 to 7181)
  AUTHORS   Burrows,C., Abd Latip,N., Lam,S.J., Carpenter,L., Sawicka,K.,
            Tzolovsky,G., Gabra,H., Bushell,M., Glover,D.M., Willis,A.E. and
            Blagden,S.P.
  TITLE     The RNA binding protein Larp1 regulates cell division, apoptosis
            and cell migration
  JOURNAL   Nucleic Acids Res 38 (16), 5542-5553 (2010)
   PUBMED   20430826
REFERENCE   8  (bases 1 to 7181)
  AUTHORS   Meek,S.E., Lane,W.S. and Piwnica-Worms,H.
  TITLE     Comprehensive proteomic analysis of interphase and mitotic
            14-3-3-binding proteins
  JOURNAL   J Biol Chem 279 (31), 32046-32054 (2004)
   PUBMED   15161933
REFERENCE   9  (bases 1 to 7181)
  AUTHORS   Horke,S., Reumann,K., Schweizer,M., Will,H. and Heise,T.
  TITLE     Nuclear trafficking of La protein depends on a newly identified
            nucleolar localization signal and the ability to bind RNA
  JOURNAL   J Biol Chem 279 (25), 26563-26570 (2004)
   PUBMED   15060081
  REMARK    GeneRIF: Nuclear trafficking of La protein depends on a newly
            identified nucleolar localization signal and the ability to bind
            RNA
REFERENCE   10 (bases 1 to 7181)
  AUTHORS   Chauvet,S., Maurel-Zaffran,C., Miassod,R., Jullien,N., Pradel,J.
            and Aragnol,D.
  TITLE     dlarp, a new candidate Hox target in Drosophila whose orthologue in
            mouse is expressed at sites of epithelium/mesenchymal interactions
  JOURNAL   Dev Dyn 218 (3), 401-413 (2000)
   PUBMED   10878606
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC112169.2.
            
            On or before Dec 13, 2018 this sequence version replaced
            XM_005268404.3, NM_033551.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1965299,
                              SAMEA1966682 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000518297.6/ ENSP00000428589.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-817               AC112169.2         147904-148720       c
            818-879             AC112169.2         113711-113772       c
            880-945             AC112169.2         113387-113452       c
            946-1120            AC112169.2         111301-111475       c
            1121-1249           AC112169.2         110374-110502       c
            1250-1450           AC112169.2         110097-110297       c
            1451-1613           AC112169.2         109835-109997       c
            1614-1758           AC112169.2         108778-108922       c
            1759-1927           AC112169.2         104338-104506       c
            1928-2097           AC112169.2         104055-104224       c
            2098-2490           AC112169.2         101698-102090       c
            2491-2614           AC112169.2         100684-100807       c
            2615-2820           AC112169.2         100352-100557       c
            2821-2927           AC112169.2         99790-99896         c
            2928-3079           AC112169.2         98065-98216         c
            3080-3224           AC112169.2         95494-95638         c
            3225-3334           AC112169.2         92741-92850         c
            3335-3462           AC112169.2         92457-92584         c
            3463-7181           AC112169.2         86492-90210         c
FEATURES             Location/Qualifiers
     source          1..7181
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.2"
     gene            1..7181
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /note="La ribonucleoprotein 1, translational regulator"
                     /db_xref="GeneID:23367"
                     /db_xref="HGNC:HGNC:29531"
                     /db_xref="MIM:612059"
     exon            1..817
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             382..3672
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     la-related protein 1; La ribonucleoprotein domain family
                     member 1"
                     /codon_start=1
                     /product="la-related protein 1 isoform 2"
                     /protein_id="NP_291029.2"
                     /db_xref="GeneID:23367"
                     /db_xref="HGNC:HGNC:29531"
                     /db_xref="MIM:612059"
                     /translation="MATQVEPLLPGGATLLQAEEHGGLVRKKPPPAPEGKGEPGPNDV
                     RGGEPDGSARRPRPPCAKPHKEGTGQQERESPRPLQLPGAEGPAISDGEEGGGEPGAG
                     GGAAGAAGAGRRDFVEAPPPKVNPWTKNALPPVLTTVNGQSPPEHSAPAKVVRAAVPK
                     QRKGSKVGDFGDAINWPTPGEIAHKSVQPQSHKPQPTRKLPPKKDMKEQEKGEGSDSK
                     ESPKTKSDESGEEKNGDEDCQRGGQKKKGNKHKWVPLQIDMKPEVPREKLASRPTRPP
                     EPRHIPANRGEIKGSESATYVPVAPPTPAWQPEIKPEPAWHDQDETSSVKSDGAGGAR
                     ASFRGRGRGRGRGRGRGRGGTRTHFDYQFGYRKFDGVEGPRTPKYMNNITYYFDNVSS
                     TELYSVDQELLKDYIKRQIEYYFSVDNLERDFFLRRKMDADGFLPITLIASFHRVQAL
                     TTDISLIFAALKDSKVVEIVDEKVRRREEPEKWPLPPIVDYSQTDFSQLLNCPEFVPR
                     QHYQKETESAPGSPRAVTPVPTKTEEVSNLKTLPKGLSASLPDLDSENWIEVKKRPRP
                     SPARPKKSEESRFSHLTSLPQQLPSQQLMSKDQDEQEELDFLFDEEMEQMDGRKNTFT
                     AWSDEESDYEIDDRDVNKILIVTQTPHYMRRHPGGDRTGNHTSRAKMSAELAKVINDG
                     LFYYEQDLWAEKFEPEYSQIKQEVENFKKVNMISREQFDTLTPEPPVDPNQEVPPGPP
                     RFQQVPTDALANKLFGAPEPSTIARSLPTTVPESPNYRNTRTPRTPRTPQLKDSSQTS
                     RFYPVVKEGRTLDAKMPRKRKTRHSSNPPLESHVGWVMDSREHRPRTASISSSPSEGT
                     PTVGSYGCTPQSLPKFQHPSHELLKENGFTQHVYHKYRRRCLNERKRLGIGQSQEMNT
                     LFRFWSFFLRDHFNKKMYEEFKQLALEDAKEGYRYGLECLFRYYSYGLEKKFRLDIFK
                     DFQEETVKDYEAGQLYGLEKFWAFLKYSKAKNLDIDPKLQEYLGKFRRLEDFRVDPPM
                     GEEGNHKRHSVVAGGGGGEGRKRCPSQSSSRPAAMISQPPTPPTGQPVREDAKWTSQH
                     SNTQTLGK"
     exon            818..879
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            880..945
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1120
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1249
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1450
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1613
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1758
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1927
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2097
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2490
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2491..2614
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2615..2820
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2821..2927
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2928..3079
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3080..3224
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3225..3334
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3335..3462
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3463..7181
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7159..7164
                     /regulatory_class="polyA_signal_sequence"
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /note="hexamer: AATAAA"
     polyA_site      7181
                     /gene="LARP1"
                     /gene_synonym="Lar1; LARP; Lhp1"
                     /note="major polyA site"
ORIGIN      
        1 gtccatattg ctgcagcccc cgagccggga agcccgggcc gccccggggg cgggggggag
       61 ggagggacgg gactagaagc ctgccgggct cggggtgggg gcgtcttgcg aggaacgggc
      121 ggggggggac gcacgcctag gaggcctgga ctgcagagtg gggggccttc ctcccccccc
      181 gccccgctag tgggcctcgg atttacggcg gctgcatcta actgggaggg ggccgcacct
      241 cgcgtgaacc ccgacccttc tctgcaggga ctggggccca gcgccccgga ggaaggcgtc
      301 gcgggcgctc tgctagccaa gttcgaggcg ggggaggcag cctcgggcgc gcccggcttc
      361 tccggggggg cgggcgcgca gatggccact caggtggagc cgctgctgcc tgggggcgcc
      421 acgctcttgc aggccgaaga gcacgggggg ctggtgagga agaagccgcc gccggcgccc
      481 gagggcaagg gcgagcccgg gccaaacgac gtccgcgggg gggagccgga cggcagcgct
      541 cggagacccc ggccgccctg cgccaagccg cacaaggagg gcaccgggca gcaggagcgc
      601 gagagcccgc ggccgctgca gctgcccggc gccgaaggcc cggccatcag cgacggggag
      661 gagggcggcg gcgagccagg cgctggcgga ggagctgccg gagccgcggg cgcggggcgc
      721 cgggacttcg tggaagcccc cccgcccaag gtgaacccgt ggactaagaa cgcattgccg
      781 ccggtcctga ccaccgtgaa cggacagtcc cccccagaac actctgctcc agccaaggtg
      841 gtgagggcag ctgttcctaa acagcgcaaa ggcagcaagg ttggtgactt tggagatgca
      901 atcaattggc ccacacctgg agagatagcc cacaagagtg ttcagccaca gtcccacaag
      961 cctcagccta cccgtaaact gccacccaag aaggacatga aggaacagga gaaaggagaa
     1021 gggagtgata gtaaggagag tccaaaaacc aaatcagatg aatcagggga ggaaaagaat
     1081 ggagatgagg attgccagcg aggcgggcag aagaagaaag gaaacaaaca caagtgggtt
     1141 ccattacaaa tagacatgaa gcctgaagtg cccagagaga aactggcttc acgccccact
     1201 cgcccaccgg agcctagaca catacctgcc aatcgcggag agatcaaagg gtctgagtct
     1261 gccacctacg tgcccgtggc cccccccacc ccagcctggc aaccagagat caaaccggag
     1321 cctgcctggc acgaccagga tgagacatcg agtgtgaaga gtgatggggc tggtggggcg
     1381 cgggcttcct tccgtggccg tggacggggg cgtggtcgcg gccggggacg cggccggggt
     1441 ggcactcgaa cccattttga ctaccagttt ggctaccgaa agtttgatgg tgtggagggg
     1501 cctcgtacgc ccaagtacat gaacaacatc acctactact ttgacaatgt cagcagcacc
     1561 gagctttaca gtgtggatca ggaactgctc aaagactaca tcaagcgcca gattgaatac
     1621 tacttcagcg tggacaattt agagcgagac ttcttcctgc gaaggaaaat ggatgctgat
     1681 ggtttcctac ccatcaccct tattgcttcc ttccaccgag tgcaggccct taccactgac
     1741 atttcactca tctttgcggc cctaaaggac agcaaggtgg tggagatcgt tgatgagaaa
     1801 gttcgtagga gggaggaacc agaaaagtgg cctcttcccc caatagtgga ttattcacag
     1861 actgatttct cccagcttct caactgccct gaatttgttc cccgtcagca ctaccaaaag
     1921 gagacagagt cggcacctgg ctctcctcgt gcagtcaccc cagtgccaac caaaacagag
     1981 gaggtcagca acctaaagac actacccaag ggcctgtctg ccagcctgcc tgacctggat
     2041 tctgagaact ggattgaagt gaagaagagg cctcggccat ccccagcacg gcccaagaag
     2101 tcagaggagt ccagattttc ccacctgacc tctctgcctc agcagctgcc ttcccagcag
     2161 ctgatgtcca aggatcagga tgagcaagag gaactggatt ttctgtttga cgaggagatg
     2221 gagcagatgg atgggcggaa gaacaccttc actgcctggt ctgatgagga atctgactat
     2281 gagattgatg acagggatgt caacaagatc ctcattgtca cccagacacc acattacatg
     2341 cgccggcacc caggggggga ccgcacaggc aaccacacct cgcgtgccaa gatgagcgcc
     2401 gaactggcca aggtcattaa tgatggcctc ttctactatg agcaggacct gtgggctgaa
     2461 aagtttgaac ctgagtattc ccagatcaag caagaagtcg agaacttcaa aaaggtcaat
     2521 atgatcagcc gggagcagtt tgacacactg acccctgagc cccctgtgga tcccaaccag
     2581 gaagttcctc ctgggccacc tcggttccag caagttccta cggatgccct ggccaacaag
     2641 ttgtttggtg ctcctgagcc ctccaccatc gcccgctctc taccaaccac tgtcccagag
     2701 tcaccaaact accgcaacac caggacccct cgcactcccc ggacaccaca gctcaaagac
     2761 tcaagccaga catcacggtt ttacccagtg gtgaaagaag gacggacact ggatgccaag
     2821 atgcctcgaa aaagaaagac aagacacagt tcaaacccac ccttggagag ccatgtgggc
     2881 tgggtgatgg attcccgtga gcacaggccc cgtactgctt ccatcagctc cagcccctca
     2941 gaagggacgc ctacagttgg cagctatggc tgtacccctc agtcattgcc caagttccag
     3001 catccttccc atgaactgct caaggaaaat ggcttcacac aacacgtcta ccataagtat
     3061 cgtaggcgct gccttaatga gcggaaacgc ttgggcattg gccagtctca ggagatgaac
     3121 acactcttcc gcttctggtc cttcttcctc cgagatcact tcaacaaaaa gatgtatgag
     3181 gagttcaagc agctggctct ggaggacgcc aaagaaggct acagatatgg tttggagtgc
     3241 ctttttcgat actacagtta tggcctggaa aagaagttcc ggctggacat attcaaggat
     3301 tttcaggagg aaacggtgaa ggactatgaa gctggccaac tgtatgggct ggagaagttc
     3361 tgggccttct tgaaatattc caaagccaaa aatttggaca ttgaccccaa actgcaagaa
     3421 tacctcggca aattccgacg tcttgaagac ttccgagtag atccccccat gggtgaggag
     3481 ggcaaccaca agcgacactc agtggtagca ggaggtggcg gcggtgaggg caggaagcgg
     3541 tgcccctccc agtcttccag caggcctgct gccatgatca gccaaccccc tacaccaccc
     3601 accggccagc ctgtccggga agatgccaaa tggacaagcc agcactcgaa cacacagact
     3661 ttgggaaagt gaaaagctcc ttagccctgg ggcttgaggg gggaaagggg tagggtgggt
     3721 aagagtccat gggggtgccc agtcccagga aaggggacaa tgaagggaca ggcctggagt
     3781 tactaggaca ggcctttgtg ctgagtagca atgtatacac catttgggct atcagaggta
     3841 cccctgggca ggagcctcta catccccttc cccctcctct ctccatgact cttgacatcc
     3901 tagcttcttc taagggggga gggaaagggg ggagattttt atatatatat acatatatat
     3961 atatcaagtt ttaaattatt gatagttcat ctggattacc aaaatcactc tgcagccctg
     4021 cccgaggcta gtaggctgca accctggtcc ccacccctaa cctcctgctc cccctcaagc
     4081 caactatgca gcccacaaga aggccctgcg ggccccccca ttgcccagca ctgtctcata
     4141 gaaggctctg gtggtacctc tgggccccag gagcatcagc cccttgatca tctggggttt
     4201 gtcatcacca tattttctcc ctgctgttcc caccatgccc ttctgccatc ttctgggaga
     4261 aggaaaccaa aggatctaaa actggggttt gggggaaggt ttcagcctct ccccactccc
     4321 cttgccccac accctttact ccccagccca gagagacgct gcttttacca ggaaagacta
     4381 ttgaaagatg ttttatttta tttttctctg acctttccat ccttgaaaaa atggggaaaa
     4441 aagaagaaaa aagacaaaat cgaccataaa agaccaaaaa aaaaaaaaaa atcagaaaac
     4501 ccccacctaa tccacagaaa gtaatgtctt tcccctcccc ttggaatttt tgttttgttt
     4561 ttggaaataa tattttttta aaagttgcct tattgtggag cgggaatctg aaatacccaa
     4621 atgcctgttt tcctcggtgg agtcaacccg aagagctccc accttctctg gatgtgcctg
     4681 ggcttggact ggctagaatc tttctctgga ctgttgcatg tacagtgcct ccatcctgga
     4741 ggcaagagag ttgggagtgg ctcgaatcag agccgtgccc aagatatccc tgctgttgca
     4801 tcgtttgaag ctgacgtcct gtgtctgtac actgctgcca ctgttgtgtc ctcgctctgc
     4861 ttgctgttgc ctcacgccag gccccgtcct gccgtgacac ccttcatcct acccttggaa
     4921 ccccaaggcc aagttggttc aaactgttgg agaacagagt tggcctgcat ctggaacaca
     4981 cttgtcctca gcttaccatc tcctcacacc ccagagtgga aaggtgaaca cctgcagctg
     5041 aggcttggaa acgtttcttg tgttgccctg aaaaatcttt gagacctcag ggaggctctg
     5101 tctctcttaa aaggtggaga aagatgccat tctctcccta aggtctggtg gagtctcccc
     5161 atcttgcata cccttctgca agccatctat ctctgctcac tctccaattg acccgcctgg
     5221 gaacaaggga tgaggaggag ttgggggctg gggggaatcc tgccagttgg tgaagccctg
     5281 tggcaggaag gtatatgtgg acatagagta tacctgattc tctttcttca gccactgact
     5341 gcttgggttg ggctgtgaat gataatggaa tggctggagt ctgctgttgt cagaaggcag
     5401 ggagggtgat gaaggactga cccacatgga ctgggatgtg tgtcggttat gggcatgact
     5461 gcacgttcac tctcagtggg atctgggcaa catggagttc attgtcctgt tgcttactta
     5521 ctgcaatgtc tttggccctc cttttcaact ggttcctctg ttgggcccaa aggttgggag
     5581 taggagacag tatcccaggc tgacaagggc ttgcccttta ccttgggcac cttgttaatt
     5641 tttagcctgt gcccttcccc acctttgccc tcccagtggt tggtatgtgg gaagcccatc
     5701 tcagttcctg tgacttcatg tctcaaacca aggatgagcg tctggtctct gctatgatgg
     5761 tggtatccga ggcctttccc tgcccagtct ggtgcctgcc ccacattgta ccggacactg
     5821 gattcctgga cccccttctc ctttcctttc tttccttcag gtcacgcagc cctgtactgt
     5881 atccagcacc acagaaacct cagtgttttt cctctgctgg tttggggcac aaggaagcct
     5941 tagggtatgg ggaaaggctg ttattaccta gagtttactc ccaggccagg gggctgccat
     6001 cttcttcaca gacatccctg aaaggaagcc cctttggggc agggaggtga ggacttcatc
     6061 tcaacatcgg ctggtggttg gtaggggagc tttttctttt ctttcctttt tttttgtttt
     6121 tgtttttgtt tttgtttttg gtaacatgtt aggagttaat gttgcaaaga gtagtttaca
     6181 tcttcacttt ctgaagacac ttgaatttag gaccgatgta tctgtgacaa gcatgccaga
     6241 agtggcaggg gccatcaggg ctaaccactt cacacctacc atcgtcccat ggggatccaa
     6301 gacctgagat aaagcaacag cctgcccaga tccctctgtt catcctatcc cttccaaggt
     6361 tggtccatgc caacataacc tctgggcatc agacatcagc aggtctgtgt gcctcagccc
     6421 tgttaagggg caggtttctc tttagccctc ttcctgcact tgggagcaaa ggcactacca
     6481 gtagagaagg gccatccagc cgtgccccag cctggacccc tggggctcag atagaggtgc
     6541 tgagcccctg tgtcaaagtt gttaaatgtt tttgttttgt tccattgtag ctcttttttt
     6601 ttttttttcc cctttcctgg tgattgattt tacaaaagaa agtaagctgc ttagaaggcc
     6661 ctggaaggga agtgaggagg agggacaagg aagatgacta gttacggagg gtgagggttg
     6721 ttttttgcca aaaagcctgg gtagagtgat ctgaattatc tggcaccctc ctgaatggaa
     6781 ccccagagta cctcctgtgt ggaagggtcc ctggattttc cctaacaccc accctctccc
     6841 ccttcagcca tgctgatggc agagaagata agaacttgga gcccatttct cactggagag
     6901 gaaaacttgt catctggctt tgcggagaag gttccacctt acgctcgtag tacattatct
     6961 ttactatgtg ctaggatatc atatttaaaa ggacaaaaaa atgtaaaata cttgaatgag
     7021 cttgtattat aacattaata ttattgagag tatctgcttt ccaggctgaa gtgattcatt
     7081 cattattcta gtcctgcttt agtcctttgt aatttgtggt aattatgctt ttctttttaa
     7141 tacaaaaaaa tgtataaaaa taaacacttg aaaaggcaaa a
//
